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Auditory Feature Extraction and Processing

Research Project

Project/Area Number 17023027
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

OHMORI Harunori  Kyoto University, 医学研究科, 教授 (30126015)

Co-Investigator(Kenkyū-buntansha) ISHII Takahiro  京都大学, 医学研究科, 准教授 (40303812)
KUBA Hirosi  京都大学, 医学研究科, 助教 (10362469)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥105,100,000 (Direct Cost: ¥105,100,000)
Fiscal Year 2009: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2008: ¥20,100,000 (Direct Cost: ¥20,100,000)
Fiscal Year 2007: ¥19,300,000 (Direct Cost: ¥19,300,000)
Fiscal Year 2006: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 2005: ¥24,000,000 (Direct Cost: ¥24,000,000)
Keywords聴覚 / 特徴抽出 / シナプス / 音源定位 / 両耳間時差 / 外側毛帯核 / 両耳間音圧差 / 位相差 / 方位選択性 / 角状核 / 同時検出 / 層状核 / 上オリーブ核 / 音圧 / 両耳間時間差 / 大細胞核 / 蝸牛神経核 / H電流 / K電流 / FRET / calpain
Research Abstract

We have intended to understand mechanisms of feature extraction and processing of sound information as activities of synapse and individual neuronal cells. Features of sounds such as time and intensity are important binaural cues for localizing the source Interaural time differences (ITDs) and interaural level differences (ILDs) are known extracted and processed in parallel by separate pathways in the brainstem auditory nuclei. ITD cues are small, and processing of that cue is optimized along the frequency axis by both morphological and physiological specializations. Moreover, we found that ITD and ILD cues are not processed independently but cooperatively to improve the detection of interaual differences. Thus, we have succeeded to understand some principal mechanism of auditory information processing in the brainstem nuclei.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (39 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (26 results) (of which Peer Reviewed: 16 results) Presentation (4 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Interaural phase difference modulates the neural activity in the nucleus angularis and improves the processing of level difference cue in the lateral lemniscal nucleus in the chicken.2010

    • Author(s)
      Sato T, Fukui I, Ohmori H
    • Journal Title

      Neuroscience Research 66

      Pages: 198-212

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaural phase difference modulates the neural activity in the nucleus angularis and improves the processing of level difference cue in the lateral lemniscal nucleus in the chicken2010

    • Author(s)
      Sato T, Fukui I, Ohmori H
    • Journal Title

      Neuroscience Research 66

      Pages: 198-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of axonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick.2009

    • Author(s)
      Kuba, H., Ohmori, H
    • Journal Title

      Journal of Physiology 587

      Pages: 87-100

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The modulation by intensity of the processing of interaural timing cues for localizing sounds.2009

    • Author(s)
      Eri Nishino, H Ohmori.
    • Journal Title

      Molecular Neurobiology 40

      Pages: 157-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of zxonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick2009

    • Author(s)
      Kuba H, Ohmori H
    • Journal Title

      J Physiology 587

      Pages: 87-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭の小さな動物における音源定位神経機構の考察。2008

    • Author(s)
      大森治紀、西野恵里、佐藤達雄
    • Journal Title

      蛋白質・核酸・酵素 53(4)

      Pages: 518-524

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sound-Intensity-Dependent Compensation for the Small Interaural Time Difference Cue for Sound Source Localization.2008

    • Author(s)
      Eri Nishino, R. Yamada, H. Kuba, H. Hioki, T. Furuta, T. Kaneko, H. Ohmori
    • Journal Title

      Journal of Neuroscience 28

      Pages: 7153-7164

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presynaptic GABAB receptors modulate synaptic facilitation and depression at distinct synanses in2008

    • Author(s)
      Irie T, Ohmori H
    • Journal Title

      BBRC 367

      Pages: 503-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sound-intensity-dependent compensation for the small interaural time difference cue for sound source2008

    • Author(s)
      Nishino E, Yamada R, Kuba H, Hioki H, Furuta T, Kaneko T
    • Journal Title

      J Neuroscience 28

      Pages: 7153-7164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presynaptic GABAB receptors modulate synaptic facilitation and depression at distinct synapses in2008

    • Author(s)
      TomohikoIrie, HarunoriOhmori
    • Journal Title

      BBRC 367.2

      Pages: 503-508

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tytophan-scanning mutagenesis in the Sl domain of mammalian HCN channel reveals residues critical for2007

    • Author(s)
      Ishii, M. T., Nakashima, N. & Ohmori, H
    • Journal Title

      J. Physiology 579.2

      Pages: 291-301

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels2007

    • Author(s)
      Takahiro M Ishii, Noriyuki Nakashima, Kenji Takatsuka &
    • Journal Title

      BBRC 359-3

      Pages: 592-598

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axonal site of spike initiation enhances auditory coincidence detection.2006

    • Author(s)
      Kuba, H.Ishii, M.T., Ohmori, H
    • Journal Title

      Nature 444

      Pages: 1069-1072

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of GIRK Channels by Muscarinic Receptors and Group II Metabotropic Glutamate Receptors Suppresses Golgi Cell Activity in the Cochlear Nucleus of Mice.2006

    • Author(s)
      Tomohiko Irie, Iwao Fukui, Harunori Ohmori
    • Journal Title

      J Neurophysiology 96

      Pages: 2633-2644

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of phase information at low sound frequency innucleus magnocellularis of the chicken.2006

