Structural and molecular bases for development and maturation of competitive synaptic wiring

• Project/Area Number: 17023001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: WATANABE Masahiko Hokkaido University, 大学院・医学研究科, 教授 (70210945)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥106,900,000 (Direct Cost: ¥106,900,000); Fiscal Year 2009: ¥21,200,000 (Direct Cost: ¥21,200,000); Fiscal Year 2008: ¥19,100,000 (Direct Cost: ¥19,100,000); Fiscal Year 2007: ¥18,900,000 (Direct Cost: ¥18,900,000); Fiscal Year 2006: ¥23,000,000 (Direct Cost: ¥23,000,000); Fiscal Year 2005: ¥24,700,000 (Direct Cost: ¥24,700,000)
• Keywords: 小脳 / シナプス / グルタミン酸 / 発達 / 遺伝子改変動物 / グルタミン酸トランスポーター / 登上線維 / mGluR1 / プルキンエ細胞 / グルタミン酸受容体 / セレベリン / GluRd2 / シナプス形成 / 遺伝子ノックアウトマウス

Research Abstract

An enormous number of homotypic and heterotypic inputs innervate given neurons, and establish functional neural circuits through their competition. In this study, I undertook cellular and molecular mechanisms underlying the competitive circuit development in the cerebellum, a center of motor learning and coordination. I have identified that glutamate receptor GluD2 on Purkinje cells and Cbln1 released from granule cells coordinately regulate the formation and maintenance of parallel fiber synapses, and the establishment and maintenance of climbing fiber mono-innervation.

Research Products

• [Journal Article] Endocannabinoids and CB1 receptors mediate C-fiber-dependent heterosynaptic plasticity in spinalcord. (2009)
  • Author(s): Pernia-Andrade AJ, Kato A, Witschi R, Nyilas R, Katona I, Freund TF, Watanabe M, Filitz J, Koppert W, Schuttler J, Guangchen J, Neugebauer V, Marcasino G, Lutz B, Vanegas H, Zeilhofer HU
  • Journal Title: Science 325 Pages: 760-764
  • Peer Reviewed
• [Journal Article] NMDA receptor GluN2B (GluRe2/NR2B) subunit Is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. (2009)
  • Author(s): Akashi K, Kakizaki T, Kamiya H, Fukaya M, Yamasaki M, Abe M, Natsume R, Watanabe M, Sakimura K
  • Journal Title: J. Neurosci 29 Pages: 10869-10882
  • Peer Reviewed
• [Journal Article] Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. (2009)
  • Author(s): Yasaka T, Hughes DI, Polgar E, Nagy GG, Watanabe M, Riddell JS, Todd AJ
  • Journal Title: J. Neurosci 29 Pages: 13401-13409
  • Peer Reviewed
• [Journal Article] Rescue of abnormal phenotypes in d2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the d2 glutamate receptor. (2009)
  • Author(s): Torashima T, Iizuka1 A, Horiuchi H, Mitsumura K, Yamasaki M, KoyamaC, Takayama K, Iino M, Watanabe M, Hirai H
  • Journal Title: Eur J Neurosci 30 Pages: 355-365
  • Peer Reviewed
• [Journal Article] Functional coupling between mGluR1 and Cav3. 1 T-type calcium channels underlies parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. (2009)
  • Author(s): Hildebr, ME, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, Schneider T, Hescheler J, Kano M, Sakimura K, Watanabe M, Dieudonne S, Snutch TP
  • Journal Title: J. Neurosci 29 Pages: 9668-9682
  • Peer Reviewed
• [Journal Article] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. (2009)
  • Author(s): Hashimoto K, Ichikawa R, Kitamura K, Watanabe M, Kano M
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluRδ2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. (2009)
  • Author(s): Kakegawa W, Miyazaki T, Kohda K, Matsuda K, Emi K, Motohashi J, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. (2009)
  • Author(s): Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • Journal Title: Eur J Neurosci 29 Pages: 707-717
  • Peer Reviewed
• [Journal Article] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. (2009)
  • Author(s): Zhang J, Xu T, Hallett PJ, Watanabe M, Grant SGN, Isacson O, Yao W-D
  • Journal Title: J. Neurosci 29 Pages: 2948-2960
  • Peer Reviewed
• [Journal Article] Cbln1 accumulates and colocalizes with Cbln3 and GluRd2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum. (2009)
  • Author(s): Miura E, Matsuda K, Morgan JI, Yuzaki M, Watanabe M
  • Journal Title: Eur J Neurosci 29 Pages: 693-706
  • Peer Reviewed
• [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses : Lessons from GluRd2 knockout mice (2009)
  • Author(s): Hashimoto K, et al.
  • Journal Title: Neuroscience 162 Pages: 601-611
  • Peer Reviewed
• [Journal Article] Endocannabinoid-mediated control of synaptic transmission (2009)
  • Author(s): Kano M, et al.
  • Journal Title: Physiol.Rev. 89 Pages: 309-380
  • Peer Reviewed
• [Journal Article] Generation of L7-tTA knock-in mice (2009)
  • Author(s): Echigo R, et al.
  • Journal Title: Kobe Journal of Medical Sciences 54
  • Peer Reviewed
• [Journal Article] Purkinje cell compartmentation of the Chiroptera (2009)
  • Author(s): Kim JY, et al.
  • Journal Title: J.Comp.Neurol. 517 Pages: 193-209
  • Peer Reviewed
• [Journal Article] Protective effects of free radial scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture (2009)
  • Author(s): Hisano K, et al.
  • Journal Title: J.Anesth. 23 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Phospholipase CB4 in the medial septum controls cholinergic thetaoscillations and anxiety behaviors (2009)
  • Author(s): Shin J, et al.
  • Journal Title: J.Neurosci 29 Pages: 15375-15385
  • Peer Reviewed
• [Journal Article] IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina (2009)
  • Author(s): Katsumata O, et al.
  • Journal Title: Eur J Neurosci 30 Pages: 1509-1516
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase B promotes dendritic outgrowth and spine maturation in developing hippocampal neurons (2009)
  • Author(s): Hozumi Y, et al.
  • Journal Title: BMC Neurosci 10 Pages: 99-99
  • Peer Reviewed
• [Journal Article] Endocannabinoids and CB1 receptors mediate C-fiber-dependent heterosynaptic plasticity in spinalcord (2009)
  • Author(s): Pernia-Andrade AJ, et al.
  • Journal Title: Science 325 Pages: 760-764
  • Peer Reviewed
• [Journal Article] NMDA receptor GluN2B(GluRe2/NR2B)subunit Is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses (2009)
  • Author(s): Akashi K, et al.
  • Journal Title: J.Neurosci 29 Pages: 10869-10882
  • Peer Reviewed
• [Journal Article] Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord (2009)
  • Author(s): Yasaka T, et al.
  • Journal Title: J.Neurosci 29 Pages: 13401-13409
  • Peer Reviewed
• [Journal Article] Lentiviral-vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice (2009)
  • Author(s): Iizuka A, et al.
  • Journal Title: Neurobiol Dis 35 Pages: 457-465
  • Peer Reviewed
• [Journal Article] Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats (2009)
  • Author(s): Matsuzaki H, et al.
  • Journal Title: Eur J Phramacol 615 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Rescue of abnormal phenotypes in d2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the d2 glutamate receptor (2009)
  • Author(s): Torashima T, et al.
  • Journal Title: Eur J Neurosci 30 Pages: 355-365
  • Peer Reviewed
• [Journal Article] Phospholipase Cb4 expression identifies a novel subset of unpolar brush cells in the adult mouse cerebellum (2009)
  • Author(s): Chung S-H, et al.
  • Journal Title: Cerebellum 8 Pages: 267-276
  • Peer Reviewed
• [Journal Article] Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses (2009)
  • Author(s): Tarusawa E, et al.
  • Journal Title: J.Neurosci 29 Pages: 12896-12908
  • Peer Reviewed
• [Journal Article] Functional coupling between mGluR1 and Cav3.1 T-type calcium channels underlies parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines (2009)
  • Author(s): Hildebrand ME, et al.
