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Integrative studies on cortico -basal ganglia link involved in organizing actions

Research Project

Project/Area Number 17021050
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

TAKADA Masahiko  Tokyo Metropolitan Organization for Medical Research, 霊長類研究所, 教授 (00236233)

Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥83,100,000 (Direct Cost: ¥83,100,000)
Fiscal Year 2009: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2008: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2006: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2005: ¥18,500,000 (Direct Cost: ¥18,500,000)
Keywords神経科学 / 脳-神経 / 大脳基底核 / 大脳皮質 / ドーパミン / パーキンソン病遺伝子治療 / ウイルスベクター / パーキンソン病 / 遺伝子治療 / 運動領野 / 前頭前野 / 運動制御 / 行動発現 / 狂犬病ウイルス / サル
Research Abstract

By means of retrograde transneuronal labeling technique with rabies virus, the structural basis for cerebral networks involved in execution and control of actions was analyzed in macaque monkeys. Particularly, the precise architectures of loop circuits linking the primary motor cortex and the basal ganglia/cerebellum, and parietotemporal-prefrontal-motor cortical networks were elucidated in this project. Moreover, basic approaches to gene therapy for Parkinson's disease were attempted to express functional molecules for protecting nigral dopamine neurons against degeneration/loss by gene transfer thereinto with recombinant viral vectors.Recruitment of the calcium-binding protein, calbindin, into the dopamine neurons successfully prevented the onset of parkinsonian insults in macaque monkeys treated withMPTP.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (98 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (46 results) (of which Peer Reviewed: 33 results) Presentation (40 results) Book (10 results) Remarks (2 results)

  • [Journal Article] Motor and nonmotor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques.2010

    • Author(s)
      Hashimoto M, Takahara D, Hirata Y, Inoue K, Miyachi S, Nambu A, Tanji J, Takada M, Hoshi E.
    • Journal Title

      European Journal of Neuroscience Vol.31

      Pages: 1402-1413

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques.2010

    • Author(s)
      Hashimoto M.
    • Journal Title

      European Journal of Neuroscience 31

      Pages: 1402-1413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans.2009

    • Author(s)
      Zheng Y, Watakabe A, Takada M, Kakita A, Namba H, Takahashi H, Yamamori T, Nawa H.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry Vol.33

      Pages: 701-706

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transdural Doppler ultrasonography monitors cerebral blood flow changes in relation to motor tasks.2009

    • Author(s)
      Hatanaka N, Tokuno H, Nambu A, Takada M.
    • Journal Title

      Cerebral Cortex Vol.19

      Pages: 820-831

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transdural Doppler ultrasonography monitors cerebral blood flow changes in relation to motor tasks.2009

    • Author(s)
      Hatanaka N.
    • Journal Title

      Cerebral Cortex 19

      Pages: 820-831

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans.2009

    • Author(s)
      Zheng Y.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psvchiatry 33

      Pages: 701-706

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys.2008

    • Author(s)
      Tachibana Y, Kita H, Chiken S, Takada M, Nambu A.
    • Journal Title

      European Journal of Neuroscience Vol.27

      Pages: 238-253

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys2008

    • Author(s)
      Tachibana Y, Kita H, Chiken S, Takada M, Nambu A
    • Journal Title

      Eur J Neurosci 27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本基礎老化学会編, アドスリー2008

    • Author(s)
      高田昌彦, 井上謙一
    • Journal Title

      サル類モデル.老化・老年病研究のための動物実験ガイドブック

      Pages: 78-87

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A network mechanism underlying hippocampal seizure-like synchronous oscillations.2008

    • Author(s)
      Isomura Y, Fujiwara-Tsukamoto Y, Takada M
    • Journal Title

      Neurosci Res, 61

      Pages: 227-233

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Motor cortical control of internal pallidal activity through glutamatergic and GABAeric inputs in awake monkes2008

    • Author(s)
      Tachibana Y, Kita H, Chiken S, Takada M, Nambu A
    • Journal Title

