Brain information processing mechanism on goal-directed behavior based on motivation

• Project/Area Number: 17022052
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Tsukuba
• Principal Investigator: SHIDARA Munetaka University of Tsukuba, 大学院・人間総合科学研究科, 教授 (10357189)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥62,700,000 (Direct Cost: ¥62,700,000); Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥10,400,000); Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥11,700,000); Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥11,700,000); Fiscal Year 2006: ¥13,600,000 (Direct Cost: ¥13,600,000); Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000)
• Keywords: 報酬期待 / 報酬価値 / 単一ニューロン記録 / 前部帯状皮質 / 背側縫線核 / 前部島皮質 / セロトニンニューロン / 行動決定 / 前部帶状皮質 / 島皮質

Research Abstract

Neuronal activities were investigated while monkeys performed the multi-trial reward schedule task with variable reward amount. In rostral part of anterior cingulate cortex neurons responded at the first trial of the schedule, then gradually decreased through schedule progress. In anterior insular cortex neurons responded when there was possibility to obtain reward. In dorsal raphe nucleus there were neurons that responded in non-rewarded trials. In decision-making task monkey's choice behavior could be explained by exponential discounting model of reward value.

Research Products

• [Journal Article] 島皮質における報酬期待ニューロンの発火特性 ―新しい情報コーディングの可能性― (2010)
  • Author(s): 設楽宗孝
  • Journal Title: Clinical Neuroscience 28 Pages: 383-385
• [Journal Article] 創造性とスポーツトレーニング[コメントー脳科学的観点から] (2008)
  • Author(s): 設楽宗孝
  • Journal Title: 体育の科学 58 Pages: 114-116
• [Journal Article] A comparison of reward-contingent neuronal activity in monkey orbitofrontal cortex and ventral striatum: guiding actions toward rewards. (2007)
  • Author(s): Simmons, JM., Ravel, S., Shidara, M. Richmond, BJ.
  • Journal Title: Ann N Y Acad Sci. 1121 Pages: 376-94
  • Peer Reviewed
• [Journal Article] Mode changes in activity of single neurons in anterior insular cortex across trials during multi-trial reward schedules. (2007)
  • Author(s): Mizuhiki, T., Richmond, BJ., Shidara M.
  • Journal Title: Neurosci Res. 57 Pages: 587-91
  • NAID: 10024414174
  • Peer Reviewed
• [Journal Article] A Comparison of Reward-Contingent Neuronal Activity in Monkey Orbitofrontal Cortex and Ventral Striatum. Guiding Actions toward (2007)
  • Author(s): Simmons JM
  • Journal Title: Annals of the New York Academy of Sciences 1121 Pages: 376-394
  • Peer Reviewed
• [Journal Article] Mode changes in activity of single neurons in anterior insular cortex across trials during multi-trial reward schedules. (2007)
  • Author(s): Mizuhiki, T.
  • Journal Title: Neuroscience Research 57 Pages: 587-591
• [Journal Article] A model to explain the emergence of reward expectancy neurons using reinforcement learning and neural network. (2006)
  • Author(s): Ishii, S.
  • Journal Title: Neurocomputing 69 Pages: 587-591
• [Journal Article] Neuronal firing in anterior cingulate neurons changes modes across trials in single states of multitrial reward schedules. (2005)
  • Author(s): Shidara, M., Mizuhiki, T., Richmond BJ.
  • Journal Title: Exp Brain Res. 163 Pages: 242-5
  • Peer Reviewed
• [Journal Article] Neuronal firing in anterior cingulate neurons changes modes across trials in single states of multitrial reward schedules. (2005)
  • Author(s): Shidara, M.
  • Journal Title: Experimental Brain Research 163 Pages: 242-245
• [Journal Article] Effect of visual noise on pattern recognition. (2005)
  • Author(s): Shidara, M.
  • Journal Title: Experimental Brain Research 163 Pages: 239-241
• [Presentation] The behavioral response of the monkey during a decision-making task to chose reward schedule and amount (2009)
  • Author(s): Mizuhiki T
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] Single neuronal responses in monkey dorsal raphe nucleus during multi-trial reward schedule task with different reward amount (2009)
  • Author(s): Inaba K
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA(アメリカ)
  • Year and Date: 2009-10-21
• [Presentation] Effects of the reward proximity and amount on neuronal signals in rostral part of monkey anterior cingulate cortex (2009)
  • Author(s): Toda K
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA(アメリカ)
  • Year and Date: 2009-10-21
• [Presentation] A comparison of reward-related neuronal responses in the monkey limbic system (2009)
  • Author(s): Simmons JM
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA(アメリカ)
