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Search for Parkinson-related genes and their functional analysis

Research Project

Project/Area Number 17019044
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

TODA Tatsushi  Osaka University, 大学院・医学研究科, 教授 (30262025)

Co-Investigator(Kenkyū-buntansha) MURATA Miho  国立精神・神経医療研究センター, 神経内科, 部長 (30282643)
HATTORI Nobutaka  順天堂大学, 医学部, 教授 (80218510)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥35,200,000 (Direct Cost: ¥35,200,000)
Fiscal Year 2009: ¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 2008: ¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 2007: ¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 2006: ¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 2005: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordsパーキンソン病 / 多因子病 / SNP / 病患感受性遺伝子 / 薬剤副作用 / オーダーメイド医療 / マイクロサテライト / ゲノムワイド関連解析 / 疾患感受性遺伝子
Research Abstract

To identify PD-susceptibility variants, we performed a GWAS and two replication studies. Our data show two novel PD-susceptibility loci, involvement of causal genes of autosomal dominant parkinsonism in typical PD, and the possibility that population differences underlie genetic heterogeneity in PD.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (163 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (133 results) (of which Peer Reviewed: 78 results) Presentation (19 results) Book (3 results) Remarks (8 results)

  • [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease2009

    • Author(s)
      Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T.
    • Journal Title

      Nature Genet 41

      Pages: 1303-1307

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease2009

    • Author(s)
      Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Durr A, Eblan MJ, Fahn S, Farrer MJ, Fung HC, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen GJ, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, Spitz M, Tan EK, Tayebi N, Toda T, Troiano AR, Tsuji S, Wittstock M, Wolfsberg TG, Wu YR,
    • Journal Title

      N Engl J Med 361

      Pages: 1651-1661

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregate inhibitors to the expanded polyglutamine stretch.2009

    • Author(s)
      Okamoto Y, Nagai Y, Fujikake N, Popiel HA, Yoshioka T, Toda T, Inui T.
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 634-639

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice.2009

    • Author(s)
      Popiel HA, Nagai Y, Fujikake N, Toda T.
    • Journal Title

      Neurosci Lett 449

      Pages: 87-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease.2009

    • Author(s)
      Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, Hattori N, Murata M, Toda T, Tsuji S.
    • Journal Title

      Arch Neurol 66

      Pages: 571-576

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests.2009

    • Author(s)
      Shikishima C, Hiraishi K, Yamagata S, Sugimoto Y, Takemura R, Ozaki K, Okada M, Toda T, Ando J.
    • Journal Title

      Intelligence 37

      Pages: 256-267

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy.2009

    • Author(s)
      Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T.
    • Journal Title

      Hum Mol Genet 18

      Pages: 621-631

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice.2009

    • Author(s)
      Popiel HA
    • Journal Title

      Neurosci Lett 449

      Pages: 87-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregate inhibitors to the expanded polyglutamine stretch.2009

    • Author(s)
      Okamoto Y
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 634-639

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study on polyglutamine binding peptide QBP1.2009

    • Author(s)
      Tomita K
    • Journal Title

      Bioorg Med Chem 17

      Pages: 1259-1263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A locus for ophthalmo-acromelic syndrome mapped to 10p 11.23.2009

    • Author(s)
      Hamanoue H
    • Journal Title

      Am J Med Genet 419A

      Pages: 336-342

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy.2009

    • Author(s)
      Kanagawa M
    • Journal Title

      Hum Mol Genet 18

      Pages: 621-631

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease.2009

    • Author(s)
      Mitsui J
    • Journal Title

      Arch Neurol 66

      Pages: 571-576

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests.2009

    • Author(s)
      Shikishima C
    • Journal Title

      Intelligence 37

      Pages: 256-267

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the complex 7q21.3 rearrangement in a patient with bilateral split-foot malformation and hearing loss.2009

    • Author(s)
      Saitsu H
    • Journal Title

      Am J Med Genet 149A

      Pages: 1224-1230

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy (FCMD) patient.2009

    • Author(s)
      Xiong H
    • Journal Title

      Am J Med Genet 149A

      Pages: 2403-2408

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.2009

    • Author(s)
      Sidransky E
    • Journal Title

      N Engl J Med 361

      Pages: 1651-1661

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.2009

    • Author(s)
      Satake W
    • Journal Title

      Nature Genet 41

      Pages: 1303-1307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性パーキンソン病は孤発性パーキンソンのモデルになるか?2009