  • Journal Title: J.Neurosci 29 Pages: 9668-9682
  • Peer Reviewed
• [Journal Article] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum (2009)
  • Author(s): Hashimoto K, et al.
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] Kinase-dead knock-in mouse revealed an essential role of CaMKll a kinase activity in dendritic spine enlargement, LTP and learning (2009)
  • Author(s): Yamagata Y, et al.
  • Journal Title: J.Neurosci. 29 Pages: 7607-7618
  • Peer Reviewed
• [Journal Article] Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells (2009)
  • Author(s): Cabello N
  • Journal Title: J.Neurochem. 109 Pages: 1497-1507
  • Peer Reviewed
• [Journal Article] Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia (2009)
  • Author(s): Nyilas R, et al.
  • Journal Title: Eur.J.Neurosci. 29 Pages: 1964-1978
  • Peer Reviewed
• [Journal Article] CB1 receptor activation and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain (2009)
  • Author(s): Furuse S, et al.
  • Journal Title: Anesthesiology 111 Pages: 173-186
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluRd2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo (2009)
  • Author(s): Kakegawa W, et al.
  • Journal Title: J.Neurosci. 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • Author(s): Fukushima, F., et al.
  • Journal Title: ProS ONE 4
  • Peer Reviewed
• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum (2009)
  • Author(s): Matsuda K, et al.
  • Journal Title: Eur J Neurosci 29 Pages: 707-717
  • Peer Reviewed
• [Journal Article] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex (2009)
  • Author(s): Zhang J, et al.
  • Journal Title: J.Neurosci 29 Pages: 2948-2960
  • Peer Reviewed
• [Journal Article] Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits (2009)
  • Author(s): Todd AJ, et al
  • Journal Title: Eur J Neurosci 29 Pages: 718-726
  • Peer Reviewed
• [Journal Article] Cbln1 accumulates and colocalizes with Cbln3 and GluRd2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum (2009)
  • Author(s): Miura E, et al.
  • Journal Title: Eur J Neurosci 29 Pages: 693-706
  • Peer Reviewed
• [Journal Article] Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model (2009)
  • Author(s): Kawakami Y, et al.
  • Journal Title: Neurosci.Res. 63 Pages: 184-193
  • Peer Reviewed
• [Journal Article] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence (2009)
  • Author(s): Sanda M, et al.
  • Journal Title: Brain Res. 251 Pages: 7-15
  • Peer Reviewed
• [Journal Article] Type 1 cannabinoid receptor(CB1)-containing axons innervate the hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons (2009)
  • Author(s): Deli L, et al.
  • Journal Title: Endocrinology 50 Pages: 98-103
  • Peer Reviewed
• [Journal Article] The endocannabinoid system is modulated in response to spinal cord injury in rats (2009)
  • Author(s): Garcia-Ovejero D, et al.
  • Journal Title: Neurobiol.Disease 3 Pages: 57-71
  • Peer Reviewed
• [Journal Article] CB1 cannabinoid receptor-dependent and-independent inhibition of depolarization-induced calcium influx in oligodendrocytes (2009)
  • Author(s): Mato S, et al.
  • Journal Title: Glia 57 Pages: 295-306
  • Peer Reviewed
• [Journal Article] Type 1 cannabinoid receptor (CB1)-containing axons innervate the hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons (2009)
  • Author(s): Deli L, Wittmann G, Kallo I, Lechan RM, Watanabe M, Liposits Z, Fekete C
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] The endocannabinoid system is modulated in response to spinal cord injury in rats (2009)
  • Author(s): Garcia-Ovejero D, Arevalo-Martin A, Petrosino S, Docagne F, Hagen C, Bisogno T, Watanabe M, Guaza C, Di Marzo M, Molina-Holgado E
  • Journal Title: Neurobiol. Disease (in press)
  • Peer Reviewed
• [Journal Article] CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. (2009)
  • Author(s): Mato S, Alberdi E, Ledent C, Watanabe M, Matute C
  • Journal Title: Glia (in press)
  • Peer Reviewed
• [Journal Article] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence (2009)
  • Author(s): Sanda M, Kamata A, Katsumata O, Fukunaga K, Watanabe M, Kondo K, Sakaaami H
  • Journal Title: Brain Res (in press)
  • Peer Reviewed
• [Journal Article] Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, aserine deficiency disorder model (2009)
  • Author(s): Kawakami Y, Yoshida K, Hoon Yang J, Azuma N, Tanaka H, Sakai K, Hashikawa T, Watanabe M, Kuhara S, Hirabayashi Y, Furuya S
  • Journal Title: Neurosci. Res (in press)
  • Peer Reviewed
• [Journal Article] Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits (2009)
  • Author(s): Todd AJ, Polgar E, Yasaka T, Bailey MES, Watt C, Watanabe M
  • Journal Title: Eur J Neurosci (in press)
  • Peer Reviewed
• [Journal Article] PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex (2009)
  • Author(s): Zhang J, Xu T, Hallett PJ, Watanabe M, Grant SGN, Isacson O, Yao W-D
  • Journal Title: J. Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synaoses in the cerebellum (2009)
  • Author(s): Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • Journal Title: Eur J Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • Author(s): Fukushima, F., Nakao, K., Shinoe, T., Fukaya, M., Muramatsu S, Sakimura, K., Kataoka, H., Mori, H., Watanabe, M., Manabe, T., Mishina, M
  • Journal Title: ProS ONE 4
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluRδ2 recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo (2009)
  • Author(s): Kakegawa W, Miyazaki T, Kohda K, Matsuda K, Emi K, Motohashi J, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Left-right asymmetry of the hippocampal synapses with different subunit allocation of glutamate receptors. (2008)
  • Author(s): Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 19498-19503
  • Peer Reviewed
• [Journal Article] Phospholipase Cb3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. (2008)
  • Author(s): Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, Hokfelt T
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 20004-20008
  • Peer Reviewed
• [Journal Article] Predominant expression of phospholipase Cb1 in telencephalic principal neurons and cerebellar interneurons, and its close allocation with related signaling molecules in somatodendritic neuronal elements. (2008)
  • Author(s): Fukaya M, Uchigashima M, Nomura S, Hasegawa Y, Kikuchi H, Watanabe M
  • Journal Title: Eur J Neurosci 28 Pages: 1744-1759
  • Peer Reviewed
• [Journal Article] Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. (2008)
  • Author(s): Shimizu H, Fukaya M, Yamasaki M, Watanabe M, Manabe T, Kamiya H
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11998-12003
  • Peer Reviewed
• [Journal Article] Spinocerebellar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Cav2. 1 channels. (2008)
  • Author(s): Watase K, Barrett CF, Miyazaki T, Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM, Mizusawa H, Tsien RW, Zoghbi HY
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11987-11992
  • Peer Reviewed
• [Journal Article] Enhanced cerebellar LTD induction and OKR adaptation in mice lacking delphilin. (2008)
  • Author(s): Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita M, Yamazaki Y, Mori, M., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T., Mishina, M.