      Eur J Neurosci (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient gene transfer via retrograde transport in rodent and primate brains by an HIV-1-based vector pseudotyped with rabies virus glycoprotein.2007

    • Author(s)
      Kato S, Inoue K, Kobayashi K, Yasoshima Y, Miyachi S, Inoue S, Hanawa H, Shimada T, Takada M, Kobayashi K.
    • Journal Title

      Human Gene Therapy Vol.18

      Pages: 1141-1151

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2007

    • Author(s)
      Kanamatsu T, Otuki T, Tokuno H, Nambu A, Takada M, Okamoto K, Watanabe H, Umeda M, Tsukada Y.
    • Journal Title

      Brain Research Vol.1181

      Pages: 142-148

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal integration by stochastic recurrent network dynamics with bimodal neurons.2007

    • Author(s)
      Okamoto H, Isomura Y, Takada M, Fukai T.
    • Journal Title

      Journal of Neurophysiology Vol.97

      Pages: 3859-3867

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Layer and frequency dependences of phase response properties of pyramidal neurons in rat motor cortex.2007

    • Author(s)
      Tsubo Y, Takada M, Reyes A, Fukai T.
    • Journal Title

      European Journal of Neuroscience Vol.25

      Pages: 3429-3441

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity.2007

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M.
    • Journal Title

      European Journal of Neuroscience Vol.25

      Pages: 2713-2725

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex.2007

    • Author(s)
      Lu X, Miyachi S, Ito Y, Nambu A, Takada M.
    • Journal Title

      European Journal of Neuroscience Vol.25

      Pages: 2374-2382

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential characteristics of HIV-based vs. SIV-based lentiviral vector systems: gene delivery to neurons and axonal transport of expressed gene.2007

    • Author(s)
      Kitagawa R, Miyachi S, Hanawa H, Takada M, Shimada T.
    • Journal Title

      Neuroscience Research Vol.57

      Pages: 550-558

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal specificity of α-synuclein toxicity and effect of parkin co-expression in primates.2007

    • Author(s)
      Yasuda T, Miyachi S, Kitagawa R, Wada K, Nihira T, Ren Y-R, Hirai Y, Ageyama N, Terao K, Shimada T, Takada M, Mizuno Y, Mochizuki H.
    • Journal Title

      Neuroscience Vol.144

      Pages: 743-753

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient gene transfer via retrograde transport in rodent and primate brains by an HIV-1-based vector pseudotyped with rabies virus glycoprotein2007

    • Author(s)
      Kato S, Inoue K, Kobayashi K, Yasoshima Y, Miyachi S, Inoue S, Hanawa H, Shimada T, Takada M, Kobayashi K
    • Journal Title

      Hum Gene Ther 18

      Pages: 1141-1151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the rates of the tricarboxylic acid (TCA) cycle and glutamine synthesis in the monkey brain with hemiparkinsonisminduced by intracarotid infusion of 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP): studies bynon-invasive^13C-magnetic resonance spectroscopy.2007

    • Author(s)
      Kanamatsu T, Otuki T, Tokuno H, Nambu A, Takada M, Okamoto K, Watanabe H, Umeda M, Tsukada Y
    • Journal Title

      Brain Res 1181

      Pages: 142-148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal integration by stochastic recurrent network dynamics with bimodal neurons2007

    • Author(s)
      Okamoto H, Isomura Y, Takada M, Fukai, T
    • Journal Title

      J Neurophysiol 97

      Pages: 3859-3867

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Layer and frequency dependences of phase response properties of pyramidal neurons in rat motor cortex2007

    • Author(s)
      Tsubo Y, Takada M, Reyes A, Fukai T
    • Journal Title

      Eur J Neurosci 25

      Pages: 3429-3441

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct types of ionic modulation of GABA actions in pyramidal cells and intemeurons during electrical induction of hippocampal seizure-like network activity2007

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M
    • Journal Title

      Eur J Neurosci 25

      Pages: 2713-2725

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of nrimary motor cortex2007

    • Author(s)
      Lu X, Miyachi S, Ito Y, Nambu A, Takada M
    • Journal Title

      Eur J Neurosci 25

      Pages: 2374-2382

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential characteristics of HIV-basedvs. SIV-based lentiviral vectorsystems: gene delivery to neurons and axonal transport of expressed gene2007

