Role of the cortico-basal ganglia system in action and cognition

• Project/Area Number: 17022032
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KIMURA Minoru Kyoto Prefectural University of Medicine, 脳科学研究所, 教授 (40118451)
• Co-Investigator(Kenkyū-buntansha): FUSHIKI Shinji 京都府立医科大学, 医学研究科, 教授 (80150572) ; NAKAGAWA Masanori 京都府立医科大学, 医学研究科, 教授 (50198040) ; UEDA Yasumasa 京都府立医科大学, 医学研究科, 講師 (60332954)
• Project Period (FY): 2005 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥201,900,000 (Direct Cost: ¥201,900,000); Fiscal Year 2009: ¥39,200,000 (Direct Cost: ¥39,200,000); Fiscal Year 2008: ¥39,700,000 (Direct Cost: ¥39,700,000); Fiscal Year 2007: ¥41,500,000 (Direct Cost: ¥41,500,000); Fiscal Year 2006: ¥40,000,000 (Direct Cost: ¥40,000,000); Fiscal Year 2005: ¥41,500,000 (Direct Cost: ¥41,500,000)
• Keywords: 大脳基底核 / 線条体 / ドーパミン系 / 視床CM核 / 報酬価値 / 意志決定 / 行動選択 / 長期的報酬予測 / 動機づけ / ドーパミン / アクション / 行動戦略

Research Abstract

We showed that neuronal activity in the striatum represents reward value of action options and actions associated with reward values. In the intralaminar nuclei of thalamus, CM nucleus, we demonstrated specific neuronal activation at the request of unanticipated action while the subjects were anticipated higher-value action. The results suggested involvement of the CM nucleus in second-best solution for long-term goal. Furthermore, we found that midbrain dopamine neurons encode long-term reward value and its expectation error, which may play a critical role in achieving long-term goal through multi-step actions.

Research Products

• [Journal Article] Inactivation of the putamen selectively impairs reward history-based action selection. (2011)
  • Author(s): Muranishi M, Inokawa H, Yamada H, Ueda Y, Matsumoto N, Nakagawa M, Kimura M.
  • Journal Title: Exp Brain Res. 209(2) Pages: 235-246
  • Peer Reviewed
• [Journal Article] Inactivation of the putamen selectively impairs reward history-based action selection. (2011)
  • Author(s): Muranishi M.
  • Journal Title: Exp Brain Res. Volume: 209(2) Pages: 235-246
  • Peer Reviewed
• [Journal Article] Juxtacellular labeling of tonically active neurons and phasically active neurons in the rat striatum. (2010)
  • Author(s): Inokawa H, Yamada H, Matsumoto N, Muranishi M, Kimura M.
  • Journal Title: Neuroscience 168(2) Pages: 395-404
  • Peer Reviewed
• [Journal Article] Juxtacellular labeling of tonically active neurons and phasically active neurons in the rat striatum. (2010)
  • Author(s): Inokawa H.
  • Journal Title: Neuroscience Volume: 168(2) Pages: 395-404
  • Peer Reviewed
• [Journal Article] Optical imaging of interaural time difference representation in rat auditory cortex. (2009)
  • Author(s): Tsytsarev V, Fukuyama H, Pope D, Pumbo E., Kimura M.
  • Journal Title: Front.Neuroeng. 2 Pages: 2-2
  • Peer Reviewed
• [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action. (2009)
  • Author(s): Minamimoto T, Hori Y., Kimura M.
  • Journal Title: Brain Res.Bull. 78 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Neuronal encoding of reward value and direction of actions in the primate putamen. (2009)
  • Author(s): Hori Y, Minamimoto T, Kimura M.
  • Journal Title: J Neurophysiol 102 Pages: 3530-3543
  • Peer Reviewed
• [Journal Article] Optical imaging of interaural time difference representation in rat auditory cortex (2009)
  • Author(s): Tutsarev V Fukuyama H, Pope D, Pumbo E. & Kimura M.
  • Journal Title: Front Neuroeng 2 Pages: 2-2
  • Peer Reviewed
• [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action (2009)
  • Author(s): Minamimoto T, Hori Y. & Kimura M.
  • Journal Title: Brain Research Bulletin 78 Pages: 75-79
  • Peer Reviewed
• [Journal Article] CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease (2009)
  • Author(s): Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OM. & Yamada M.