  • Journal Title: PLoS One 3(5)(on-line journal)
  • Peer Reviewed
• [Journal Article] Cbln1 Regulates Rapid Formation and Maintenance of Excitatory Synapses in Mature Cerebellar Purkinje Cells in vitro and in vivo. (2008)
  • Author(s): Ito-Ishida A, Miura E, Emi K, Matsuda K, Iijima K, Narumi S, Kondo T, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci 28 Pages: 5920-5930
  • Peer Reviewed
• [Journal Article] Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors. (2008)
  • Author(s): Patrizi A, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, Strata P, Varoqueaux F, Brose N, Fritschy JM, Sassoe-Pognetto M
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 13151-13156
  • Peer Reviewed
• [Journal Article] Dual coupling of T-type Ca2+ channels shapes sleep-related oscillations in thalamic dendrites. (2008)
  • Author(s): Cueni L, Canepari M, Lujan R, Watanabe M, Bond CT, Adelman JP, Luthi A
  • Journal Title: Nature Neurosci 11 Pages: 683-692
  • Peer Reviewed
• [Journal Article] Glutamate transporters regulate lesion-induced period plasticity in the developing somatosensory cortex. (2008)
  • Author(s): Takasaki C, Okada R, Mitani A, Fukaya M, Yamasaki M, Fujihara Y, ShirakawaT, Tanaka K, Watanabe M
  • Journal Title: J. Neurosci 28 Pages: 4995-5006
  • Peer Reviewed
• [Journal Article] Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP4. (2008)
  • Author(s): Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: Neuron 57 Pages: 730-745
  • Peer Reviewed
• [Journal Article] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses. (2008)
  • Author(s): Lin MT, Lujan R, Watanabe M, Adelman JP, Maylie J
  • Journal Title: Nature Neurosci. 11 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals. (2008)
  • Author(s): Nyilas R, Dudok B, Urban GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, Katona I
  • Journal Title: J Neurosci 28 Pages: 1058-1063
  • Peer Reviewed
• [Journal Article] Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. (2008)
  • Author(s): Ludanyi A, Erass L, Czirjak S, Vajda J, Halasz P, Watanabe M, Palkovits M, Magloczky Z, Freund TF, Katona I
  • Journal Title: J Neurosci 28 Pages: 2976-2990
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRd2 (2008)
  • Author(s): Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M, Kawahara S, Watanabe M, Yuzaki M
  • Journal Title: J Neurosci 28 Pages: 1460-468
  • Peer Reviewed
• [Journal Article] Multiple substrates for synaptic cannabinoid signaling in dopaminergic and non-dopaminergic neurons of the ventral tegmental area (2008)
  • Author(s): Matvas F, Urban GM. Watanabe M, Mackie K, Aimmer A, Freund TF Katona I
  • Journal Title: Neuropharmacology 54 Pages: 95-107
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2 (2008)
  • Author(s): Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M, Kawahara S, Watanabe M, Yuzaki M.
  • Journal Title: J Neurosci 28 Pages: 1460-1468
  • Peer Reviewed
• [Journal Article] IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts and localizes with PSD-95 at excitatory synapses (2008)
  • Author(s): Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, Suzuki T, Fukunaga K, Watanabe M, Kondo K
  • Journal Title: Neurosci Res 60 Pages: 199-212
  • Peer Reviewed
• [Journal Article] Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals (2008)
  • Author(s): Nyilas R, Dudok B, Urban GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, Katona I
  • Journal Title: J Neurosci 28 Pages: 1058-1063
  • Peer Reviewed
• [Journal Article] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses (2008)
  • Author(s): Lin MT, Luian R, Watanabe M, Adelman JP, Maylie J
  • Journal Title: Nature Neurosci 11 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Effects of FAK ablation on cerebellar foliation, Bergmann glia and climbing fiber territory on Purkinje cells (2008)
  • Author(s): Watanabe F, Miyazaki T, Takeuchi T, Fukaya M, Nomura T, Noguchi S, Mori H, Sakimura K, Watanabe M, Mishina M(Correspondinq author)
  • Journal Title: Eur. J. Neurosci 27 Pages: 836-854
  • Peer Reviewed
• [Journal Article] Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn (2008)
  • Author(s): Polgar E. Watanabe M, Hartmann B,Grant SGN, Todd TA
  • Journal Title: Mol Pain(on-line journal) 4 Pages: 5-5
  • Peer Reviewed
• [Journal Article] Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IE180 (2008)
  • Author(s): Tomioka Y, Miyazaki M,Taharaguchi S, Yoshino S, Morimatsu M. Uede T, Ono E, Watanabe M(Corresponding author)
  • Journal Title: Eur. J. Neurosci 27 Pages: 2115-2132
  • Peer Reviewed
• [Journal Article] Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions (2008)
  • Author(s): Yasumura M, Uemura T, Yamasaki M,Sakimura K, Watanabe M, Mishina M
  • Journal Title: Neurosci Lett 433 Pages: 146-151
  • Peer Reviewed
• [Journal Article] Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP4 (2008)
  • Author(s): Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: Neuron 57 Pages: 730-745
  • Peer Reviewed
• [Journal Article] Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adultmouse CNS. (2008)
  • Author(s): Miwa H, Fukaya M, Watabe AM, Watanabe M. Manabe T
  • Journal Title: J. Physiol 586(10) Pages: 2539-2550
  • Peer Reviewed
• [Journal Article] Cell type-specific subunit composition of G-protein-gated potassium channels in the cerebellum (2008)
  • Author(s): Aguado C, Colon J, Ciruela F,Schlaudraff F, Cabariero MJ, Perry C, Watanabe M, Liss B, Wickman K,Lujan R
  • Journal Title: J Neurochem 105 Pages: 497-511
  • Peer Reviewed
• [Journal Article] Glutamate transporters regulate lesion-induced period plasticity in the developing somatosensory cortex (2008)
  • Author(s): Takasaki C, Okada R, Mitani A, Fukaya, M., Yamasaki M, Fujihara Y, Shirakawa T, Tanaka K, Watanabe M.(Corresponding author)
  • Journal Title: J. Neurosci 28 Pages: 4995-5006
  • Peer Reviewed
• [Journal Article] Dual coupling of T-type Ca2+ channels shapes sleep-related oscillations in thalamic dendrites (2008)
  • Author(s): Cueni L, Canepari M, Lujan R, Watanabe M, Bond CT, Adelman JP, Luthi A
  • Journal Title: Nature Neurosci 11 Pages: 683-692
  • Peer Reviewed
• [Journal Article] Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors (2008)
  • Author(s): Patrizi A, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, Strata P, Varoqueaux F, Brose N, Fritschy JM, Sassoe-Pognetto M
  • Journal Title: Proc. Natl. Acad. Sci. USA 105(35) Pages: 13151-13156
  • Peer Reviewed
• [Journal Article] Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102 (2008)
  • Author(s): Mao P, Tao Y-X, Fukaya M, Li D, Tao T, Watanabe M, Johns RA
  • Journal Title: IUBMB (International Union of Biochemistry and Molecular Biology) Life 60 Pages: 684-692
  • Peer Reviewed
• [Journal Article] Cbln1 Regulates Rapid Formation and Maintenance of Excitatory Synapses in Mature Cerebellar Purkinje Cells in vitro and in vivo (2008)
  • Author(s): Ito-Ishida A, Miura E, Emi K, Matsuda K, lijima K, Narumi S, Kondo T, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: J. Neurosci 28 Pages: 5920-5930
  • Peer Reviewed
• [Journal Article] N-Ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after infla mmation (2008)
  • Author(s): Katano T, Furue H, Okuda-Ashitaka E, Tagaya M, Watanabe M, Yoshimura M, Ito S
  • Journal Title: Eur. J. Neurosci 27 Pages: 3161-3170
  • Peer Reviewed
• [Journal Article] Enhanced cerebellar LTD induction and OKR adaptation in mice lacking delphilin (2008)
  • Author(s): Takeuchi, T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T., Yamashita M, Yamazaki Y, Mori, M., Sakimura, K., Kawamoto, S., Watanabe, M., Hirano, T., Mishina, M.
