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Role of the cortico-basal ganglia system in action and cognition

Research Project

Project/Area Number 17022032
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KIMURA Minoru  Kyoto Prefectural University of Medicine, 脳科学研究所, 教授 (40118451)

Co-Investigator(Kenkyū-buntansha) FUSHIKI Shinji  京都府立医科大学, 医学研究科, 教授 (80150572)
NAKAGAWA Masanori  京都府立医科大学, 医学研究科, 教授 (50198040)
UEDA Yasumasa  京都府立医科大学, 医学研究科, 講師 (60332954)
Project Period (FY) 2005 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥201,900,000 (Direct Cost: ¥201,900,000)
Fiscal Year 2009: ¥39,200,000 (Direct Cost: ¥39,200,000)
Fiscal Year 2008: ¥39,700,000 (Direct Cost: ¥39,700,000)
Fiscal Year 2007: ¥41,500,000 (Direct Cost: ¥41,500,000)
Fiscal Year 2006: ¥40,000,000 (Direct Cost: ¥40,000,000)
Fiscal Year 2005: ¥41,500,000 (Direct Cost: ¥41,500,000)
Keywords大脳基底核 / 線条体 / ドーパミン系 / 視床CM核 / 報酬価値 / 意志決定 / 行動選択 / 長期的報酬予測 / 動機づけ / ドーパミン / アクション / 行動戦略
Research Abstract

We showed that neuronal activity in the striatum represents reward value of action options and actions associated with reward values. In the intralaminar nuclei of thalamus, CM nucleus, we demonstrated specific neuronal activation at the request of unanticipated action while the subjects were anticipated higher-value action. The results suggested involvement of the CM nucleus in second-best solution for long-term goal. Furthermore, we found that midbrain dopamine neurons encode long-term reward value and its expectation error, which may play a critical role in achieving long-term goal through multi-step actions.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (102 results)

All 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article (53 results) (of which Peer Reviewed: 31 results) Presentation (36 results) Book (12 results) Remarks (1 results)

  • [Journal Article] Inactivation of the putamen selectively impairs reward history-based action selection.2011

    • Author(s)
      Muranishi M, Inokawa H, Yamada H, Ueda Y, Matsumoto N, Nakagawa M, Kimura M.
    • Journal Title

      Exp Brain Res. 209(2)

      Pages: 235-246

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inactivation of the putamen selectively impairs reward history-based action selection.2011

    • Author(s)
      Muranishi M.
    • Journal Title

      Exp Brain Res.

      Volume: 209(2) Pages: 235-246

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Juxtacellular labeling of tonically active neurons and phasically active neurons in the rat striatum.2010

    • Author(s)
      Inokawa H, Yamada H, Matsumoto N, Muranishi M, Kimura M.
    • Journal Title

      Neuroscience 168(2)

      Pages: 395-404

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Juxtacellular labeling of tonically active neurons and phasically active neurons in the rat striatum.2010

    • Author(s)
      Inokawa H.
    • Journal Title

      Neuroscience

      Volume: 168(2) Pages: 395-404

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging of interaural time difference representation in rat auditory cortex.2009

    • Author(s)
      Tsytsarev V, Fukuyama H, Pope D, Pumbo E., Kimura M.
    • Journal Title

      Front.Neuroeng. 2

      Pages: 2-2

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action.2009

    • Author(s)
      Minamimoto T, Hori Y., Kimura M.
    • Journal Title

      Brain Res.Bull. 78

      Pages: 75-79

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal encoding of reward value and direction of actions in the primate putamen.2009

    • Author(s)
      Hori Y, Minamimoto T, Kimura M.
    • Journal Title

      J Neurophysiol 102

      Pages: 3530-3543

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging of interaural time difference representation in rat auditory cortex2009

    • Author(s)
      Tutsarev V Fukuyama H, Pope D, Pumbo E. & Kimura M.
    • Journal Title

      Front Neuroeng 2

      Pages: 2-2

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action2009

    • Author(s)
      Minamimoto T, Hori Y. & Kimura M.
    • Journal Title

      Brain Research Bulletin 78

      Pages: 75-79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease2009

    • Author(s)
      Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OM. & Yamada M.
    • Journal Title

