Molecular mechanism of neural functions underlying sensory behaviors in the nematode C.elegans

• Project/Area Number: 17024023
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: MORI Ikue Nagoya University, 大学院・理学研究科, 教授 (90219999)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥72,400,000 (Direct Cost: ¥72,400,000); Fiscal Year 2009: ¥12,100,000 (Direct Cost: ¥12,100,000); Fiscal Year 2008: ¥11,100,000 (Direct Cost: ¥11,100,000); Fiscal Year 2007: ¥15,700,000 (Direct Cost: ¥15,700,000); Fiscal Year 2006: ¥16,600,000 (Direct Cost: ¥16,600,000); Fiscal Year 2005: ¥16,900,000 (Direct Cost: ¥16,900,000)
• Keywords: 感覚神経細胞 / 温度受容 / 温度走性 / Cエレガンス / 神経回路

Research Abstract

Animals modify their behaviors upon reception of various environmental stimuli. It however remains largely unknown how, at the molecular level, the stimuli are processed and integrated in the nervous system, thereby generating the behavioral outputs. To address molecular mechanism on sensory reception and neural plasticity, we utilized thermotaxis behavior, a temperature memory and feeding state-regulated behavior, in the small nematode Caenorhabditis elegans. C.elegans is an ideal system to elucidate molecular basis of behavioral plasticity because of its complete knowledge of neural wiring and powerful accessibility to genetic and molecular analyses. We showed here that 1) temperature is not only sensed but also remembered by AFD and AWC sensory neurons, 2) starvation signal inhibits thermotaxis interneurons that are downstream of AFD and AWC through insulin-like peptide, and 3) association between temperature and feeding state requires functional changes in thermotaxis interneurons. We also found that Lithium, a drug for patients with bipolar disorder, affects synaptic localization in RIA interneuron, which is essential for proper thermotaxis behavior.

Research Products

• [Journal Article] elegans phototransduction requires a G protein-mediated cGMP pathway and a taste receptor homolog (2010)
  • Author(s): Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z, Xu S, C
  • Journal Title: Nature Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans (2010)
  • Author(s): Jurado, P., Kodama, E., Tanizawa, Y., Mori, I
  • Journal Title: Genes, Brain and Behavior 9 Pages: 120-127
  • Peer Reviewed
• [Journal Article] Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans. (2010)
  • Author(s): Jurado, P., Kodama, E.., Tanizawa, Y., Mori, I.
  • Journal Title: Genes, Brain and Behavior 9 Pages: 120-127
  • Peer Reviewed
• [Journal Article] C.elegans phototransduction requires a G protein-mediated cGMP path way and a taste receptor homolog (accepted) (2010)
  • Author(s): Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, Kang L, Yu Y, Ma D, Xu T, Mori I, Xie Z, XuS
  • Journal Title: Nature Neuroscience (未定)
  • Peer Reviewed
• [Journal Article] 線虫(C.elegans)の行動を制御する神経回路における嗅覚ニューロンによる温度の感知 (2009)
  • Author(s): 森郁恵、久原篤
  • Journal Title: Science, Japanese Scientists in Science 2008サイエンスに載った日本人研究者 Pages: 20-20
• [Journal Article] Aging : shall we take the high road? (2009)
  • Author(s): Mori, I., Sasakura H.
  • Journal Title: Current Biology 19
  • Peer Reviewed
• [Journal Article] 線虫(C. elegans)の行動を制御する神経回路における嗅覚ニューロンによる温度の感知 (2009)
  • Author(s): 森郁恵, 久原篤
  • Journal Title: Science, Japanese Scientists in Science 2008サイエンスに載った日本人研究者 Pages: 20-20
• [Journal Article] Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans (2008)
  • Author(s): Kuhara, A. *, Okumura, M. *, Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., Mori I
  • Journal Title: Science 320 Pages: 803-807
  • Peer Reviewed
• [Journal Article] 温度学習行動の分子神経回路メカニズム,蛋白質核酸酵素増刊号神経の分化, 回路形成 (2008)
  • Author(s): 久原篤, 笹倉寛之, 木全翼, 森郁恵
  • Journal Title: 機能発現 53 Pages: 580-586
• [Journal Article] Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans (2008)
  • Author(s): Kuhara, A., Okumura, M., Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., and Mori I.