    • Author(s)
      Kitagawa R, Miyachi S, Hanawa H, Takada M, Shimada T
    • Journal Title

      Neurosci Res 57

      Pages: 550-558

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal specificity of a-synuclein toxicity and effect of parkinco-expression in primates2007

    • Author(s)
      Yasuda T, Miyachi S, Kitagawa R, Wada K, Nihira T, Ren Y-R, Hirai Y, Ageyama N, Terao K, Shimada T, Takada M, Mizuno Y, Mochizuki H
    • Journal Title

      Neuroscience 144

      Pages: 743-753

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential characteristics of HIV-based vs. SIV-based lentiviral vector systems : gene delivery to neurons and axonal transport of expressed gene.2007

    • Author(s)
      Kitagawa R, Miyachi S, Hanawa H, Takada M, Shimada T
    • Journal Title

      Neurosci Res 57

      Pages: 550-558

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex.2006

    • Author(s)
      Miyachi S, Lu X, Imanishi M, Sawada K, Nambu A, Takada M.
    • Journal Title

      Neuroscience Research Vol.56

      Pages: 300-308

    • NAID

      10019273022

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.2006

    • Author(s)
      Saito M, Murai Y, Bae Y, Akaike T, Takada M, Kang Y.
    • Journal Title

      Journal of Neurophysiology Vol.96

      Pages: 1887-1901

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparable GABAergic mechanisms of hippocampal seizure-like activity in post-tetanic and low-Mg2+ conditions.2006

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Takada M.
    • Journal Title

      Journal of Neurophysiology Vol.95

      Pages: 2013-2019

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex.2006

    • Author(s)
      Miyachi S, Lu X, Imanishi M, Sawada K, Nambu A, Takada M
    • Journal Title

      Neurosci Res 56

      Pages: 300-308

    • NAID

      10019273022

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparable GABAergic mechanisms of hippocampal seizure-like activity in post-tetanic and low-Mg^<2+> conditions.2006

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Takada M
    • Journal Title

      J Neurophysiol 95

      Pages: 2013-2019

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparable GABAergic mechanisms of hippocampal seizure-like activity in post-tetanic and low-Mg^<2+>.2006

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Takada M
    • Journal Title

      J Neurophysiol. 95

      Pages: 2013-2019

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Down-regulation of metabotropic glutamate receptor 1αin globus pallidus and substantia nigra of parkinsonian monkeys.2005

    • Author(s)
      Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, Takada M.
    • Journal Title

      European Journal of Neuroscience Vol.22

      Pages: 3241-3254

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Input□ output organization of jaw movement-related areas in monkey frontal cortex.2005

    • Author(s)
      Hatanaka N, Tokuno H, Nambu A, Inoue T, Takada M.
    • Journal Title

      The Journal of Comparative Neurology Vol.492

      Pages: 401-425

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Region-specific modulation of electrically induced synchronous oscillations in the rat hippocampus and cerebral cortex.2005

    • Author(s)
      Kaneda K, Fujiwara-Tsukamoto Y, Isomura Y, Takada M.
    • Journal Title

      Neuroscience Research Vol.52

      Pages: 83-94

    • NAID

      10016476186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organization of multisynaptic inputs from prefrontal cortex to primary motor cortex as revealed by retrograde transneuronal transport of rabies virus.2005

    • Author(s)
      Miyachi S, Lu X, Inoue S, Iwasaki T, Koike S, Nambu A, Takada M.
    • Journal Title

      The Journal of Neuroscience Vol.25

      Pages: 2547-2556

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys.2005

    • Author(s)
      Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, Takada M
    • Journal Title

      Eur J Neurosci. 22

      Pages: 3241-3254

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Input-output organization of jaw movement-related areas in monkey frontal cortex.2005

    • Author(s)
      Hatanaka N, Tokuno H, Nambu A, Inoue T, Takada M
    • Journal Title