      Brain Res 1251

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis2009

    • Author(s)
      Kasai T, Tokuda T, Ishigami N, Sasayama H, Foulds P, Mitchell DJ Mann DM, Allsop D. & Nakagawa M
    • Journal Title

      Acta Neuropathol 117

      Pages: 55-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebr aM after exposure to low doses of bisphenol A2008

    • Author(s)
      Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y. & Fushiki S.
    • Journal Title

      Biochem Biophys Res Comm 376

      Pages: 563-567

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of autonomic malfunction in idiopathic normal pressure hydrocephalus2008

    • Author(s)
      Kuriyama N, Tokuda T, Kondo M, Miyamoto J, Yamada K, Ushijima Y, Ushijima S, Takayasu N, Niwa F, Nakagawa M.
    • Journal Title

      Clin Auton Res 18

      Pages: 213-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrograde jugular flow associated with idiopathic normal pressure hydrocephalus2008

    • Author(s)
      Kuriyama N, Tokuda T, Miyamoto J, Takayasu N, Kondo M, Nakagawa M.
    • Journal Title

      Ann Neurol 64

      Pages: 217-221

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro2008

    • Author(s)
      Kasai T, Tokuda T, Yamaguchi N, Watanabe Y, Kametani F, Nakagawa M, Mizuno T.
    • Journal Title

      Neurosci Lett 436

      Pages: 52-56

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyms in the hippocampus by the chemokine stromal cell-derived factor 1 alpha2008

    • Author(s)
      Ohshima Y, Kubo T, Koyama R, Nakaaawa M, Yamashita T.
    • Journal Title

      J Neurosci 28

      Pages: 8344-8353

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Japanese CADASIL families exhibiting Notch3 mutation R75P not involving cysteine residue2008

    • Author(s)
      Mizuno T, Muranishi M, Torugun Tango H, Nagakane Y, Kudeken 1 Kawase Y, Kawabe K, Oshima F, Yaoi T, Itoh K, Fushiki S, Nakagawa M.
    • Journal Title

      Inter Med 47

      Pages: 2067-2072

    • NAID

      130000079803

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral white matter damage in frontotemporal dementia assessed 13.3 diffusion tensor tractography2008

    • Author(s)
      Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M, Mori S Nishimura T Nakagawa M
    • Journal Title

      Neuroradiology 50

      Pages: 605-611

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of CCG repeats in Huntingtin gene among HD patients and normal populations of Japan2008

    • Author(s)
      Morovvati S, Nakagawa M, Osame M, Karami A.
    • Journal Title

      Archives of Medical Research 39

      Pages: 131-133

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gray and white matter vulnerability2008

    • Author(s)
      Nagakane Y, Yamada K, Ohara T, Yoshikawa K, Kuriyama N, Takayasu N, Kasai T, Yuki N, Nishimura T, Mizuno T, Nakagawa M.
    • Journal Title

      Stroke 39

      Pages: 494-496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cAMP-dependent regulation of spinesin / TMPRSS5 gene expression in astrocytes2008

    • Author(s)
      Yamaguchi T, Watanabe Y, Tanaka M, Nakagawa M, Yamaguchi N.
    • Journal Title

      I Neurosci Res 86

      Pages: 610-617

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferred involvement of the basal ganglia after lenticulostriate infarction as a possible indicator of different gary and white matter vulnerability2008

    • Author(s)
      Nagakane Y, Nakagawa M.et. al.
    • Journal Title

      Stroke 39

      Pages: 494-496

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An adult form of Alexander disease : a novel mutation in glial fibrillary acidic protein.2007

    • Author(s)
      Ohnari K, Yamano M, Uozumi T, Hashimoto T, Tsuji S., Nakagawa M.
    • Journal Title

      J Neurol. 254

      Pages: 1390-1394

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] History- and current instruction-based coding of forthcoming behavioral outcomes in the striatum.2007

