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Functional connectivity and relationship among reward-related and reward expectancy-related brain areas in goal-directed behavior

Research Project

Project/Area Number 17022050
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

WATANABE Masataka  Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 特任研究員 (50092383)

Co-Investigator(Kenkyū-buntansha) KODAMA Tohru  財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 (20195746)
HIKOSAKA Kazuo  川崎医療福祉大学, 医療技術学部, 教授 (60129004)
HONNDA Yoshiko  財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (50142154)
KOJIMA Takashi  財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (30225429)
KUWAHATA Taku  財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (70415537)
Co-Investigator(Renkei-kenkyūsha) SAKAGAMI Masamichi  玉川大学, 脳科学研究所, 教授
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥64,900,000 (Direct Cost: ¥64,900,000)
Fiscal Year 2009: ¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2008: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2007: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2006: ¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2005: ¥14,600,000 (Direct Cost: ¥14,600,000)
Keywords報酬 / 報酬期待 / 動機づけ / ニューロン活動 / ドーパミン / 前頭連合野 / 線条体 / サル / ゲーム / 内発的動機づけ
Research Abstract

For survival and reproduction, organisms work to obtain rewards (food, liquid or mates). For humans, beautiful or interesting objects are also rewarding. This study was conducted to clarify what brain areas are responsible for detecting/expecting the reward, and how these reward-related areas interact. It was found that (1)the prefrontal cortex is involved in integrating cognitive and motivational information ; and (2)dopamine in the prefrontal cortex and striatum plays important roles in goal-directed behavior.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (67 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (31 results) (of which Peer Reviewed: 17 results) Presentation (23 results) Book (13 results)

  • [Journal Article] Default mode of brain activity demonstrated by PET imaging in awake monkeys -higher rest-related than working memory-related activity in medial cortical areas.2009

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K., Tsutui, K-I., Tsukada, H., Watanabe, M.
    • Journal Title

      J. Neurosci. 29

      Pages: 14463-14471

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 報酬の脳内機構2009

    • Author(s)
      渡邊正孝
    • Journal Title

      Annual Review神経 25

      Pages: 1-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Default mode of brain activity demonstrated by PET imaging in a wake monkeys -higher rest-related than working memory-related activity in medial cortical areas.2009

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka. K., Tsntsui, K., Tsukada, H., Watanabe, M
    • Journal Title

      Journal of Neuroscience 29

      Pages: 14463-14471

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳科学の将来-動物研究の視点から2009

    • Author(s)
      渡辺正孝
    • Journal Title

      三田評論

      Pages: 26-31

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 情動の脳内機構:喜び(報酬)2009

    • Author(s)
      渡辺正孝
    • Journal Title

      BRAIN MEDICAL 21

      Pages: 41-46

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 報酬の脳内機構2009

    • Author(s)
      渡辺正孝
    • Journal Title

      Annual Review神経2009

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 前頭連合野と報酬期待2008

    • Author(s)
      渡邊正孝
    • Journal Title

      分子精神医学 8(2)

      Pages: 87-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] 学習意欲と前頭連合野2008

    • Author(s)
      渡邊正孝
    • Journal Title

      BRAIN and NERVE 60(7)

      Pages: 815-824

    • Related Report
      2009 Final Research Report
  • [Journal Article] 報酬の脳内表現2008

    • Author(s)
      筒井健一郎、渡邊正孝
    • Journal Title

      生理心理学と精神生理学 26(1)

      Pages: 5-16

    • NAID

      130004624583

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前頭連合野と報酬期待2008

    • Author(s)
      渡辺正孝
    • Journal Title

      分子精神医学 8

      Pages: 87-90

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 報酬の脳内表現2008

    • Author(s)
      筒井健一郎、渡辺正孝
    • Journal Title

      生理心理学と精神生理学 26

      Pages: 5-16

    • NAID

      130004624583

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 学習意欲と前頭連合野2008

    • Author(s)
      渡辺正孝
    • Journal Title

      BRAIN and NERVE 60

      Pages: 815-824

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Functional Specialization of the Primate Frontal Cortex during Decision Making.2007

    • Author(s)
      Lee, D., Rushworth, M.F.S., Walton, M.E., Watanabe, M., Sakagami, M.
    • Journal Title

      J. Neurosci. 27

      Pages: 8170-8173

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integration of cognitive and motivational information in the primate lateral prefrontal cortex.2007