    • Author(s)
      水田依久子
    • Journal Title

      Frontiers in Parkinson Disease 2

      Pages: 79-87

    • Related Report
      2009 Annual Research Report
  • [Journal Article] パーキンソン病関連遺伝子の全ゲノム関連解析2009

    • Author(s)
      戸田達史
    • Journal Title

      最新医学 64

      Pages: 872-879

    • Related Report
      2009 Annual Research Report
  • [Journal Article] パーキンソン病のゲノムワイド関連解析2009

    • Author(s)
      戸田達史
    • Journal Title

      細胞 41

      Pages: 198-202

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 孤発性パーキンソン病の分子遺伝学2009

    • Author(s)
      三井純, 戸田達史
    • Journal Title

      実験医学 増刊 27

      Pages: 1854-1859

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 福山型先天性筋ジストロフィー2009

    • Author(s)
      戸田達史
    • Journal Title

      小児科 50

      Pages: 899-906

    • NAID

      10008311277

    • Related Report
      2009 Annual Research Report
  • [Journal Article] パーキンソン病のゲノミックス2009

    • Author(s)
      戸田達史
    • Journal Title

      老年精神医学雑誌 20

      Pages: 973-979

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 福山型筋ジストロフィーおよび類縁疾患の病態・治療戦略2009

    • Author(s)
      戸田達史
    • Journal Title

      臨床神経学 49

      Pages: 859-862

    • NAID

      10026290982

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy2009

    • Author(s)
      Kanagawa M
    • Journal Title

      Hum Mol Genet 18

      Pages: 621-631

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregate inhibitors to the expanded polyglutamine stretch2009

    • Author(s)
      Okamoto Y
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 634-639

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study on polyglutamine binding peptide QBP12009

    • Author(s)
      Tomita K
    • Journal Title

      Bioorg Med Chem 17

      Pages: 1259-1263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease2009

    • Author(s)
      Mitsui J
    • Journal Title

      Arch Neurol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests2009

    • Author(s)
      Shikishima C
    • Journal Title

      Intelligence (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease.2008

    • Author(s)
      Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo SI, Mizuno Y, Toda T, Hattori N.
    • Journal Title

      J Hum Genet 53

      Pages: 1012-1015

    • NAID

      10025584966

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of sarcospan in muscles of Fukuyama congenital muscular dystrophy.2008

    • Author(s)
      Wakayama Y, Inoue M, Kojima H, Yamashita S, Shibuya S, Jimi T, Hara H, Matsuzaki Y, Oniki H, Kanagawa M, Kobayashi K, Toda T.
    • Journal Title

      Histol Histopathol 23

      Pages: 1425-1438

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.2008

    • Author(s)
      Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T.
    • Journal Title

      J Biol Chem 283

      Pages: 26188-26197

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation2008

    • Author(s)
      Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.
    • Journal Title

      Nature Neurosci 11

      Pages: 923-931

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calbindin 1, fibroblast growth factor 20, and・-synuclein in Parkinson's disease.2008

    • Author(s)
      Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Hum Genet 124

      Pages: 89-94

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinson's disease2008

    • Author(s)
      Kumazawa R, Tomiyama H, Li Y, Imamichi Y, Funayama M, Yoshino H, Yokochi F, Fukusako T, Takehisa Y, Kashihara K, Kondo T, Elibol B, Bostantjopoulou S, Toda T, Takahashi H, Yoshii F, Mizuno Y, Hattori N.
    • Journal Title

      Arch Neurol 65

      Pages: 802-808

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seizure-genotype relationship in Fukuyama-type congenital muscular dystrophy.2008

    • Author(s)
      Yoshioka M, Higuchi Y, Fujii T, Aiba H, Toda T.
    • Journal Title

      Brain Dev 30

      Pages: 59-67

    • NAID

      10024137147

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease2008

    • Author(s)
      Kumazawa R
    • Journal Title

      Arch Neurol 65

      Pages: 802-808

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calbindin 1, fibroblast growth factor 20, and a-synuclein in Parkinson's disease2008

    • Author(s)
      Mizuta I
    • Journal Title

      Hum Genet 124

      Pages: 89-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation2008

    • Author(s)
      Sato S
    • Journal Title

      Nature Neurosci 11

      Pages: 923-931

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones2008

    • Author(s)
      Fujikake N
    • Journal Title

      J Biol Chem 283

      Pages: 26188-26197

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of sarcospan in muscles of Fukuyama congenital muscular dystrophy2008