    • Author(s)
      Yamada H, Matsumoto N., Kimura M.
    • Journal Title

      J Neurophysiol. 98

      Pages: 3557-3567

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] History-and current instruction-based coding of forthcoming behavioral outcomes in the striatum2007

    • Author(s)
      Yamada H, Matsumoto N. & Kimura, M.
    • Journal Title

      J Neurophysiol 98

      Pages: 3557-3567

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An adult form of Alexander disease: a new mutation in Glial Fibrillary Acidic Protein2007

    • Author(s)
      Ohnari K, Nakagawa M., et. al.
    • Journal Title

      J Neurol 254

      Pages: 1390-1394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatotopic organization of thalamocortical projection fibers as assessed with MR tractography2007

    • Author(s)
      Yamada K, Nakagawa M., et. al.
    • Journal Title

      Radiology 242

      Pages: 840-845

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The functional alteration of mutant GFAP depends on the located domain: Morphological and functional studies using astrocytoma-derived cells2007

    • Author(s)
      Yoshida T, Nakagawa M., et. al.
    • Journal Title

      J Hum Genet 52

      Pages: 362-369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to bisphenol A affects adult murine neocortical structure2007

    • Author(s)
      Nakamura K, Itoh K, Sugimoto T. & Fushiki S.
    • Journal Title

      Neurosci Lett 420

      Pages: 100-105

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What does the habenula tell dopamine neurons?(総説)2007

    • Author(s)
      Kimura, M., Satoh, T. & Matsumoto, N.
    • Journal Title

      Nat Neurosci 10

      Pages: 677-678

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Stroke-independent association between metabolic syndrome and functional dependence, depression, and low quality of life in elderly community-dwelling brazilian people.2007

    • Author(s)
      Roriz-Cruz, M., Rosset, I., Wada, T., Sakagami, T., Nakagawa, M., 他10名
    • Journal Title

      J. Am. Geriatr. Soc. 55・3

      Pages: 374-382

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MR tractography depicting damage to the arcuate fasciculus in a patient with conduction aphasia.2007

    • Author(s)
      Yamada, K., Nagakane, Y., Mizuno, T., Hosomi, A., Nakagawa, M., Nishimura, T.
    • Journal Title

      Neurology 68・10

      Pages: 789-789

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Somatotopic organization of thalamocortical projection fibers as assessed with MR tractography.2007

    • Author(s)
      Yamada, K., Nagakane, Y., Yoshikawa, K., Kizu, O., Ito, H., Nakagawa, M.他5名
    • Journal Title

      Radiology 242・3

      Pages: 840-845

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prenatal exposure to bisphenol A affects adult murine neocortical structure.2007

    • Author(s)
      Nakamura, K., Itoh, K., Sugimoto, T., Fushiki, S.
    • Journal Title

      Neurosci. Lett. doi:10. 1016/j.neulet.2007.02.093

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Autosomal dominant leukodystrophy with axonal spheroids and pigmented glia : clinical and neuropathological characteristics.2006

    • Author(s)
      Itoh, K., Shiga, K., Shimizu, K., Muranishi, M., Nakagawa, M., Fushiki, S.
    • Journal Title

      Acta. Neuropathol. 111・1

      Pages: 39-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microbleeds in Alzheimer Disease Are More Related to Cerebral Amyloid Angiopathy than Cerebrovascular Disease.2006

    • Author(s)
      Nakata-Kudo, Y., Mizuno, T., Yamada, K., Shiga, K, Nakagawa, M., 他4名
    • Journal Title

      Dement. Geriatr. Cogn. Disord. 22・1

      Pages: 8-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complex visual hallucination and mirror sign in posterior cortical atrophy.2006

    • Author(s)
      Yoshida, T., Yuki, N., Nakagawa, M.
    • Journal Title

      Acta. Psychiatr. Scand. 114・1

      Pages: 62-65

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.2006

    • Author(s)
      Tokuda, T., Salem, S.A., Allsop, D., Mizuno, T., Nakagawa, M., 他4名
    • Journal Title

      Biochem. Biophys. Res. Commun. 349・1

      Pages: 162-166

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of pre- and neonatal exposure to bisphenol A on murine brain development.2006