    • Author(s)
      IWAO FUKUI, TATSUO SATO, HARUNORI. OHMORI
    • Journal Title

      J Neurophysiology 96

      Pages: 642-651

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescent labeling of rat auditory brainstem circuits for synaptic and electrophysiological studies2006

    • Author(s)
      Atsuko Maruyama, Harunori Ohmori
    • Journal Title

      Journal of Neuroscience Methods 152

      Pages: 163-172

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Improvement of phase information at low sound frequency in nucleus magnocellularis of the chicken2006

    • Author(s)
      IWAO FUKUI, TATSUO SATO, HARUNORI OHMORI
    • Journal Title

      J Neurophysiology 96

      Pages: 642-651

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recovery of hair cell function after damage induced by gentamicin in organ culture of rat vestibular maculae2006

    • Author(s)
      Akiko Taura, Ken Kojima, Juichi Ito, Harunori Ohmori
    • Journal Title

      Brain Research 1098

      Pages: 33-48

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of GIRK Channels by Muscarinic Receptors and Group II Metabotropic Glutamate Receptors Suppresses2006

    • Author(s)
      Tomohiko Irie, Iwao Fukui, Harunori Ohmori
    • Journal Title

      J Neurophysiology 96

      Pages: 2633-2644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of perfluorooctane sulfate on action potentials and currents in cultured rat cerebellar Purkinje cells2006

    • Author(s)
      Harada KH, Ishii TM, Takatsuka K, Koizumi A, Ohmori H
    • Journal Title

      BBRC 351.1

      Pages: 240-245

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Axonal site of spike initiation enhances auditory coincidence detection2006

    • Author(s)
      Kuba, H., Ishii, M.T., Ohmori, H
    • Journal Title

      Nature 444

      Pages: 1069-1072

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hyperpolarization-activated cyclicnucleotide gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick.2005

    • Author(s)
      Rei Yamada, Hiroshi Kuba, Takahiro M. Ishii, Harunori Ohmori
    • Journal Title

      Journal of Neuroscience 25

      Pages: 8867-8877

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick.2005

    • Author(s)
      Hiroshi Kuba, Rei Yamada, Iwao Fukui, Harunori Ohmori
    • Journal Title

      Journal of Neuroscience 25

      Pages: 1924-1934

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick2005

    • Author(s)
      Hiroshi Kuba, Rei Yamada, Iwao Fukui, Harunori Ohmori
    • Journal Title

      Journal of Neuroscience 25.8

      Pages: 1924-1934

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel Ca2+ indicator protein using FRET and calpain-sensitive2005

    • Author(s)
      Kenji Takatsuka, Takahiro M.Ishii, Harunori Ohmori
    • Journal Title

      Biochemical and Biophysical Research Communications 336

      Pages: 316-323

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hyperpolarization-activated cyclic-nucleotide gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick2005

    • Author(s)
      Rei Yamada, Hiroshi Kuba, Takahiro M.Ishii, Harunori Ohmori
    • Journal Title

      Journal of Neuroscience 25.39

      Pages: 8867-8877

    • Related Report
      2005 Annual Research Report
  • [Presentation] Sound intensity dependent compensation for the small ITD cue in the chicken.2009

    • Author(s)
      Ohmori H.
    • Organizer
      36th IUPS Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Sound intensity dependent compensation for the small ITD cue in the chicken2009

    • Author(s)
      大森治紀
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 聴覚情報の受容と処理の神経機構2008

    • Author(s)
      大森治紀
    • Organizer
      第3回ERA-OAE研究会
    • Place of Presentation
      東京、慶応義塾大学
    • Year and Date
      2008-07-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抑制性神経回路調節による両耳間・時間差検出感度の最適化2007

    • Author(s)
      大森 治紀
    • Organizer
      日本耳学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Book] 聴覚、標準生理学第7版(監修小沢瀞司、福田康一郎編集本間研一、大森治紀、大橋俊夫)2009

    • Author(s)
      大森治紀
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 聴覚、標準生理学第7版2009

    • Author(s)
      大森治紀
    • Total Pages
      1024
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 標準生理学第5版のうち聴覚2005

    • Author(s)
      大森治紀
    • Total Pages
      1111
    • Publisher
      医学書院
    • Related Report
      2005 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/J/grad_school/introduction/1603/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/J/grad_school/introduction/1603/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.nbiol.med.kyoto-u.ac.jp

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] polypeptide having intracellular calcium ion indicator function2006

    • Inventor(s)
      Ohmori H, Ishii T, Takatsuka K
    • Industrial Property Rights Holder
      Kyoto University
    • Filing Date
      2006-05-09
    • Acquisition Date
      2010-01-12
    • Related Report
      2009 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞内カルシウムイオン指示機能を有するポリペプチド2005

    • Inventor(s)
      大森治紀、石井孝広、高塚賢二
    • Industrial Property Rights Holder
      京都大学
    • Filing Date
      2005-08-18
    • Acquisition Date
      2007-03-01
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞内カルシウムイオン指示機能を有するポリペプチド2005

    • Inventor(s)
      大森 治紀, 石井 孝広, 高塚 賢二
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2005-238034
    • Filing Date
      2005-08-18
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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