A research on a type of motor control by the cerebellum
| Project/Area Number |
17022033
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Juntendo University |
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Principal Investigator |
KITAZAWA Shigeru Juntendo University, 医学部, 教授 (00251231)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Toshimitsu 順天堂大学, 医学部, 助教 (00250704)
LU Xiao-fan 順天堂大学, 医学部, 客員准教授 (20360703)
TAKASHIMA Ichiro 産業技術総合研究所, 脳神経情報研究部門, 研究員 (90357351)
NISHIMORI Yasunori 産業技術総合研究所, 脳神経情報研究部門, 研究員 (00357724)
INOUE Masato 順天堂大学, 医学部, 助教 (10423047)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥43,900,000 (Direct Cost: ¥43,900,000)
Fiscal Year 2009: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2008: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2007: ¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2005: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | 小脳 / 運動制御 / 最適化 / プルキンエ細胞 / 単純スパイク / サッカード / サッケード / 前頭眼野 / 補足眼野 / 到達運動 / BMI / マルチ電極 / プリズム順応 / 運動学習 |
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| Research Abstract |
We investigated how the cerebellum contributes to the generation of smooth motor commands. For this purpose, we carried out experiments in arm and eye movements. As a result, we showed that simple spike activities recorded from Purkinje cells in the cerebellum encoded dynamics of the arm movements. The results support the hypothesis that the cerebellum optimizes dynamics of the movements. As for eye movements, we estimated onset times, directions and amplitudes of saccadic eye movements from the neural activities recorded from cerebral cortices. We were successful in calculating optimized motor commands to achieve the estimated eye movements.
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Report
(6 results)
Research Products
(44 results)
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[Journal Article] Statistical parametric mapping of immunopositive cell density2006
Author(s)
Wada, M., Yoshimi, K., Higo, N., Ren, Y.R., Mochizuki, H., Mizuno, Y., Kitazawa, S.
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Journal Title
Neuroscience Research 56・1
Pages: 96-102
NAID
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[Journal Article] Cortical activity in multiple motor areas during sequential finger movements : an application of independent component analysis.2005
Author(s)
Kansaku, K, Muraki, S, Umeyama, S, Nishimori, Y, Kochiyama, T, Yamane, S, Kitazawa, S.
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Journal Title
Neuroimage 28・3
Pages: 669-681
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[Presentation] Estimating saccade timing and targets from neural activity : Comparison of the macaque frontal eye field and the supplementary eye field2008
Author(s)
Ohmae, S., Lu, X., Uchida, Y., Takahashi, T., Nishimori, Y., Kodaka, Y., Takashima, I., Kitazawa S.
Organizer
38th Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2008-11-19
Related Report
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[Presentation] Estimating saccade timing and targets from neural activity: Comparison of the macaque frontal eye field and the supplementary eye field.2008
Author(s)
Ohmae, S., Lu, X., Uchida, Y., Takahashi, T., Nishimori, Y., Kodaka, Y., Takashima, I., Kitazawa S.
Organizer
38th Annual meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2008-11-17
Related Report
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[Presentation] Flag manifolds for subspace ICA problems.2007
Author(s)
Y., Nishimori・S., Akaho・S. A., Abdallah・M. D., Plumbley.
Organizer
International Conference on Acoustics, Speech, and Signal Processing (ICASSP 2007)
Place of Presentation
Honolulu, Hawaii, USA
Year and Date
2007-04-15
Related Report
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