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Higher sensory processing mechanisms investigated by transcranial imaging of mouse cortical activities

Research Project

Project/Area Number 17023020
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNiigata University

Principal Investigator

SHIBUKI Katsuei  Niigata University, 脳研究所, 教授 (40146163)

Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥75,300,000 (Direct Cost: ¥75,300,000)
Fiscal Year 2009: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2008: ¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2007: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2006: ¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2005: ¥17,800,000 (Direct Cost: ¥17,800,000)
Keywordsフラビン蛋白蛍光 / 経頭蓋イメージング / 体性感覚野 / 視覚野 / 聴覚野 / マウス / 末梢神経損傷 / 神経因性疼痛 / Meissner小体 / GDNF / 眼優位性可塑性 / 斜視 / 片眼プリズム / 頭頂連合野 / プロトカドヘリン / 臨界期 / 末梢神経 / 自発発火 / 活動依存的可塑性 / 痛覚過敏症 / NMDA受容体 / 尺骨神経 / 正中神経 / 橈骨神経
Research Abstract

Endogenous green fluorescence signals derived from mitochondria reflect activity-dependent changes in brain metabolism, and may be exploited in functional brain imaging. Endogenous flavoprotein fluorescence imaging in mice is especially important because the transparent skull of mice allows transcranial fluorescence imaging of cortical activities. Using this technique, we investigated cortical activities and experiencedependent plasticity in the somatosensory, visual and auditory cortices of mice.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (52 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (35 results) (of which Peer Reviewed: 24 results) Presentation (9 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Cortical depression in the mouse auditory cortex after sound discrimination learning2010

    • Author(s)
      Ohshima S, Tsukano H, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K
    • Journal Title

      Neurosci Res 67

      Pages: 51-58

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial imaging of somatotopic map plasticity after tail cut in mice2010

    • Author(s)
      Kitaura H, Hishida R, Shibuki K
    • Journal Title

      Brain Res 1319

      Pages: 54-59

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial imaging of somatotopic map plasticity after tail cut in mice.2010

    • Author(s)
      Kitaura H, Hishida R, Shibuki K
    • Journal Title

      Brain research 1319

      Pages: 54-59

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical depression in the mouse auditory cortex after sound discrimination learning.2010

    • Author(s)
      Ohshima S, Shibuki K, 他5名
    • Journal Title

      Neuroscience research (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity dependent glial swelling is impaired in aquaporin-4 knockout mice2009

    • Author(s)
      Kitaura H, Tsujita M, Kakita A, Shibuki K, Sakimura K, Kwee KL, Nakada T:
    • Journal Title

      Neurosci Res 64

      Pages: 208-212

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial flavoprotein fluorescence imaging of mouse cortical activity and plasticity2009

    • Author(s)
      Tohmi M, Takahashi K, Kubota Y, Hishida R, Shibuki K
    • Journal Title

      J Neurochem 109Suppl.1

      Pages: 3-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial flavoprotein fluorescence imaging of mouse cortical activity and plasticity.2009

    • Author(s)
      Tohmi M, Shibuki K, 他3名
    • Journal Title

      Journal of Neurochemistry 109 Suppl 1

      Pages: 3-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial flavoprotein fluorescence imaging of mouse cortical activity and plasticity2009

    • Author(s)
      Tohmi M 他4名
    • Journal Title

      Journal of Neurochemistry (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activity dependent glial swelling is impaired in aquaporin-4 knockout mice2009

    • Author(s)
      Kit aura H 他6名
    • Journal Title

      Neuroscience Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マウス大脳皮質感覚野の経験による修飾2009

    • Author(s)
      澁木克栄, 他7名
    • Journal Title

      生体の科学 60

      Pages: 75-80

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Transcranial photo-inactivation of neural activities in the mouse auditory cortex2008

    • Author(s)
      Kubota Y, Kamatani D, Tsukano H, Ohshima S, Takahashi K, Hishida R, Kudoh M, Takahashi S, Shibuki K
    • Journal Title

      Neurosci Res 60

      Pages: 422-430

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial photo-inactivation of neural activities in the mouse auditory cortex.2008

    • Author(s)
      Kubota Y, 他8名
    • Journal Title

      Neurosicence Research 60

      Pages: 422-430

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感覚野経験依存的可塑性の経頭蓋蛍光イメージング2008

    • Author(s)
      澁木克栄, 他4名
    • Journal Title

      蛋白質 核酸 酵素 53(No.4)