    • Author(s)
      Wakayama Y
    • Journal Title

      Histol Histopathol 23

      Pages: 1425-1438

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease2008

    • Author(s)
      Tomiyama H
    • Journal Title

      J Hum Genet 53

      Pages: 1012-1015

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of the aggregate inhibitor peptide QBP 1 into the mouse brainusing PTDs and its therapeutic effect on polyglutamine disease mice2008

    • Author(s)
      Popiel HA
    • Journal Title

      Neurosci Lett 449

      Pages: 87-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 福山型筋ジストロフィー2008

    • Author(s)
      戸田達史
    • Journal Title

      ビジュアル疾患解説眼で見る遺伝病とターナー症候群 2

      Pages: 6-7

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 孤発性パーキンソン病のゲノムワイドスクリーニング2008

    • Author(s)
      戸田達史
    • Journal Title

      ゲノム医学 8

      Pages: 21-26

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 認知と遺伝子2008

    • Author(s)
      小林千浩
    • Journal Title

      Cognition and Dementia 7

      Pages: 35-43

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 筋ジストロフィー2008

    • Author(s)
      谷口真理子
    • Journal Title

      小児内科 40

      Pages: 1308-1314

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 孤発性パーキンソン病のメカニズム2008

    • Author(s)
      水田依久子
    • Journal Title

      成人病と生活習慣病 38

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Alzheimer病と遺伝2008

    • Author(s)
      戸田達史
    • Journal Title

      成人病と生活習慣病 38

      Pages: 1205-1210

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 福山型筋ジストロフィーの発見とその類縁疾患における病態2008

    • Author(s)
      戸田達史
    • Journal Title

      蛋白質核酸酵素 53

      Pages: 1771-1780

    • NAID

      40016244595

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Mutation analysis of the PINKJ gene in 391 patients with Parkinson's disease.2008

    • Author(s)
      Kumazawa, R
    • Journal Title

      Arch Neurol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype.2007

    • Author(s)
      Kano H, Kurahashi H, Toda T.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 19034-19039

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of polyglutamine protein oligomers in cells by fluorescence correlation spectroscopy.2007

    • Author(s)
      Takahashi Y, Okamoto Y, Popiel HA, Fujikake N, Toda T, Kinjo M, Nagai Y.
    • Journal Title

      J Biol Chem 282

      Pages: 24039-24048

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redefining the disease locus of 16q22. 1-linked autosomal dominant cerebellar ataxia.2007

    • Author(s)
      Amino T, Ishikawa K, Toru S, Ishiguro T, Sato N, Tsunemi T, Murata M, Kobayashi K, Inazawa J, Toda T, Mizusawa H.
    • Journal Title

      J Hum Genet 52

      Pages: 643-649

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial tandem duplication of GRIA3 in a male with mental retardation.2007

    • Author(s)
      Chiyonobu T, Hayashi S, Kobayashi K, Morimoto M, Miyanomae Y, Nishimura A, Nishimoto A, Ito C, Imoto I, Sugimoto T, Jia Z, Inazawa J, Toda T.
    • Journal Title

      Am J Med Genet 143

      Pages: 1448-1455

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population2007

    • Author(s)
      Satake W, Mizuta I, Suzuki S, Nakabayashi Y, Ito C, Watanabe M, Takeda A, Hasegawa K, Sakoda S, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Neuroreport 18

      Pages: 937-940

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007

    • Author(s)
      Nagai Y, Inui T, Popiel HA, Fujikake N, Hasegawa K, Urade Y, Goto Y, Naiki H, Toda T.
    • Journal Title

      Nature Struct Mol Biol 14

      Pages: 332-340

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mouse.2007

    • Author(s)
      Saito F, Masaki T, Saito Y, Nakamura A, Takeda S, Shimizu T, Toda T, Matsumura K.
    • Journal Title

      J Neurochem 101

      Pages: 1712-1722

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LRRK2 G2385R variant is a risk factor for parkinson disease in Asian population.2007

    • Author(s)
      Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neuroreport 18

      Pages: 273-275

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamine- induced neurodegeneration in vivo.2007

