Experience-dependent remodeling of visual neural circuits.

• Project/Area Number: 17023033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tottori University
• Principal Investigator: HATA Yoshio Tottori University, 大学院・医学系研究科, 教授 (40212146)
• Co-Investigator(Kenkyū-buntansha): ICHISAKA Satoshi 鳥取大学, 医学部, 助教 (50359874) ; SATO Takemasa 鳥取大学, 医学部, 助教 (80346345) ; AKASAKI Takafumi 鳥取大学, 大学院・医学系研究科, 助教 (30335393)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥63,500,000 (Direct Cost: ¥63,500,000); Fiscal Year 2009: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2008: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2007: ¥11,300,000 (Direct Cost: ¥11,300,000); Fiscal Year 2006: ¥13,300,000 (Direct Cost: ¥13,300,000); Fiscal Year 2005: ¥16,100,000 (Direct Cost: ¥16,100,000)
• Keywords: 眼優位可塑性 / 生後発達 / 大脳皮質視覚野 / 臨界期 / ヘッブ則 / 眼優位性 / 可塑性 / 片眼遮蔽 / 視覚野 / ERK / ヘツブ則 / MAPK / 抑制

Research Abstract

In the developing visual cortex, inappropriate neural connections are eliminated in an experience-dependent manner. This study demonstrated that the input axons to the visual cortex are eliminated when cortical cells do not respond to input activities mainly based on presynaptic mechanisms.

Research Products

• [Journal Article] Cortical activity regulates corticothalamic synapses in dorsal lateral geniculate nucleus of rats. (2009)
  • Author(s): Yoshida M, Satoh T, Nakamura KC, Kaneko T, Hata Y
  • Journal Title: Neurosci. Res. 64 Pages: 118-127
• [Journal Article] Experience-driven axon retraction in the pharmacologically inactivated visual cortex does not require synaptic transmission. (2009)
  • Author(s): Watanabe K, Morishima Y, Toigawa M, Hata Y
  • Journal Title: PLoS ONE 4
• [Journal Article] Cortical activity regulates corticothalamic synapses in dorsal lateral geniculate nucleus of rats. (2009)
  • Author(s): Yoshida M, et al.
  • Journal Title: Neuroscience research 64 Pages: 118-127
  • Peer Reviewed
• [Journal Article] Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus (2009)
  • Author(s): Katoh-Semba R, et al.
  • Journal Title: Neuroscience 163 Pages: 352-361
  • Peer Reviewed
• [Journal Article] Experience-driven axon retraction in the pharmacologically inactivated visual cortex does not require synaptic transmission (2009)
  • Author(s): Watanabe, K., et.al.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Effects of anesthesia on immunohistochemical detection of phosphorylated extracellular signal-regulated kinase in cerebral cortex. (2008)
  • Author(s): Takamura H, Ichisaka S, Watanabe K, Toigawa M, Hata Y
  • Journal Title: J. Neurosci. Meth. 170 Pages: 300-304
• [Journal Article] A novel cell transplantation protocol and its application to an ALS mouse model (2008)
  • Author(s): Morita, E., et.al.
  • Journal Title: Exp. Neurol 213 Pages: 431-438
  • Peer Reviewed
• [Journal Article] A phase advance of the light-dark cycle stimulates production of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex : association with the activation of CREB (2008)
  • Author(s): Katoh-Semba, R., et.al.
  • Journal Title: J. Neurochem 106 Pages: 2131-2142
  • Peer Reviewed
• [Journal Article] Effects of anesthesia on immunohistochemical detection of phosphorylated extracellular signal-regulated kinase in cerebral cortex. (2008)
  • Author(s): Takamura, H., et. al.