      J Comp Neurol 492

      Pages: 401-425

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Region-specific modulation of electrically induced synchronous oscillations in the rat hippocampus and cerebral cortex2005

    • Author(s)
      Kaneda K Fujiwara-Tsukamoto Y, Isomura Y, Takada M
    • Journal Title

      Neurosci Res 52

      Pages: 83-94

    • NAID

      10016476186

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Organization of multisynaptic inputs from prefrontal cortex to primary motor cortex as revealed by retrograde transneuronal transport of rabies virus.2005

    • Author(s)
      Miyachi S, Lu X, Inoue S, Iwasaki T, Koike S, Nambu A, Takada M
    • Journal Title

      J Neurosci 25

      Pages: 2547-2556

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transdural Doppler ultrasonography monitors cerebral blood flow changes in relation to motor tasks.

    • Author(s)
      Hatanaka N, Tokuno H, Nambu A, Takada M
    • Journal Title

      Cereb Cortex (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal integration by stochastic recurrent network dynamics with bimodal neurons.

    • Author(s)
      Okamoto H, Isomura Y, Takada M, Fukai, T
    • Journal Title

      J. Neurophysiol (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity.

    • Author(s)
      Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M
    • Journal Title

      Eur. J. Neurosci (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex.

    • Author(s)
      Lu X, Miyachi S, Ito Y, Nambu A, Takada M
    • Journal Title

      Eur J Neurosci (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Cerebral network for behavioral control : parietal/temporal-prefrontal-motor links.2010

    • Author(s)
      Takada M.
    • Organizer
      56th NIBB Conference
    • Place of Presentation
      Okazaki
    • Year and Date
      2010-03-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経路選択的細胞操作法の開発2010

    • Author(s)
      井上謙一
    • Organizer
      CREST研究領域「脳の機能発達と学習メカニズムの解明」第7回領域内研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] メタンフェタミン前処理がD5ドーパミン受容体欠損マウスに及ぼす逆説的な効果2010

    • Author(s)
      林崎誠二
    • Organizer
      CREST研究領域「脳の機能発達と学習メカニズムの解明」第7回領域内研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 我が国から発信する霊長類脳科学研究の新しい展開2010

    • Author(s)
      高田昌彦
    • Organizer
      東北大学包括的脳科学研究・教育推進センター設立記念シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2010-01-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウイルスベクターを用いた霊長類脳への遺伝子導入2009

    • Author(s)
      高田昌彦
    • Organizer
      富山大学医学部・大学院講義
    • Place of Presentation
      富山
    • Year and Date
      2009-12-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Organization of multisynaptic inputs to MT and V4 of macaques: Their hierarchic ranks and converging geniculate inputs from magno- and parvocellular layers.2009

    • Author(s)
      Ninomiya T, Sawamura H, Inoue K, Takada M.
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Their hierarchic ranks and converging geniculate inputs from magno-and parvocellular layers.2009

    • Author(s)
      Ninomiya T.
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 背側運動前野肩領域への前頭葉入力様式2009

    • Author(s)
      平田快洋
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラットの腹側海馬CA1野から側頭葉難聴覚野への間接投射の解析2009

    • Author(s)
      山崎吉之
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] サル線条体介在ニューロンの運動関連活動2009

    • Author(s)
      高良沙幸
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット網膜における運動検出に関与するアマクリン細胞の同定2009

    • Author(s)
      雁木美衣
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] LGNからV4、MTへの多シナプス性入力様式2009

    • Author(s)
      二宮太平
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウイルスベクターを用いた黒質ドーパミン細胞へのカルビンディン遺伝子導入によるパーキンソン病の進行抑制2009

    • Author(s)
      井上謙一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] D5ドーパミン受容体のドーパミントランスポーター機能への関与2009

    • Author(s)
      林崎誠二
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小脳から大脳皮質背側運動前野への入力様式2009

    • Author(s)
      橋本雅史
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] グルタミン酸非依存性「proto-afterdischarge」の発生に関与する海馬インターニューロンサブタイプの同定2009

