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Integrative approach for the cortical control of eye and hand movements

Research Project

Project/Area Number 17021041
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

ISA Tadashi  National Institute for Physiological Sciences, 発達生理学研究系, 教授 (20212805)

Co-Investigator(Kenkyū-buntansha) ENDO Toshiaki  生理学研究所, 発達生理学研究系, 助手 (30353436)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,500,000 (Direct Cost: ¥49,500,000)
Fiscal Year 2009: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2008: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2007: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2006: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2005: ¥9,900,000 (Direct Cost: ¥9,900,000)
Keywords大脳皮質 / 上丘 / 皮質脊髄路 / 脊髄固有細胞 / サッケード / 精密把持 / サル / 盲視 / 眼球サッケード運動 / 作業記憶 / 視覚的意識 / 単一神経細胞活動記録 / 脊髄損傷 / 運動野 / 霊長類 / 遺伝子発現 / 可塑性 / リハビリテーション / サッケード運動 / 上肢運動 / 電気生理学 / 運動学習 / 脳損傷後機能代償 / 上肢到達運動
Research Abstract

After the lesion of the primary visual cortex, visually guided saccadic eye movements towards the targets presented in the affected visual field recovers within 1-2 months in monkeys. After the recovery, the visual signal is processed mainly by the superior colliculus (SC). Under particular circumstances, the direct visual inputs from the retina to the superficial layer of the SC can directly activate the neurons in the intermediate layer of the SC and then the further activation of the saccade generator circuits downstream in the brainstem triggers ultra-short latency saccades named express saccades.
After the lesion of the direct cortico-motoneuronal connections from the primary motor cortex to hand motoneurons, dexterous finger movements are once impaired but recover through training within 1-2 months in monkeys. Such recovery is contributed by the indirect cortico-motoneuronal pathway mediated by propriospinal neurons located a few segments rostral to motoneurons.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (115 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (47 results) (of which Peer Reviewed: 35 results) Presentation (57 results) Book (7 results) Remarks (4 results)

  • [Journal Article] Functional differences between cortical and subcortical visual pathway in spatial attention: inhibition of return and attention capture.2010

    • Author(s)
      Ikeda T, Yoshida M, Isa T.
    • Journal Title

      Journal of Cognitive Neuroscience (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploring the superior colliculus in vitro.2009

    • Author(s)
      Isa T, Hall WC
    • Journal Title

      Journal of Neurophysiology

      Pages: 2581-2593

    • Related Report
      2009 Final Research Report
  • [Journal Article] Saccade control after V1 lesion revisited.2009

    • Author(s)
      Isa T, Yoshida M
    • Journal Title

      Current Opinion in Neurobiology

    • Related Report
      2009 Final Research Report
  • [Journal Article] Increased expression of the growth-associated protein-43 gene in the sensorimotor cortex of the macaque monkey after lesioning of the lateral corticospinal tract.2009

    • Author(s)
      Higo N, Nishimura Y, Murata Y, Oishi T, Saito K, Takahashi M, Tsuboi F, Isa T
    • Journal Title

      Journal of Comparative Neurology 516

      Pages: 493-506

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different pedunculopontine tegmental neurons signal predicted and actual task rewards.2009

    • Author(s)
      Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y
    • Journal Title

      Journal of Neuroscience 29

      Pages: 4858-4870

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord injury.2009

    • Author(s)
      Nishimura Y, Isa T
    • Journal Title

      The Neuroscientist 15

      Pages: 436-444

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A common subcortical oscillatory network contributes to recovery after spinal cord injury.2009

    • Author(s)
      Nishimura Y, Morichika Y, Isa T
    • Journal Title

      Brain 132

      Pages: 709-721

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different pedunculopontine tegmental neurons signal predicted and actual task rewards2009

    • Author(s)
      Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y
    • Journal Title

      Journal of Neuroscience 29

      Pages: 4858-4870

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice with altered myelin proteolipid protein gene expression show schizophrenia-related behavior accompanied by abnormal neuron-glial interaction and conduction velocity2009