  • Journal Title: Science 320 Pages: 803-807
  • Peer Reviewed
• [Journal Article] A single sensory neuron directs both attractive and repulsive odor preferences (2008)
  • Author(s): Mori I.
  • Journal Title: Neuron 59 Pages: 839-840
  • Peer Reviewed
• [Journal Article] 温度学習行動の分子神経回路メカニズム (2008)
  • Author(s): 久原篤, 笹倉寛之, 木全翼, 森郁恵
  • Journal Title: 蛋白質核酸酵素増刊号神経の分化, 回路形成, 機能発現 53 Pages: 580-586
• [Journal Article] 線虫C. elegansの温度走性をもちいた感覚と学習行動の遺伝学的研究 (2008)
  • Author(s): 久原篤, 森郁恵
  • Journal Title: 生物物理 48(3) Pages: 167-173
• [Journal Article] 線虫におけるGタンパクを介した温度感知行動 (2008)
  • Author(s): 久原篤, 森郁恵
  • Journal Title: 細胞工学特集号行動を支配する遺伝子 27(11) Pages: 1106-1111
• [Journal Article] 神経回路の活動と接続のライブイメージング (2008)
  • Author(s): 久原篤, 木全翼, 森郁恵
  • Journal Title: 実験医学増刊号ライブイメージングで解き明かす多彩な生命現象 26(17) Pages: 89-95
• [Journal Article] 温度学習行動の分子神経回路メカニズム (2008)
  • Author(s): 久原 篤、笹倉 寛之、木全 翼、森郁恵
  • Journal Title: 蛋白質 核酸 酵素 増刊号 神経の分化, 回路形成, 機能発現 53(4) Pages: 580-586
  • Peer Reviewed
• [Journal Article] Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity (2007)
  • Author(s): Mori, I., Sasakura, H., Kuhara, A
  • Journal Title: Current Opinion in Neurobiology 17 Pages: 712-719
  • Peer Reviewed
• [Journal Article] Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity (2007)
  • Author(s): Mori, I, Sasakura, H., Kuhara, A.
  • Journal Title: Current Opinion in Neurobiology 17 Pages: 712-719
  • Peer Reviewed
• [Journal Article] 温度受容ニューロンにおけるGタンパクを介した新規温度受容伝達メカニズム (2007)
  • Author(s): 久原 篤、奥村 将年、森郁恵
  • Journal Title: 生物の科学, 遺伝 21 Pages: 250-252
  • Peer Reviewed
• [Journal Article] Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans (2006)
  • Author(s): Kuhara, A., Mori, I
  • Journal Title: J Neurosci 154 Pages: 9355-9364
• [Journal Article] Insulin-like signaling and the neural circuit for integrative behavior in C. elegans (2006)
  • Author(s): Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K.D., Okumura, M., Tomioka, M., Iino, Y., Mori, I
  • Journal Title: Genes Dev 20 Pages: 2955-2960
• [Journal Article] Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans (2006)
  • Author(s): Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T., Mori, I
  • Journal Title: Genes Dev 20 Pages: 3296-3310
• [Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans (2006)
  • Author(s): Inada, H., Ito, H., Satterlee, J. Sengupta, P., Matsumoto, K., Mori, I
  • Journal Title: Genetics 172 Pages: 2239-2252
• [Journal Article] Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans (2006)
  • Author(s): Ito, H., Inada, H., Mori, I
  • Journal Title: J. Neurosci. Meth 154 Pages: 45-52
• [Journal Article] Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans. (2006)
  • Author(s): Kuhara, A., Mori, I.
