| Project/Area Number |
17022033
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Juntendo University |
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Principal Investigator |
KITAZAWA Shigeru Juntendo University, 医学部, 教授 (00251231)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Toshimitsu 順天堂大学, 医学部, 助教 (00250704)
LU Xiao-fan 順天堂大学, 医学部, 客員准教授 (20360703)
TAKASHIMA Ichiro 産業技術総合研究所, 脳神経情報研究部門, 研究員 (90357351)
NISHIMORI Yasunori 産業技術総合研究所, 脳神経情報研究部門, 研究員 (00357724)
INOUE Masato 順天堂大学, 医学部, 助教 (10423047)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥43,900,000 (Direct Cost: ¥43,900,000)
Fiscal Year 2009: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2008: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2007: ¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2005: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | 小脳 / 運動制御 / 最適化 / プルキンエ細胞 / 単純スパイク / サッカード / サッケード / 前頭眼野 / 補足眼野 / 到達運動 / BMI / マルチ電極 / プリズム順応 / 運動学習 |
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| Research Abstract |
We investigated how the cerebellum contributes to the generation of smooth motor commands. For this purpose, we carried out experiments in arm and eye movements. As a result, we showed that simple spike activities recorded from Purkinje cells in the cerebellum encoded dynamics of the arm movements. The results support the hypothesis that the cerebellum optimizes dynamics of the movements. As for eye movements, we estimated onset times, directions and amplitudes of saccadic eye movements from the neural activities recorded from cerebral cortices. We were successful in calculating optimized motor commands to achieve the estimated eye movements.
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