      Pages: 512-517

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Long-term depression induced by local tetanic stimulation in the rat auditory cortex2007

    • Author(s)
      Watanabe K, Kamatani D, Hishida R, Kudoh M, Shibuki K
    • Journal Title

      Brain Res 1166

      Pages: 20-28

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex2007

    • Author(s)
      Kitaura H, Uozumi N, Tohmi M, Yamazaki M, Sakimura K, Kudoh M, Shimizu T, Shibuki K
    • Journal Title

      Neurosci Res 59

      Pages: 160-171

    • NAID

      10024417303

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experience-dependent formation of activity propagation patterns at the somatosensory S1 and S2 boundary in rat cortical slices2007

    • Author(s)
      Kamatani D, Hishida R, Kudoh M, Shibuki K
    • Journal Title

      Neuroimage 35

      Pages: 47-57

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional local connections with differential activity-dependence and critical periods surrounding the primary auditory cortex in rat cerebral slices2007

    • Author(s)
      Hishida R, Kamatani D, Kitaura H, Kudoh M, Shibuki K
    • Journal Title

      Neuroimage 34

      Pages: 679-693

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term depression induced by local tetanic stimulation in the rat auditory cortex.2007

    • Author(s)
      watanabe K, 他4名
    • Journal Title

      Brain Research 1166

      Pages: 20-28

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of nitric oxide as a vasodilator in neurovascular coupling of mousc somatosensory cortex.2007

    • Author(s)
      Kitaura H, 他7名
    • Journal Title

      Neurosicence Research 59

      Pages: 160-171

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experience-dependent formation of activity propagation pattems at the somatosensory S1 and S2 boundary in rat cortical slices.2007

    • Author(s)
      Kamatani, D., Hishida, R., Kudoh, M., Shibuki, K.
    • Journal Title

      Neuroimage. 35

      Pages: 47-57

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Functional local connections with differential activity-dependence and critical periods surrounding the primary auditory cortex in rat cerebral slices.2007

    • Author(s)
      Hishida, R., Kamatani, D., Kitaura, H., Kudoh, M., Shibuki K.
    • Journal Title

      Neuroimage. 34

      Pages: 679-693

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex2006

    • Author(s)
      Tohmi M, Kitaura H, Komagata S, Kudoh M, Shibuki K
    • Journal Title

      J Neurosci 26

      Pages: 11775-11785

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats2006

    • Author(s)
      Kudoh M, Nakayama Y, Hishida R, Shibuki K
    • Journal Title

      Neuroreport 17

      Pages: 1761-1766

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex2006

    • Author(s)
      Kudoh M, Shibuki K
    • Journal Title

      Learn Mem 13

      Pages: 690-698

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the auditory cortex in discrimination learning by rats2006

    • Author(s)
      Ono K, Kudoh M, Shibuki K
    • Journal Title

      Eur J Neurosci 23

      Pages: 1623-1632

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice2006

    • Author(s)
      Takahashi K, Hishida R, Kubota Y, Kudoh M, Takahashi S, Shibuki K
    • Journal Title

      Eur J Neurosci 23

      Pages: 1265-1276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice2006

    • Author(s)
      Takao T, Murakami H, Fukuda M, Kawaguchi T, Kakita A, Takahashi H, Kudoh M, Tanaka R, Shibuki K
    • Journal Title

      Neuroreport 17

      Pages: 267-271

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats2006

    • Author(s)
      Shibuki K, Ono K, Hishida R, Kudoh M
    • Journal Title

      Neuroimage 30

      Pages: 735-744

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the auditory association cortex for discrimination of vowel-like sounds in rats.2006

    • Author(s)
      Kudoh, M., Nakayama, Y., Hishida, R., Shibuki, K.
    • Journal Title

      Neuroreport. 17

      Pages: 1761-1766

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex.2006

    • Author(s)
      Kudoh, M., Shibuki, K.
    • Journal Title

      Learn. Mem. 13

      Pages: 690-698

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex.2006

    • Author(s)
      Tohmi, M., Kitaura, H., Komagata, S., Kudoh, M., Shibuki.K.
    • Journal Title