    • Author(s)
      Popiel HA, Nagai Y, Fujikake N, Toda T.
    • Journal Title

      Mol Ther 15

      Pages: 303-309

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LRRK2 G2385R variant is a risk factor for parkinson disease in Asian population.2007

    • Author(s)
      Funayama, M
    • Journal Title

      Neuroreport 18

      Pages: 273-275

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mouse.2007

    • Author(s)
      Saito, F
    • Journal Title

      J Neurochem 101

      Pages: 1712-1722

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.2007

    • Author(s)
      Satake, W
    • Journal Title

      Neuroreport 18

      Pages: 937-940

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A toxic monomeric conformet of the polyglutamine protein.2007

    • Author(s)
      Nature, Y
    • Journal Title

      Nature Struct Mol Biol 14

      Pages: 332-340

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial tandem duplication of GRIA3 in a male with mental retardation.2007

    • Author(s)
      Chiyonobu, T
    • Journal Title

      Am J Med Genet 143

      Pages: 1448-1455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redefining the disease locus of 1 6q22.1-linked autosomal dominant cerebellar ataxia.2007

    • Author(s)
      Amino, T
    • Journal Title

      J Hum Genet 52

      Pages: 643-649

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of polyglutamine protein oligolners in cells by fluorescence correlation spectroscopy.2007

    • Author(s)
      Takahashi, Y
    • Journal Title

      J Biol Chem 282

      Pages: 24039-24048

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seizure-genotype relationship in Fukuyama-type congenital muscular dystrophy.2007

    • Author(s)
      Yoshioka, M
    • Journal Title

      Brain Dev 30

      Pages: 59-67

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse_dactylaplasia phenotype.2007

    • Author(s)
      Kano, H
    • Journal Title

      Proc Nati Acad Sci USA 104

      Pages: 19034-19039

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポリグルタミン病に対する治療戦略2007

    • Author(s)
      永井義隆
    • Journal Title

      BRAIN NERVE 59

      Pages: 393-404

    • Related Report
      2007 Annual Research Report
  • [Journal Article] パーキンソン病の分子遺伝学2007

    • Author(s)
      戸田達史
    • Journal Title

      BRAIN NERVE 59

      Pages: 815-523

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 班会議に行こう?贈る言葉あれこれ2007

    • Author(s)
      戸田達史
    • Journal Title

      分子細胞治療リレー放談 6

      Pages: 494-494

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 神経疾患とゲノム2007

    • Author(s)
      戸田達史
    • Journal Title

      最新医学 62S

      Pages: 2153-2163

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 福山型遺伝子フクチン同定のヒント,幸運とそれから2007

    • Author(s)
      戸田達史
    • Journal Title

      臨床神経学 47

      Pages: 743-748

    • NAID

      10020102471

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ポストゲノム時代の神経疾患の分子遺伝学2007

    • Author(s)
      戸田達史
    • Journal Title

      神経治療学 24

      Pages: 641-645

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 福山型先天性筋ジストロフィー2007

    • Author(s)
      戸田達史
    • Journal Title

      Clin Neurosci 26

      Pages: 163-167

    • NAID

      10008311277

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Protein transduction domain-mediated delivery of the aggregate inhibitor peptide QBP1 suppresses polyglutamine-induced neurodegeneration in vivo.2007

    • Author(s)
      Popiel HA
    • Journal Title

      Mol Ther 15

      Pages: 303-309

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LRRK2 G2385R variant is a risk factor for parkinson disease in Asian population.2007

    • Author(s)
      Funayama M
    • Journal Title

      Neuroreport (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mouse.2007

    • Author(s)
      Saito F
    • Journal Title

      J Neurochem (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.2007

    • Author(s)
      Satake W
    • Journal Title

      Neuroreport (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007

    • Author(s)
      Nagai Y
    • Journal Title

      Nat Struct Mol Biol (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Partial tandem duplication of GRIA3 in a male with mental retardation.2007

    • Author(s)
      Chiyonobu T
    • Journal Title

      Am J Med Genet (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PARK 1, PARK4 (α -synuclein)2007

    • Author(s)
      水田依久子
    • Journal Title

      Clin Neurosci 25

      Pages: 72-73

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Registry of adolescent and young adult twins in the Tokyo area.2006

    • Author(s)
      Shikishima C, Ando J, Ono Y, Toda T, Yoshimura K.
    • Journal Title

      Twin Res Hum Genet 9

      Pages: 811-816

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The genetic and molecular basis of muscular dystrophy: roles of cell-matrix linkage in the pathogenesis.2006