  • Journal Title: J. Neurosci. Meth. (印刷中)
  • Peer Reviewed
• [Journal Article] Monocular deprivation enhances the nuclear signalling of extracellular signal-regulated kinase in the developing visual cortex. (2007)
  • Author(s): Takamura H, Ichisaka S, Hayashi C, Maki H, Hata Y
  • Journal Title: Eur. J. Neurosci. 26 Pages: 2884-2898
• [Journal Article] Neuroprotective effect of transcorneal electrical stimulation on the acute phase of optic nerve injury. (2007)
  • Author(s): Miyake K, Yoshida M, Inoue Y, Hata Y
  • Journal Title: Invest. Ophthal. Vis. Sci. 48 Pages: 2356-2361
• [Journal Article] Experience-driven axon retraction without binocular imbalance in developing visual cortex. (2007)
  • Author(s): Haruta M, Hata Y
  • Journal Title: Curr. Biol. 17 Pages: 37-42
• [Journal Article] Monocular deprivation enhances the nuclear signaling of extracellular signat-regulated kinase in the developing visual cortex. (2007)
  • Author(s): Takamura, H., et. al.
  • Journal Title: Eur. J. Neurosci 26 Pages: 2884-2898
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of transcorneal electrical stimulation on acute phase of optic nerve injury. (2007)
  • Author(s): Miyake K., et. al.
  • Journal Title: Invest. Ophthabnol. Vis. Sci. 48 Pages: 2356-2361
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of transcorneal electrical stimulation on acute phase of optic nerve injury. (2007)
  • Author(s): Miyake, K. et al.
  • Journal Title: Invest. Ophthalmol. Vis. Sci. (印刷中)
• [Journal Article] Experience-driven axon retraction without binocular imbalance in developing visual cortex. (2007)
  • Author(s): Haruta, M., Hata, Y
  • Journal Title: Curr. Biol. 17 Pages: 37-42
• [Journal Article] Substrate specificity of a chimera made from Xenopus SGLT1-like protein and rabbit SGLT1. (2006)
  • Author(s): Nagata, K., Hata, Y.
  • Journal Title: Biochim. Biophys. Acta 1758 Pages: 747-754
• [Journal Article] Experience-dependent regulation of nuclear extracellular signal-regulated kinase activity in rat visual cortex. (2006)
  • Author(s): Takamura et al.
  • Journal Title: Neurosci. Res. 55 suppl.
• [Journal Article] Activity Dependent Plasticity of Feedback Projection from the Primary Visual Cortex to the Dorsal Lateral Geniculate Nucleus. (2006)
  • Author(s): Yoshida et al.
  • Journal Title: Neurosci. Res. 55 suppl.
• [Journal Article] Early change of ocular dominance by brief monocular deprivation in the pharmacologically inhibitedvisual cortex of kittens. (2006)
  • Author(s): Morishima Y. et al.
  • Journal Title: J. Physiol. Sci. 56(suppl.)
• [Journal Article] Recovery of binocular responses after brief monocular deprivation in kittens. (2005)
  • Author(s): Kameyama K, Hata Y, Tsumoto T
  • Journal Title: Neuroreport 16 Pages: 1447-1450
• [Journal Article] Recovery of binocular responses after briefmonocular deprivation in kittens. (2005)
  • Author(s): Kameyama K. et al.
  • Journal Title: Neuroreport 16 Pages: 1447-1450
• [Journal Article] Recovery from monocular visual deprivation effect in anesthetized and paralyzed kittens. (2005)
  • Author(s): Kameyama K. et al.
  • Journal Title: Soc. Neurosci. Abst. 31
• [Journal Article] Experience dependent retraction of geniculocortical arbors in the pharmachologically inhibited visual cortex. (2005)
  • Author(s): Hata Y.et al.
  • Journal Title: Soc. Neurosci. Abst. 31
• [Journal Article] Early phase of the reverse ocular dominance plasticity in the pharmacologically inhibited visual cortex. (2002)
  • Author(s): Morishima et al.
  • Journal Title: Neurosci. Res. 55 suppl.