  • Journal Title: PLoS One(on-line journal) 3(5)
  • Peer Reviewed
• [Journal Article] Spinocerebellar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Cav2.1 channels (2008)
  • Author(s): Watase K, Barrett CF, Miyazaki T, Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM, Mizusawa H, Tsien RW, Zoghbi HY
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11987-11992
  • Peer Reviewed
• [Journal Article] Use-dependent amplification of presynaptic Ca^<2+> signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. (2008)
  • Author(s): Shimizu H, Fukaya M, Yamasaki M, Watanabe M, Manabe T, Kamiya H
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11998-12003
  • Peer Reviewed
• [Journal Article] Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats (2008)
  • Author(s): Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschop J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschop MH
  • Journal Title: Diabetes 57 Pages: 2977-2991
  • Peer Reviewed
• [Journal Article] Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant (2008)
  • Author(s): Tachikawa M, Fujinawa J, Takahashi M, Kasai Y, Fukaya M, Sakai K, Yamazaki M, Tomi M, Watanabe M, Sakimura K, Terasaki T, Hosoya K
  • Journal Title: J. Neurochem 107 Pages: 768-778
  • Peer Reviewed
• [Journal Article] Loss of Hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration (2008)
  • Author(s): Tamai K, Tanaka N, Toyoshima M, Yamamoto N, Owada Y, Kiyonari H, Ueno Y, Ono M, Shimosegawa T, Watanabe M, Sugamura K
  • Journal Title: Am. J. Pathol 173 Pages: 1806-1817
  • Peer Reviewed
• [Journal Article] Predominant expression of phospholipase Cβ1 in telencephalic principal neurons and cerebellar interneurons, and its close allocation with related signaling molecules in somatodendritic neuronal elements (2008)
  • Author(s): Fukaya M, Uchigashima M, Nomura S, Hasegawa Y, Kikuchi H, Watanabe M(Corresponding author)
  • Journal Title: Eur J Neurosci 28 Pages: 1744-1759
  • Peer Reviewed
• [Journal Article] Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain (2008)
  • Author(s): Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, Hokfelt T
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 20004-20008
  • Peer Reviewed
• [Journal Article] Left-right asymmetry of the hippocampal synapses with different subunit allocation of glutamate receptors (2008)
  • Author(s): Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shiqemoto R
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 19498-19503
  • Peer Reviewed
• [Journal Article] Large projection neurons in lamina l of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors (2008)
  • Author(s): Polgar E, Al-Khater K, Shehab S, Watanabe M. Todd AJ
  • Journal Title: J. Neurosci 28 Pages: 13150-13160
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase β accumulates on the perisynaptic site of medium spiny neurons in the striatum (2008)
  • Author(s): Hozumi Y, Fukaya M, Adachi N, Saito N, Otani K, Kondo H, Watanabe M, Goto K
  • Journal Title: Eur J Neurosci 28 Pages: 2409-2422
  • Peer Reviewed
• [Journal Article] Cbln1 accumulates and colocalizes with Cbln3 and GluRδ2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum (2008)
  • Author(s): Miura E, Matsuda K, Morgan JI, Yuzaki M, Watanabe M (Corresponding author)
  • Journal Title: Eur J Neurosci 29 Pages: 693-706
  • Peer Reviewed
• [Journal Article] RGS2 modulates GABAB receptor-GIRK channel coupling in dopamine neurons of the ventral tegmental area. (2007)
  • Author(s): Labouebe G, Lomazzi M, Cruz HG, Lujan R, Li M, Yanagawa Y., Obata K., Watanabe M, Wickman K, Slesinger P, Luscher C
  • Journal Title: Nature Neurosci 10 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Regulation of long-term depression and climbing fiber territory by GluRd2 at parallel fiber synapses through its cariboxyl terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Uemura T, Kakizawa T, Yamasaki M, Sakimura K, Watanabe M, Iino M, Mishina M
  • Journal Title: J Neurosci 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. (2007)
  • Author(s): Nishiyama H, Fukaya M, Watanabe M, Linden D
  • Journal Title: Neuron 56 Pages: 472-487
  • Peer Reviewed
• [Journal Article] Involvement of nitric ocide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells. (2007)
  • Author(s): Makara JK, Katona I, Nyiri G, Nemeth B, Watanabe M, Vente J de, Freund TF, Hajos N
  • Journal Title: J. Neurosci 27 Pages: 10211-10222
  • Peer Reviewed
• [Journal Article] Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. (2007)
  • Author(s): Uchigashima M, Fukaya M, Watanabe M, Kamiya H
  • Journal Title: J. Neurosci 27 Pages: 8088-8100
  • Peer Reviewed
• [Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. (2007)
  • Author(s): Uchigashima M, Narushima M, Fukaya M, Katona I, Kano M, Watanabe M
  • Journal Title: J. Neurosci. 27 Pages: 3663-3676
  • NAID: 120005183167
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• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S. Kishimoto, Y., Hashimoto, K., Miyazaki, T. Furutani, K., Shimizu H, Fukaya M, Nishi, M., Sakagami, H., Ikeda A, Kondo, H., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
  • Journal Title: EMBO J. 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Ca2+ permeability of the channel pore is not essential for the d2 glutamate receptor to regulate synaptic plasticity and motor coordination. (2007)
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. 579 Pages: 729-735
  • Peer Reviewed
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly. (2007)
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. 25 Pages: 1049-1057
  • Peer Reviewed
• [Journal Article] Phospholipase Cb is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. (2007)
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci 25 Pages: 659-672
  • Peer Reviewed
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2007)
  • Author(s): Narushima M, Uchigashima M, Matsui M, Manabe T, Watanabe M, Kano M
  • Journal Title: J. Neurosci. 27 Pages: 496-506
  • Peer Reviewed
• [Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4(LDP-4)expressed in brain. (2007)
  • Author(s): Takagaki, K., Shima, H., Tanuma, N., Nomura, M., Satoh, T., Watanabe, M., Kikuchi, K.
  • Journal Title: Mol. Cell. Biochem. 296 Pages: 177-184
  • Peer Reviewed
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2007)
  • Author(s): Narushima, M., Uchigashima, M., Matsui, M., Manabe, T., Watanabe, M., Kano, M.
  • Journal Title: J. Neurosci 27 Pages: 496-506
  • Peer Reviewed
• [Journal Article] Number and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replica labeling. (2007)
  • Author(s): Masugi-Tokita, M., Tarusawa, E., Watanabe, M., Molnar, E., Fujimoto, K., Shigemoto, R.
  • Journal Title: J. Neurosci. 27 Pages: 2135-2144
  • Peer Reviewed
• [Journal Article] Phospholipase CB3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in morse Purkinje cell subsets. (2007)
  • Author(s): Nomura, S., Fukaya, M., Tsujioka, T., Wu, D., Watanabe, M.
  • Journal Title: Eur. J. Neurosci 25 Pages: 659-672
  • Peer Reviewed
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. (2007)
  • Author(s): Takagishi, Y., Hashimoto, H., Kayahara, T., Watanabe, M., Otsuka, H., Mizoguchi, A., Kano, M., Murata, Y.
  • Journal Title: Dev. Neurobiol. 67 Pages: 909-923
  • Peer Reviewed
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly. (2007)
  • Author(s): Iijima, T., Miura, E., Matsuda, K., Kondo, T., Kamekawa, Y., Watanabe, M., Yuzaki, M.
  • Journal Title: Eur. J. Neurosci. 25 Pages: 1049-1057
  • Peer Reviewed
• [Journal Article] Ca^<2+> Permeability of the channel pore is not essential for the 2 glutam ate receptor to regulate synaptic plasticity and motor coordination. (2007)
  • Author(s): Kakegawa, W., Miyazaki, T., Hirai, H., Motohashi, J., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: J. Physiol. (London) 579 Pages: 729-735
  • Peer Reviewed
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney. (2007)
  • Author(s): Takasaki, C., Miura, E., Watanabe, M.
  • Journal Title: Biomed. Res. 28 Pages: 61-69
  • NAID: 130004903731
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
  • Journal Title: EMBO J. 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Phospholipase C 4 expression reveals the continuity of cerebellar topography through development. (2007)
  • Author(s): Marzban, H., Chung, S., Watanabe, M., Hawkes, R.
  • Journal Title: J. Comp. Neurol. 502 Pages: 857-871
  • Peer Reviewed
• [Journal Article] Phosphorylation of extracellular signal-regulated kinase in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation. (2007)
  • Author(s): Polgar, E., Campbell, AD., MacIntyre, LM., Watanabe, M., Todd AJ
  • Journal Title: Mol. Pain 3 Pages: 4-4
  • Peer Reviewed
• [Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. (2007)
  • Author(s): Uchigashima, M., Narushima, M., Fukaya, M., Katona, I., Kano, M., Watanabe, M.