    • Author(s)
      Tando, S., Itoh, K., Yaoi, T., Ikeda, J., Fujiwara, S., Fushiki, S.
    • Journal Title

      Brain Dev. doi:10. 1016/j.braindev.2006.10.003

    • NAID

      10024136092

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Murine neocortical histogenesis is perturbed by prenatal exposure to low-doses of bisphenol A.2006

    • Author(s)
      Nakamura, K., Itoh, K., Yaoi, T., Fujiwara, Y., Sugimoto, T., Fushiki, S.
    • Journal Title

      J. Neurosci. Res. 84・6

      Pages: 1197-1205

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Representation of action-specific reward values in the striatum.2005

    • Author(s)
      Samejima K, Ueda Y, Doya K., Kimura M.
    • Journal Title

      Science 310

      Pages: 1337-1340

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complementary process to response bias in the centromedian nucleus of the thalamus.2005

    • Author(s)
      Minamimoto T, Hori Y., Kimura M.
    • Journal Title

      Science 308

      Pages: 1798-1801

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complementary process to response bias in the centromedian nucleus of the thalamus.2005

    • Author(s)
      Minamimoto T, Hori Y, Kimura M.
    • Journal Title

      Science 308・5729

      Pages: 1798-1801

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Representation of action-specific reward values in the striatum.2005

    • Author(s)
      Samejima K, Ueda Y, Doya K, Kimura M.
    • Journal Title

      Science 310・5752

      Pages: 1337-1340

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system.2005

    • Author(s)
      Ohta Y, Itoh K, Yaoi T, Tando S, Fukui K, Fushiki S.
    • Journal Title

      Brain Res Dev Brain Res 156・1

      Pages: 23-31

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prenatal low-dose X-irradiation affects connexins 43 and 26 in developing mouse neocortex.2005

    • Author(s)
      Yamanaka T, Itoh K, Yaoi T, Nojima K, Ohta Y, Fujiwara Y, Mineura K, Fushiki S
    • Journal Title

      Acta Histochem Cytochem 38

      Pages: 223-228

    • NAID

      110003161322

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular changes in neurons of rat nucleus ambiguous after axotomy, as revealed by a novel method of in vivo fluorescence neuronal labeling combined with single-cell RT-PCR.2005

    • Author(s)
      Hirota R, Itoh K, Yaoi T, Bamba H, Uno T, Hisa Y, Fushiki S.
    • Journal Title

      Acta Histochem Cytochem 38

      Pages: 229-235

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy.2005

    • Author(s)
      Shiga K, Yamada K, Yoshikawa K, Mizuno T, Nishimura T, Nakagawa M
    • Journal Title

      J Neurol 252・5

      Pages: 589-596

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Discrepancy between clinical and pathological diagnoses of CBD and PSP.2005

    • Author(s)
      Mizuno T, Shiga K, Nakata Y, Nagura J, Nakase T, Ueda Y, Takanashi Y, Urasaki K, Oyamada Y, Fushiki S, Nishikawa J, Yasuhara M, Nakajima K, Nakagawa M.
    • Journal Title

      J Neurol 252・6

      Pages: 687-697

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autonomic nervous evaluation in the early stages of olivopontocerebellar atrophy.2005

    • Author(s)
      Kuriyama N, Mizuno T, Iida A, Watanabe Y, Nakagawa M.
    • Journal Title

      Auton Neurosci 123・1-2

      Pages: 87-93

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cognitive impairment and frontal-subcortical geriatric syndrome are associated with metabolic syndrome in a stroke-free population.

    • Author(s)
      Roriz-Cruz, M., Rosset, I., Wada, T., Sakagami, T., Nakagawa, M., 他11名
    • Journal Title

      Neurobiol. Aging (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The functional alteration of mutant GFAP depends on the located domain : Morphological and functional studies using astrocytoma-derived cells.

    • Author(s)
      Yoshida, T., Tomozawa, Y., Arisato, T., Okamoto, Y., Hirano, H., Nakagawa, M
    • Journal Title

      J. Hum. Genet. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An adult form of Alexander disease : a new mutation in Glial Fibrillary Acidic Protein.