    • Author(s)
      Sakagami, M., Watanabe, M.
    • Journal Title

      Ann. NY Acad. Sci. 1104

      Pages: 89-10

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integration of cognitive and motivational context information in the primate prefrontal cortex.2007

    • Author(s)
      Watanabe, M., Sakagami, M.
    • Journal Title

      Cer. Cor. 17

      Pages: 101-109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of anticipated reward in cognitive behavioral control.2007

    • Author(s)
      Watanabe, M.
    • Journal Title

      Cur. Opin. Neurobiol. 17

      Pages: 213-219

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reward expectancy-related prefrontal neuronal activities - are they neural substrates of‘affective' working memory?2007

    • Author(s)
      Watanabe, M., Hikosaka, K., Sakagami, M., Shirakawa, S.
    • Journal Title

      Cortex 43

      Pages: 53-64

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Domain-related differentiation of working memory in the Japanese macaque (Macaca fuscata) frontal cortex: a positron emission tomography study.2007

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K, Tsutsui, K, Tsukada, H, Watanabe, M.
    • Journal Title

      Eur. J. Neurosci. 25

      Pages: 2523-2535

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Domain-related differentiation of working memory in the Japanese macaque (Macaca fuscata) frontal cortex:a positron emission tomography study2007

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K., Tsutsui, K., Tsukada, H. & Watanabe, M.
    • Journal Title

      European Journal of Neuroscience 25

      Pages: 2523-2535

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integration of cognitive and motivational information in the primatelateral prefrontal cortex2007

    • Author(s)
      Sakagajni, M. & Watanabe, M.
    • Journal Title

      Annals of New York Academy of Sciences 1104

      Pages: 89-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integration of cognitive and motivational context information in the primate prefrontal cortex2007

    • Author(s)
      Watanabe, M, & Sakagami, M.
    • Journal Title

      Cerebral Cortex 17

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of anticipated reward in cognitive behavioral control2007

    • Author(s)
      Watanabe, M.
    • Journal Title

      Current Opinion in Neurobiology 17

      Pages: 213-219

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional specialization of the primate frontal cortex during decision making.2007

    • Author(s)
      Lee, D., Rushworth, M. F. S., Walton M. E., Watanabe M. & Sakagami, M.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 8170-8173

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reward expectancy-related prefrontal neuronal activities - are they neural substrates of 'affective' working memory?2007

    • Author(s)
      Watanabe, M., Hikosaka, K., Sakagami, M., Shirakawa, S
    • Journal Title

      Cortex 43

      Pages: 53-64

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Domain-related differentiation of working memory in the Japanese macaque (Macaca fuscata) frontal cortex : a positron emission tomography study.2007

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K, Tsutsui, K, Tsukada, H, Watanabe, M.
    • Journal Title

      European Journal of Neuroscience 25

      Pages: 2523-2535

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Integration of cognitive and motivational information in the primate lateral prefrontal cortex.2007

    • Author(s)
      Sakagami, M., Watanabe, M.
    • Journal Title

      Annals of New York Academy of Sciences (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of anticipated reward in cognitive behavioral control.2007

    • Author(s)
      Watanabe, M.
    • Journal Title

      Current Opinion in Neurobiology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Integration of cognitive and motivational context information in the primate prefrontal cortex.2007

    • Author(s)
      Watanabe, M., Sakagami, M.
    • Journal Title

      Cerebral Cortex (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.2006

    • Author(s)
      Kobayashi, S., Nomoto, K., Watanabe, M., Hikosaka, O., Schultz, W., Sakagami, M.
    • Journal Title

      Neuron 51

      Pages: 861-870

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional significance of delay-period activity of primate prefrontal neurons in relation to spatial working memory and reward/omission-of-reward expectancy.2005

    • Author(s)
      Watanabe, M., Hikosaka, K., Sakagami, M., Shirakawa, S.
    • Journal Title

      Exp. Brain Res. 166

      Pages: 263-276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional significance of delay-period activity of primate prefrontal neurons in relation to spatial working memory and reward/omission-of-reward expectancy.2005

    • Author(s)
      Watanabe, M., Hikosaka, K., Sakagami, M., Shirakawa, S.
    • Journal Title

      Experimental Brain Research 166

      Pages: 263-276

    • Related Report
      2005 Annual Research Report
  • [Presentation] Executive and motivational control of behavior and the primate prefrontal cortex.2010