  • Journal Title: J. Neurosci. 27 Pages: 363-3676
  • NAID: 120005183167
  • Peer Reviewed
• [Journal Article] Distribution of type 1 cannabinoid receptor(CB1)immunoreactive axons in the mouse hypothalamus. (2007)
  • Author(s): Wittmann, G., Deli, L., Kallo, I., Hraboviszky, E., Watanabe, M., Loposits, Z., Fekete, C.
  • Journal Title: J. Comp. Neurol. 503 Pages: 270-279
  • Peer Reviewed
• [Journal Article] Expression of the vesicular glutamate trasporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. (2007)
  • Author(s): Brumovsky, P., Watanabe, M., Hokfelt, T.
  • Journal Title: Neuroscience 147 Pages: 469-490
  • Peer Reviewed
• [Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions. (2007)
  • Author(s): Nakamura, K., Hirai, H., Torashima, T., Miyazaki, T., Tsurui, H., Xiu, Y., Ohtsuji, M., Lin, Q.S., Tsukamoto, K., Nishimura, H., Ono, M., Watanabe, M., Hirose, S.
  • Journal Title: Mol. Cell Biol. 27 Pages: 5128-5134
  • Peer Reviewed
• [Journal Article] Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. (2007)
  • Author(s): Uchigashima, M., Fukaya, M., Watanabe, M., Kamiya, H.
  • Journal Title: J.Neurosci. 27 Pages: 8088-8100
  • Peer Reviewed
• [Journal Article] Identification of the sites of 2-arachidonoylglycerol synthesis and actionimply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. (2007)
  • Author(s): Matyas, F., Urban, GM., Watanabe, M., Mackie, K., Aimmer, A., Freund, TF., Katona, I.
  • Journal Title: Neuropharmacology 54 Pages: 95-107
  • Peer Reviewed
• [Journal Article] Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and non-motoneuronal phenotypes. (2007)
  • Author(s): Niemann, S., Kanki, H., Fukui, Y., Takao, K., Fukaya, M., Hynynen, MN., Churchill, MJ., Shefner, JM., Bronson, RT., Watanabe, M., Brown, Jr, R., Miyakawa, T., Itohara, S., Hayashi, Y.
  • Journal Title: Eur.J.Neurosci. 26 Pages: 1407-1420
  • Peer Reviewed
• [Journal Article] Involvement of nitric ocide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells. (2007)
  • Author(s): Makara, JK., Katona, I., Nyiri, G., Nemeth, B., Watanabe, M., Vente, Jde., Freund, TF., Hajos, N.
  • Journal Title: J.Neurosci. 27 Pages: 10211-10222
  • Peer Reviewed
• [Journal Article] Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. (2007)
  • Author(s): Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M., Yuzak, M.
  • Journal Title: Autophagy 3 Pages: 591-596
  • Peer Reviewed
• [Journal Article] Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. (2007)
  • Author(s): Nishiyama, H., Fukaya, M., Watanabe, M., Linden, D.
  • Journal Title: Neuron 56 Pages: 472-487
  • Peer Reviewed
• [Journal Article] Altered features in mutant cerebellar Purkinje cells lacking junctophilins. (2007)
  • Author(s): Ikeda, A., Miyazaki, T., Kakizawa, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M., Takeshima, H.
  • Journal Title: Biochem.Biophys.Res.Commun. 363 Pages: 835-839
  • Peer Reviewed
• [Journal Article] Regulation of long-term depression and climbing fiber territory by GluRe2 at parallel fiber synapses through its cariboxyl terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Uemura, T., Kakizawa, T., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M., Mishina, M.
  • Journal Title: J Neurosci 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Early postnatal stress affects the serotoergic function in the median raphe nuclei of adult rats. (2007)
  • Author(s): Konno, K., Matsumoto, M., Togashi, H., Yamaguchi, T., Izumi, T., Watanabe, M., Iwanaga, T., Yoshioka, M.
  • Journal Title: Brain Res. 1172 Pages: 60-66
  • Peer Reviewed
• [Journal Article] RGS2 modulates GABAB receptor-GIRK channel coupling in dopamine neurons of the ventral tegmental area. (2007)
  • Author(s): Labouebe, G., Lomazzi, M., Cruz, HG., Lujan, R., Li, M., Yanagawa, Y., Obata, K., Watanabe, M., Wickman, K., Slesinger, P., Luscher, C.
  • Journal Title: Nature Neurosci 10 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M., Kano, M
  • Journal Title: J Physiol. 585 Pages: 549-563
  • Peer Reviewed
• [Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (2007)
  • Author(s): Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K
  • Journal Title: Mol. Cell. Biochem. 296 Pages: 177-184
• [Journal Article] Number and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replica labeling. (2007)
  • Author(s): Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R
  • Journal Title: J. Neurosci. 27 Pages: 2135-2144
• [Journal Article] Phospholipase Cβ3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. (2007)
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci. 25 Pages: 659-672
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. (2007)
  • Author(s): Takagishi Y, Hashimoto H, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, Kano M, Murata Y
  • Journal Title: J. Neurobiol. (in press)
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly. (2007)
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. (in press)
• [Journal Article] Ca^<2+> permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination. (2007)
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. (in press)
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney. (2007)
  • Author(s): Takasaki C, Miura E, Watanabe M
  • Journal Title: Biomed Res (in press)
  • NAID: 130004903731
• [Journal Article] Indispensability of glutamate transporter GLAST and GLT1 to brain development. (2006)
  • Author(s): Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo K, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 12161-12166
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• [Journal Article] Abundant distribution of TARP g-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K
  • Journal Title: Eur. J. Neurosci 24 Pages: 2177-2190
  • Peer Reviewed
• [Journal Article] Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. (2006)
  • Author(s): Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 10811-10816
  • Peer Reviewed
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M
  • Journal Title: Eur. J. Neurosci. 24 Pages: 750-760
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• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T
  • Journal Title: EMBO J. 25 Pages: 2867-2877
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• [Journal Article] Localization of diacylglycerol lipase-a round postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006)
  • Author(s): Yoshida T, Fukaya M, Uchigashima M, Kamiya H, Kano M, Watanabe M
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
  • Peer Reviewed
• [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M
  • Journal Title: J. Neurochem. 97 Pages: 1431-1446
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• [Journal Article] CB1 is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. (2006)
  • Author(s): Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M
  • Journal Title: J. Neurosci. 26 Pages: 2991-3001
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• [Journal Article] Impaired cerebellar functions in mutant mice lacking DNER. (2006)
  • Author(s): Tohgo A, Eiraku M, Miyazaki T, Miura E, Ono K, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H
  • Journal Title: Mol. Cell. Neurosci. 31 Pages: 326-333
  • Peer Reviewed
• [Journal Article] Complementary stripes of phospholipase Cs3 and Cs4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna JT, Marzban H, Watanabe M, Hawkes R
  • Journal Title: J. Comp. Neurol. 496 Pages: 303-313
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• [Journal Article] Complementary stripes of phospholipase Cβ3 and Cβ4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna JT, Marzban H, Watanabe M, Hawkes R
  • Journal Title: J. Comp. Neurol. 496 Pages: 303-313
• [Journal Article] Improved methods for ultracryotomy of CNS tissue for ultrastructural and immunogold analyses. (2006)
  • Author(s): Akagi T, Ishida K, Hanasaka T, Hayashi S, Watanabe M, Hashikawa T, Tohoyama K
  • Journal Title: J Neurosci. Methods 153 Pages: 276-282
• [Journal Article] The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. (2006)
  • Author(s): Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M
  • Journal Title: J. Neurosci. 26 Pages: 2291-3001
  • NAID: 120007186992
• [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M (Corresponding author)
  • Journal Title: J. Neurochem. 97 Pages: 1431-1446
• [Journal Article] Diacylglycerol kinase ζ is involved in the process of cerebral infarction. (2006)
  • Author(s): Nakano T, Hozumi Y, Ali H, Saino-Saito S, Kamii H, Sato S, Kayama T, Watanabe M, Kondo H, Goto K
  • Journal Title: Eur. J. Neurosci. 23 Pages: 1427-1435
• [Journal Article] Localization of diacylglycerol lipase-α around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006)
  • Author(s): Yoshida T, Fukaya M, Uchigashima M, Kamiya H, Kano M, Watanabe M (Corresponding author)
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
• [Journal Article] Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse-Possible implications for pain processing. (2006)
  • Author(s): Brumovsky PR, Hygge-Brakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hokfelt T
  • Journal Title: J. Chem. Neuroanat. 31 Pages: 243-262
• [Journal Article] Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells an expression of Atg4B in various rat tissues. (2006)
  • Author(s): Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y
  • Journal Title: Autophagy 2 Pages: 200-208
• [Journal Article] Gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia. (2006)
  • Author(s): Sasaki H, Hozumi Y, Hasegawa H, Ito T, Takagi M, Ogino T, Watanabe M, Goto K
  • Journal Title: Cell Tissue Res. 326 Pages: 35-42
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M(Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 750-760
• [Journal Article] Functional uncoupling between Ca^<2+> release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. (2006)
  • Author(s): Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 10811-10816
• [Journal Article] Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. (2006)
  • Author(s): Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H
  • Journal Title: FEBS Lett. 580 Pages: 4057-4064
• [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K(Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2177-2190
  • NAID: 120000955769
• [Journal Article] Depolarization-induced suppression of inhibition mediated by endocannabinoid at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. (2006)
  • Author(s): Narushima M, Uchigashima M, Hashimoto K, Watanabe M, Kano M
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2246-2252
• [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells. (2006)
  • Author(s): Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T
  • Journal Title: Pharmacol. Res. 23 Pages: 1235-1242
• [Journal Article] Impaired cerebellar functions in mutant mice lacking DNER. (2006)
  • Author(s): Tohgo, A., Eiraku, M., Miyazaki, T., Miura, E., Ono, K., Kawaguchi, S., Nishi, M., Watanabe, M., Hirano, T., Kengaku, M., Takeshima, H.
