Studies on signaling molecules that regulates dynamics of neural network formation
| Project/Area Number |
17024006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MASU Masayuki University of Tsukuba, 大学院・人間総合科学研究科, 教授 (20243032)
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| Co-Investigator(Kenkyū-buntansha) |
MASU Kazuko 筑波大学, 大学院・人間総合科学研究科, 講師 (50344883)
SHIOMI Kensuke 筑波大学, 大学院・人間総合科学研究科, 講師 (00311598)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥98,700,000 (Direct Cost: ¥98,700,000)
Fiscal Year 2009: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2008: ¥18,900,000 (Direct Cost: ¥18,900,000)
Fiscal Year 2007: ¥18,900,000 (Direct Cost: ¥18,900,000)
Fiscal Year 2006: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2005: ¥21,400,000 (Direct Cost: ¥21,400,000)
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| Keywords | 脳・神経 / 発生 / 糖鎖 / 脂質 / 発生・分化 / 神経科学 / ヘパラン硫酸 / スルファターゼ / オートタキシン / LPA / 神経回路 |
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| Research Abstract |
Neural circuits are formed by the combined actions of extracellular signals that regulate cell differentiation, axon guidance, and synaptogenesis. In this study, we focus on novel sulfatases (SulfFP1 and SulfFP2) that hydrolyzes 6-O-sulfate in the heparan sulfate chain, and also on Enpp2 involved in extracellular production of lysophosphatidic acid. We have shown that dynamic regulation of heparan sulfate and lipid mediators plays important roles in neural development.
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Report
(6 results)
Research Products
(102 results)
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[Journal Article] Genetic marking of hematopoietic stem and endothelial cells: Identification of the Tmtsp genes encoding a novel cell-surface protein with the thrombospondin-1 domain.2006
Author(s)
Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi, T., Shiomi K., Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H.
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Journal Title
Blood 107
Pages: 4317-4325
Related Report
Peer Reviewed
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