    • Author(s)
      塚元葉子
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 淡蒼球内節から大脳皮質背側運動前野への入力様式2009

    • Author(s)
      星期
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウイルスベクターを用いた霊長類モデル作出と遺伝子治療2009

    • Author(s)
      高田昌彦
    • Organizer
      シンポジウム「霊長類を用いた精神神経疾患モデルの現況と展望」、第52回日本神経化学大会
    • Place of Presentation
      群馬
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Efficient gene transfer system through retrograde axonal transport with a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein.2008

    • Author(s)
      S Kato, K Inoue, K Kobayashi, Y Yasoshima, S Miyachi, S Inoue, H Hanawa, T Shimada, M Takada, K Kobayashi.
    • Organizer
      第38回北米神経学会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Efficient retrograde gene transfer into primate brain with an HIV-1-based Ientiviral vector pseudotyped with rabies virus glycoprotein2008

    • Author(s)
      K Inoue, S Kato, K Kobayashi, Y Yasoshima, S Miyachi, S Inoue, H Hanawa, T Shimada, K Kobayashi, M Takada.
    • Organizer
      第38回北米神経学会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] The dorsal aspect of area 46 (area 46d) and dorsal premotor cortex (PMd) receive specific, as well as common, inputs from the frontal and parietal cortex2008

    • Author(s)
      Y Saga, D Takahara, S miyachi, K Samejima, M takada, J Tanji, E Hoshi.
    • Organizer
      第38回北米神経学会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] アルファシヌクレイン過剰発現によるパーキンソン病モデルザルの開発とパーキン遺伝子導入によるパーキンソン病の抑制2008

    • Author(s)
      山崎吉之、井上謙一、仁平友子、遠藤歩、島田隆、望月秀樹、水野美邦、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] マカクザルにおける後頭部頭頂皮質から前頭前野背外側部と背側運動前野への投射様式2008

    • Author(s)
      佐賀洋介、難波克己、高原大輔、射場美智代、鮫島和行、高田昌彦、丹治順、星英司
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳皮質頭頂連合野から一次運動野への多シナプス性投射様式2008

    • Author(s)
      澤田香織、宮地重弘、山下晶子、勝山成美、今西美知子、黒田呈子、泰羅雅登、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] マカクザルにおける腹側運前野指領域の皮質内結合2008

    • Author(s)
      平田快洋、星英司、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ディレイディスカウンティングを用いた選択行動課題遂行の分子基盤2008

    • Author(s)
      林崎誠二、今西美知子、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parkin遺伝子治療2008

    • Author(s)
      望月秀樹、安田徹、仁平友子、服部信孝、高田昌彦、島田隆、水野美邦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] サル線条体介在ニューロンの活動様式2008

    • Author(s)
      高良沙幸、畑中伸彦、高田昌彦、南部篤
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規逆行輸送組換え体レンチウイルスベクターの開発2008

    • Author(s)
      加藤茂樹、井上謙一、小林憲太、八十島安伸、宮地重弘、井上智、塙秀樹、島田隆、高田昌彦、小林和人
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 海馬スライスにおけるCNQX/AP5抵抗性の同期的振動活動の発生メカニズム2008

    • Author(s)
      塚本葉子、礒村宜和、今西美知子、深井朋樹、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前頭前野腹側部から運動前野背側部への経シナプス投射2008

    • Author(s)
      高原大輔、星英司、宮地重弘、井上謙一、南部篤、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 霊長類神経系における改変シュードタイプウイルスベクターを用いた逆行性遺伝子導入法2008

    • Author(s)
      井上謙一、加藤成樹、小林憲太、宮地重弘、島田隆、小林和人、高田昌彦
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Arrangement of cerebellar interpositus nucleus neurons projecting multisynaptically to primary motor cortex vs prefrontal cortex2007

    • Author(s)
      Lu X, Miyachi S, Ito Y, Nambu A, Kitazawa S, Takada M
    • Organizer
      第37回北米神経科学学会大会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of prefrontal cortex inactivation on reproduction of memorized time2007