    • Author(s)
      Tanaka H, Tanaka K, Ma J, Isa T, Tanda K, Miyakawa T, Suzuki A, Ishibashi T, Baba H, Shigemoto R, Ono K, Ikenaka K
    • Journal Title

      Journal of Neuroscience 29

      Pages: 8363-8371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of the growth-associated protein-43 gene in the sensorimotor cortex of the macaque monkey after lesioning of the lateral corticospinal tract2009

    • Author(s)
      Higo N, Nishimura Y, Murata Y, Oishi T, Saito K, Takahashi M, Tsuboi F, Isa T
    • Journal Title

      Journal of Comparative Neurology 516

      Pages: 493-506

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord injury2009

    • Author(s)
      Nishimura Y, Isa T
    • Journal Title

      The Neuroscientist(review) 15

      Pages: 436-444

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring the superior colliculus in vitro2009

    • Author(s)
      Isa T, Hall WC
    • Journal Title

      Journal of Neurophysiology(review) 102

      Pages: 2581-2593

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale reorganization of corticofugal fibers after neonatal hemidecortication for functional restoration of forelimb movements2009

    • Author(s)
      Takahashi M, Vattanajun A, Umeda T, Isa K, Isa T
    • Journal Title

      European Journal of Neuroscience 30

      Pages: 1878-1887

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A subcortial oscillatory netowork contributes to recovery of hand dexterity after spinal cord injury2009

    • Author(s)
      Nishimura Y, Morichika Y, Isa T
    • Journal Title

      Brain (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus.2008

    • Author(s)
      Kaneda K, Isa K, Yanagawa Y, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 11071-11078

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Striate cortical lesions affect deliberate decision and control of saccade: implication for blindsight.2008

    • Author(s)
      Yoshida M, Takaura K, Kato R, Ikeda T, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 517-10530

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus.2008

    • Author(s)
      Sooksawate T, Isa K, Isa T
    • Journal Title

      Journal of Neurophysiology 100

      Pages: 2702-2711

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording.2008

    • Author(s)
      Phongphanphanee P, Kaneda K, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 9309-9318

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic Ih ensures high-fidelity spike responses of motion sensitive neurons in rat superior colliculus.2008

    • Author(s)
      Endo T, Tarusawa E, Notomi T, Kaneda K, Hirabayashi M, Shigemoto R, Isa T
    • Journal Title

      Journal of Neurophysiology 99

      Pages: 2066-2076

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of burst activity through pre- and postsynaptic GABAB receptors in mouse superior colliculus.2008

    • Author(s)
      Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 816-827

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal profiles of field potentials in mouse superior colliculus2008

    • Author(s)
      Phongphanphanee P, Isa K, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 9309-9318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus2008

    • Author(s)
      Sooksawate T, Isa, K, Isa T
    • Journal Title

      Journal of Neurophysiology 100

      Pages: 2702-2711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striate cortical lesions affect deliberate decision and control of saccade : Implication for blindsight2008

    • Author(s)
      Yoshida M, Takaura K, Kato R, Ikeda T, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 10541-10548

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus2008

    • Author(s)
      Kaneda K, Isa K, Yanagawa Y, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 11071-11078

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of burst activity through pre-and postsynaptic GABA_B receptors in mouse superior colliculus.2008

    • Author(s)
      Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 816-827

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic Ih ensures high-fidelity spike responses of motion sensitive neurons in rat superior colliculus.2008

    • Author(s)
      Endo T, Tarusawa E, Notomi T, Kaneda K, Hirabayashi M, Shigemoto R, Isa T
    • Journal Title

      Journal of Neurophysiology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct and indirect cortico-motoneuronal pathways and control of hand/arm movements.2007

    • Author(s)
      Isa, T., Ohki, Y., Alstermark, B., Pettersson, L-G., Sasaki, S
    • Journal Title

