Patterning dendritic arbors : molecular mechanisms controlling branching and arbor size
Project/Area Number |
17024025
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
UEMURA Tadashi Kyoto University, 大学院・生命科学研究科, 教授 (80213396)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥101,900,000 (Direct Cost: ¥101,900,000)
Fiscal Year 2009: ¥21,200,000 (Direct Cost: ¥21,200,000)
Fiscal Year 2008: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2007: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2006: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2005: ¥19,000,000 (Direct Cost: ¥19,000,000)
|
Keywords | 樹状突起 / 神経細胞 / ショウジョウバエ / 細胞骨格 / Rhoファミリー / 分子遺伝学 / 神経回路形成 / カドヘリンスーパーファミリー / 樹上突起 / 分子遺伝子 / 遺伝学 / カドヘリン |
Research Abstract |
Dendrites allow neurons to integrate information from sensory or synaptic inputs. The spatial disposition and local density of branches within the arbor limit the number and type of inputs. We have shown that a group of transcriptional regulators are expressed selectively in subclasses and that they exert their cell-autonomous functions to control formation of the class-specific arbors. Our genetical as well as in vivo cell-biological approaches have revealed an important link between microtubule motors and organelles, such as endosomes, in controlling branch density and spatial disposition of branches within dendritic arbors. Finally we have found that a novel family of mitochondrial proteins is important for preventing breakage of dendritic branches.
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Report
(6 results)
Research Products
(84 results)
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[Journal Article] Mitochondrial Protein Preli-like Is Required for Development of Dendritic Arbors and Prevents Their Regression in the Drosophila Sensory Nervous System.2009
Author(s)
Tsubouchi, A., Tsuyama, T., Fujioka, M., Kohda, H., Okamoto-Furuta, K., Aigaki, T., Uemura, T.
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Journal Title
Development 136
Pages: 3757-3766
Related Report
Peer Reviewed
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[Journal Article] Multidendritic sensory neurons in the adult Drosophila abdomen : origins, dendritic morphology, and segment- and age-dependent programmed cell death.2009
Author(s)
Shimono, K., Fujimoto, A., Tsuyama, T., Yamamoto-Kochi, M., Sato, M., Hattori, Y., Sugimura, K., Usui, T., Kimura, K., Uemura, T.
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Journal Title
Neural Development 4
Pages: 37
Related Report
Peer Reviewed
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[Journal Article] Spatial Control of Branching within Dendritic Arbors by Dynein-Dependent Transport of Rab5-Endosomes.2008
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., Ohkura, H., M.Rolls, M., Ishikawa, F., Uemura, T.
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Journal Title
Nature Cell Biology 10
Pages: 1164-1171
Related Report
Peer Reviewed
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[Journal Article] Opposing roles in neurite growth control by two 7-pass transmembrane cadherins.2007
Author(s)
Shima, Y., Kawaguchi, S., Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T., Uemura, T.
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Journal Title
Nature Neuroscience 10
Pages: 963-969
Related Report
Peer Reviewed
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[Journal Article] Polarity and intracellular compartmentalization of Drosophila neurons.2007
Author(s)
M Rolls, M., Satoh, D., J Clyne, P., L Henner, L., Uemura, T., Q Doe, Q.
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Journal Title
Neural Development 2
Pages: 7-21
Related Report
Peer Reviewed
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[Presentation] Control of Dendritic Self-Avoidance by Seven-Pass Transmembrane Cadherin in Drosophila Sensory Neurons.2008
Author(s)
Usui, T., Horiuchi, S., Matsubara, D., Shimono, K., Kimura, H. & Uemura, T
Organizer
CDB Symposium 2008
Place of Presentation
Kobe
Year and Date
20080324-26
Related Report
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[Presentation] Control of proximal-distal distribution of dendritic branches requires transport of Rab5 endosome by dynein.2007
Author(s)
佐藤大祐, 佐藤太一, 津山泰一, M. Rolls, M., Q. Doe, C., 大倉洋之, 斉藤基輝, 石川冬木, 上村匡
Organizer
第30回日本分子生物学会年会第80回日本生化学会大会合同大会
Place of Presentation
横浜
Year and Date
20071211-15
Related Report
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[Presentation] Control of Dendritic Self-Avoidance by Signaling of the Seven-Pass Transmembrane Cadherin.2007
Author(s)
Usui, T., Horiuchi, S., Matsubara, D., Shimono, K., Kimura, H. & Uemura, T
Organizer
第30回日本分子生物学会年会第80回日本生化学会大会合同大会
Place of Presentation
横浜
Year and Date
20071211-15
Related Report
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[Presentation] Reexamination of Control of Dendritic Avoidance by 7-pass Transmembrane Cadherin in Drosophila Sensory Neurons.2007
Author(s)
Usui, T., Horiuchi, S., Matsubara, D., Shimono, K., Kimura, H. & Uemura, T
Organizer
国際生物学賞受賞記念講演会
Place of Presentation
京都
Year and Date
20071121-22
Related Report
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[Presentation] Control of Proximal-Distal Distribution of Branching Points in Dendritic Trees of Drosophila Sensory Neurons.2007
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., M. Rolls, M., Ohkura, H., Ishikawa, F., & Uemura. T
Organizer
国際生物学賞受賞記念講演会
Place of Presentation
京都
Year and Date
20071121-22
Related Report
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[Presentation] Control of Proximal-Distal Distribution of Branching Points in Dendritic Trees of Drosophila Sensory Neurons.2007
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., M. Rolls, M., Ohkura, H., Ishikawa, F., & Uemura. T
Organizer
第8回日本ショウジョウバエ研究集会
Place of Presentation
淡路
Year and Date
20070702-04
Related Report
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[Presentation] Control of Dendritic Avoidance by Signaling of the Seven-Pass Transmembrane Cadherin.2007
Author(s)
Usui, T., Horiuchi, S., Matsubara, D., Shimono, K., Kimura, H. & Uemura, T
Organizer
第8回日本ショウジョウバエ研究集会
Place of Presentation
淡路
Year and Date
20070702-04
Related Report
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[Presentation] Control of Proximal-Distal Distribution of Branching Points in Dendritic Trees of Drosophila Sensory Neurons.2007
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., M. Rolls, M., Ohkura, H., Ishikawa, F., & Uemura. T
Organizer
第40回日本発生生物学会・第59回日本細胞生物学会合同大会
Place of Presentation
福岡
Year and Date
20070528-30
Related Report
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[Presentation] Reexamination of Control of Dendritic Avoidance by 7-pass Transmembrane Cadherin in Drosophila Sensory Neurons.2007
Author(s)
Usui, T., Horiuchi, S., Matsubara, D., Shimono, K., Kimura, H. & Uemura, T
Organizer
第40回日本発生生物学会・第59回日本細胞生物学会合同大会
Place of Presentation
福岡
Year and Date
20070528-30
Related Report
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