    • Author(s)
      Ohnari, K., Yamano, M., Uozumi, T., Hashimoto, T., Tsuji, S., Nakagawa, M.
    • Journal Title

      J. Neurol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Value signals for decision and action selection in the basal ganglia2011

    • Author(s)
      Kimura M.
    • Organizer
      Janelia Conference Neural Circuits of Decision-Making
    • Place of Presentation
      Janelia Farm Research Campus, VA, USA
    • Year and Date
      2011-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differential encoding of reward value and its prediction error by dopamine neurons located in ventromedial and dorsolateral parts of the midbrain2010

    • Author(s)
      Enomoto K.
    • Organizer
      The 40th annual meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Top-down signal from the frontal cortex regulates social value orientation.2010

    • Author(s)
      Haruno M.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場,愛知県
    • Year and Date
      2010-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dopamine neurons in ventromedial and dorsolateral part of the midbrain differentially encode reward value and its error.2010

    • Author(s)
      Enomoto K.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸国際会議揚,兵庫県
    • Year and Date
      2010-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルの視床CM 核細胞の報酬予告と行動に対する応答2009

    • Author(s)
      山中航, 堀由紀子, 上田康雅, 木村實
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場,愛知県
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of the basal ganglia in valuation and selection of actions.2009

    • Author(s)
      Kimura M, Yamada H, Enomoto K, Matsumoto N, Hori Y, Ueda Y., Yamanaka K.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      国立京都国際会館,京都府
    • Year and Date
      2009-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] BPA胎生期曝露がマウス大脳皮質形成過程に及ぼす影響2009

    • Author(s)
      伏木信次.
    • Organizer
      環境ホルモン学会第20回講演会
    • Place of Presentation
      東京(特別講演)
    • Year and Date
      2009-02-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adaptation of reward-based free-choices is impaired by D1 but not U 2 dopamine receptor antagonist in the striatum2008

    • Author(s)
      Ueda Y, Samejima K, Yamanak K, Dova K, Kimura M.
    • Organizer
      The 38th annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adaptation of reward-based free-choices is impaired by D1 but not D2 dopamine receptor antagonist in the striatum.2008

    • Author(s)
      Ueda Y, Samejima K, Yamanaka K, Doya K, Kimura M.
    • Organizer
      The 38th annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 被殻へのムシモル注入による報酬価値に基づく行動選択の障害2008

    • Author(s)
      村西学, 井之川仁, 山田洋, 木村實
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム,東京都
    • Year and Date
      2008-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 被殻へのムシモル注入による報酬価値に基づく行動選択の障害2008

    • Author(s)
      村西学、井之川仁、山田洋、木村實.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高次脳機能障害外来の1年間-専門的医療と包括的支援の必要性-2008

    • Author(s)
      武澤信夫, 西萩恵, 高ノ原恭子, 近藤正樹, 中川正法.
    • Organizer
      第32回日本高次脳機能障害学会総会
    • Place of Presentation
      松山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経変性疾患における進行性非流暢性失語3例の臨床的特徴-言語症状と脳機能画像所見から-2008

    • Author(s)
      高ノ原恭子, 栗山長門, 近藤正樹, 中川正法, 長谷斉
    • Organizer
      第32回日本高次脳機能障害学会総会
    • Place of Presentation
      松山
    • Related Report
      2008 Annual Research Report
  • [Presentation] CADASILにおける脳血管反応性2008

    • Author(s)
      水野敏樹, 永金義成, 細見明子, 近藤正樹, 徳田隆彦, 久保田隆生, 奥山智緒, 西村恒彦, 中川正法
    • Organizer
      第27回日本認知症学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2008 Annual Research Report
  • [Presentation] CJD患者髄液中ではα-synucleinの断片ペプチドが増加している2008

    • Author(s)
      笠井高士, 徳田隆彦, 石神紀子, 中川正法, 坪井義夫
    • Organizer
      第27回日本認知症学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 三次元動作解析によるパーキンソン病患者歩行の検討2008