  • Journal Title: Brain Res 1251 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis (2009)
  • Author(s): Kasai T, Tokuda T, Ishigami N, Sasayama H, Foulds P, Mitchell DJ Mann DM, Allsop D. & Nakagawa M
  • Journal Title: Acta Neuropathol 117 Pages: 55-62
  • Peer Reviewed
• [Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebr aM after exposure to low doses of bisphenol A (2008)
  • Author(s): Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y. & Fushiki S.
  • Journal Title: Biochem Biophys Res Comm 376 Pages: 563-567
  • Peer Reviewed
• [Journal Article] Evaluation of autonomic malfunction in idiopathic normal pressure hydrocephalus (2008)
  • Author(s): Kuriyama N, Tokuda T, Kondo M, Miyamoto J, Yamada K, Ushijima Y, Ushijima S, Takayasu N, Niwa F, Nakagawa M.
  • Journal Title: Clin Auton Res 18 Pages: 213-220
  • Peer Reviewed
• [Journal Article] Retrograde jugular flow associated with idiopathic normal pressure hydrocephalus (2008)
  • Author(s): Kuriyama N, Tokuda T, Miyamoto J, Takayasu N, Kondo M, Nakagawa M.
  • Journal Title: Ann Neurol 64 Pages: 217-221
  • Peer Reviewed
• [Journal Article] Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro (2008)
  • Author(s): Kasai T, Tokuda T, Yamaguchi N, Watanabe Y, Kametani F, Nakagawa M, Mizuno T.
  • Journal Title: Neurosci Lett 436 Pages: 52-56
  • Peer Reviewed
• [Journal Article] Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyms in the hippocampus by the chemokine stromal cell-derived factor 1 alpha (2008)
  • Author(s): Ohshima Y, Kubo T, Koyama R, Nakaaawa M, Yamashita T.
  • Journal Title: J Neurosci 28 Pages: 8344-8353
  • Peer Reviewed
• [Journal Article] Two Japanese CADASIL families exhibiting Notch3 mutation R75P not involving cysteine residue (2008)
  • Author(s): Mizuno T, Muranishi M, Torugun Tango H, Nagakane Y, Kudeken 1 Kawase Y, Kawabe K, Oshima F, Yaoi T, Itoh K, Fushiki S, Nakagawa M.
  • Journal Title: Inter Med 47 Pages: 2067-2072
  • NAID: 130000079803
  • Peer Reviewed
• [Journal Article] Cerebral white matter damage in frontotemporal dementia assessed 13.3 diffusion tensor tractography (2008)
  • Author(s): Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M, Mori S Nishimura T Nakagawa M
  • Journal Title: Neuroradiology 50 Pages: 605-611
  • Peer Reviewed
• [Journal Article] Analysis of CCG repeats in Huntingtin gene among HD patients and normal populations of Japan (2008)
  • Author(s): Morovvati S, Nakagawa M, Osame M, Karami A.
  • Journal Title: Archives of Medical Research 39 Pages: 131-133
  • Peer Reviewed
• [Journal Article] Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gray and white matter vulnerability (2008)
  • Author(s): Nagakane Y, Yamada K, Ohara T, Yoshikawa K, Kuriyama N, Takayasu N, Kasai T, Yuki N, Nishimura T, Mizuno T, Nakagawa M.
  • Journal Title: Stroke 39 Pages: 494-496
  • Peer Reviewed
• [Journal Article] The cAMP-dependent regulation of spinesin / TMPRSS5 gene expression in astrocytes (2008)
  • Author(s): Yamaguchi T, Watanabe Y, Tanaka M, Nakagawa M, Yamaguchi N.
  • Journal Title: I Neurosci Res 86 Pages: 610-617
  • Peer Reviewed
• [Journal Article] Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gary and white matter vulnerability (2008)
  • Author(s): Nagakane Y, Nakagawa M.et. al.
  • Journal Title: Stroke 39 Pages: 494-496
  • Peer Reviewed
• [Journal Article] An adult form of Alexander disease : a novel mutation in glial fibrillary acidic protein. (2007)
  • Author(s): Ohnari K, Yamano M, Uozumi T, Hashimoto T, Tsuji S., Nakagawa M.