      Physiology 22

      Pages: 145-152

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time-dependent central compensatory mechanism of finger dexterity after spinal-cord injury.2007

    • Author(s)
      Nishimura Y, Onoe T, Morichika Y, Perfiliev S, Tsukada H, Isa T
    • Journal Title

      Science 318

      Pages: 1150-1155

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identity of a pathway for saccadic suppression.2007

    • Author(s)
      Lee PH, Sooksawate T, Yanagawa Y, Isa K, Isa T, Hall WC
    • Journal Title

      Proceedings of National Academy of Sciences, USA 104

      Pages: 6824-6827

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys.2007

    • Author(s)
      Nishimura Y, Onoe T, Morichika Y, Tsukada H, Isa T
    • Journal Title

      Neuroscience Research 59

      Pages: 243-250

    • NAID

      10024417714

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentially expressed genes among motor and prefrontal areas of macaque neocortex.2007

    • Author(s)
      Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Sai to K, Tsuboi F, Takahashi M, Isa T, Kojima T
    • Journal Title

      Biochemical and Biophysical Research Communications 362

      Pages: 665-669

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identity of a pathway for saccadic suppression.2007

    • Author(s)
      Lee PH, Sooksawate T, Yanagawa Y, Isa K, Isa T, Hall WC
    • Journal Title

      Proceedings of National Academy of Sciences USA Vol. 104

      Pages: 6824-6827

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantitative analysis of saccade-like rapid eye movements in C57BL/6 mice.2007

    • Author(s)
      Sakatani T, Isa T
    • Journal Title

      Neuroscience Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct and indirect cortico-motoneuronal pathways and control of hand/arm movements.2007

    • Author(s)
      Isa T, Ohki Y, Alstermark B, Pettersson LG, Sasaki S
    • Journal Title

      Physiology Vol. 22

      Pages: 145-152

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Properties of cholinergic responses in neurons in the intermediate gray layer of rat superior colliculus.2006

    • Author(s)
      Sooksawate T, Isa T
    • Journal Title

      European Journal of Neuroscience 24

      Pages: 3096-3108

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey.2006

    • Author(s)
      Isa T, Ohki Y, Seki K, Alstermark B
    • Journal Title

      Journal of Neurophysiology 95

      Pages: 3674-3685

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Properties of cholinergic responses in neurons in the intermediate gray layer of rat superior colliculus.2006

    • Author(s)
      Sooksawate T, Isa T
    • Journal Title

      European Journal of Neuroscience Vol. 24

      Pages: 3096-3108

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey.2006

    • Author(s)
      Isa T, Ohki Y, Seki K, Alstermark B
    • Journal Title

      Journal of Neurophysiology Vol. 95

      Pages: 3674-3685

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Electrophysiological abnormalities precede apparent histological demyelination in the central nervous system of mice overexpressing proteolipid protein.2006

    • Author(s)
      Tanaka, Ikenaka K, Isa T
    • Journal Title

      Journal of Neuroscience Research Vol. 84

      Pages: 1206-1216

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Properties of propriospinal neurones in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurones in the macaque monkey.2006

    • Author(s)
      Isa T, Ohki Y, Seki K, Alstermark B
    • Journal Title

      Journal of Neurophysiology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.2005

    • Author(s)
      Endo T, Yanagawa Y. Obata K, Isa T.
    • Journal Title

      Journal of Neurophysiology 94

      Pages: 3893-3902

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organization of interlaminar interactions in the rat superior colliculus.2005

    • Author(s)
      Saito Y, Isa T
    • Journal Title

      Journal of Neurophysiology 93

      Pages: 2898-2907

    • Related Report
      2009 Final Research Report 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of local nicotinic activation of the superior colliculus on saccades in monkeys.2005

