| Project/Area Number |
17019058
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Miyazaki |
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Principal Investigator |
HAYASHI Tetsuya University of Miyazaki, フロンティア科学実験総合センター, センター長 (10173014)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Yoshitoshi 宮崎大学, フロンティア科学実験総合センター, 助教 (40363585)
OOKA Tadasuke 宮崎大学, 医学部, 助教 (50363594)
TOBE Toru 大阪大学, 医学系研究科, 准教授 (70207596)
IIDA Tetsuya 大阪大学, 微生物病研究所, 教授 (90221746)
KUWAHARA Tomomi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60263810)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥151,800,000 (Direct Cost: ¥151,800,000)
Fiscal Year 2009: ¥30,900,000 (Direct Cost: ¥30,900,000)
Fiscal Year 2008: ¥30,800,000 (Direct Cost: ¥30,800,000)
Fiscal Year 2007: ¥30,800,000 (Direct Cost: ¥30,800,000)
Fiscal Year 2006: ¥31,100,000 (Direct Cost: ¥31,100,000)
Fiscal Year 2005: ¥28,200,000 (Direct Cost: ¥28,200,000)
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| Keywords | 病原性大腸菌 / 腸内常在菌 / 多様性 / 病原性 / 腸炎ビブリオ / 疫学ツールの開発 / 腸内常在菌叢 / III型分泌系 / 発現制御 / O抗原合成遺伝子 / 常在菌 / バクテリオファージ |
|---|
| Research Abstract |
By performing a series of genome sequencing and functional analyses of enterohemorrhagic Ecsherichia coli (EHEC) and related enteropathogens. we succeeded in developing a rapid O157 EHEC strain typing system, obtaining the complete genome sequences of three major non-O157 EHECs, and improving our understanding of functions and evolution mechanisms of type III secretion mechanisms and other virulence systems of these pathogens. In addition, we succeeded in clarifying the genetic and functional differences of adult and infant gut microbiota by comparative metagenomic analysis and obtaining the complete genome sequences of 3 bacterial species (4 strains, including an unculturable bacterium) residing in intestine.
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