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Establishment of the support system for SNP analyses and identification of disease-associated genes

Research Project

Project/Area Number 17020003
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

TOKUNAGA Katusshi  The University of Tokyo, 大学院・医学系研究科, 教授 (40163977)

Co-Investigator(Kenkyū-buntansha) OHASHI Jun  筑波大学, 人間総合科学研究科, 准教授 (80301141)
MIYADERA Hiroko  東京大学, 大学院・医学系研究科, 助教 (40361464)
HONDA Makoto  (財)東京都医学研究機構, 東京都精神医学総合研究所, 副参与研究員(研究職) (50370979)
KEICHO Naoto  国立国際医療センター研究所, 呼吸器疾患研究部, 部長(研究職) (80332386)
Research Collaborator MIYAGAWA Yaku  東京大学, 大学院・医学系研究科, 助教 (20512263)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥564,000,000 (Direct Cost: ¥564,000,000)
Fiscal Year 2009: ¥113,300,000 (Direct Cost: ¥113,300,000)
Fiscal Year 2008: ¥112,300,000 (Direct Cost: ¥112,300,000)
Fiscal Year 2007: ¥112,300,000 (Direct Cost: ¥112,300,000)
Fiscal Year 2006: ¥112,300,000 (Direct Cost: ¥112,300,000)
Fiscal Year 2005: ¥113,800,000 (Direct Cost: ¥113,800,000)
Keywords疾患感受性遺伝子 / SNP / ゲノムワイド関連解析(GWAS) / 糖尿病 / ナルコレプシー / パニック障害 / 結核 / SNP(単一塩基多型) / 疾患関連遺伝子 / ゲノムワイド関連分析 / アルツハイマー病 / 2型糖尿病 / ゲノム多型 / 疾患遺伝子 / 感染症 / 脳神経疾患 / バイオテクノロジー / 多系統萎縮症 / マラリア / SNPタイピング
Research Abstract

We established a high-throughput SNP typing system, and contributed to the finding of two new susceptibility genes to type 2 diabetes and genome-wide association studies (GWAS) for panic disorder, Alzheimer disease, multiple system atrophy, type 1 diabetes, etc. Furthermore, we identified two new susceptibility genes to narcolepsy by GWAS, and performed genome-wide linkage study and candidate gene analyses for tuberculosis and malaria.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (107 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (74 results) (of which Peer Reviewed: 61 results) Presentation (8 results) Book (10 results) Remarks (10 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus2010

    • Author(s)
      Okamoto K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen, O, Fujita T, Kamatani N, Iwamoto Y, Tokunaga K
    • Journal Title

      Am. J. Hum. Genet. 86

      Pages: 54-64

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype2010

    • Author(s)
      Miyagawa T, Honda M, et al.
    • Journal Title

      Journal of Human Genetics 55

      Pages: 63-65

    • NAID

      10030733344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus2010

    • Author(s)
      Okamoto K, Iwasaki N, et al.
    • Journal Title

      American Journal of Human Genetics 86

      Pages: 54-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping Human Genetic Diversity in Asia2009

    • Author(s)
      The HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, 他90名, 76番目Tokunaga K
    • Journal Title

      Science 326

      Pages: 1541-1545

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C2009

    • Author(s)
      Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M
    • Journal Title

      Nat. Genet. 41

      Pages: 1105-1109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Narcolepsy is strongly associated with the TCR alpha locus2009

    • Author(s)
      Hallmayer J, Faraco J, Ling L, 他45名、19番目Miyagawa T、42番目Tokunaga K
    • Journal Title

      Nat. Genet. 41

      Pages: 708-711

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the association2009

    • Author(s)
      Miyake K, Yang W, Hara K, 他32名、24番目Tokunaga K
    • Journal Title

      J. Hum. Genet. 54

      Pages: 236-241

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population.2009

    • Author(s)
      Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y
    • Journal Title

      J. Hum. Genet. 54

      Pages: 122-126

    • NAID

      10030729336

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype independently confer susceptibility to CNS hypersomnias (Essential Hyhpersomnia)2009