  • Journal Title: J Neurosci 154 Pages: 9355-9364
• [Journal Article] Insulin-like signaling and the neural circuit for integrative behavior in C. elegans. (2006)
  • Author(s): Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K.D., Okumura, M., Tomioka, M., Iino, Y., Mori, I.
  • Journal Title: Genes Dev 20 Pages: 2955-2960
• [Journal Article] Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. (2006)
  • Author(s): Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T., Mori, I.
  • Journal Title: Genes Dev 20 Pages: 3296-3310
• [Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. (2006)
  • Author(s): Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K., Mori, I.
  • Journal Title: Genetics 172 Pages: 2239-2252
• [Journal Article] Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans. (2006)
  • Author(s): Ito, H., Inada, H., Mori, I.
  • Journal Title: J. Neurosci. Meth. 154 Pages: 45-52
• [Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Gaenorhabditis elegans (2006)
  • Author(s): Inada, I., Ito, H., Satterlee, J., Sengupta, P., Mataumoto, K., Mori I.
  • Journal Title: Genetics (in press)
• [Journal Article] Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans. (2006)
  • Author(s): Ito, H., Inada, H., Mari, I.
  • Journal Title: Journal of Neuroscience Methods (in press)
• [Journal Article] Diverse regulation of sensory signaling by nPKC-epsilon/eta TTX-4 in the nematode C.elegans. (2005)
  • Author(s): Okochi, Y., Kimura, K.D., Ohta, A., Mori, I.
  • Journal Title: EMBO Journal 24 Pages: 2127-2137
• [Journal Article] Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1 (2005)
  • Author(s): Sasakura, H., Inada, H., Kuhara, A., Fusaoka, E., Takemoto, D., Takeuchi, K., Mori, I.
  • Journal Title: EMBO Journal 24 Pages: 1477-1488
• [Journal Article] Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans. (2005)
  • Author(s): Mohri, A., Kodama, E., Kimura, K.D., Koike, M., Mizuno, T., Mori, I
  • Journal Title: Genetics 169 Pages: 1437-1450
• [Presentation] 線虫における神経コード (2010)
  • Author(s): 森郁恵
  • Organizer: 平成21年度「バイオ分子センサー」連携研究公開シンポジウム
  • Place of Presentation: 自然科学研究機構 岡崎カンファレンスセンター中会議室(岡崎)
  • Year and Date: 2010-01-15
• [Presentation] 神経活動の定量的光操作から見えてきた神経の暗号 (2010)
  • Author(s): 久原篤, 森郁恵
  • Organizer: 定量生物学の会 第二回年会
  • Place of Presentation: 大阪大学(大阪)
• [Presentation] Neural circuits regulating C. elegans memory-based behavior (2009)
  • Author(s): Ikue Mori
  • Organizer: 第4回MCCS-Asiaシンポジウム
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-15
• [Presentation] Neural coding of behaviors in C. elegans (2009)
  • Author(s): Ikue Mori
  • Organizer: ISDB2009, 2009. 9. 6-10, Edinburgh International Conference Centre
  • Place of Presentation: Edinburgh, UK