  • Journal Title: J Neurol. 254 Pages: 1390-1394
  • Peer Reviewed
• [Journal Article] History- and current instruction-based coding of forthcoming behavioral outcomes in the striatum. (2007)
  • Author(s): Yamada H, Matsumoto N., Kimura M.
  • Journal Title: J Neurophysiol. 98 Pages: 3557-3567
  • Peer Reviewed
• [Journal Article] History-and current instruction-based coding of forthcoming behavioral outcomes in the striatum (2007)
  • Author(s): Yamada H, Matsumoto N. & Kimura, M.
  • Journal Title: J Neurophysiol 98 Pages: 3557-3567
  • Peer Reviewed
• [Journal Article] An adult form of Alexander disease: a new mutation in Glial Fibrillary Acidic Protein (2007)
  • Author(s): Ohnari K, Nakagawa M., et. al.
  • Journal Title: J Neurol 254 Pages: 1390-1394
  • Peer Reviewed
• [Journal Article] Somatotopic organization of thalamocortical projection fibers as assessed with MR tractography (2007)
  • Author(s): Yamada K, Nakagawa M., et. al.
  • Journal Title: Radiology 242 Pages: 840-845
  • Peer Reviewed
• [Journal Article] The functional alteration of mutant GFAP depends on the located domain: Morphological and functional studies using astrocytoma-derived cells (2007)
  • Author(s): Yoshida T, Nakagawa M., et. al.
  • Journal Title: J Hum Genet 52 Pages: 362-369
  • Peer Reviewed
• [Journal Article] Prenatal exposure to bisphenol A affects adult murine neocortical structure (2007)
  • Author(s): Nakamura K, Itoh K, Sugimoto T. & Fushiki S.
  • Journal Title: Neurosci Lett 420 Pages: 100-105
  • Peer Reviewed
• [Journal Article] What does the habenula tell dopamine neurons?(総説) (2007)
  • Author(s): Kimura, M., Satoh, T. & Matsumoto, N.
  • Journal Title: Nat Neurosci 10 Pages: 677-678
• [Journal Article] Stroke-independent association between metabolic syndrome and functional dependence, depression, and low quality of life in elderly community-dwelling brazilian people. (2007)
  • Author(s): Roriz-Cruz, M., Rosset, I., Wada, T., Sakagami, T., Nakagawa, M., 他10名
  • Journal Title: J. Am. Geriatr. Soc. 55・3 Pages: 374-382
• [Journal Article] MR tractography depicting damage to the arcuate fasciculus in a patient with conduction aphasia. (2007)
  • Author(s): Yamada, K., Nagakane, Y., Mizuno, T., Hosomi, A., Nakagawa, M., Nishimura, T.
  • Journal Title: Neurology 68・10 Pages: 789-789
• [Journal Article] Somatotopic organization of thalamocortical projection fibers as assessed with MR tractography. (2007)
  • Author(s): Yamada, K., Nagakane, Y., Yoshikawa, K., Kizu, O., Ito, H., Nakagawa, M.他5名
  • Journal Title: Radiology 242・3 Pages: 840-845
• [Journal Article] Prenatal exposure to bisphenol A affects adult murine neocortical structure. (2007)
  • Author(s): Nakamura, K., Itoh, K., Sugimoto, T., Fushiki, S.
  • Journal Title: Neurosci. Lett. doi:10. 1016/j.neulet.2007.02.093
• [Journal Article] Autosomal dominant leukodystrophy with axonal spheroids and pigmented glia : clinical and neuropathological characteristics. (2006)
  • Author(s): Itoh, K., Shiga, K., Shimizu, K., Muranishi, M., Nakagawa, M., Fushiki, S.
  • Journal Title: Acta. Neuropathol. 111・1 Pages: 39-45
• [Journal Article] Microbleeds in Alzheimer Disease Are More Related to Cerebral Amyloid Angiopathy than Cerebrovascular Disease. (2006)
  • Author(s): Nakata-Kudo, Y., Mizuno, T., Yamada, K., Shiga, K, Nakagawa, M., 他4名
  • Journal Title: Dement. Geriatr. Cogn. Disord. 22・1 Pages: 8-14
• [Journal Article] Complex visual hallucination and mirror sign in posterior cortical atrophy. (2006)
  • Author(s): Yoshida, T., Yuki, N., Nakagawa, M.