  • Journal Title: Mol.Cell.Neurosci. (in press)
• [Journal Article] Complementary stripes of phospholipase Cβ3 and Cβ4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna, J.T., Marzban, H., Watanabe, M., W, Hawkes, R.
  • Journal Title: J.Comp.Neurol. (in press)
• [Journal Article] Improved methods for ultracryotomy of CNS tissue for ultrastructural and immunogold analyses. (2006)
  • Author(s): AKagi, T., Ishida, K., Hanasaka, T., Hayashi, S., Watanabe, M., Hashikawa, T., Tohoyama, K.
  • Journal Title: J.Neurosci.Methods (in press)
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2006)
  • Author(s): Kakizawa, S., Miyazaki, T., Iino, M., Watanabe, M., Kano, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa S, Miyazaki T, Iino M, Watanabe M, Kano M
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 19180-19185
  • Peer Reviewed
• [Journal Article] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • Author(s): Hirai H, Pang Z, Bao D, Miyazaki T, Li L, Miura E, Parris J, Rong Y, Watanabe M, Yuzaki M, Morgan JI
  • Journal Title: Nature Neurosci. 8 Pages: 1534-1541
  • Peer Reviewed
• [Journal Article] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • Author(s): Klausberger T, Marton LF, O'Neill J, Huck JHJ, Dalezios Y, Fuentealba P, Suen W-Y, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P
  • Journal Title: J. Neurosci. 25 Pages: 9782-9793
  • Peer Reviewed
• [Journal Article] Spatial diversity in gene expression for VDCCg subunit family in developing and adult mouse brains. (2005)
  • Author(s): Fukaya M, Yamazaki M, Sakimura K, Watanabe M
  • Journal Title: Neurosci. Res. 53 Pages: 376-383
  • Peer Reviewed
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in e1 knock-out mice. (2005)
  • Author(s): Wu Y, Kawakami R, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R
  • Journal Title: J. Neurosci. 25 Pages: 9213-9226
  • Peer Reviewed
• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y
  • Journal Title: Neuron 47 Pages: 201-213
  • Peer Reviewed
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Miyazaki T, Watanabe M, Tanaka K, Ozawa
  • Journal Title: J. Neurosci. 25 Pages: 8788-8793
  • Peer Reviewed
• [Journal Article] Control of synaptic connection by glutamate receptor d2 n the mature cerebellum. (2005)
  • Author(s): Takeuchi T, Miyazaki T, Watanabe M, Mori H, Sakimura K, Mishina M
  • Journal Title: J. Neurosci. 25 Pages: 2146-2156
  • Peer Reviewed
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya M, Hayashi Y, Watanabe M
  • Journal Title: Eur. J. Neurosci. 21 Pages: 1432-1436
  • Peer Reviewed
• [Journal Article] Rescue of abnbormal phenotypes of the d glutamate receptor-null mice by mutant d transgenes. (2005)
  • Author(s): Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: EMBO Rep 6 Pages: 90-95
  • Peer Reviewed
• [Journal Article] Rescue of abnbormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. (2005)
  • Author(s): Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda S., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: EMBO report 6 Pages: 90-95
• [Journal Article] Retinotectal transmission in the optic tectum of rainbow trout. (2005)
  • Author(s): Kinosnita, M., Fuyaka M., Tojima, T., Kojima, S., Ando, H., Watanabe, M., Urano, A., Ito, E.
  • Journal Title: J.Comp.Neurol. 484 Pages: 249-259
• [Journal Article] Evidence for creatine biosynthesis in Muller glia. (2005)
  • Author(s): Nakashima, T., Tomi, M., Tachikawa M., Watanabe M., Terasaki, T., Hosoya, K.
  • Journal Title: Glia 52 Pages: 47-52
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya M.Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 21 Pages: 1432-1436
• [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the mature cerebellum. (2005)
  • Author(s): Takeuchi, T., Miyazaki T., Watanabe M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J.Neurosci. 25 Pages: 2143-2156
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Taxayasu Y., Iino, M., Kakegawa, W., Maeno, H., Watase, K., Wada K., Miyazaki, T., Watanabe, M., Tanaka, K., Ozawa, S.
  • Journal Title: J.Neurosci. 25 Pages: 8788-8793
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M.Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells 10 Pages: 785-792
• [Journal Article] Ptfla, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y.V., Fukuda, A., Fuse, T., Matsuo, N., Sone, M., Watanabe, M., Bito, H., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., Nabeshima, Y.
  • Journal Title: Neuron 47 Pages: 201-213
• [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. (2005)
  • Author(s): Tachikawa, M., Watanabe, M., Hori, S., Fukaya, M., Ohtsuki, S., Asashima1, T., Terasaki, T.
  • Journal Title: J.Neurochem. 95 Pages: 294-304
• [Journal Article] Autoantibodies and cell-mediated autoimmunity to NMDA-type GluTe2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. (2005)
  • Author(s): Takahashi, Y., Mori, H.Mishina, M., Watanabe, M., Kondo, N., Shomomura, J., Kubota, Y., Matsuda, K., Fukushima, K., Shiroma, M., Akasaka, N., Nishida, H., Imamura, A., Watanabe, H., Sugiyama, N., Ikezawa, M., Fujiwara, T.
  • Journal Title: Epilepsia 46 Pages: 152-158
• [Journal Article] Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. (2005)
  • Author(s): Abe, T., Matsumura, S., Katano, T., Mabuchi, T., Takagi, K., Xu, L., Yamamoto, A., Hattori, K., Yagi, T., Watanabe, M., Nakazawa, T., Yamamoto, T., Mishina, M., Nakai, Y., Ito, S.
  • Journal Title: Eur.J.Nerosci. 22 Pages: 1445-1455
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. (2005)
  • Author(s): Wu, Y., Kawakami, R., Fukaya, M., Sakimura, K., Mishina, M., Watanabe M., Ito, I., Shigemoto, R.