      J. Neurosci. 26

      Pages: 11775-11785

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Roles of the auditory cortex in discrimination learning by rats.2006

    • Author(s)
      Ono K, Kudoh M, Shibuki K
    • Journal Title

      European Journal of Neuroscience 23

      Pages: 1623-1632

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.2006

    • Author(s)
      Takahashi K, Hishida R, Kubota Y, Kudoh M, Takahashi S, Shibuki K
    • Journal Title

      European Journal of Neuroscience 23

      Pages: 1265-1276

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice.2006

    • Author(s)
      Takao T, Murakarni H, Fukuda M, Kawaguchi T, Kakita A, Takahashi H, Kudoh M, Tanaka R, Shibuki K
    • Journal Title

      NeuroReport 17

      Pages: 267-271

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats.2005

    • Author(s)
      Shibuki K, Ono K, Hishida R, Kudoh M
    • Journal Title

      Neurolmage Epub ahead of print, Nov.4

    • Related Report
      2005 Annual Research Report
  • [Presentation] 酸素代謝を反映するフラビン蛋白蛍光を用いた脳機能イメージング2009

    • Author(s)
      澁木克栄
    • Organizer
      第43回酸素ダイナミクス研究会
    • Place of Presentation
      東京(島津製作所)
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcranial flavoprotein fluorescence imaging of experience-dependentcortical plasticity2008

    • Author(s)
      Shibuki K
    • Organizer
      The 3rd ISN Special Neurochemistry Conference 8th International Meeting on Brain Energy Metabolism
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transcranial flavoprotein fluorescence imaging of neural activitiesin the mouse auditory cortex after sound discrimination learning2007

    • Author(s)
      Ohshima S, 他4名
    • Organizer
      第12回聴覚研究フォーラム
    • Place of Presentation
      大津市
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Transcranial fluorescence imaging of cortical responsesto harmonic and inharmonic sounds in the mouse auditory cortex.2007

    • Author(s)
      Tsukano H, 他4名
    • Organizer
      第12回聴覚研究フォーラム
    • Place of Presentation
      大津市
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 経頭蓋電気刺激を用いた麻酔下マウス皮質間結合の活性化2007

    • Author(s)
      菱田竜一, 他2名
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 末梢神経の自発発火阻止によって誘発されるマウス体性感覚野応答の増強2007

    • Author(s)
      駒形成司, 他4名
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視覚空間情報とヒゲ空間情報の不一致で生ずる斜視マウス視覚野応答の抑圧2007

    • Author(s)
      吉武講平, 他3名
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスバレル野切片の視床刺激応答の経験依存的可塑性2007

    • Author(s)
      渡邉健児, 他4名
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 言語音認識機構のラットモデル:聴覚野に依存する合成言語音の弁別学習2007

    • Author(s)
      工藤雅治, 他3名
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Book] Flavoprotein fluorescence imaging of experience-dependent cortical plasticity in rodents(Frostig R ed)2009

    • Author(s)
      Shibuki K, Hishida R, Tohmi M, Takahashi K, Kitaura H, Kubota Y
    • Publisher
      CRC Press
    • Related Report
      2009 Final Research Report
  • [Book] Flavoprotein fluorescence imaging of experience-dependent corticalplasticity in rodents In : In Vivo Optical Imaging of Brain Function. 2nd Edition (Frostig R ed)2009

    • Author(s)
      Shibuki K, 他5名
    • Total Pages
      528
    • Publisher
      Chapman & Hall/CRC
    • Related Report
      2008 Annual Research Report
  • [Book] Coupling of brain function and metabolism: Endogenous flavoprotein fluorescence imaging of neural activities by local changes in energy metabolism.(Gibson G and Dienel G, ed, Handbook of Neurochemistry & Molecular Neurobiology)2007

    • Author(s)
      Shibuki K, Hishida R, Kitaura H, Takahashi K, Tohmi M
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Coupling of brain function and metabolism : Endogenous flavoprotein fluorescence imaging of neural activities by local changes in energy metabolism. In Handbook of Neurochemistry & Molecular Neurobiology. 3rd Edition, Vol. 5, Neural Energy Utilization (Gibson G and Dienel G, ed).2007

    • Author(s)
      Shibuki, K., Hishida, R., Kitaura, H., Takahashi, K., Tohmi, M.
    • Publisher
      Springer, New York
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.acjp/~physio/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/

    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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