    • Author(s)
      Kanagawa M, Toda T.
    • Journal Title

      J Hum Genet 51

      Pages: 915-927

    • NAID

      10019380269

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of a-dystroglycan.2006

    • Author(s)
      Xiong H, Kobayashi K, Tachikawa M, Manya H, Takeda S, Chiyonobu T, Fujikake N, Wang F, Nishimoto A, Morris GE, Nagai Y, Kanagawa M, Endo T, Toda T.
    • Journal Title

      Biochem Biophys Res Commun 350

      Pages: 935-941

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Candidate genes for male factor infertility- validation.2006

    • Author(s)
      Mori T, Kurahashi H, Shinka T, Nakahori Y, Taniguchi M, Toda T, Iwamoto T.
    • Journal Title

      Fertil Steril 86

      Pages: 1553-1554

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of Fukuyama-type congenital muscular dystrophy with a very mild mental deficit.2006

    • Author(s)
      Hino-Fukuyo N, Haginoya K, Hayashi YK, Nishino I, Murakami T, Nonaka I, Togashi K, Tanaka S, Takayanagi M, Yokoyama H, Sakamoto O, Abe T, Toda T, Iinuma K.
    • Journal Title

      Neuromuscul Disord 16

      Pages: 274-276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant neuromuscular junctions and delayed terminal muscle fiber maturation in・-dystroglycanopathies2006

    • Author(s)
      Taniguchi M, Kurahashi H, Noguchi S, Fukudome T, Okinaga T, Tsukahara T, Tajima Y, Ozono K, Nishino I, Nonaka I, Toda T.
    • Journal Title

      Hum Mol Genet 15

      Pages: 1279-1289

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple candidate gene analysis identifies a-synuclein as a susceptibility gene for sporadic Parkinson's disease.2006

    • Author(s)
      Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T.
    • Journal Title

      Hum Mol Genet 15

      Pages: 1151-1158

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of muscles from Fukuyama-type congenital muscular dystrophy and laminin-・2 deficient congenital muscular dystrophy; is congenital muscular dystrophy a primary fibrotic disease?2006

    • Author(s)
      Taniguchi M, Kurahashi H, Noguchi S, Sese J, Okinaga T, Tsukahara T, Guicheney P, Ozono K, Nishino I, Morishita S, Toda T.
    • Journal Title

      Biochem Biophys Res Commun 342

      Pages: 489-502

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical heterogeneity of a-synuclein gene duplication in Parkinson's disease.2006

    • Author(s)
      Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N.
    • Journal Title

      Ann Neurol 59

      Pages: 298-309

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.2006

    • Author(s)
      Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu CS, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N.
    • Journal Title

      Mov Disord 21

      Pages: 1102-1108

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective effect of novel histone deacetylase inhibitors against polyglutamine toxicity.2006

    • Author(s)
      Kariya S, Hirano M, Uesato S, Nagai Y, Nagaoka Y, Furiya Y, Asai H, Fujikake N, Toda T, Ueno S.
    • Journal Title

      Neurosci Lett 392

      Pages: 213-215

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple candidate gene analysis identifies α-synuclein as a susceptibility gene for sporadic Parkinson's disease.2006

    • Author(s)
      Mizuta I
    • Journal Title

      Hum Mol Genet 15

      Pages: 1151-1158

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profiling of muscles from Fukuyama-type congenital muscular dystrophy and laminin-a2 deficient congenital muscular dystrophy; is congenital muscular dystrophy a primary fibrotic disease?2006

    • Author(s)
      Taniguchi M
    • Journal Title

      Biochem Biophys Res Commun 342

      Pages: 489-502

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Aberrant neuromuscular junctions and delayed terminal muscle fiber maturation in α-dystroglycanopathies.2006

    • Author(s)
      Taniguchi M
    • Journal Title

      Hum Mol Genet 15

      Pages: 1279-1289

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A case of Fukuyama-type congenital muscular dystrophy with a very mild mental deficit.2006

    • Author(s)
      Hino-Fukuyo N
    • Journal Title

      Neuromuscul Disord 16

      Pages: 274-276

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.2006

    • Author(s)
      Tomiyama H
    • Journal Title

      Mov Disord 21

      Pages: 1102-1108

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Candidate genes for male factor infertility-validation.2006