• [Presentation] 発達脳の可塑性とその臨界期-視覚系をモデルとして- (2010)
  • Author(s): 畠義郎
  • Organizer: 第51回日本小児神経学会総会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-28
• [Presentation] 視覚経験による視覚中枢神経回路の再編成 (2010)
  • Author(s): 畠義郎
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-16
• [Presentation] シナプス伝達を阻害した視覚野に見られる経験依存的な入力軸索の退縮 (2009)
  • Author(s): 畠義郎, 他
  • Organizer: 第61回日本生理学会中国四国地方会
  • Place of Presentation: 山口
  • Year and Date: 2009-11-21
• [Presentation] 覚醒ラットを用いた外側膝状体電気刺激による人工的光知覚の行動学的評価 (2009)
  • Author(s): 久保悠介, 他
  • Organizer: 第61回日本生理学会中国四国地方会
  • Place of Presentation: 山口
  • Year and Date: 2009-11-21
• [Presentation] Postnatal development of endocannabinoid system in developing mouse visual cortex (2009)
  • Author(s): Taisuke Yoneda, et al.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Developmental changes of signaling molecules that regulate neurite outgrowth and myelination in the rat orbitofrontal and visual cortex (2009)
  • Author(s): Satoshi Ichisaka, et al.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Experience-driven axon reorganization in the visual system (2009)
  • Author(s): Yoshio Hata
  • Organizer: 第32回日本神経科学大会Symposium「中枢神経系のマップ形成とその再編成」
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Experience-driven axon reorganization in the visual system (2009)
  • Author(s): Yoshio Hata
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] シナプス伝達を阻害した視覚皮質における経験依存的な入力軸索の退縮 (2009)
  • Author(s): 渡邉佳奈, 他
  • Organizer: 第13回視覚科学フォーラム研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-09-02
• [Presentation] Experience-driven retraction of geniculocortical axons following cortical inactivation by preventing synaptic transmission (2009)
  • Author(s): Kana Watanabe, Yu Morishima, Masahito Toigawa, Yoshio Hata
  • Organizer: 第36回国際生理学会世界大会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] ラット前頭眼窩野と視覚野における神経突起伸展や髄鞘化に関わる分子の生後発達変化 (2008)
  • Author(s): 一坂吏志, 他
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] 視覚経験によって引き起こされる視床皮質投射軸索の退縮 (2008)
  • Author(s): 畠義郎
  • Organizer: 第31回日本神経科学大会Workshop「神経活動依存的な回路網形成の制御機構-プレかポストかどっちが大事」
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 発達期マウス視覚野におけるカンナビノイド受容体1の発現 (2008)
  • Author(s): 米田泰輔, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 視覚経験によって引き起こされる視床皮質投射軸索の退縮 (2008)
  • Author(s): 畠義郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 薬理学的に抑制された視覚野における年齢依存的軸索退縮 (2008)
  • Author(s): 森島佑, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] 脳損傷後の回復における感覚入力の影響 (2008)
  • Author(s): 村田奈保子, 他
  • Organizer: 第42回日本作業療法学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-06-21
• [Presentation] 自由行動下ラットの外側膝状体ニューロンの持続活動への視覚環境の効果 (2008)
  • Author(s): 田金裕一郎, 赤崎孝文, 久保悠介, 畠義 郎
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] 損傷視覚野の回復における視覚入力の影響 (2008)
  • Author(s): 村田奈保子, 他
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] Activity-dependent regulation of mGluR1a and VGluT1 in the lateral geniculate nucleus of rat. (2007)
  • Author(s): Yoshida, M., Satoh, T., Nakamura, K., Kaneko, T., Hata, Y.
  • Organizer: 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-03
• [Presentation] Regulation of nuclear extracellular signal-regulated kinase activity in developing visual cortex. (2007)
  • Author(s): Takamura, H., Ichisaka, S., Hayashi, C., Maki, H., Hata, Y.