    • Author(s)
      Watanabe M, Kobayashi Y, Inoue Y, Isa T
    • Journal Title

      Journal of Neurophysiology 93

      Pages: 519-534

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.2005

    • Author(s)
      Endo T, Yanagawa Y., Obata K, Isa T.
    • Journal Title

      Journal of Neurophysiology 94

      Pages: 3893-3902

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Electrophysiological and morphological properties of identified crossed tecto-reticular neurons in the rat superior colliculus.2005

    • Author(s)
      Sooksawate T, Saito Y, Isa T
    • Journal Title

      Neuroscience Research 52

      Pages: 174-184

    • NAID

      10016476607

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Saccade control after V1 lesion revisited

    • Author(s)
      Isa T, Yoshida M
    • Journal Title

      Current Opinion in Neurobiology(review) (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord Injury (review)

    • Author(s)
      Nishimura Y, Isa T
    • Journal Title

      The Neuroscientist (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 失われた機能を補う脳のしくみ~脊髄損傷と視覚障害~2009

    • Author(s)
      伊佐正
    • Organizer
      第5回CREST公開シンポジウム
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] What's required for brain-machine interfaces for neuron-rehabilitaion?2009

    • Author(s)
      伊佐正
    • Organizer
      第36回国際生理学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄損傷後の機能代償機構-霊長類モデルでの実験的研究2009

    • Author(s)
      伊佐正
    • Organizer
      名古屋ペイン2009・日本ペインクリニック学会第43回大会第31回日本疼痛学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] How to recover ; strategies for the damaged brain2009

    • Author(s)
      伊佐正
    • Organizer
      脳科学セミナー
    • Place of Presentation
      慶応大学(東京)
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 損傷脳の機能回復戦略2009

    • Author(s)
      伊佐正
    • Organizer
      山形ニューロサイエンス研究会
    • Place of Presentation
      山形大学(山形)
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] ブレインマシンインターフェイス:基礎神経科学から臨床応用へ2009

    • Author(s)
      伊佐正
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lateral connections int he superficial and intermediate layers of mouse superior colliculus2009

    • Author(s)
      伊佐正
    • Organizer
      Symposium at 19th Annual Meeting of the Society for the Neural Control of Movements. Hawaii
    • Place of Presentation
      ハライ(米国)
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 霊長類を用いた脳科学研究の展望2009

    • Author(s)
      伊佐正
    • Organizer
      SORSTシンポジウム(3)
    • Place of Presentation
      コクヨホール(東京)
    • Year and Date
      2009-04-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄損傷後の機能回復戦略の統合的研究2009

    • Author(s)
      伊佐正
    • Organizer
      第9回 Osaka University Advanced Medical Seminer
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄損傷後の機能回復機構2009

    • Author(s)
      伊佐正
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山全日空ホテル(岡山)
    • Year and Date
      2009-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cortical Compensatory Mechanism After Spinal-Cord Injury2009

    • Author(s)
      伊佐正
    • Organizer
      The 56th NIBB Conference "Neocortical Organization"
    • Place of Presentation
      岡崎コンファレンスセンター(愛知)
    • Year and Date
      2009-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spinal cord interneuronal network and functional electrical stimulation of the spinal cord with chronically implanted electrodes.2009

    • Author(s)
      伊佐正
    • Organizer
      日英ブレイン・マシン・インターフェース国際ワークショップ
    • Place of Presentation
      有楽町朝日ホール
    • Year and Date
      2009-02-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Spinal cord interneuronal network and functional electrical stimulation of the spinal cord with chronically implanted electrodes2009

    • Author(s)
      伊佐正
    • Organizer
      日英ブレイン・マシン・インターフェース国際ワークショップ
    • Place of Presentation
      有楽町朝日ホール
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳・脊髄損傷後の機能回復過程の可視化2009

    • Author(s)
      伊佐正
    • Organizer
      第3回分子イメージング研究センターシンポジウム
    • Place of Presentation
      放射線医学総合研究所
    • Year and Date
      2009-01-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脊髄損傷後の機能回復戦略2008