  • Journal Title: J.Neurosci. 25 Pages: 9213-9226
  • NAID: 120002697619
• [Journal Article] Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains. (2005)
  • Author(s): Fukaya, M.Yamazaki, M., Sakimura, K., Watanabe, M.
  • Journal Title: Neurosci.Res. 53 Pages: 376-383
  • NAID: 10017131285
• [Journal Article] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • Author(s): Klausberger, T., Marton, L.F., O'Neill, J., Huck, J.H.J., Dalezios, Y., Fuentealba, P., Suen, W.-Y, Papp, E., Kaneko T., Watanabe, M., JCsicsvari, J., Somogyi, P.
  • Journal Title: J.Neurosci. 25 Pages: 9782-9793
• [Journal Article] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • Author(s): 6.Hirai, H., Pang, Z., Bao, D., Miyazaki, T., Li, L., Parris, J., Rong, Y., Watanabe, M., Yuzaki, M., Morgan, J.I.
  • Journal Title: Nature Neurosci. 8 Pages: 1534-1541
• [Journal Article] Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach. (2005)
  • Author(s): Iwanaga, T., Goto, M., Watanabe, M.
  • Journal Title: Biomed.Res. 26 Pages: 271-278
  • NAID: 130004903697
• [Journal Article] Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission.
  • Author(s): Yamasaki M, Matsui M, Watanabe M
  • Journal Title: J. Neurosci (in press)
  • NAID: 120002414847
  • Peer Reviewed
• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor d2, a bidirectional synaptic organizer.
  • Author(s): Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Itoh-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M
  • Journal Title: Science (in press)
  • Peer Reviewed
• [Journal Article] Signaling cascade of diacylglycerol kinase BB in the pituitary intermediate lobe : dopamine D2 receptor/phospholipase CB4/diacylglycerol kinase B/protein kinase Ca.
  • Author(s): Hozumi Y, et al.
  • Journal Title: Histochem.Cytochem (In press)
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRe2.
  • Author(s): Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M., Yuzaki, M.
  • Journal Title: J Neurosci (In press)
  • Peer Reviewed
• [Journal Article] IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts and localizes with PSD-95 at extitatory synapses.
  • Author(s): Sakagami, H., Sanda, M., Fukaya, M., Miyazaki, T., Sukegawa, J., Yanagisawa, T., Suzuki, T., Fukunaga, K., Watanabe, M., Kondo, K.
  • Journal Title: Neurosci Res (In press)
  • Peer Reviewed
• [Journal Article] Down-regulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.
  • Author(s): Ludanyi, A., Erass, L., Czirjak, s., Vajda, J., Halasz, P., Watanabe, M., Palkovits, M., Magloczky, Z., Freund, TF., Katona, I.
  • Journal Title: J Neurosci (In press)
  • Peer Reviewed
• [Journal Article] Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.
  • Author(s): Nyilas, R., Dudok, B., Urban, GM., Mackie, K., Watanabe, M., Cravatt, BF., Freund, TF., Katona, I.
  • Journal Title: J Neurosci (In press)
  • Peer Reviewed
• [Journal Article] SK2 channel plasticity contributes to LTP at Shaffer collateral-CA1 synapses.
  • Author(s): Lin, MT., Lujan, R., Watanabe, M., Adelman, JP., Maylie, J.
  • Journal Title: Nature Neurosci. (In press)
  • Peer Reviewed
• [Journal Article] Effects of FAK ablation on cerebellar foliation,Bergmann glia and climbing fiber territory on Purkinje cells.
  • Author(s): Watanabe, F., Miyazaki, T., Takeuchi, T., Fukaya, M., Nomura, T., Noguchi, S., Mori, H., Sakimura, K., Watanabe, M., Mishina, M.
  • Journal Title: Eur.J.Neurosci. (In press)
  • Peer Reviewed
• [Presentation] Trafficking mode of AMPA-type glutamate receptors in Bergmann glia (2010)
  • Author(s): Masahiro Fukaya
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(岩手市)
• [Presentation] グルタミン酸受容体GluD2は側方側枝による異所性支配を抑制し、登上線維単-支配の維持に関わっている (2010)
  • Author(s): 宮崎太輔
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(岩手市)
• [Presentation] mGluR1シグナル伝達系依存的な余剰登上線維除去過程 (2010)
  • Author(s): 山崎美和子
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(岩手市)
• [Presentation] 歯状回分子層における2-アラキドノイルグリセロール伝達様式の形態学的解析 (2010)
  • Author(s): 内ヶ島基政
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(岩手市)
• [Presentation] マウス小脳におけるKCC2の細胞発現と細胞内局在に関する免疫組織化学的検討 (2010)
  • Author(s): 河北一誠
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(岩手市)
• [Presentation] GLAST is essential for cytological differentiation of Bergmann glia and climbing fiber monoinnervation by suppressing ectopic innervation (2009)
  • Author(s): 宮崎太輔, et al.
  • Organizer: XXXVI International Congress of Physiological Science
  • Place of Presentation: 京都国際会議場(京都)
• [Presentation] Preferential expression of M1 mAChR in dendrites and spines of cortical principal cells and its anatomical evidence for volume transmission (2009)
  • Author(s): 山崎美和子, et al.
  • Organizer: XXXVI International Congress of Physiological Science
  • Place of Presentation: 京都国際会議場(京都)
• [Presentation] Immunohistochemical localization of molecules for 2-arachidonoylglycerol-mediated retrograde signaling in the mouse dentate gyros (2009)
  • Author(s): 内ヶ島基政, et al.
  • Organizer: XXXVI International Congress of Physiological Science
  • Place of Presentation: 京都国際会議場(京都)
• [Presentation] Cellular expression and synaptic localization of NMDA receptor GluN2B and GluN2D subunits in the mouse somatosensory cortex (2009)
  • Author(s): 渡辺雅彦
  • Organizer: 22th Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: BEXCO(Busan, Korea)
• [Presentation] Distinct cellular expression and synaptic localization of NMDA receptor GluN2B and GluN2D subunits in the mouse somatosensory cortex (2009)
  • Author(s): 渡辺雅彦
  • Organizer: 第32回日本神経科学大会 Neuro2009
  • Place of Presentation: 国際会議場(名古屋)
• [Presentation] GLAST is essential to maintain climbing fiber monoinnervation and glialsynapse enwrapping to cerebellar Purkinje cells (2009)
  • Author(s): 宮崎太輔
  • Organizer: 第32回日本神経科学大会 Neuro2009
  • Place of Presentation: 国際会議場(名古屋)
• [Presentation] Preferential localization of M1 mAChR in spines and thin dendrites of cortical principal neurons and its anatomical evidence for volume transmission (2009)
  • Author(s): 山崎美和子
  • Organizer: 第32回日本神経科学大会 Neuro2009
  • Place of Presentation: 国際会議場(名古屋)
• [Presentation] マウス歯状回における2-アラキドノイルグリセロールを介した逆行性伝達抑制機構の形態学的基盤解析 (2009)
  • Author(s): 内ヶ島基政、山崎美和子, 渡辺雅彦
  • Organizer: 第55回日本解剖学会 東北・北海道支部学術集会
  • Place of Presentation: 東北大学(仙台市)
• [Presentation] マウス小脳および海馬におけるセクレトグラニンII(SgII)の局在様式 (2009)
  • Author(s): 宮崎太輔・渡辺雅彦
  • Organizer: 第114回解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] M1受容体を介するコリン作動性神経の伝達様式とシナプス伝達調節機構 (2009)
  • Author(s): 山崎美和子, 渡辺雅彦
  • Organizer: 第114回解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] マウス歯状回における2-アラキドノイルグリセロールを介した逆行性伝達抑制機構に関与する分子の免疫組織化学的分布 (2009)
  • Author(s): 内ヶ島基政・渡辺雅彦
  • Organizer: 第114回解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] マウス小脳ピンスーにおける化学的シナプス伝達機構の検討 (2009)
  • Author(s): 岩倉淳, 渡辺雅彦
  • Organizer: 第114回解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] 成体マウス大脳皮質におけるニューロン周囲オリゴデンドロサイトの化学的特性の検討 (2009)
  • Author(s): 高崎千尋・内ヶ島基政・渡辺雅彦
  • Organizer: 第114回解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] マウス小脳ピンスーにおける化学的シナプス伝達機構の形態学的検討 (2008)
  • Author(s): 岩倉淳, 渡辺雅彦
  • Organizer: 2008年日本顕微鏡学会北海道支部会
  • Place of Presentation: 北海道大学
  • Year and Date: 2008-12-01
• [Presentation] 登上線維プルキンエ細胞投射系による単一支配化への分子機構 (2008)
  • Author(s): 渡辺 雅彦
  • Organizer: 第113回日本解剖学会シンポジウム
  • Place of Presentation: 大分県・大分大学
  • Year and Date: 2008-03-29
• [Presentation] Coordinated molecular organization of 2-arachidonoyl glycerol-mediated endocannabinoid signaling triggered by mGluR activation. (2008)
  • Author(s): Watanabe M
  • Organizer: 6th International Meeting on Metabotropic Glutamate Receptors
  • Place of Presentation: Sicily (Italy)
• [Presentation] Glutamate transporters provide a 'winner-takes-more' strategy to activity-dependent synapse refinement. (2008)
  • Author(s): Watanabe, M
  • Organizer: The 38th Seiriken/Soukendai International Conference (Stock and flow of functional molecules in synapses.