• [Presentation] Neural coding of temperature memory-regulated behavior in C. elegans (2009)
  • Author(s): Ikue Mori
  • Organizer: グローバルCOEプログラム「システム生命科学の展開:生命機能の設計」国際シンポジウム"Frontiers of Genes, Neural Circuits and Behavior"
  • Place of Presentation: 名古屋大学(名古屋)
• [Presentation] Components orchestrating the neural circuit for behavior (2009)
  • Author(s): Mori, I
  • Organizer: Janelia Farm Research Conference on Neural Circuit and Behavior in C. elegans II: Towards the Ultimate Model
  • Place of Presentation: Virginia, USA
• [Presentation] 温度感知行動を司る神経回路システム～分子生理学者が目指すシスラムズバイオロジー～ (2009)
  • Author(s): 久原篤, 森郁恵
  • Organizer: 生理研研究会
  • Place of Presentation: 生理学研究所(岡崎)
• [Presentation] Neural coding of behaviors in C.elegans (2009)
  • Author(s): Ikue Mori
  • Organizer: ISDB2009
  • Place of Presentation: Edinburgh International Conference Centre (Edinburgh, UK)
• [Presentation] Neural coding of temperature memory-regulated behavior in C.elegans (2009)
  • Author(s): Ikue Mori
  • Organizer: グローバルCOEプログラム「システム生命科学の展開 : 生命機能の設計」国際シンポジウム"Frontiers of Genes, Neural Circuits and Behavior"
  • Place of Presentation: 名古屋大学(名古屋)
• [Presentation] C.elegans温度受容ニューロンにおいて広いレンジの温度受容を制御するGタンパク共役型受容体(GPCR)の解析 (2009)
  • Author(s): 笹倉寛之, 鈴木啓太, 伊藤浩子, 森郁恵
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学(松本)
• [Presentation] Insights into the mechanisms of Caenorhabditis elegans memory (2009)
  • Author(s): Paula Jurado, Ikue Mori
  • Organizer: 2009 European Conference on Nematode Neurobiology
  • Place of Presentation: Downing College (Cambridge, UK)
• [Presentation] Regulation of a neural circuit for thermotactic behavior by non-neuronal cells (2009)
  • Author(s): 杉拓磨、西田征央、森郁恵
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Components orchestrating the neural circuit for behavior (2009)
  • Author(s): Mori, I.
  • Organizer: Janelia Farm Research Conference on Neural Circuit and Behavior in C. elegans II : Towards the Ultimate Model
  • Place of Presentation: Virginia, USA
• [Presentation] Comprehensive analysis of neural circuit controlling behavior in C. elegans (2008)
  • Author(s): Mori, I
  • Organizer: Gordon Research Conference "Molecular & Cellular Neurobiology"
  • Place of Presentation: Hong Kong, China
• [Presentation] Calcineurin is required for behavioral plasticity in C. elegans (2008)
  • Author(s): Mori, I
  • Organizer: FASEB Summer Research Conference "Calcium and Cell Function"
  • Place of Presentation: Colorado, USA
• [Presentation] Comprehensive Studies on a Neural Circuit for Worm Thermotaxis (2008)
  • Author(s): Mori, I
  • Organizer: CDB Symposium: Turning Neurons into a Nervous System
  • Place of Presentation: Kobe, Japan
• [Presentation] G protein-coupled temperature sensing by an olfactory neuron in C. elegans (2008)