  • Journal Title: Acta. Psychiatr. Scand. 114・1 Pages: 62-65
• [Journal Article] Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. (2006)
  • Author(s): Tokuda, T., Salem, S.A., Allsop, D., Mizuno, T., Nakagawa, M., 他4名
  • Journal Title: Biochem. Biophys. Res. Commun. 349・1 Pages: 162-166
• [Journal Article] Effects of pre- and neonatal exposure to bisphenol A on murine brain development. (2006)
  • Author(s): Tando, S., Itoh, K., Yaoi, T., Ikeda, J., Fujiwara, S., Fushiki, S.
  • Journal Title: Brain Dev. doi:10. 1016/j.braindev.2006.10.003
  • NAID: 10024136092
• [Journal Article] Murine neocortical histogenesis is perturbed by prenatal exposure to low-doses of bisphenol A. (2006)
  • Author(s): Nakamura, K., Itoh, K., Yaoi, T., Fujiwara, Y., Sugimoto, T., Fushiki, S.
  • Journal Title: J. Neurosci. Res. 84・6 Pages: 1197-1205
• [Journal Article] Representation of action-specific reward values in the striatum. (2005)
  • Author(s): Samejima K, Ueda Y, Doya K., Kimura M.
  • Journal Title: Science 310 Pages: 1337-1340
  • Peer Reviewed
• [Journal Article] Complementary process to response bias in the centromedian nucleus of the thalamus. (2005)
  • Author(s): Minamimoto T, Hori Y., Kimura M.
  • Journal Title: Science 308 Pages: 1798-1801
  • Peer Reviewed
• [Journal Article] Complementary process to response bias in the centromedian nucleus of the thalamus. (2005)
  • Author(s): Minamimoto T, Hori Y, Kimura M.
  • Journal Title: Science 308・5729 Pages: 1798-1801
• [Journal Article] Representation of action-specific reward values in the striatum. (2005)
  • Author(s): Samejima K, Ueda Y, Doya K, Kimura M.
  • Journal Title: Science 310・5752 Pages: 1337-1340
• [Journal Article] Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system. (2005)
  • Author(s): Ohta Y, Itoh K, Yaoi T, Tando S, Fukui K, Fushiki S.
  • Journal Title: Brain Res Dev Brain Res 156・1 Pages: 23-31
• [Journal Article] Prenatal low-dose X-irradiation affects connexins 43 and 26 in developing mouse neocortex. (2005)
  • Author(s): Yamanaka T, Itoh K, Yaoi T, Nojima K, Ohta Y, Fujiwara Y, Mineura K, Fushiki S
  • Journal Title: Acta Histochem Cytochem 38 Pages: 223-228
  • NAID: 110003161322
• [Journal Article] Molecular changes in neurons of rat nucleus ambiguous after axotomy, as revealed by a novel method of in vivo fluorescence neuronal labeling combined with single-cell RT-PCR. (2005)
  • Author(s): Hirota R, Itoh K, Yaoi T, Bamba H, Uno T, Hisa Y, Fushiki S.
  • Journal Title: Acta Histochem Cytochem 38 Pages: 229-235
• [Journal Article] Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy. (2005)
  • Author(s): Shiga K, Yamada K, Yoshikawa K, Mizuno T, Nishimura T, Nakagawa M
  • Journal Title: J Neurol 252・5 Pages: 589-596
• [Journal Article] Discrepancy between clinical and pathological diagnoses of CBD and PSP. (2005)
  • Author(s): Mizuno T, Shiga K, Nakata Y, Nagura J, Nakase T, Ueda Y, Takanashi Y, Urasaki K, Oyamada Y, Fushiki S, Nishikawa J, Yasuhara M, Nakajima K, Nakagawa M.
  • Journal Title: J Neurol 252・6 Pages: 687-697
• [Journal Article] Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy. (2005)
  • Author(s): Kuriyama N, Mizuno T, Iida A, Watanabe Y, Nakagawa M.
  • Journal Title: Auton Neurosci 123・1-2 Pages: 87-93
• [Journal Article] Cognitive impairment and frontal-subcortical geriatric syndrome are associated with metabolic syndrome in a stroke-free population.
  • Author(s): Roriz-Cruz, M., Rosset, I., Wada, T., Sakagami, T., Nakagawa, M., 他11名
  • Journal Title: Neurobiol. Aging (in press)
• [Journal Article] The functional alteration of mutant GFAP depends on the located domain : Morphological and functional studies using astrocytoma-derived cells.