    • Author(s)
      Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGFBP3 colocalizes with and regulates hypocretin(orexin)2009

    • Author(s)
      Honda M, Eriksson K, Zhang S, Tanaka S, Lin L, Salehi A, Helsla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria2009

    • Author(s)
      Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J
    • Journal Title

      Malaria Journal 8

    • NAID

      120007131371

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide SNP-based linkage analysis of tuberculosis in Thais2009

    • Author(s)
      Mahasirimongkol S, Yanai H, Nishida N, Ridruechai C, Matsushita I, Ohashi J, Summanapan S, Yamada N, Moolphate S, Chuchotaworn C, Chapraser A, Manosuthi W, Kantipong P, Kantiwaittaya S, Sura T, Khusmith S, Tokunaga K, Sawanpanyaleert P, Keicho N
    • Journal Title

      Genes Immun. 10

      Pages: 77-83

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGFBP3 colocalizes with and regulates hypocretin(orexin)2009

    • Author(s)
      Honda M, Eriksson K, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602haplotype independently confer susceptibility to CNS hypersomnias(Essential Hyhpersomnia)2009

    • Author(s)
      Miyagawa T, Honda M, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of HLA-class II alleles with SARS in the Vietnamese population2009

    • Author(s)
      Keicho N, Itoyama S, et al.
    • Journal Title

      Human Immunology 70

      Pages: 527-531

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and risk factors for tuberculosis infection among hospital workers in Hanoi, Viet Nam2009

    • Author(s)
      Lien LT, Hang NTL, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population2009

    • Author(s)
      Otowa T, Yoshida E, et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 122-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the association2009

    • Author(s)
      Miyake K, Yang W, et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 236-241

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Narcolepsy is strongly associated with the TCR alpha locus2009

    • Author(s)
      Hallmayer J, Faraco J, et al.
    • Journal Title

      Nature Genetics 41

      Pages: 708-711

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C2009

    • Author(s)
      Tanaka Y, Nishida N, et al.
    • Journal Title

      Nature Genetics 41

      Pages: 1105-1109

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mapping Human Genetic Diversity in Asia2009

    • Author(s)
      Abdulla MA, Ahmed I, et al.
    • Journal Title

      Science 326

      Pages: 1541-1545

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide SNP-based linkage analysis of tuberculosis in Thais2009

    • Author(s)
      Mahasirimongkol S
    • Journal Title

      Genes Immun 10(1)

      Pages: 77-83

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Functional SNP in the CR1 Promoter Region Contributes to Protection against Cerebral Malaria.2008

    • Author(s)
      Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai H, Naka I, Putaporntip C, Jongwutiwes S, Tokunaga K.
    • Journal Title

      J. Infect. Dis. 198

      Pages: 1880-1891

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variant between CPT1B and CHKB associated with susceptibility to narcolepsy2008

    • Author(s)
      Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, Tokunaga K
    • Journal Title

      Nat. Genet. 40

      Pages: 1324-1328

    • Related Report
      2009 Final Research Report
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MCY, Ma RCW, So WY,Chan JCN, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M
    • Journal Title

      Nat. Genet. 40

      Pages: 1092-1097

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the performance of Affymetrix SNP Array 6. 0 platform with 400 Japanese individuals2008

    • Author(s)
      Nishida N, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, Uehara Y, Inoue I, Tokunaga K
    • Journal Title

      BMC Genomics 9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness2008

    • Author(s)
      Fujimoto A, Kimura R, Ohashi J, Omi K, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Furusawa T, Nakazawa M, Ohtsuka R, Tokunaga K
    • Journal Title

      Hum. Mol. Genet. 17

      Pages: 835-843

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand.2008

    • Author(s)
      Nuchnoi P, Ohashi J, Kimura R, Hananantachai H, Naka I, Krudsood S, Looareesuwan S, Tokunaga K, Patarapotikul J.
    • Journal Title

      Ann. Hum. Genet. 72

      Pages: 327-336

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4, 087 Japanese subjects2008

    • Author(s)
      Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, Kasuga M
    • Journal Title

