Integrative studies on cortico -basal ganglia link involved in organizing actions
| Project/Area Number |
17021050
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
TAKADA Masahiko Tokyo Metropolitan Organization for Medical Research, 霊長類研究所, 教授 (00236233)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥83,100,000 (Direct Cost: ¥83,100,000)
Fiscal Year 2009: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2008: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2006: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2005: ¥18,500,000 (Direct Cost: ¥18,500,000)
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| Keywords | 神経科学 / 脳-神経 / 大脳基底核 / 大脳皮質 / ドーパミン / パーキンソン病遺伝子治療 / ウイルスベクター / パーキンソン病 / 遺伝子治療 / 運動領野 / 前頭前野 / 運動制御 / 行動発現 / 狂犬病ウイルス / サル |
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| Research Abstract |
By means of retrograde transneuronal labeling technique with rabies virus, the structural basis for cerebral networks involved in execution and control of actions was analyzed in macaque monkeys. Particularly, the precise architectures of loop circuits linking the primary motor cortex and the basal ganglia/cerebellum, and parietotemporal-prefrontal-motor cortical networks were elucidated in this project. Moreover, basic approaches to gene therapy for Parkinson's disease were attempted to express functional molecules for protecting nigral dopamine neurons against degeneration/loss by gene transfer thereinto with recombinant viral vectors.Recruitment of the calcium-binding protein, calbindin, into the dopamine neurons successfully prevented the onset of parkinsonian insults in macaque monkeys treated withMPTP.
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Report
(6 results)
Research Products
(98 results)
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[Journal Article]2007
Author(s)
Kanamatsu T, Otuki T, Tokuno H, Nambu A, Takada M, Okamoto K, Watanabe H, Umeda M, Tsukada Y.
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Journal Title
Brain Research Vol.1181
Pages: 142-148
Related Report
Peer Reviewed
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[Journal Article] Neuronal specificity of α-synuclein toxicity and effect of parkin co-expression in primates.2007
Author(s)
Yasuda T, Miyachi S, Kitagawa R, Wada K, Nihira T, Ren Y-R, Hirai Y, Ageyama N, Terao K, Shimada T, Takada M, Mizuno Y, Mochizuki H.
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Journal Title
Neuroscience Vol.144
Pages: 743-753
Related Report
Peer Reviewed
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[Journal Article] Changes in the rates of the tricarboxylic acid (TCA) cycle and glutamine synthesis in the monkey brain with hemiparkinsonisminduced by intracarotid infusion of 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP): studies bynon-invasive^13C-magnetic resonance spectroscopy.2007
Author(s)
Kanamatsu T, Otuki T, Tokuno H, Nambu A, Takada M, Okamoto K, Watanabe H, Umeda M, Tsukada Y
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Journal Title
Brain Res 1181
Pages: 142-148
Related Report
Peer Reviewed
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[Journal Article] Neuronal specificity of a-synuclein toxicity and effect of parkinco-expression in primates2007
Author(s)
Yasuda T, Miyachi S, Kitagawa R, Wada K, Nihira T, Ren Y-R, Hirai Y, Ageyama N, Terao K, Shimada T, Takada M, Mizuno Y, Mochizuki H
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Journal Title
Neuroscience 144
Pages: 743-753
Related Report
Peer Reviewed
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