  • Author(s): Yoshida, T., Tomozawa, Y., Arisato, T., Okamoto, Y., Hirano, H., Nakagawa, M
  • Journal Title: J. Hum. Genet. (in press)
• [Journal Article] An adult form of Alexander disease : a new mutation in Glial Fibrillary Acidic Protein.
  • Author(s): Ohnari, K., Yamano, M., Uozumi, T., Hashimoto, T., Tsuji, S., Nakagawa, M.
  • Journal Title: J. Neurol. (in press)
• [Presentation] Value signals for decision and action selection in the basal ganglia (2011)
  • Author(s): Kimura M.
  • Organizer: Janelia Conference Neural Circuits of Decision-Making
  • Place of Presentation: Janelia Farm Research Campus, VA, USA
  • Year and Date: 2011-03-06
• [Presentation] Differential encoding of reward value and its prediction error by dopamine neurons located in ventromedial and dorsolateral parts of the midbrain (2010)
  • Author(s): Enomoto K.
  • Organizer: The 40th annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Top-down signal from the frontal cortex regulates social value orientation. (2010)
  • Author(s): Haruno M.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場,愛知県
  • Year and Date: 2010-09-04
• [Presentation] Dopamine neurons in ventromedial and dorsolateral part of the midbrain differentially encode reward value and its error. (2010)
  • Author(s): Enomoto K.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸国際会議揚,兵庫県
  • Year and Date: 2010-09-03
• [Presentation] サルの視床CM 核細胞の報酬予告と行動に対する応答 (2009)
  • Author(s): 山中航, 堀由紀子, 上田康雅, 木村實
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場,愛知県
  • Year and Date: 2009-09-16
• [Presentation] Involvement of the basal ganglia in valuation and selection of actions. (2009)
  • Author(s): Kimura M, Yamada H, Enomoto K, Matsumoto N, Hori Y, Ueda Y., Yamanaka K.
  • Organizer: The 36th Congress of the International Union of Physiological Sciences (IUPS2009)
  • Place of Presentation: 国立京都国際会館,京都府
  • Year and Date: 2009-07-29
• [Presentation] BPA胎生期曝露がマウス大脳皮質形成過程に及ぼす影響 (2009)
  • Author(s): 伏木信次.
  • Organizer: 環境ホルモン学会第20回講演会
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2009-02-24
• [Presentation] Adaptation of reward-based free-choices is impaired by D1 but not U 2 dopamine receptor antagonist in the striatum (2008)
  • Author(s): Ueda Y, Samejima K, Yamanak K, Dova K, Kimura M.
  • Organizer: The 38th annual meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2008-11-17
• [Presentation] Adaptation of reward-based free-choices is impaired by D1 but not D2 dopamine receptor antagonist in the striatum. (2008)
  • Author(s): Ueda Y, Samejima K, Yamanaka K, Doya K, Kimura M.
  • Organizer: The 38th annual meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] 被殻へのムシモル注入による報酬価値に基づく行動選択の障害 (2008)
  • Author(s): 村西学, 井之川仁, 山田洋, 木村實
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム,東京都
  • Year and Date: 2008-07-10
• [Presentation] 被殻へのムシモル注入による報酬価値に基づく行動選択の障害 (2008)
  • Author(s): 村西学、井之川仁、山田洋、木村實.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 高次脳機能障害外来の1年間-専門的医療と包括的支援の必要性- (2008)
  • Author(s): 武澤信夫, 西萩恵, 高ノ原恭子, 近藤正樹, 中川正法.