      J. Hum. Genet. 53

      Pages: 174-180

    • NAID

      10021248002

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda
    • Journal Title

      Nat. Genet 40(9)

      Pages: 1092-1097

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variant between CPT1 B and CHKB associated with susceptibility to narcolepsy2008

    • Author(s)
      Miyagawa T
    • Journal Title

      Nat. Genet 40(11)

      Pages: 1324-1328

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals2008

    • Author(s)
      Nishida N
    • Journal Title

      BMC Genomics 9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of genome-wide association studies of type 2 diabetes susce ptibility in Japan2008

    • Author(s)
      Horikawa Y
    • Journal Title

      J. Clin. Endocrinol. Metab 93(8)

      Pages: 3136-3141

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate data cleaning method for genome-wide association study2008

    • Author(s)
      Miyagawa T
    • Journal Title

      J. Hum. Genet 53(10)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional SNP in the CR1 promoter region contributes to protection against cerebral Malaria2008

    • Author(s)
      Teeranaipong P
    • Journal Title

      J. Infect Dis 198(12)

      Pages: 1880-1891

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder.2008

    • Author(s)
      Amano K
    • Journal Title

      Psychiat. Genet. 18-1

      Pages: 1-10

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic multiple candidate gene approach for identification of susceptible genes and susceptible pathways for hypertension: a millennium genome project for hypertension.2008

    • Author(s)
      Kohara K
    • Journal Title

      Hypertens. Res. 31-2

      Pages: 203-212

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type2 diabetes in 4,087 Japanese subjects.2008

    • Author(s)
      Miyake K
    • Journal Title

      J. Hum. Genet. 53-2

      Pages: 174-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erytematosus in Japanese: Support for a crucial role of intron 1 polymorphisms.2008

    • Author(s)
      Kawasaki A
    • Journal Title

      Arth. Rheum. 58-3

      Pages: 826-834

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A scan for genetic determinants of human hair morpholgoy: EDAR is associataed with Asian hair thickness.2008

    • Author(s)
      Fujimoto A
    • Journal Title

      Hum. Mol. Genet. 17-6

      Pages: 835-843

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of Promoter and Coding Regions of the Arylamine N-Acetyltransferase 2 (NAT2) Gene in the lndonesian Population: Proposal for a New Nomenclature.2008

    • Author(s)
      Yuliwulandari R
    • Journal Title

      J. Hum. Genet. 53-3

      Pages: 201-209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese.2008

    • Author(s)
      Ueta M
    • Journal Title

      Mol. Vis. 14

      Pages: 550-555

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assocaition of TNFRSF4 gene polymorphisms with essential hypertension.2008

    • Author(s)
      Mashimo Y
    • Journal Title

      J. Hypertens. 26-5

      Pages: 902-913

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand.2008

    • Author(s)
      Nuchnoi P
    • Journal Title

      Ann. Hum. Genet. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of LILRA2 (ILT1, IIR7) splice site polymorphism with systemic lupus erytematosus and microscopic polyangiitis.2008

    • Author(s)
      Mamegano K
    • Journal Title

      Genes lmmun. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class l in Northeast Asians2008

    • Author(s)
      Hirayasu K
    • Journal Title

      Am. J. Hum. Genet. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between TNF-a (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand2007

    • Author(s)
      Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Krudsood S, Looareesuwan S, Tokunaga K
    • Journal Title

      Tissue Antigens 69

      Pages: 277-280

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Further development of multiplex SNP typing method, DigiTag2 assay2007

    • Author(s)
      Nishida N, Tanabe T, Takasu M, Suyama A, Tokunaga K
    • Journal Title

      Anal. Biochem. 364

      Pages: 78-85

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study between the TNXB locus and schizophrenia in a Japanese population.2007

    • Author(s)
      Tochigi M
    • Journal Title

      Am. J. Med. Genet. B Neuropsychiatr. Genet. 144-3

      Pages: 305-309

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erytematosus in Japanese.2007

    • Author(s)
      Kawasaki A
    • Journal Title

      Rheumatology 46-5

      Pages: 776-782

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further development of multiplex SNP typing method, DigiTag2 assay.2007