    • Author(s)
      Yumoto N, Lu X, Miyachi S, Nambu A, Fukai T, Takada M
    • Organizer
      第37回北米神経科学学会大会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Organization of multisynaptic inputs from temporal and parietal lobesto prefronal cortex in macaque monkeys2007

    • Author(s)
      Hirata Y, Miyachi S, InoueK-I, Hoshi E, Takada M
    • Organizer
      第37回北米神経科学学会大会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] A neuronal pathway for conditional motor behavior:organization of multisynaptic input to dorsal premotor cortex from inferior temporal cortex in macaque monkeys2007

    • Author(s)
      Takahara D, Hoshi E, Hirata Y, Inoue K, Miyachi S, Nambu A, Takada M
    • Organizer
      第37回北米神経科学学会大会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] マカクザルにおける頭頂葉から前頭前皮質への多シナプス性入力様式2007

    • Author(s)
      平田 快洋, 宮地 重弘, 井上 謙一, 今西 美知子, 高田 昌彦
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット海馬CA1野から側頭葉聴覚野への多シナプス性投射2007

    • Author(s)
      山崎 吉之, 石塚 典生, 塚田 稔, 高田 昌彦
    • Organizer
      第30圓日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 海馬局所神経回路におけるCNQX/AP5抵抗性の同期的振動活動2007

    • Author(s)
      塚元 葉子, 礒村 宜和, 今西 美知子, 深井 朋樹, 高田 昌彦
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 時間認知におけるaj-JL前頭前野の役割2007

    • Author(s)
      湯本 直杉, 陸 焼峰, 宮地 重弘, 南部 篤, 深井 朋樹, 高田 昌彦
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Book] 生体の科学(特集 脳科学のモデル実験動物, 61)2010

    • Author(s)
      高田昌彦, 井上謙一
    • Related Report
      2009 Final Research Report
  • [Book] 生体の科学(「特集脳科学のモデル実験動物」高次脳機能の解明と精神・神経経患の克服のためのサルモデル)2010

    • Author(s)
      高田昌彦
    • Total Pages
      6
    • Related Report
      2009 Annual Research Report
  • [Book] Brain and Nerve(「特集神経回路解析法の最近の進歩」狂犬病ウイルスによる多シナプス性神経路の解析法)2010

    • Author(s)
      高田昌彦
    • Total Pages
      10
    • Related Report
      2009 Annual Research Report
  • [Book] Brain and Nerve(「特集大脳基底核-分子基盤から臨床まで」概論)2009

    • Author(s)
      高田昌彦
    • Total Pages
      2
    • Related Report
      2009 Annual Research Report
  • [Book] Brain and Nerve2009

    • Author(s)
      高田昌彦
    • Total Pages
      2
    • Publisher
      学会印象記第38回北米神経科学大会
    • Related Report
      2009 Annual Research Report
  • [Book] 日本臨床(増刊号パーキンソン病)2009

    • Author(s)
      高田昌彦
    • Total Pages
      7
    • Related Report
      2009 Annual Research Report
  • [Book] Medical Rio(パーキンソン病克服にむけた新規遺伝子治療法の開発)2009

    • Author(s)
      高田昌彦
    • Total Pages
      6
    • Related Report
      2009 Annual Research Report
  • [Book] The Basal Ganglia IX2009

    • Author(s)
      Takada M.
    • Total Pages
      9
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] 大脳基底核の生理、病態生理.Clinical Neuroscience(臨床神経科学)メインテーマ「Parkinson病-What's new?」2007

    • Author(s)
      高田 昌彦
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 大脳基底核の生理、病態生理.Clinical Neuroscience(臨床神経科学)メインテーマ「Parkinson病-What's new?」2006

    • Author(s)
      高田昌彦
    • Publisher
      中外医学社
    • Related Report
      2006 Annual Research Report
  • [Remarks] 東京都神経科学総合研究所

    • URL

      http://tmin.ac.jp/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks] 東京都神経科学総合研究所

    • URL

      http://tmin.ac.jp/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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