Molecular mechanism of neural functions underlying sensory behaviors in the nematode C.elegans
Project/Area Number |
17024023
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Nagoya University |
Principal Investigator |
MORI Ikue Nagoya University, 大学院・理学研究科, 教授 (90219999)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥72,400,000 (Direct Cost: ¥72,400,000)
Fiscal Year 2009: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2008: ¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2007: ¥15,700,000 (Direct Cost: ¥15,700,000)
Fiscal Year 2006: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2005: ¥16,900,000 (Direct Cost: ¥16,900,000)
|
Keywords | 感覚神経細胞 / 温度受容 / 温度走性 / Cエレガンス / 神経回路 |
Research Abstract |
Animals modify their behaviors upon reception of various environmental stimuli. It however remains largely unknown how, at the molecular level, the stimuli are processed and integrated in the nervous system, thereby generating the behavioral outputs. To address molecular mechanism on sensory reception and neural plasticity, we utilized thermotaxis behavior, a temperature memory and feeding state-regulated behavior, in the small nematode Caenorhabditis elegans. C.elegans is an ideal system to elucidate molecular basis of behavioral plasticity because of its complete knowledge of neural wiring and powerful accessibility to genetic and molecular analyses. We showed here that 1) temperature is not only sensed but also remembered by AFD and AWC sensory neurons, 2) starvation signal inhibits thermotaxis interneurons that are downstream of AFD and AWC through insulin-like peptide, and 3) association between temperature and feeding state requires functional changes in thermotaxis interneurons. We also found that Lithium, a drug for patients with bipolar disorder, affects synaptic localization in RIA interneuron, which is essential for proper thermotaxis behavior.
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Report
(6 results)
Research Products
(89 results)
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[Journal Article] elegans phototransduction requires a G protein-mediated cGMP pathway and a taste receptor homolog2010
Author(s)
Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z, Xu S, C
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Journal Title
Nature Neuroscience (in press)
Related Report
Peer Reviewed
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[Journal Article] C.elegans phototransduction requires a G protein-mediated cGMP path way and a taste receptor homolog (accepted)2010
Author(s)
Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z, XuS
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans2008
Author(s)
Kuhara, A. *, Okumura, M. *, Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., Mori I
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Journal Title
Science 320
Pages: 803-807
Related Report
Peer Reviewed
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[Journal Article] Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans2008
Author(s)
Kuhara, A., Okumura, M., Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., and Mori I.
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Journal Title
Science 320
Pages: 803-807
Related Report
Peer Reviewed
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[Journal Article] Insulin-like signaling and the neural circuit for integrative behavior in C. elegans2006
Author(s)
Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K.D., Okumura, M., Tomioka, M., Iino, Y., Mori, I
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Journal Title
Genes Dev 20
Pages: 2955-2960
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[Journal Article] Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans2006
Author(s)
Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T., Mori, I
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Journal Title
Genes Dev 20
Pages: 3296-3310
Related Report
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[Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans2006
Author(s)
Inada, H., Ito, H., Satterlee, J. Sengupta, P., Matsumoto, K., Mori, I
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Journal Title
Genetics 172
Pages: 2239-2252
Related Report
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[Journal Article] Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.2006
Author(s)
Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K.D., Okumura, M., Tomioka, M., Iino, Y., Mori, I.
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Journal Title
Genes Dev 20
Pages: 2955-2960
Related Report
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[Journal Article] Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.2006
Author(s)
Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T., Mori, I.
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Journal Title
Genes Dev 20
Pages: 3296-3310
Related Report
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[Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.2006
Author(s)
Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K., Mori, I.
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Journal Title
Genetics 172
Pages: 2239-2252
Related Report
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[Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Gaenorhabditis elegans2006
Author(s)
Inada, I., Ito, H., Satterlee, J., Sengupta, P., Mataumoto, K., Mori I.
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Journal Title
Related Report
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[Journal Article] Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L12005
Author(s)
Sasakura, H., Inada, H., Kuhara, A., Fusaoka, E., Takemoto, D., Takeuchi, K., Mori, I.
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Journal Title
EMBO Journal 24
Pages: 1477-1488
Related Report
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[Journal Article] Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans.2005
Author(s)
Mohri, A., Kodama, E., Kimura, K.D., Koike, M., Mizuno, T., Mori, I
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Journal Title
Genetics 169
Pages: 1437-1450
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[Presentation] Studies on neuronal function of a novel and conserved protein TTX-82007
Author(s)
Miyara, A., Ohta, A., Okochi, Y., Okumura, M., Takano, R., Kuhara, A.& Mori, I.
Organizer
16th International C. elegans Meeting
Place of Presentation
Los Angeles CA, USA
Related Report
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[Presentation] Analysis of aho-3 gene that plays a role in an associative learning between cultivation temperature and feeding state in C. elegans2007
Author(s)
Nishio, N., Mohri, A., Kodama, E., Kuhara, A., Kimura, K.& Mori, I.
Organizer
16th International C. elegans Meeting
Place of Presentation
Los Angeles CA, USA
Related Report
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