    • Author(s)
      Nishida N
    • Journal Title

      Anal. Biochem. 364

      Pages: 78-85

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The genotype of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria.2007

    • Author(s)
      Naka l
    • Journal Title

      J. Hum. Genet. 52-5

      Pages: 476-479

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 of the CFTR gene.2007

    • Author(s)
      Mai HN
    • Journal Title

      Int. J. Tubers. Lung Dis. 11-7

      Pages: 808-813

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of entire HLA-A gene accompanied by an insertion of aretrotransposon.2007

    • Author(s)
      Takasu M
    • Journal Title

      Tissue Antigens 70-2

      Pages: 144-150

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients.2007

    • Author(s)
      Doi K
    • Journal Title

      Hypertens. Res. 30-12

      Pages: 1193-1198

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between TNF-α(TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.2007

    • Author(s)
      Hananantachai H, Patarapotikul J, Ohashi J, et al.
    • Journal Title

      Tissue Antigens 69 3

      Pages: 277-280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Further development of multiplex SNP typing method, DigiTag2 assay.2007

    • Author(s)
      Nishida N^*, Tanabe T, Takasu M, et al.
    • Journal Title

      Analytical Biochemistry 364 1

      Pages: 78-85

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genome-wide association analysis of human narcolepsy and a new resistance gene2006

    • Author(s)
      Kawashima M, Tamiya G, Oka A, Hohjoh H, Juji T, Ebisawa T, Honda Y, Inoko H, Tokunaga K
    • Journal Title

      Am. J. Hum. Genet. 79

      Pages: 252-263

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte nuclear factor-4{alpha} P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population2006

    • Author(s)
      Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, Kadowaki T
    • Journal Title

      Diabetes 55

      Pages: 1260-1264

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A SNP in the ABCC11 gene is the determinant of human earwax type2006

    • Author(s)
      Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko V, Alipov G, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano C, Ghandami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray J, Saito S, Nakamura Y, Niikawa N
    • Journal Title

      Nat. Genet. 38

      Pages: 324-330

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism In the AMPKα2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population2006

    • Author(s)
      Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga M, Nagai R, Kadowaki T
    • Journal Title

      Diabetes 55

      Pages: 919-923

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism in the AMPKα2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.2006

    • Author(s)
      Horikoshi M, Hara K, Ohashi J, et al.
    • Journal Title

      Diabetes 55 4

      Pages: 919-923

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ADAM33 Polymorphisms are associated with asthma susceptibility in a Japanese population.2006

    • Author(s)
      Noguchi E, Ohtsuki Y, Tokunaga K, et al.
    • Journal Title

      Clinical and Experimental Allergy 36 5

      Pages: 602-608

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genome-wide association analysis of human narcolepsy and a new resistance gene.2006

    • Author(s)
      Kawashima M, Tamiya G, Oka A, et al.
    • Journal Title

      American Journal of Human Genetics 79 280

      Pages: 252-263

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of B cell inhibitory receptor polymorphisms for systemic lupus erythematosus : a negative times a negative makes a positive.2006

    • Author(s)
      Tsuchiya N, Honda Z, Tokunaga K
    • Journal Title

      Journal of Human Genetics 51 9

      Pages: 741-750

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DigiTag assay for multiplex SNP typing with high success rate.2006

    • Author(s)
      Nishida N, et al.
    • Journal Title

      Anal.Biochem. 346・2

      Pages: 281-288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] FcγRIIB lle232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreased affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling2005

    • Author(s)
      Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, Tokunaga K, Honda Z
    • Journal Title

      Hum. Mol. Genet. 14

      Pages: 2881-2892

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis.2005

    • Author(s)
      Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K
    • Journal Title

      Hum. Mol. Genet. 14

      Pages: 2469-2480

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positional identification of an asthma susceptibility gene on human chromosome 5q332005

    • Author(s)
      Noguchi E, Yokouchi Y, Zhang J, Shibuya K, Shibuya A, Bannai M, Tokunaga K, Doi H, Tamari M, Shimizu M, Shirakawa T, Shibasaki M, Ichikawa K, Arinami T
    • Journal Title