  • Author(s): Atsushi Kuhara, Masatoshi Okumura, Ayako Okazaki, Sayaka Tachikawa, and Ikue Mori
  • Organizer: Neuro 2008
  • Place of Presentation: 東京
• [Presentation] C.elegans温度受容ニューロンに特異的に発現するGタンパク共役型受容体(GPCR)の解析 (2008)
  • Author(s): 笹倉寛之, 鈴木啓太, 伊藤浩子, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫C.elegansにおけるGαを介した温度受容機構に関与する新規変異の解析 (2008)
  • Author(s): 岡崎史子, 久原篤, 立川さやか, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 種を超えて保存された新規因子TTX-8の神経細胞における機能解析 (2008)
  • Author(s): 宮良晶子, 太田茜, 大河内善史, 奥村将人, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫の温度情報処理を制御する神経回路におけるグルタミン酸作動性シナプス伝達の解析 (2008)
  • Author(s): 大西憲幸, 久原篤, 奥村将年, 大河内善史, 稲田仁, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 光駆動性チャネルをもちいた線虫C. elegansの温度走性に関わる神経回路の活性調節 (2008)
  • Author(s): 下和田智康, 久原篤, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] C.elegansにおいて、新規加水分解酵素AHO-3は温度と餌条件の連合学習に関与する (2008)
  • Author(s): 西尾奈々, 毛利亮子, 児玉英志, 木村幸太郎, 久原篤, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] C.elegansの新規温度走性変異体nj24の解析 (2008)
  • Author(s): 延命大士, 西尾奈々, 赤坂茉莉, 久原篤, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] Insights into the molecular mechanisms of Caenorhabditis elegans memory (2008)
  • Author(s): フラドパオラ, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫C.elegansにおける温度走性行動を基にした意思決定(Decision making)に異常を示す変異体 (2008)
  • Author(s): 後藤冬樹, フラドパオラ, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫C.elegansにおける温度受容から温度記憶の形成への変換に関する転写連動モデル (2008)
  • Author(s): 杉拓磨, 西田征央, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫C.elegansの記憶形成におけるタンパク質の翻訳後修飾の役割の解明 (2008)
  • Author(s): 西田征央, 杉拓磨, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫C.elgansの中枢介在ニューロンにおけるイノシトールを介したシナプス細胞内局在機構の遺伝学的解析 (2008)
  • Author(s): 木全翼, 久原篤, 谷澤欣則, 森郁恵
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
• [Presentation] 線虫の温度走性を支配する神経回路におけるグルタミン酸作動性シナプスを介した神経伝達経路の制御 (2008)
  • Author(s): 大西憲幸, 久原篤, 奥村将年, 大河内善史, 稲田仁, 森郁恵
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 線虫C.エレガンスの嗅覚ニューロンにおけるGタンパクを介した温度受容メカニズム (2007)
  • Author(s): 久原篤、奥村将年、森郁恵
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 線虫C.elegansにおけるGαを介した温度受容機構の異常を抑圧する変異体の解析 (2007)
  • Author(s): 岡崎史子、久原篤、立川さやか、森郁恵
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
• [Presentation] 線虫C.elegansの温度走性に関わる中枢介在ニューロンRIAのシナプス局在を制御する遺伝子の探索.第79回日本遺伝学会大会 (2007)
  • Author(s): 木全翼、久原篤、谷澤欣則、森郁恵
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
• [Presentation] 線虫C.elegansの温度受容ニューロンAFDにおけるGFPマーカーの発現を指標とした新規温度走性異常変異体の単離と解析 (2007)
  • Author(s): 鈴木啓太、笹倉寛之、森郁恵
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
• [Presentation] 神経細胞の細胞内小器官に局在する新規分子TTX-8が関わる分子経路の探索 (2007)
  • Author(s): 高野良、宮良晶子、久原篤、森郁恵
  • Organizer: 第79回日本遺伝学会大会、2007.9.19-09.21、岡山.