  • Organizer: 第32回日本高次脳機能障害学会総会
  • Place of Presentation: 松山
• [Presentation] 神経変性疾患における進行性非流暢性失語3例の臨床的特徴-言語症状と脳機能画像所見から- (2008)
  • Author(s): 高ノ原恭子, 栗山長門, 近藤正樹, 中川正法, 長谷斉
  • Organizer: 第32回日本高次脳機能障害学会総会
  • Place of Presentation: 松山
• [Presentation] CADASILにおける脳血管反応性 (2008)
  • Author(s): 水野敏樹, 永金義成, 細見明子, 近藤正樹, 徳田隆彦, 久保田隆生, 奥山智緒, 西村恒彦, 中川正法
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
• [Presentation] CJD患者髄液中ではα-synucleinの断片ペプチドが増加している (2008)
  • Author(s): 笠井高士, 徳田隆彦, 石神紀子, 中川正法, 坪井義夫
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
• [Presentation] 三次元動作解析によるパーキンソン病患者歩行の検討 (2008)
  • Author(s): 瀬尾和弥, 栗山長門, 久保秀一, 松井知之, 奥田求己, 棟近麻衣, 平本真知子, 東善一, 増田隆司, 畠中泰彦, 水野敏樹, 武澤信夫, 長谷斉, 中川正法
  • Organizer: 第2回Movement Disorder Society Japan
  • Place of Presentation: 京都
• [Presentation] Dynamics of mutant GFAP in glia cells using time-lapse recording (2008)
  • Author(s): Yoshida T, Sasayama H, Nakagawa M.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] The chemokine SDF-1α regulates axonal elongation and pathfinding from entorhinal cortex to dentate gyrus in hippocampus. (2008)
  • Author(s): Ohshima Y, Kubo T, Koyama R, Matuki N, Nakagawa M, Yamashita T.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 生活習慣・動脈硬化の認知機能検査に対する関与 (2008)
  • Author(s): 水野敏樹, 近藤正樹, 栗山長門, 三谷智子, 尾崎悦子, 原田早苗, 武田和夫, 渡邊能行, 中川正法
  • Organizer: 第50回日本老年医学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 当院の物忘れ外来におけるアルツハイマー型認知症の危険因子の検討 (2008)
  • Author(s): 近藤正樹, 水野敏樹, 渡邊能行, 松本早苗, 中川正法
  • Organizer: 第50回日本老年医学会学術集会
  • Place of Presentation: 千葉
• [Presentation] NOTCH3関連CADASILとNOTCH3非関連CADASIL (2008)
  • Author(s): 水野敏樹, 細見明子, 永金義成, 牧野雅弘, 巨島文子, 山本康正, 川辺清一, 山村修, 松井真, 神田益太郎, 金田大太, 鷲田和夫, 冨本秀和, 中川正法
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] CJD患者髄液中ではα-synucleinの断片ペプチドが増加している (2008)
  • Author(s): 徳田隆彦, 笠井高士, 石神紀子, 中川正法, 坪井義夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] FIG4遺伝子変異による常染色体劣性遺伝CMT4 J: 2家系の報告 (2008)
  • Author(s): 滋賀健介, 中川正法, LupskiJ, Chow C, Meisler M.
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] パーキンソン病患者におけるカベルゴリンからプラミペキソールへの切り替え方法の検討 (2008)
  • Author(s): 藤原康弘, 宮田清典, 近藤正樹, 栗山長門, 武澤信夫, 徳田隆彦, 水野敏樹, 中川正法
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] タイムラプス画像による変異GFAP導入グリア細胞の動体解析 (2008)
  • Author(s): 吉田誠克, 笹山博司, 中川正法
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] Neurosinによるα-synuclein代謝の検討 (2008)
  • Author(s): 笠井高士, 徳田隆彦, 水野敏樹, 中川正法, 渡邊義久, 山口希, 亀谷富由樹
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] 価値判断と意志決定に関わる大脳基底核の神経信号(シンポジウム講演) (2007)
  • Author(s): 木村 實
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-12-14
• [Presentation] 報酬に基づく行動選択の大脳基底核メカニズム(教育講演) (2007)
  • Author(s): 木村 實
  • Organizer: 第17回神経科学の基礎と臨床:大脳基底核の基礎と臨床Up Date
  • Place of Presentation: 大阪(バイエル薬品(株)三国オフィス新館講堂)
  • Year and Date: 2007-12-08
• [Presentation] ニューロン活動からみた大脳基底核の機能とその障害(教育講演) (2007)
  • Author(s): 木村 實
  • Organizer: Neuroscience Seminar in Kyoto
  • Place of Presentation: 京都(からすま京都ホテル)
  • Year and Date: 2007-12-01
• [Presentation] 随意運動で基底核ニューロンはどのように働いているか?(シンポジウム講演) (2007)
  • Author(s): 木村 實
  • Organizer: Movement Disorder Society, Japan 第一回学術集会
  • Place of Presentation: 東京(品川プリンスホテル)
  • Year and Date: 2007-10-05
• [Presentation] 線条体の行動価値と皮質-基底核回路の強化学習モデル (2007)
  • Author(s): 鮫島和行, 上田康雅, 銅谷賢治, 木村實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2007-09-14