    • Author(s)
      Watanabe, M.
    • Organizer
      20^<th> Annual Rotman Research Institute Conference "The Frontal Lobes"(招待講演)
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-03-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生育時光環境誘導多動モデル(ラット)へのリタリンの効果2009

    • Author(s)
      児玉亨、本多芳子、渡邊正孝、臼井節夫
    • Organizer
      第6回アジア睡眠学会/第16回日本時間生物学会学術大会合同大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regions showing task-induced deactivation and regions with the highest level of regional cerebral blood flow during rest - A monkey PET study2009

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K., Tsutui, K-I., Tsukada, H., Watanabe, M.
    • Organizer
      39th Society for Neuroscience Meeting
    • Place of Presentation
      McCormic Convention Center, Chicago, USA
    • Year and Date
      2009-10-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Regions showing task-induced deactivation and regions with the highest level of regional cerebral blood flow during rest -A monkey PET study.2009

    • Author(s)
      Kojima, T., Onoe, H., Hikosaka, K., Tsutui, K-I., Tsukada, H., Watanabe, M.
    • Organizer
      39th Society for Neuroscience Meeting
    • Place of Presentation
      Chicago,USA
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visual responsiveness of primate prefrontal neurons can be modulated by the biofeedback technique.2008

    • Author(s)
      Noritake, A., Watanabe, M., Sakagami, M.
    • Organizer
      38th Society for Neuroscience Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Primate prefrontal neuronal activity during competitive and noncompetitive video shooting games.2008

    • Author(s)
      Hosokawa T., Watanabe M
    • Organizer
      38th Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Primate prefrontal neuronal activity during competitive and noncompetitive video shooting games.2008

    • Author(s)
      Hosokawa T, Watanabe M.
    • Organizer
      38th Society for Neuroscience Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳の創造メカニズム2008

    • Author(s)
      渡辺正孝
    • Organizer
      日本創造学会
    • Place of Presentation
      日本教育大学院大学、東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] サルの抑制行動に対するメチルフェニデートの影響2008

    • Author(s)
      桑波田卓、渡邊正孝
    • Organizer
      日本心理学会第72回大会
    • Place of Presentation
      札幌
    • Year and Date
      2008-09-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Task-induced deactivation of the prefrontal and parietal areas in the monkey: a PET study.2008

    • Author(s)
      Watanabe M, Kojima T, Hikosaka K, Tsutui K, Tsukada H., Onoe H.
    • Organizer
      XXIX International Congress of Psychology
    • Place of Presentation
      Berlin
    • Year and Date
      2008-07-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Task-induced deactivation of the prefrontal and parietal areas in the monkey : a PET study2008

    • Author(s)
      Watanabe M.
    • Organizer
      XXIX International Congress of Psychology
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 勝者・敗者両方に報酬が与えられる、あるいはどちらにも与えられないという不条理な対戦ゲームにおけるサル前頭連合野ニューロン活動2008

    • Author(s)
      細川貴之渡邊正孝
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 勝者・敗者両方に報酬が与えられる、あるいはどちらにも与えられないという不条理な対戦ゲームにおけるサル前頭連合野ニューロン活動2008

    • Author(s)
      細川貴之、渡辺正孝
    • Organizer
      第31回日本神経科学大会会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生育期のメチルフェニデート長期連続投与による行動変化(2)2008

    • Author(s)
      児玉亨、本多芳子、渡辺正孝、臼井節夫
    • Organizer
      第33回日本睡眠学会定期学術会議
    • Place of Presentation
      福島
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] メチルフェニデートによるサル認知課題遂行時の注意集中レベル変化2008

    • Author(s)
      桑波田卓、児玉亨、本多芳子、渡邊正孝
    • Organizer
      第33回日本睡眠学会定期学術会議
    • Place of Presentation
      福島
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生育時における長期メチルフェニデート投与による脳内ドーパミン変化2008

    • Author(s)
      児玉亨、本多芳子、桑波田卓、渡邊正孝、臼井節夫
    • Organizer
      第33回日本睡眠学会定期学術会議
    • Place of Presentation
      福島
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 欲しいものと欲しくないものの脳内表象2007

    • Author(s)
      渡邊正孝
    • Organizer
      第12回日本神経精神医学会, 招待講演
    • Place of Presentation
      東京女子医科大学
    • Year and Date
      2007-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 意識論の最前線:心理・神経科学的知見とモデル-神経科学の立場から2007

