| Budget Amount *help |
¥123,500,000 (Direct Cost: ¥123,500,000)
Fiscal Year 2009: ¥22,200,000 (Direct Cost: ¥22,200,000)
Fiscal Year 2008: ¥20,800,000 (Direct Cost: ¥20,800,000)
Fiscal Year 2007: ¥25,900,000 (Direct Cost: ¥25,900,000)
Fiscal Year 2006: ¥27,200,000 (Direct Cost: ¥27,200,000)
Fiscal Year 2005: ¥27,400,000 (Direct Cost: ¥27,400,000)
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| Research Abstract |
In embryonic neural stem cells, Hes1 expression oscillates with a period of about two hours, and Hes1 oscillations drive oscillatory expression of the proneural gene Ngn2 and the Notch ligand Dll1. Dll1 oscillations lead to mutual activation of Notch signaling and maintenance of neural stem cells. When Hes1 expression disappears, Ngn2 is expressed in a sustained manner, thereby promoting neuronal differentiation. In the adult brain, neurogenesis from neural stem cells is essential, and neural stem cells are maintained by the Notch-Hes pathway. These results revealed the significance of the rhythmic gene Hes1 in regulation of embryonic and adult neural stem cells.
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