  • Year and Date: 2009-10-21
• [Presentation] 報酬の近さと量を操作した視覚弁別課題遂行中のアカゲザル前部帯状皮質の単一ニューロン活動 (2009)
  • Author(s): 兎田幸司
  • Organizer: 第69回日本動物心理学会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-09-26
• [Presentation] The behavioral response of the monkey performing a decision-making task of choosing reward schedule and amount (2009)
  • Author(s): Mizuhiki T
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Effects of reward proximity and amount on neural activity in the rostral anterior cingulate cortex (2009)
  • Author(s): Toda K
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Single neurons in monkey dorsal raphe nucleus responded in multitrial reward schedule task with different reward amount (2009)
  • Author(s): Inaba K
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Neural signals in the rostral part of the anterior cingulate cortex modulated by the reward proximity and amount (2009)
  • Author(s): Toda K
  • Organizer: 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-08-01
• [Presentation] Single neurons in monkey dorsal raphe nucleus during reward schedules (2009)
  • Author(s): Mizuhiki T
  • Organizer: 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-08-01
• [Presentation] Reward expectancy neuronal signals of behaving monkeys while performing multitrial reward schedules (2009)
  • Author(s): Shidara M.
  • Organizer: Eye Movement and Vision : a Symposium in Honor of Fred Miles
  • Place of Presentation: Oxford, UK(イギリス)
  • Year and Date: 2009-04-02
• [Presentation] Effects of the reward proximity and amount on neuronal signals in rostral part of monkey anterior cingulate cortex. (2009)
  • Author(s): Toda K., Mizuhiki T., Sugae-Miyamoto Y., Inaba K., Richmond BJ., Shidara M
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA.
• [Presentation] Single neuronal responses in monkey dorsal raphe nucleus during multi-trial reward schedule task with different reward amount. (2009)
  • Author(s): Inaba K., Mizuhiki T., Toda K., Ozaki S., Yaguchi K., Shidara M
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] The behavioral response of the monkey during a decision-making task to chose reward schedule and amount. (2009)
  • Author(s): Mizuhiki T., Inaba K., Yaguchi K., Shidara M.
  • Organizer: 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA.
• [Presentation] Single neurons in monkey dorsal raphe nucleus respond to reward schedules (2008)
  • Author(s): Mizuhiki, T
  • Organizer: 38th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-18
• [Presentation] Neural signals in the rostral part of the anterior cingulate cortex studied by the task with different reward amount and schedule length (2008)
  • Author(s): Toda, K
  • Organizer: 38th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-18
• [Presentation] Visual, memory and reward expectation signals in monkey perirhinal cortex during delayed conditioning (2008)
  • Author(s): Uchivama, K
  • Organizer: 38th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] アカゲザルの視覚弁別課題遂行に報酬の量とコストが及ぼす影響 (2008)
  • Author(s): Toda, K
  • Organizer: 第68回日本動物心理学会
  • Place of Presentation: 水戸
  • Year and Date: 2008-09-14
• [Presentation] Neuronal signals in the primate medial frontal cortex and neuropsychiatric disorders (2008)
  • Author(s): Shidara, M
  • Organizer: 第51回日本神経化学会大会(シンポジウム招待講演)
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Experience-dependent stimulus-reward/no-reward association during delayed conditioning (2008)
  • Author(s): Uchivama, K
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Single neurons around dorsal raphe nucleus of rhesus monkey during multi-trial reward schedules (2008)
  • Author(s): Mizuhiki, T
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] Interaction between reward size and trial number on performance of reward schedules of the monkey (2008)
  • Author(s): Toda, K
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] Distribution of dopamine D1and D2 receptors in the macaque inferior temporal cortex:Immunohistochemical and in situ hybridization analyses. (2007)
  • Author(s): Sugase-Miyamoto, Y., Takahato, T., Higo, N, Uchiyama, K., Toda, K., Yamamori, T., Shidara
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego,USA
  • Year and Date: 2007-11-05
• [Presentation] Differences between single neuronal responses in anterior and posterior insula during multi-trial reward schedules. (2007)
  • Author(s): Mizuhiki, T.
  • Organizer: 第30回日本神経科大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/basic-med/physiology/sys-neurosci/