    • Author(s)
      瀬尾和弥, 栗山長門, 久保秀一, 松井知之, 奥田求己, 棟近麻衣, 平本真知子, 東善一, 増田隆司, 畠中泰彦, 水野敏樹, 武澤信夫, 長谷斉, 中川正法
    • Organizer
      第2回Movement Disorder Society Japan
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dynamics of mutant GFAP in glia cells using time-lapse recording2008

    • Author(s)
      Yoshida T, Sasayama H, Nakagawa M.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] The chemokine SDF-1α regulates axonal elongation and pathfinding from entorhinal cortex to dentate gyrus in hippocampus.2008

    • Author(s)
      Ohshima Y, Kubo T, Koyama R, Matuki N, Nakagawa M, Yamashita T.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣・動脈硬化の認知機能検査に対する関与2008

    • Author(s)
      水野敏樹, 近藤正樹, 栗山長門, 三谷智子, 尾崎悦子, 原田早苗, 武田和夫, 渡邊能行, 中川正法
    • Organizer
      第50回日本老年医学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 当院の物忘れ外来におけるアルツハイマー型認知症の危険因子の検討2008

    • Author(s)
      近藤正樹, 水野敏樹, 渡邊能行, 松本早苗, 中川正法
    • Organizer
      第50回日本老年医学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] NOTCH3関連CADASILとNOTCH3非関連CADASIL2008

    • Author(s)
      水野敏樹, 細見明子, 永金義成, 牧野雅弘, 巨島文子, 山本康正, 川辺清一, 山村修, 松井真, 神田益太郎, 金田大太, 鷲田和夫, 冨本秀和, 中川正法
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] CJD患者髄液中ではα-synucleinの断片ペプチドが増加している2008

    • Author(s)
      徳田隆彦, 笠井高士, 石神紀子, 中川正法, 坪井義夫
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] FIG4遺伝子変異による常染色体劣性遺伝CMT4 J: 2家系の報告2008

    • Author(s)
      滋賀健介, 中川正法, LupskiJ, Chow C, Meisler M.
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] パーキンソン病患者におけるカベルゴリンからプラミペキソールへの切り替え方法の検討2008

    • Author(s)
      藤原康弘, 宮田清典, 近藤正樹, 栗山長門, 武澤信夫, 徳田隆彦, 水野敏樹, 中川正法
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] タイムラプス画像による変異GFAP導入グリア細胞の動体解析2008

    • Author(s)
      吉田誠克, 笹山博司, 中川正法
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neurosinによるα-synuclein代謝の検討2008

    • Author(s)
      笠井高士, 徳田隆彦, 水野敏樹, 中川正法, 渡邊義久, 山口希, 亀谷富由樹
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 価値判断と意志決定に関わる大脳基底核の神経信号(シンポジウム講演)2007

    • Author(s)
      木村 實
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 報酬に基づく行動選択の大脳基底核メカニズム(教育講演)2007

    • Author(s)
      木村 實
    • Organizer
      第17回神経科学の基礎と臨床:大脳基底核の基礎と臨床Up Date
    • Place of Presentation
      大阪(バイエル薬品(株)三国オフィス新館講堂)
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューロン活動からみた大脳基底核の機能とその障害(教育講演)2007

    • Author(s)
      木村 實
    • Organizer
      Neuroscience Seminar in Kyoto
    • Place of Presentation
      京都(からすま京都ホテル)
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 随意運動で基底核ニューロンはどのように働いているか?(シンポジウム講演)2007

    • Author(s)
      木村 實
    • Organizer
      Movement Disorder Society, Japan 第一回学術集会
    • Place of Presentation
      東京(品川プリンスホテル)
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 線条体の行動価値と皮質-基底核回路の強化学習モデル2007

    • Author(s)
      鮫島和行, 上田康雅, 銅谷賢治, 木村實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜,神奈川県
    • Year and Date
      2007-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ドーパミンD1受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響2007

    • Author(s)
      上田康雅, 鮫島和行, 銅谷賢治, 木村實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜,神奈川県
    • Year and Date
      2007-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 線条体の行動価値と皮質-基底核回路の強化学習モデル(シンポジウム講演)2007

