| Project/Area Number |
17019069
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
SASAZUKI Takehiko Research Institute, International Medical Center of Japan, 特任研究員 (50014121)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAWA Senji 福岡大学, 医学部, 教授 (10253535)
OKAMURA Takashi 国立国際医療センター(研究所), 感染症制御研究部, 室長 (00333790)
SORIMACHI Noeiko 国立国際医療センター(研究所), 消化器疾患研究部, 室長 (30217468)
SUZUKI Harumi 国立国際医療センター(研究所), 臨床病臨床病, 部長 (70235985)
TAKAKI Ssatoshi 国立国際医療センター(研究所), 地域保健医療研究部, 部長 (10242116)
YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥143,700,000 (Direct Cost: ¥143,700,000)
Fiscal Year 2009: ¥27,700,000 (Direct Cost: ¥27,700,000)
Fiscal Year 2008: ¥27,700,000 (Direct Cost: ¥27,700,000)
Fiscal Year 2007: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2006: ¥29,800,000 (Direct Cost: ¥29,800,000)
Fiscal Year 2005: ¥29,000,000 (Direct Cost: ¥29,000,000)
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| Keywords | 自己免疫性甲状腺疾患(AITD) / 相関解析 / 疾患感受性遺伝子 / ZFAT / 遺伝子改変マウス / 転写制御因子 / リンパ球 / FCRL3 / ZEAT / SNP / SLE |
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| Research Abstract |
We isolated a novel gene ZFAT, which contains Zn finger and AT-hook domains by genome wide linkage analysis of AITD. We found that ZFAT negatively regulates a group of genes related to cytokine production and components of antigen receptor complexes. ZFAT was shown to be important in early development, because ZFAT knockout mice were embryonic lethal. ZFAT +/- heterozygous mice showed increased lymphocytes, augmented BCR responses and delayed GvHD reactions, suggesting that ZFAT is related to B cell growth and regulation of Th1/2 balance.
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