    • Author(s)
      Mori T
    • Journal Title

      Fertil Steril 86

      Pages: 1553-1554

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of α-dystroglycan.2006

    • Author(s)
      Xiong H
    • Journal Title

      Biochem Biophys Res Commun 350

      Pages: 935-941

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The genetic and molecular basis of muscular dystrophy : roles of cell-matrix linkage in the pathogenesis.2006

    • Author(s)
      Kanagawa M
    • Journal Title

      J Hum Genet 51

      Pages: 915-927

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ジストログリカンの糖鎖修飾と先天性筋ジストロフィー2006

    • Author(s)
      金川基
    • Journal Title

      THE LUNG perspectives 14

      Pages: 323-329

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 福山型筋ジストロフィー2006

    • Author(s)
      戸田達史
    • Journal Title

      小児科診療 (小児科診療)

      Pages: 517-525

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gytoprotective effect of novel histone deacetylase inhibitors against polyglutamine toxicity.2006

    • Author(s)
      Kariya S
    • Journal Title

      Neurosci Lett 392

      Pages: 213-215

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical heterogeneity of a-synuclein gene duplication in parkinson's disease.2006

    • Author(s)
      Nishioka K
    • Journal Title

      Ann Neurol 59

      Pages: 298-309

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinicogenetic study of mutations in LRRK2 exon41 in Parkinson's disease patients from 18 countries.2006

    • Author(s)
      Tomiyama H
    • Journal Title

      Mov Disord in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression profiling of muscles from Fukuyama-type congenital muscular dystrophy and Iaminin-a2 deficient congenital muscular dystrophy ; is congenital muscular dystrophy a primary fibrotic disease?2006

    • Author(s)
      Taniguchi M
    • Journal Title

      Biochem Biophys Res Commun in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multiple candidate gene analysis identifies a-synuclein as a susceptibility gene for sporadic Parkinson's disease2006

    • Author(s)
      Mizuta I
    • Journal Title

      Hum Mol Genet in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant neuromuscular junctions and delayed terminal muscle fiber maturation in a-dystroglycanopathies.2006

    • Author(s)
      Taniguchi M
    • Journal Title

      Hum Mol Genet in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism2005

    • Author(s)
      Li Y, Tomiyama H, Sato K, Hatano Y, Yoshino H, Atsumi M, Kitaguchi M, Sasaki S, Kawaguchi S, Miyajima H, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neurology 64

      Pages: 1955-1957

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches.2005

    • Author(s)
      Kariya S, Hirano M, Nagai Y, Furiya Y, Fujikake N, Toda T, Ueno S.
    • Journal Title

      J Mol Neurosci 25

      Pages: 165-169

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basement membrane fragility underlies embryonic lethality in fukutin-null mice.2005

    • Author(s)
      Kurahashi H, Taniguchi M, Meno C, Taniguchi Y, Takeda S, Horie M, Otani H, Toda T.
    • Journal Title

      Neurobiol Dis 19

      Pages: 208-217

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of fukutin deficiency in the developing mouse brain.2005

    • Author(s)
      Chiyonobu T, Sasaki J, Nagai Y, Takeda S, Funakoshi H, Nakamura T, Sugimoto T, Toda T.
    • Journal Title

      Neuromuscul Disord 15

      Pages: 416-426

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] b4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development.2005

    • Author(s)
      Sasaki N, Manya H, Okubo R, Kobayashi K, Ishida H, Toda T, Endo T, Nishihara S.
    • Journal Title

      Biochem Biophys Res Commun 333

      Pages: 131-137

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress.2005

    • Author(s)
      Fujikake N, Nagai Y, Popiel HA, Kano H, Yamaguchi M, Toda T.
    • Journal Title

      FEBS lett 579

      Pages: 3842-3848

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An autosomal dominant cerebellar ataxia linked to chomosome 16q22.1 is associated with a single-nucleotide substitution in the 5ォ untranslated region of the gene encoding a novel protein with spectrin repeat and rho Guanine-nucleotide exchange-factor domains.2005

    • Author(s)
      Ishikawa K, Toru S, Tsunemi T, Li M, Kobayashi K, Yokota T, Amino T, Owada K, Fujigasaki H, Sakamoto M, Tomimitsu H, Takashima M, Kumagai J, Noguchi Y, Kawashima Y, Ohkoshi N, Ishida G, Gomyoda M, Yoshida M, Hashizume Y, Saito Y, Murayama S, Yamanouchi H, Mizutani T, Kondo I, Toda T, Mizusawa H.
    • Journal Title

