| Project/Area Number |
17024026
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
NODA Makoto Kyoto University, 医学研究科, 教授 (30146708)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2009: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2008: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2007: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | がん / 発生 / マウス遺伝学 / MMP / ADAM / Notch / シグナル伝達 / RECK / 細胞外マトリックス / fibronectin / 細胞密度 / 細胞移動 / 酸素濃度 / 神経筋接合部 / 骨格筋発生 / MMP7 / focal adhesion / 細胞運動 / 神経分化 / nestin / 白質病変 / MMP-2 / パーキンソン病 / Sept4 / MRF / 筋肉発生 / Rb / N-ras |
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| Research Abstract |
RECK, first identified as a transformation suppressor gene, is expressed at relatively high levels in neural precursor cells (NPCs) in mouse embryos; in Reck-deficient mice, NPCs show reduced proliferation and precocious differentiation. Our study to understand the mechanism of this phenomenon revealed that Reck inhibits ADAM10- mediated Notch-ligand shedding. We also found that in the diaphragm of late-stage embryos, Reck rapidly accumulates in the neuromuscular junctions, mainly in the secondary folds of the post-synaptic muscle membrane.
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