    • Author(s)
      渡邊正孝
    • Organizer
      日本理論心理学会第53回大会, 招待講演
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Monkeys play video games-comparison between competitive and uncompetitive situations2007

    • Author(s)
      Hosokawa, T. & Watanabe M.
    • Organizer
      Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Primate prefrontal neuronal activity during a competitive video game2007

    • Author(s)
      Hosokawa, T. & Watanabe M.
    • Organizer
      第30回日本神経科学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Working memory-related and non-working memory-related delay activity in primate prefrontal neurons2006

    • Author(s)
      Watanabe, M.
    • Organizer
      36th Society for Neuroscience meeting
    • Place of Presentation
      Symposium on "Working memory in the brain"
    • Year and Date
      2006-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Contribution of Hebb's 'Organization of Behavior' to the development of brain science.2006

    • Author(s)
      渡邊正孝
    • Organizer
      第29回日本神経科学大会シンポジュウム発表
    • Place of Presentation
      京都
    • Year and Date
      2006-07-21
    • Related Report
      2009 Final Research Report
  • [Presentation] サル用PETによるワーキングメモリー課題遂行時と安静時の脳活動の比較2005

    • Author(s)
      渡邊正孝, 小島崇, 彦坂和雄, 尾上浩隆, 塚田秀夫
    • Organizer
      第65回日本動物心理学会口頭発表
    • Place of Presentation
      千葉大学
    • Year and Date
      2005-10-09
    • Related Report
      2009 Final Research Report
  • [Book] Handbook of Reward and Decision Making((eds.) Jean-Claude Dreher and Leon Tremblay, Role of the primate lateral prefrontal cortex in integrating decision-making and motivational information.)2009

    • Author(s)
      Watanabe, M.
    • Publisher
      Elsevier
    • Related Report
      2009 Final Research Report
  • [Book] Role of the primate lateral prefrontal cortex in integrating decision-making and motivational information. In "Handbook of Reward and Decision Haking" (eds.) Jean-Claude Dreher and Leon Tremblay2009

    • Author(s)
      Watanabe M
    • Total Pages
      18
    • Publisher
      Elsevier
    • Related Report
      2009 Annual Research Report
  • [Book] 発想の大脳メカニズム「発想と企画の心理学」(高橋誠編)2009

    • Author(s)
      渡辺正孝
    • Total Pages
      14
    • Publisher
      朝倉書店(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] 認識と行動の脳科学(田中啓治編, 行動の認知科学)2008

    • Author(s)
      渡邊正孝
    • Related Report
      2009 Final Research Report
  • [Book] 社会活動と脳ー行動の原点を探る(岩田誠、河村満 編, 欲望の脳科学-サルの意志決定)2008

    • Author(s)
      渡邊正孝
    • Related Report
      2009 Final Research Report
  • [Book] メタ認知 学習力を支える高次認知機能(三宮真智子 編, メタ認知の神経科学的基礎, 第12章)2008

    • Author(s)
      渡邊 正孝
    • Related Report
      2009 Final Research Report
  • [Book] 行動の認知科学(田中啓治 編「認識と行動の脳科学」)2008

    • Author(s)
      渡辺正孝
    • Total Pages
      61
    • Publisher
      東京大学出版会
    • Related Report
      2008 Annual Research Report
  • [Book] 欲望の脳科学-サルの意思決定(岩田誠、河村満 編「社会活動と脳-行動の原点を探る」)2008

    • Author(s)
      渡辺正孝
    • Total Pages
      17
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Book] メタ認知の神経科学的基礎, 三宮真智子 編「メタ認知 学習力を支える高次認知機能」2008

    • Author(s)
      渡辺正孝
    • Total Pages
      18
    • Publisher
      北大路書房
    • Related Report
      2008 Annual Research Report
  • [Book] 記憶・思考・脳2007

    • Author(s)
      横山 詔一、渡邊 正孝
    • Total Pages
      142
    • Publisher
      新曜社
    • Related Report
      2007 Annual Research Report
  • [Book] 記憶・思考・脳2006

    • Author(s)
      横山詔一、渡邊正孝
    • Publisher
      新曜社
    • Related Report
      2009 Final Research Report
  • [Book] 思考と脳2005

    • Author(s)
      渡邊正孝
    • Publisher
      サイエンス社
    • Related Report
      2009 Final Research Report
  • [Book] 思考と脳2005

    • Author(s)
      渡辺 正孝
    • Total Pages
      203
    • Publisher
      サイエンス社
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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