      Am J Hum Genet 77

      Pages: 280-296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Founder SVA retrotransposal insertion in Fukuyama-type congenital muscular dystrophy and its origin in Japanese and Northeast Asian populations.2005

    • Author(s)
      Watanabe M, Kobayashi K, Jin F, Park KS, Yamada T, Tokunaga K, Toda T.
    • Journal Title

      Am J Med Genet 138

      Pages: 344-348

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic rearrangement at 10q24 in non-syndromic split-hand/split-foot malformation.2005

    • Author(s)
      Kano H, Kurosawa K, Horii E, Ikegawa S, Yoshikawa H, Kurahashi H, Toda T.
    • Journal Title

      Hum Genet 118

      Pages: 477-483

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005

    • Author(s)
      Saito Y, Motoyoshi Y, Kashima K, Izumiyama-Shimomura N, Toda T, Nakano I, Hasegawa M, Murayama S.
    • Journal Title

      J Neuropath Exp Neurol 64

      Pages: 1118-1126

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fukutin and a-dystroglycanopahties2005

    • Author(s)
      Toda T, Chiyonobu T, Xiong H, Tachikawa M, Kobayashi K, Manya H, Takeda S, Taniguchi M, Kurahashi H, EndoT.
    • Journal Title

      Acta Myologica 24

      Pages: 60-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches.2005

    • Author(s)
      Kariya S
    • Journal Title

      J Mol Neurosci 25

      Pages: 165-169

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Basement membrane fragility underlies embryonic lethality in fukutin-null mice.2005

    • Author(s)
      Kurahashi H
    • Journal Title

      Neurobiol Dis 19

      Pages: 208-217

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of fukutin deficiency in the developing mouse brain.2005

    • Author(s)
      Chiyonobu T
    • Journal Title

      Neuromuscul Disord 15

      Pages: 416-426

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism.2005

    • Author(s)
      Li Y
    • Journal Title

      Neurology 64

      Pages: 1955-1957

    • Related Report
      2005 Annual Research Report
  • [Journal Article] b4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development.2005

    • Author(s)
      Sasaki N
    • Journal Title

      Biochem Biophys Res Commun 333

      Pages: 131-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress.2005

    • Author(s)
      Fujikake N
    • Journal Title

      FEBS lett 579

      Pages: 3842-3848

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An autosomal dominant cerebellar ataxia linked to chomosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a novel protein with spectrin repeat and rho Guanine-nucleotide exchange-factor domains2005

    • Author(s)
      Ishikawa K
    • Journal Title

      Am J Hum Genet 77

      Pages: 280-296

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Founder SVA retrotransposal insertion in Fukuyama-type congenital muscular dystrophy and its origin in Japanese and Northeast Asian populations.2005

    • Author(s)
      Watanabe M
    • Journal Title

      Am J Hum Genet 138

      Pages: 344-348

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005

    • Author(s)
      Saito Y
    • Journal Title

      J Neuropath Exp Neurol 64

      Pages: 1118-1126

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genomic rearrangement at 10q24 in non-syndromic split-hand/split-foot malformation.2005

    • Author(s)
      Kano H.
    • Journal Title

      Hum Genet 118

      Pages: 477-483

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fukutin and a-dystroglycanopahties.2005

    • Author(s)
      Toda T
    • Journal Title

      Acta Myologica 24

      Pages: 60-30

    • Related Report
      2005 Annual Research Report
  • [Presentation] Genome-wide association study for sporadic Parkinson's disease.2009

    • Author(s)
      Tatsushi Toda
    • Organizer
      Movement Disorder Society
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Annual Research Report
  • [Presentation] パーキンソン病のゲノム解析2009

    • Author(s)
      戸田達史
    • Organizer
      第11回骨粗鬆症学会シンポジウム
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 福山型筋ジストロフィー、パーキンソン病の分子遺伝学、病態、治療展望2008

    • Author(s)
      戸田達史
    • Organizer
      人類遺伝学会教育講演
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association study for Parkinson's, disease2008

    • Author(s)
      Toda T.
    • Organizer
      ETH-JSTWorkshop on Medical Research
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genome-wide association study for Japanese Sporadic Parkinson's Disease2008