  • Organizer: 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2007-11-03
• [Presentation] 外側膝状体における代謝型グルタミン酸受容体の活動依存的調節の年齢依存性 (2007)
  • Author(s): 吉田三穂, 佐藤武正, 中村公一, 金子武嗣, 畠義郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] ラット視覚野におけるERK活性とその細胞内局在の視覚入力依存的制御 (2007)
  • Author(s): 高村明孝, 一坂吏志, 林千尋, 牧廣利, 畠義郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 視神経損傷による機能低下に対する経角膜電気刺激の保護効果 (2007)
  • Author(s): 畠義郎
  • Organizer: シンポジウム「視覚機能の回復と代行」第84回日本生理学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-20
• [Presentation] Activity-dependent regulation of mGluRla and VGluTl in the lateral geniculate nucleus of rat. (2007)
  • Author(s): Yoshida M., et. al.
  • Organizer: 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U.S.A
• [Presentation] 発達期視覚野においてBDNFタンパク質量はERK、CaMK、PI3K、p38MAPK、Cdk5阻害では変化しないが、PKA阻害により増加する (2007)
  • Author(s): 一坂吏志, 他
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 自由行動下におけるラット外側膝状体神経活動の慢性記録 (2007)
  • Author(s): 赤崎孝文, 他
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] BDNFとNT3の日内変動は幼若ラットの大脳皮質の機能発達に重要 (2007)
  • Author(s): 浜武通子, 他
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] ラット一次視覚野における層特異的脳梁結合 (2007)
  • Author(s): 佐藤武正, 他
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 遺伝か環境か?-視覚経験に依存した脳発達- (2006)
  • Author(s): 畠義郎
  • Organizer: 第51回日本人類遺伝学会教育講演
  • Place of Presentation: 米子
  • Year and Date: 2006-10-18
• [Presentation] 薬理学的に抑制された発達視覚野における逆向きの眼優位可塑性の初期変化 (2006)
  • Author(s): 森島佑, 阪本広志, 赤崎孝文, 畠義郎
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-07-19
• [Presentation] Experience-dependent regulation of extracellular signal-regulated kinase 1/2 activity and subcellular localization in rat visual cortex. (2005)
  • Author(s): Takamura, H., Ichisaka, S., Hayashi, C., Maki, H., Hata, Y.
  • Organizer: 35th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC.
  • Year and Date: 2005-11-12
• [Presentation] Experience-dependent retraction of geniculocortical arbors in the pharmachologically inhibited visual cortex. (2005)
  • Author(s): Hata, Y., Haruta, M.
  • Organizer: 35th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC.
  • Year and Date: 2005-11-12
• [Book] Synaptic elimination" in Encyclopedic Reference of Neuroscience (2009)
  • Author(s): Hata Y
  • Publisher: Springer-Verlag
• [Book] Synaptic elimination. in "Encyclopedic Reference of Neuroscience"(eds. Binder, M.D., et. al.) (2008)
  • Author(s): Hata Y.
  • Publisher: Springer-Verlag, Berlin(印刷中)
• [Book] 視覚系の可塑性とその利用には何があるか?", 神経眼科をやさしく理解するための視覚と眼球運動のすべて (2007)
  • Author(s): 三宅賢一郎, 畠義郎
  • Publisher: メジカルビュー社
• [Book] Synaptic elimination. in "Encyclopedic Reference of Neuroscience" (eds. Binder, M.D. et al.) (2007)
  • Author(s): Hata Y.
  • Publisher: Springer-Verlag, Berlin(印刷中)
• [Book] 「神経眼科をやさしく理解するための視覚と眼球運動のすべて」第4章-4「視覚系の可塑性とその利用には何があるか?」p92-97 (2007)
  • Author(s): 三宅賢一郎 他
  • Total Pages: 279
  • Publisher: メジカルビュー社
• [Book] 神経眼科をやさしく理解するための視覚と眼球運動のすべて 第4章-4「視覚系の可塑性とその利用には何があるか?」 (2006)
  • Author(s): 三宅賢一郎 他
  • Publisher: メジカルビュー社(印刷中)