      Am. J. Respir. Crit. Care Med. 172

      Pages: 183-188

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extensive polymorphisms of LILRB1 (ILT2,LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis.2005

    • Author(s)
      Kuroki K et al.
    • Journal Title

      Hum.Mol.Genet. 14・16

      Pages: 2469-2480

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Positional identification of an asthma susceptibility gene on human chromosome 5q33.2005

    • Author(s)
      Noguchi E, et al.
    • Journal Title

      Am.J.Respir.Crit.Care Med. 172・2

      Pages: 183-188

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Variations of the CFTR gene in the Hanoi-Vietnamese.2005

    • Author(s)
      Nam MH, et al.
    • Journal Title

      Am.J.Med Genet A. 136・3

      Pages: 249-253

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Strong linkage disequilibrium of a HbE variant with the (AT)_9(T)_5 repeat in the BP1 binding site upstream of the β-globin gene in Thai population.2005

    • Author(s)
      Ohashi J, et al.
    • Journal Title

      J.Hum.Genet. 50・1

      Pages: 7-11

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polymorphisms of HLA-B and HLA-DRB1 genes in Thai malaria patients.2005

    • Author(s)
      Hananantachai H, et al.
    • Journal Title

      Jpn.J.Infect.Dis. 58・1

      Pages: 25-28

    • Related Report
      2005 Annual Research Report
  • [Presentation] 疾患のゲノムワイド関連分析(GWAS)とHLA2009

    • Author(s)
      徳永勝士
    • Organizer
      日本組織適合性学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナルコレプシーのゲノムワイド関連解析:発症機序の解明を目指して2009

    • Author(s)
      徳永勝士、宮川卓, ほか
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゲノムワイド関連解析研究(GWAS)による疾患感受性遺伝子の探索とGWASデータベースの開発2008

    • Author(s)
      徳永勝士
    • Organizer
      第31回分子生物学会大会第81回日本生化学会大会合大会
    • Place of Presentation
      神戸(神戸ポートアイランド)
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多因子疾患感受性遺伝子のゲノムワイド探索2008

    • Author(s)
      徳永勝士
    • Organizer
      第53回日本人類遺伝学会大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゲノムワイド関連分析による疾患感受性遺伝子の探索2007

    • Author(s)
      徳永勝士
    • Organizer
      第30回日本分子生物学会天会 第80回日本生化学大会 合同大会
    • Place of Presentation
      横浜(パシフィコ横浜他)
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 関連解析によって得られた21番染色体上の2型糖尿病の感受性遺伝子2007

    • Author(s)
      岡本孝司
    • Organizer
      第52回日本人類遺伝学会大会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] マルチプレックスSNPタイピング法: Dig Tag2法2007

    • Author(s)
      西田奈央
    • Organizer
      第52回日本人類遺伝学会大会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] ゲノムワイドSNPタ才ピング技術の現状と将来2007

    • Author(s)
      徳永勝士
    • Organizer
      第52回日本人類遺伝学会大会シンポジウム
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Book] ヒトゲノムの多様性:ゲノムワイド多型研究のインパクト、実験医学(増刊)2009

    • Author(s)
      徳永勝士
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] ゲノムワイド関連分析による多因子疾患遺伝子の探索(肝疾患Review 2008-2009)2008

    • Author(s)
      西田奈央、徳永勝士
    • Related Report
      2009 Final Research Report
  • [Book] 医学のあゆみ「臨床ゲノム-成長と課題」225巻9号(分担執筆)2008

    • Author(s)
      西田奈央、徳永勝士
    • Total Pages
      281
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] 人類遺伝学ノート(徳永勝士編著)2007

    • Author(s)
      徳永勝士
    • Total Pages
      115
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 臨床ゲノム科学入門(永井良三(監)徳永勝士、山崎力、大木秀一(編), 遺伝子・ゲノム多型解析法の進展.)2007