    • Author(s)
      Toth T.
    • Organizer
      NINDS Workshop on the Genome-Wide Association Study on Parkinson Disease
    • Place of Presentation
      Washington D.C., USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Basement membrane fragility underlies embryonic lethality in fukutin-null mice.2007

    • Author(s)
      Taniguchi, M
    • Organizer
      The 13th World Muscle Society
    • Place of Presentation
      Taormina, Italy
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Parkinson's disease and muscular dystrophy.2007

    • Author(s)
      Toda, T
    • Organizer
      Yunyang Medical College seminar
    • Place of Presentation
      Shiyan, China
    • Year and Date
      2007-07-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent advance in Fukuyama CMD.2007

    • Author(s)
      Toda, T
    • Organizer
      The 7th French-Japanese Workshop
    • Place of Presentation
      Hayama, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional analyses of sugar chains, proteins, and genome in neurological diseases.2007

    • Author(s)
      Toda, T
    • Organizer
      COE International Symposium
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent advances in congenital muscular dystrophies.2007

    • Author(s)
      Toda, T
    • Organizer
      12nd Annual Meeting, The Chinese Society of Child Neurology
    • Place of Presentation
      WuYiShan, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本発、臨床から遺伝子へ福山型筋ジストロフィ-福山型遺伝子フクチン同定のヒント、幸運とそれから2007

    • Author(s)
      戸田達史
    • Organizer
      日本神経学会総会 企画講演
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポストゲノム時代の神経疾患の分子遺伝学と治療戦略2007

    • Author(s)
      戸田達史
    • Organizer
      日本神経治療学会総会 教育講演
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aberrant Neuromuscular Junctions and Delayed Terminal Muscle Fiber Maturation in Fukuyama-type Congenital Muscular Dystrophy.2007

    • Author(s)
      谷口真理子
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] 福山型先天性筋ジストロフィーの神経筋接合部異常と筋分化遅延について2007

    • Author(s)
      谷口真理子
    • Organizer
      第49回日本小児科神経学会総合
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本人集団におけるFCF20遺伝子とパーキンソン病の関連2007

    • Author(s)
      佐竹渉
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多数の候補遺伝子アプローチによるパーキンソン病感受性遺伝子calbindinlの同定2007

    • Author(s)
      水田依久子
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.2007

    • Author(s)
      Toda, T
    • Organizer
      11th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multiple candidate gene analysis idenfieies CALB1(calbindinl) as a susceptibility gene for sporadic Parkinson's disease.2007

    • Author(s)
      Mizuta, I
    • Organizer
      The American Society of Human Genetics 57th Annual Meeting
    • Place of Presentation
      San Diego, U.S
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association between FGF20 and Parkinson's disease and Genome-wide association study using 27,158 microatellite by The Japanese PD Susceptibility Gene Consortium.2007

    • Author(s)
      Satake, W
    • Organizer
      The American Society of Human Genetics 57th Annual Meeting
    • Place of Presentation
      San Diego, U.S
    • Related Report
      2007 Annual Research Report
  • [Book] Glycoscience Lab Manual2008

    • Author(s)
      Kanagawa M
    • Total Pages
      4
    • Publisher
      Elsevier Japan
    • Related Report
      2008 Annual Research Report
  • [Book] Glycoscience Lab Manual2008

    • Author(s)
      Kanagawa, M
    • Publisher
      Edlsevier Science Publishers(In press)
    • Related Report
      2007 Annual Research Report
  • [Book] 分子メカニズムから解き明かす 疾患のサイエンスー癌,循環器,生活習慣病,アレルギー,神経変性疾患など,あらゆる疾患の全容と臨床応用の可能性に迫る(実験医学増刊)2006

    • Author(s)
      深水昭吉
    • Total Pages
      214
    • Publisher
      羊土社
    • Related Report
      2006 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/clgene/

    • Related Report
      2009 Final Research Report
  • [Remarks] 新聞発表、その他顕著なもの

    • Related Report
      2009 Final Research Report
  • [Remarks] GWASによるパーキンソン病関連遺伝子同定平成21年11月16日、24日、NHKニュース、日本経済新聞、朝日新聞、毎日新聞、産経新聞、東京新聞、など

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/clgene/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.clgene.med.osaka-u.ac.jp/www/gyoseki.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.clgene.med.osaka-u.ac.jp/www/gyoseki.html

    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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