    • Author(s)
      伊佐正
    • Organizer
      神経科学セミナー
    • Place of Presentation
      東京都神経科学総合研究所
    • Year and Date
      2008-10-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳・脊髄部分損傷後の機能回復に関するBMIの応用に関する考え方2008

    • Author(s)
      伊佐正
    • Organizer
      日本脳神経外科学会第67回学術総会シンポジウム
    • Place of Presentation
      盛岡グランドホテル
    • Year and Date
      2008-10-01
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 機能回復と脳活動2008

    • Author(s)
      伊佐正
    • Organizer
      第2回痛みの理学療法学研究大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2008-09-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 損傷脳の生存戦略2008

    • Author(s)
      伊佐正
    • Organizer
      第16回「脳の世紀」シンポジウム
    • Place of Presentation
      有楽町朝日ホール
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 損傷脳の生存戦略2008

    • Author(s)
      伊佐正
    • Organizer
      国立精神・神経センター神経研究所研究所セミナー
    • Place of Presentation
      国立精神・神経センター
    • Year and Date
      2008-07-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構2008

    • Author(s)
      伊佐正
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 「脊髄損傷後の手指の巧緻運動の機能代償機構」神経組織の成長・再生・移植研究会2008

    • Author(s)
      伊佐正
    • Organizer
      第23回学術集会
    • Place of Presentation
      ホテルスプリングス幕張
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構2008

    • Author(s)
      伊佐正
    • Organizer
      神経組織の成長・再生・移植研究会第23回学術集会
    • Place of Presentation
      ホテルスプリングス幕張
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構2008

    • Author(s)
      伊佐正
    • Organizer
      第37回日本脊椎脊髄病学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-04-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Functional reorganization of corticospinal projections in rats with neonatal hemidecortication.2008

    • Author(s)
      梅田達也、高橋雅人、伊佐かおる、伊佐正
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      京王プラザホテル東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Changes in regional brain activities involved in manipulation task after primary motor cortex lesion: A pilot PET study with a macaque monkey2008

    • Author(s)
      村田弓、肥後範行、西村幸男、大石高生、塚田秀夫、伊佐正
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      京王プラザホテル東京
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 損傷から立ち直るための脳の仕組み2008

    • Author(s)
      伊佐正
    • Organizer
      第5回自然科学研究機構シンポジウム
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-03-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Time-Dependent Central Compensatory Mechanisms of Finger Dexterity after Spinal Cord Injury.2008

    • Author(s)
      Nishimura, Y, Onoe, H. (RIKEN), Morichika, Y., Perfiliev, S., Tukada, H., Isa, T.
    • Organizer
      The 12th Conference of Peace through Mind/Brain Science
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2008-02-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] ブレインマシンインタフェイス研究の現状と展望2008

    • Author(s)
      伊佐正
    • Organizer
      第47回日本定位・機能神経外科学会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2008-01-25
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 「脳の損傷から立ち直るために」2007

    • Author(s)
      伊佐正
    • Organizer
      CREST 第3回公開シンポジウム
    • Place of Presentation
      虎ノ門パストラル
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Choice-related modulation of neural activity in the superior colliculus of monkeys with blindsight2007

    • Author(s)
      Masatoshi Yoshida、 Kana Takaura、 Tadashi Isa
    • Organizer
      第37回Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、米国
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Saliency-based guidance of spontaneous saccades in monkeys with unilateral lesion of primary visual cortex2007

    • Author(s)
      Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Takaura, Tadashi Isa
    • Organizer
      第37回Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、米国
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Increase of intermuscular coherence independent of cortical activity during recovery from corticospinal tract lesion in monkeys2007

    • Author(s)
      Yukio Nishimura、Tadashi Isa
    • Organizer
      第37回Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、 米国
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Enhanced expression of GAP-43 mRNA in the sensorimotor cortex of the macaque monkey after the lesion of the lateral corticospinal tract2007