    • Author(s)
      徳永勝士
    • Publisher
      杏林図書
    • Related Report
      2009 Final Research Report
  • [Book] ゲノム情報と生命現象の統合的理解2007(榊佳之、伊藤隆司、辻省次、小原雄治(編), 大規模SNPタイピングによる多因子疾患遺伝子の探索, 実験医学増刊, 25(2))2007

    • Author(s)
      西田奈央、徳永勝士
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] 人類遺伝学ノート2007

    • Author(s)
      徳永勝士(編著)
    • Total Pages
      115
    • Publisher
      南山堂
    • Related Report
      2006 Annual Research Report
  • [Book] 臨床生命情報学入門(永井良三(監)山崎力、小山博史、小野木雄三(編), 疾患の遺伝学)2006

    • Author(s)
      徳永勝士
    • Publisher
      杏林図書
    • Related Report
      2009 Final Research Report
  • [Book] Single nucleotide polymorphism typing using degenerate-oligonucleotide-primed PCR- amplified products. In: Whole Genome Amplification(Ed. S. Hughes and R. Lasken)2005

    • Author(s)
      Bannai M, Tokunaga K
    • Publisher
      Scion Publishing
    • Related Report
      2009 Final Research Report
  • [Book] Whole Genome Amplification(分担執筆Chapter 2)2005

    • Author(s)
      Bannai M, Tokunaga K
    • Publisher
      Scion Publishing Ltd
    • Related Report
      2005 Annual Research Report
  • [Remarks] やせ型糖尿病遺伝子の発見(2010年1月9日)NHKニュース、朝日新聞、読売新聞など各紙

    • Related Report
      2009 Final Research Report
  • [Remarks] アジア73集団のゲノムワイドSNP解析による多様性の研究(2009年12月11日)朝日新聞、読売新聞など各紙

    • Related Report
      2009 Final Research Report
  • [Remarks] C型肝炎治療効果に関わる遺伝子の発見(2009年9月14日)朝日新聞、日経新聞など

    • Related Report
      2009 Final Research Report
  • [Remarks] 日中の眠気に関わる(ナルコレプシー感受性)遺伝子の発見(2008年9月28日)読売新聞、毎日新聞など

    • Related Report
      2009 Final Research Report
  • [Remarks] 2型糖尿病に関わる遺伝子の発見(2008年8月25日)朝日新聞、読売新聞など各紙

    • Related Report
      2009 Final Research Report
  • [Remarks] 緑の黒髪(毛髪の太さに関わる)遺伝子の発見(2007年11月20日)朝日新聞など

    • Related Report
      2009 Final Research Report
  • [Remarks] 耳垢型を決定する遺伝子の発見(2006年1月30日)毎日新聞など

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      https://www.genome-sci.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.humgenet.m.u-tokyo.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      https://www.genome-sci.jp/index.php

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 糖尿病発症及び/又は進展リスクの判定方法2008

    • Inventor(s)
      徳永勝士, ほか4名
    • Industrial Property Rights Holder
      徳永勝士, ほか4名
    • Industrial Property Number
      2008-316595
    • Filing Date
      2008-12-12
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 睡眠障害の治療及び診断方法2008

    • Inventor(s)
      徳永勝士, ほか3名
    • Industrial Property Rights Holder
      徳永勝士, ほか3名
    • Industrial Property Number
      2008-049530
    • Filing Date
      2008-02-29
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 睡眠障害の治療及び診断方法2008

    • Inventor(s)
      徳永勝士 宮川 卓 本多 裕 本多 真
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2008-049530
    • Filing Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規ナルコレプシー関連遺伝子2006

    • Inventor(s)
      徳永 勝士, 川嶋 実苗, 猪子 英俊, 本多 裕
    • Industrial Property Rights Holder
      国立大学法人東京大学, 学校法人東海大学
    • Filing Date
      2006-02-13
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 高血圧の遺伝子マーカー2005

    • Inventor(s)
      三木哲郎, ほか14名
    • Industrial Property Rights Holder
      三木哲郎, ほか14名
    • Industrial Property Number
      2005-344267
    • Filing Date
      2005-11-29
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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