Genome-wide study on pathogenesis of bacteria causing nosocomial infection
| Project/Area Number |
17019048
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUGAI Motoyuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (10201568)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥97,500,000 (Direct Cost: ¥97,500,000)
Fiscal Year 2009: ¥20,500,000 (Direct Cost: ¥20,500,000)
Fiscal Year 2008: ¥20,500,000 (Direct Cost: ¥20,500,000)
Fiscal Year 2007: ¥20,100,000 (Direct Cost: ¥20,100,000)
Fiscal Year 2006: ¥20,300,000 (Direct Cost: ¥20,300,000)
Fiscal Year 2005: ¥16,100,000 (Direct Cost: ¥16,100,000)
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| Keywords | 黄色ブドウ球菌 / 緑膿菌 / セラチア / 病原性 / マイクロアレイ / ゲノム / 院内感染 |
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| Research Abstract |
We employed Staphylococcus aureus, Serratia marcescens, Pseudomonas aeruginosa as target agent causing nosocomial infection. For S. aureus, we delineated gene sets present in S. aureus causing certain diseases and analyzed candidate genes to detect or foresee specific virulence of S. aureus. For S. marcescens, we screened for virulence-related genes by animal experiment and investigated for factors (genes) involved in human serum resistance. For P. aeruginosa, we investigated for factors (genes) involved in human serum resistance. We also analyzed characteristics and antimicrobial resistance mechanism of MDRP clones.
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Report
(7 results)
Research Products
(92 results)
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[Journal Article] Staphylococcus aureus MazF specifically cleaves pentad sequence UACAU, which is unusually highly abundant in the pathogenic adhesive factor Srap2009
Author(s)
Zhu, L., Inoue, K., Yoshizumi, S., Kobayashi, H., Ouyang, M., Kato, F., Sugai, M., Inouye, M
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Journal Title
Journal of Bacteriology 191
Pages: 3248-3255
Related Report
Peer Reviewed
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[Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia2009
Author(s)
Kikuchi, Y., Tateda, K., Fuse, E. T., Matsumoto, T., Gotoh, N., Fukushima, J. Takizawa, H., Nagase, T., Standiford, T. J., and Yamaguchi, K
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Journal Title
Pulm. Pharmacol. Ther.
Volume: 22
Pages: 333-339
Related Report
Peer Reviewed
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[Journal Article] Pseudomonas aeruginosa Las quorum-sensing autoinducer suppresses the growth and biofilm production in Legionella species2009
Author(s)
Kimura, S., Tateda, K, Ishii, Y., Horikawa, M., Miyairi, S., Gotoh, Ishiguro, M. and Yamaguchi, K
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Journal Title
Microbiology (UK)
Volume: 155
Pages: 1934-1939
Related Report
Peer Reviewed
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[Journal Article] Classification of OprD sequence and correlation with antimicrobial activity of carbapenem agents in Pseudomonas aeruginosa clinical isolates collected in Japan2009
Author(s)
Sanbongi, Y., Shimizu, A., Suzuki, T., Nagaso, H., Ida, T., Maebashi, K., and Gotoh, N
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Journal Title
Microbiol. Immunol
Volume: 53
Pages: 361-367
Related Report
Peer Reviewed
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[Journal Article] Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysine derived from bacteriophage phiMR112007
Author(s)
Rashel, M., Uchiyama, J., Ujihar, T., Uehara, Y., Kuramoto, S., Sugihara, S., Yagyu, K., Muraoka, A., Sugai, M., Hiramatsu, K., Honke, K., Matsuzaki, S
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Journal Title
Journal of Infectioius Diseases
Volume: 196
Pages: 1237-1247
Related Report
Peer Reviewed
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[Presentation] とびひの分子生物学2007
Author(s)
菅井 基行
Organizer
第44回日本細菌学会中部支部総会
Place of Presentation
竹島ホテル、蒲郡、愛知
Year and Date
2007-10-11
Description
特別講演
Related Report
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