• [Presentation] ドーパミンD1受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響 (2007)
  • Author(s): 上田康雅, 鮫島和行, 銅谷賢治, 木村實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2007-09-12
• [Presentation] 線条体の行動価値と皮質-基底核回路の強化学習モデル(シンポジウム講演) (2007)
  • Author(s): 鮫島 和行, 上田 康雅, 銅谷 賢治, 木村 實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-09-12
• [Presentation] 報酬に基づく意思決定における線条体アセチルコリン信号の役割(ポスター発表) (2007)
  • Author(s): 井之 川仁, 山田 洋, 木村 實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-09-12
• [Presentation] 複数ステップに渡る行動選択過程において、線条体がコードする強化因子(ポスター発表) (2007)
  • Author(s): 山田 洋, 井之 川仁, 木村 實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-09-10
• [Presentation] ドーパミンD1受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響(ポスター発表) (2007)
  • Author(s): 上田 康雅, 鮫島 和行, 銅谷 賢治, 木村 實
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-09-10
• [Book] Sensorimotor Learning and the Basal Ganglia In : Encyclopedia of Neuroscience. (2009)
  • Author(s): Kimura M., Ueda Y.
  • Publisher: Springer
• [Book] Neuroeconomics : Decision Making and the Brain (2009)
  • Author(s): Doya K. & Kimura M.
  • Total Pages: 538
  • Publisher: Academic Press
• [Book] The basal ganglia and the encoding of value.(In : Neuroeconomics : Decision Making and the Brain.) (2008)
  • Author(s): Doya K., Kimura M.
  • Publisher: Academic Press
• [Book] Encyclopedia of Neuroscience (2008)
  • Author(s): Kimura M. & Ueda Y.
  • Total Pages: 4399
  • Publisher: Springer
• [Book] 図説分子病態学(筋神経疾患と三塩基反復配列) (2008)
  • Author(s): 中川正法
  • Publisher: 中外医学社
• [Book] 生命倫理と医療理改訂2版(遺伝子診断と遺伝カウンセリング) (2008)
  • Author(s): 中川正法
  • Publisher: 金芳堂
• [Book] Modulation of striate circuits by dopamine and acetylcholine. In : Microcircuits : The interface between neurons and global brain function. (2006)
  • Author(s): Bergman H, Kimura M., Wickens J.R.
  • Publisher: The MIT press
• [Book] Microcircuits, molecules and motivated behavior-microcircuits in the striatum. In : Microcircuits : The interface between neurons and global brain function. (2006)
  • Author(s): Bergman H, Graybiel AM, Kimura M, Plenz D, Seung HS, Surmeier DJ., Wickens JR.
  • Publisher: The MIT press
• [Book] Motivational Signals of Dopamine Neurons. In : Recent Breakthroughs in Basal Ganglia Research. (2006)
  • Author(s): Kimura M, Satoh T, Sato T, Enomoto, K., Matsumoto N.
  • Publisher: Nova Science Publishers
• [Book] Microcircuits : The interface between neurons and global brain function. (Modulation of striate circuits by dopamine and acetylcholine. pp149-164.) (2006)
  • Author(s): Bergman, H., Kimura, K., Wickens, J.R.
  • Total Pages: 472
  • Publisher: MIT Press (Eds. By Grillner, S. ＆ Graybiel A.M.)
• [Book] Microcircuits : The interface between neurons and global brain function. (Microcircuits, molecules and motivated behavior : microcircuits in the striatum. pp165-190.) (2006)
  • Author(s): Bergman, H., Bolam, P., Graybiel, A.M., Kimura, K., Plenz, D., Seung, S., 他2名
  • Total Pages: 472
  • Publisher: MIT Press (Eds. By Grillner, S. ＆ Graybiel A.M.)
• [Book] Recent Breakthroughs in Basal Ganglia Research. (Motivational Signals of Dopamine Neurons. pp81-90) (2006)
  • Author(s): Kimura, M., Satoh, T., Sato, T., Enomoto, K., Matsumoto, N.
  • Total Pages: 450
  • Publisher: Nova Science Publishers, New York. (Ed. By Bezard, E.)
• [Remarks]
  • URL: http://www.togo-nou.nips.ac.jp/