    • Author(s)
      鮫島 和行, 上田 康雅, 銅谷 賢治, 木村 實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 報酬に基づく意思決定における線条体アセチルコリン信号の役割(ポスター発表)2007

    • Author(s)
      井之 川仁, 山田 洋, 木村 實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 複数ステップに渡る行動選択過程において、線条体がコードする強化因子(ポスター発表)2007

    • Author(s)
      山田 洋, 井之 川仁, 木村 實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] ドーパミンD1受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響(ポスター発表)2007

    • Author(s)
      上田 康雅, 鮫島 和行, 銅谷 賢治, 木村 實
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Book] Sensorimotor Learning and the Basal Ganglia In : Encyclopedia of Neuroscience.2009

    • Author(s)
      Kimura M., Ueda Y.
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Neuroeconomics : Decision Making and the Brain2009

    • Author(s)
      Doya K. & Kimura M.
    • Total Pages
      538
    • Publisher
      Academic Press
    • Related Report
      2008 Annual Research Report
  • [Book] The basal ganglia and the encoding of value.(In : Neuroeconomics : Decision Making and the Brain.)2008

    • Author(s)
      Doya K., Kimura M.
    • Publisher
      Academic Press
    • Related Report
      2010 Final Research Report
  • [Book] Encyclopedia of Neuroscience2008

    • Author(s)
      Kimura M. & Ueda Y.
    • Total Pages
      4399
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Book] 図説分子病態学(筋神経疾患と三塩基反復配列)2008

    • Author(s)
      中川正法
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report
  • [Book] 生命倫理と医療理改訂2版(遺伝子診断と遺伝カウンセリング)2008

    • Author(s)
      中川正法
    • Publisher
      金芳堂
    • Related Report
      2008 Annual Research Report
  • [Book] Modulation of striate circuits by dopamine and acetylcholine. In : Microcircuits : The interface between neurons and global brain function.2006

    • Author(s)
      Bergman H, Kimura M., Wickens J.R.
    • Publisher
      The MIT press
    • Related Report
      2010 Final Research Report
  • [Book] Microcircuits, molecules and motivated behavior-microcircuits in the striatum. In : Microcircuits : The interface between neurons and global brain function.2006

    • Author(s)
      Bergman H, Graybiel AM, Kimura M, Plenz D, Seung HS, Surmeier DJ., Wickens JR.
    • Publisher
      The MIT press
    • Related Report
      2010 Final Research Report
  • [Book] Motivational Signals of Dopamine Neurons. In : Recent Breakthroughs in Basal Ganglia Research.2006

    • Author(s)
      Kimura M, Satoh T, Sato T, Enomoto, K., Matsumoto N.
    • Publisher
      Nova Science Publishers
    • Related Report
      2010 Final Research Report
  • [Book] Microcircuits : The interface between neurons and global brain function. (Modulation of striate circuits by dopamine and acetylcholine. pp149-164.)2006

    • Author(s)
      Bergman, H., Kimura, K., Wickens, J.R.
    • Total Pages
      472
    • Publisher
      MIT Press (Eds. By Grillner, S. & Graybiel A.M.)
    • Related Report
      2006 Annual Research Report
  • [Book] Microcircuits : The interface between neurons and global brain function. (Microcircuits, molecules and motivated behavior : microcircuits in the striatum. pp165-190.)2006

    • Author(s)
      Bergman, H., Bolam, P., Graybiel, A.M., Kimura, K., Plenz, D., Seung, S., 他2名
    • Total Pages
      472
    • Publisher
      MIT Press (Eds. By Grillner, S. & Graybiel A.M.)
    • Related Report
      2006 Annual Research Report
  • [Book] Recent Breakthroughs in Basal Ganglia Research. (Motivational Signals of Dopamine Neurons. pp81-90)2006

    • Author(s)
      Kimura, M., Satoh, T., Sato, T., Enomoto, K., Matsumoto, N.
    • Total Pages
      450
    • Publisher
      Nova Science Publishers, New York. (Ed. By Bezard, E.)
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.togo-nou.nips.ac.jp/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2022-07-14  

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