    • Author(s)
      Noriyuki Higo、Yukio Nishimura、Yumi Murata、Takao Ooishi、Kimika Saitoh、Humiharu Tsuboi、Tadashi Isa
    • Organizer
      第37回Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、 米国
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene expression analysis of motor-related areas and prefrontal area of the monkey neocortex2007

    • Author(s)
      Akira Satoh、Yukio Nishimura、Takao Ooishi、Noriyuki Higo、Yumi Murata、Hirotaka Onoe、Tadashi Isa
    • Organizer
      第37回Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、 米国
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Function of striatal visual pathway in visual attention: inhibition of return and attention capture2007

    • Author(s)
      Takuro Ikeda, Tadashi Isa
    • Organizer
      第37回Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center、米国
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] サル大脳新皮質の運動関連領野と前頭前野における網羅的遺伝子発現解析2007

    • Author(s)
      佐藤明、西村幸男、大石高生、肥後範行、村田弓、尾上浩隆、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルの頸髄レベルでの皮質脊髄路切断後における手指巧緻性の回復;C2での切断とC5での切断の回復比較2007

    • Author(s)
      坪井史治、西村幸男、斎藤紀美香、高橋雅人、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニホンザル盲視モデルにおける残存視覚に対応した神経活動2007

    • Author(s)
      吉田正俊、高浦加奈、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 精密把持遂行時の皮質一手指筋間コヒーレンスの空間的分布2007

    • Author(s)
      西村幸男、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 注意の誘引と復帰抑制における一次視覚野の機能の解明2007

    • Author(s)
      池田琢朗、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 外側皮質脊髄路損傷後の回復過程における神経成長関連タンパクGAP-43の脳内発現2007

    • Author(s)
      肥後範行、西村幸男、村田弓、大石高生、斎藤紀美香、坪井史治、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 皮質脊髄路損傷後に大脳皮質活動とは独立したEMG-EMGコヒーレンスは増大する2007

    • Author(s)
      西村幸男、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Plasticity for functional restoration of forelimb movements following neonatal unilateral decortication.2007

    • Author(s)
      Anusara Vattanajun、高橋雅人、伊佐かおる、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Large-scale change in the corticofugal projections in rats with neonatal hemi-decortication.2007

    • Author(s)
      高橋雅人、Anusara Vattanajun、梅田達也、伊佐かおる、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黒質網様部から上丘中間層GABA作動性ニューロンへの抑制性入力2007

    • Author(s)
      伊佐かおる、金田勝幸、柳川右千夫、小幡邦彦、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 注視解除による視覚探索への影響2007

    • Author(s)
      加藤利佳子、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] サル皮質脊髄路:一次運動野における手指制御領域から脊髄への軸索投射の定量的解析2007

    • Author(s)
      齋藤紀美香、西村幸男、大石高生、肥後範行、村田弓、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 一次視覚野除去後の損傷視野内における視覚運動変換過程への上丘の寄与2007

    • Author(s)
      高浦加奈、吉田正俊、伊佐正
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neural correlate of residual vision in monkey with blindsight.2007

    • Author(s)
      asatoshi Yoshida, Kana Takaura, Tadashi Isa
    • Organizer
      第11回Association for the Scientific Study of Consciousness
    • Place of Presentation
      米国
    • Year and Date
      2007-06-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural correlate of residual vision in monkey with blindsight2007

    • Author(s)
      Masatoshi Yoshida、Kana Takaura、Tadashi Isa
    • Organizer
      第11回Association for the Scientific Study of Consciousness
    • Place of Presentation
      ラスベガス、Imperial Palace Hotel
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 「一次視覚野損傷後の視覚運動変換機構-盲視モデルとしての考察-」2007

    • Author(s)
      伊佐正
    • Organizer
      玉川大学脳科学研究所設立記念シンポジウム
    • Place of Presentation
      玉川学園チャペル
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Is residual vision in monkeys with unilateral lesion in the primary visual cortex like normal, near-threshold vision?2007