  • Place of Presentation: 岡山
• [Presentation] Gタンパクを介した温度受容メカニズムと温度情報伝達の機能的神経回路 (2007)
  • Author(s): 久原篤、奥村将年、森郁恵
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
• [Presentation] 線虫の温度情報処理に関わる神経回路におけるグルタミン酸を介した頭部運動ニューロンの制御機構の解析 (2007)
  • Author(s): 大西憲幸、久原篤、奥村将年、大河内善史、稲田仁、森郁恵
  • Organizer: 第30回日本神経科学会大会
  • Place of Presentation: 横浜
• [Presentation] 線虫C.elegansのRIAニューロンをモデル系としたシナプス細胞内局在の解析 (2007)
  • Author(s): 木全翼、久原篤、谷澤欣則、森郁恵
  • Organizer: 第30回日本神経科学会大会
  • Place of Presentation: 横浜
• [Presentation] 種を超えて保存されている新規温度走性因子ttx-8の解析 (2007)
  • Author(s): 宮良晶子、太田茜、大河内善史、奥村将年、高野良、久原篤、森郁恵
  • Organizer: 第30回日本神経科学会大会
  • Place of Presentation: 横浜
• [Presentation] 線虫C.elegansにおいて、新規加水分解酵素AHO-3は温度と餌条件の連合学習に関与する (2007)
  • Author(s): 西尾奈々、毛利亮子、児玉英志、木村幸太郎、久原篤、森郁恵
  • Organizer: 第30回日本神経科学会大会
  • Place of Presentation: 横浜
• [Presentation] 線虫C.elegansにおけるGαを介した温度受容機構に関わる新規遺伝子の単離 (2007)
  • Author(s): 岡崎史子、久原篤、立川さやか、森郁恵
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 線虫C.elegansの温度受容ニューロンAFDにおけるGFPマーカーの発現を指標とした新規温度走性異常変異体の単離と解析 (2007)
  • Author(s): 鈴木啓太、笹倉寛之、森郁恵
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] G protein-coupled novel temperature sensing mechanism (2007)
  • Author(s): Kuhara, A., Okumura, M., Kimura, KD., Matsumoto, K. & Mori, I
  • Organizer: Neuro 2007
  • Place of Presentation: Yokohama, Japan
• [Presentation] Genetical analysis of subcelluar localization of synapses in RIA interneuron essential for thermotaxis (2007)
  • Author(s): Kimata, T., Kuhara, A., Tanizawa, Y. & Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Analysis and screening of genes involved in thermosensory signaling (2007)
  • Author(s): Sasakura, H., Suzuki, K., Itoh, H., Sugi, T.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Studies on neuronal function of a novel and conserved protein TTX-8 (2007)
  • Author(s): Miyara, A., Ohta, A., Okochi, Y., Okumura, M., Takano, R., Kuhara, A.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Analysis of aho-3 gene that plays a role in an associative learning between cultivation temperature and feeding state in C. elegans (2007)
  • Author(s): Nishio, N., Mohri, A., Kodama, E., Kuhara, A., Kimura, K.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Olfactory neuron senses temperature through the G protein-coupled signaling (2007)
  • Author(s): Kuhara, A., Okumura, M., Kimura, KD., Matsumoto, K.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Calcium imaging of the thermotaxis neural circuit: toward combinatorial feed back analysis between in vivo neurobiology and in silico computation (2007)
  • Author(s): Kuhara, A., Ohnishi, N., Kodama, E.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Isolation of new mutants defective in G protein-coupled thermosensation (2007)
  • Author(s): Tachikawa, S., Kuhara, A., Okazaki, A.& Mori, I.
  • Organizer: 16th International C. elegans Meeting
  • Place of Presentation: Los Angeles CA, USA
• [Presentation] Molecular mechanisms of decision making in Caenorhabditis elegans (2007)
  • Author(s): Jurado, P.& Mori, I.
  • Organizer: Neuro 2007
  • Place of Presentation: Yokohama, Japan
• [Book] 蛋白質核酸酵素増刊号神経の分化, 回路形成, 機能発現53(4), 温度学習行動の分子神経回路メカニズム (2008)
  • Author(s): 久原篤、笹倉寛之、木全翼、森郁恵
• [Book] 線虫C. elegansの温度走性をもちいた感覚と学習行動の遺伝学的研究 (2008)
  • Author(s): 久原 篤、森郁恵
  • Publisher: 生物物理 (印刷中)
• [Book] 温度学習行動の分子神経回路メカニズム (2008)
  • Author(s): 久原 篤、笹倉 寛之、木全 翼、森郁恵
  • Publisher: 蛋白質 核酸 酵素 増刊号 神経の分化,回路形成,機能発現53(4)
• [Book] 温度受容ニューロンにおけるGタンパクを介した新規温度受容伝達メカニズム (2007)
  • Author(s): 久原 篤、奥村 将年、森郁恵
  • Publisher: 生物の科学,遺伝21