  • Place of Presentation: Okazaki (Japan)
• [Presentation] GLAST is essential for the maintenance of climbing fiber monoinnervation through preventing local ectopic innervations to neighbouring and remote Purkinje cells and promoting cytological differentiation of Bergmann glia (2008)
  • Author(s): Miyazaki T, Yamasaki M, Kouichi Tanaka K, Watanabe M.
  • Organizer: 6^<th> FENS Forum of Europian Neuroscience
  • Place of Presentation: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [Presentation] Preferential localization of muscarinic M1 receptor in spines and thin dendrites of cortical principal neurons and its anatomical evidence for volume transmission (2008)
  • Author(s): Yamasaki M, Watanabe M.
  • Organizer: 6^<th> FENS Forum of Europian Neuroscience
  • Place of Presentation: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [Presentation] Distinct cellular and subcellular expression of calcineurins in the mouse cerebellum (2008)
  • Author(s): Miura E, Watanabe M.
  • Organizer: 6^<th> FENS Forum of Europian Neuroscience
  • Place of Presentation: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [Presentation] Monoacylglycerol lipase is expressed not only in presynaptic terminals, butalso in astrocytes in the mouse forebrain (2008)
  • Author(s): Uchigashima M, Watanabe M.
  • Organizer: 6^<th> FENS Forum of Europian Neuroscience
  • Place of Presentation: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [Presentation] Glutamate transporters magnify critical period plasticity in developing somatosensory cortex (2008)
  • Author(s): Takasaki C, Okada R, Mitani A, Fukaya M, Hujihara Y, Shirakawa T, Kouichi Tanaka K, Watanabe M.
  • Organizer: 6^<th> FENS Forum of Europian Neuroscience
  • Place of Presentation: The Ceneva Palexpo Conference Center, Geneva, Switzerland
• [Presentation] マウス小脳におけるプルキンエ細胞のPKCγバンド状発現 (2008)
  • Author(s): 江本美穂, 渡辺雅彦
  • Organizer: Neuro 2008第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] GLASTはバーグマングリアの形態分化および登上線維単一支配の維持に必要である (2008)
  • Author(s): 宮崎太輔, 渡辺雅彦
  • Organizer: 日本解剖学会第54回東北・北海道連合支部学術集会
  • Place of Presentation: 市民プラザ・ビッグアイ(郡山市)
• [Presentation] M1アセチルコリン受容体はマウスの大脳皮質・海馬の投射ニューロンに豊富に発現している (2008)
  • Author(s): 山崎美和子, 渡辺雅彦
  • Organizer: 日本解剖学会第54回東北・北海道連合支部学術集会
  • Place of Presentation: 市民プラザ・ビッグアイ(郡山市)
• [Presentation] マウス線条体における内因性カンナビノイド2-アラキドノイルグリセロールを介した逆行性伝達抑制の分子機構 (2007)
  • Author(s): 内ヶ島基政, 渡辺雅彦
  • Organizer: 日本顕微鏡学会北海道支部会
  • Place of Presentation: 札幌・コンペンションセンター
  • Year and Date: 2007-12-01
• [Presentation] 神経系における内在性カンナビノイドの分子解剖学 (2007)
  • Author(s): 渡辺 雅彦
  • Organizer: 日本麻酔科学会北海道東北支部第55回北海道麻酔科学会
  • Place of Presentation: 札幌・北海道大学
  • Year and Date: 2007-09-08
• [Presentation] 神経系における内在性カンナビノイドの合成・分解とその生理作用 (2007)
  • Author(s): 渡辺 雅彦
  • Organizer: 第28回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 札幌・札幌医大
  • Year and Date: 2007-09-01
• [Presentation] 小脳における登上線維-介在ニューロン間シナプス選択的に発現するNMDA受容体NR3Aサブユニットの分子解剖学的解析 (2007)
  • Author(s): 深谷 昌弘、渡辺 雅彦
  • Organizer: 第53回東北・北海道連合支部学術集会
  • Place of Presentation: 札幌・北海道医療大学
• [Presentation] バーグマングリアに発現するAMPA型グルタミン酸受容体の輸送様式 (2007)
  • Author(s): 深谷昌弘、渡辺雅彦>
  • Organizer: Neuro 2007 第30回日本神経科学大会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] GLAST分子欠損マウスにおけるバーグマングリアの形態分化異常および形態学的登上線維多重支配 (2007)
  • Author(s): 宮崎太輔, 田中光一, 渡辺雅彦
  • Organizer: Neuro 2007 第30回日本神経科学大会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] Mlムスカリン性アセチルコリン受容体は終脳の投射ニューロンに豊富に発現している (2007)
  • Author(s): 山崎美和子、飯塚尭、渡辺雅彦
  • Organizer: Neuro 2007 第30回日本神経科学大会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] マウス終脳の特定の介在神経におけるPKC&alphaおよびPKC&gammaの細胞発現パターンの解析 (2007)
  • Author(s): 三浦会里子, 窪田圭志, 渡辺雅彦
  • Organizer: Neuro 2007 第30回日本神経科学大会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] 線条体における2-アラキドノイルグリセロールを介した逆行性シグナル伝達に関与する分子の細胞内配置 (2007)
  • Author(s): 内ヶ島基政, 鳴島円, 深谷昌弘, Istvan Katona, 狩野方伸, 渡辺雅彦
  • Organizer: Neuro 2007 第30回日本神経科学大会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] Subcellular arrangement of molecules 2-arachidonlyl-glycerol-mediated retrograde signaling in the striatum. (2007)
  • Author(s): Motokazu, Uchigashima., Madoka, Narushima., Masahiro, Fukaya., Istvan, Katona., Masanobu, Kano., Masahiko, Watanabe.
  • Organizer: IBRO World Congress of Neuroscience
  • Place of Presentation: Melbourne, Australia
• [Presentation] Selective localization of NR3A subunit at climbing fiber-interneuron synapses in the cerebellum. (2007)
  • Author(s): Masahiro, Fukaya., Masahiko, Watanabe.
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego, California.USA
• [Book] みる見るわかる脳・神経科学入門講座改訂版 (2008)
  • Author(s): 渡辺雅彦
  • Publisher: 羊土社
• [Book] 脳神経外科学大系1。神経科学, (山浦晶総編集) (2006)
  • Author(s): 渡辺雅彦
  • Publisher: 中山書店
• [Book] 組織細胞化学2005, (日本組織細胞化学会編) (2005)
  • Author(s): 渡辺雅彦
  • Publisher: 学際企画
• [Remarks]
  • URL: http://www.med.hokudai.ac.jp/~anat-2w/