    • Author(s)
      Masatoshi Yoshida, Kana Takaura, Tadashi Isa
    • Organizer
      第7回Vision Science Society年会
    • Place of Presentation
      米国
    • Year and Date
      2007-05-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Is residual vision in monkeys with unilateral lesion in the primary visual cortex like normal, near-threshold vision?2007

    • Author(s)
      Masatoshi Yoshida, Kana Takaura, Tadashi Isa
    • Organizer
      第7回Vision Science Society年会
    • Place of Presentation
      サラソタハイアットホテル、フロリダ、米国
    • Year and Date
      2007-05-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of striatal visual pathway in Inhibition of Return2007

    • Author(s)
      Takuro Ikeda, Tadashi Isa
    • Organizer
      第7回Vision Science Society年会
    • Place of Presentation
      サラソタ ハイアットホテル、フロリダ、米国
    • Year and Date
      2007-05-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Top-down attention on the visuomotor processing without the primary visual cortex(V1): an experimental study in monkeys with unilateral lesion of V12007

    • Author(s)
      Tadashi Isa
    • Organizer
      第7回Vision Science Society年会
    • Place of Presentation
      米国
    • Year and Date
      2007-05-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Top-down attention onthe visuomotor processing without the primary visual cortex(V1): an experimental study in monkeys with uilateral lesion of V12007

    • Author(s)
      Tadashi Isa
    • Organizer
      第7回 Vision Science Society 年会
    • Place of Presentation
      サラソタ ハイアットホテル、フロリダ、米国
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Investigation of spontaneous saccades based on the saliency model in monkeys with unilateral lesion of primary visual cortex2007

    • Author(s)
      Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Takaura, Tadashi Isa
    • Organizer
      第7回 Vision Science Society 年会
    • Place of Presentation
      サラソタ ハイアットホテル、フロリダ、米国
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Book] Handbook of Microcircuits.(eds G. Shepherd. S. Grillner., The Superior Colliculus.)2010

    • Author(s)
      Kaneda K, Isa T
    • Publisher
      MIT Press(in press)
    • Related Report
      2009 Final Research Report
  • [Book] Eyes, Retina and Visual System of the Mouse(eds Calupa Leo.M. & Willliams R, Superior colliculus and saccade generation in mice.)2008

    • Author(s)
      Sakatani T, Isa T
    • Publisher
      MIT Press
    • Related Report
      2009 Final Research Report
  • [Book] Eyes, Retina and Visual System of the Mouse(eds Calupa Leo. M. & William R)(分担執筆)2008

    • Author(s)
      Sakatani T, Isa T
    • Total Pages
      12
    • Publisher
      MIT Press
    • Related Report
      2008 Annual Research Report
  • [Book] 運動制御回路の構造・機能と損傷後機能代償。ブレインサイエンス・レビュー(分担執筆)2007

    • Author(s)
      伊佐 正
    • Total Pages
      18
    • Publisher
      ブレインサイエンス振興財団
    • Related Report
      2007 Annual Research Report
  • [Book] 脳・脊髄損傷後の機能回復に関する研究の動向。ブレイン・マシン・インタフェース2007

    • Author(s)
      伊佐 正
    • Total Pages
      25
    • Publisher
      (編)「脳を活かす」研究会
    • Related Report
      2007 Annual Research Report
  • [Book] Microcircuit of the Superior Colliculus: A Neuronal Machine that Determines Timing and Endpoint of Saccadic Eye Movements.(Background paper for 93rd Dahlem Workshop on Microcircuits; The interface between Neurons and Global Brain Function)2006

    • Author(s)
      Isa T, Sparks D
    • Related Report
      2009 Final Research Report
  • [Book] Microcircuits. The interface between neurons and global brain function. (eds. S. Grillner & A.M. Graybiel)2006

    • Author(s)
      Isa T, Sparks D
    • Publisher
      MIT Press
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/hbfp/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/news/2007/20080221/

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/news/2007/20080131/

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/news/2007/20071214/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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