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Regulation of neuronal differentiation and plasticity at posttranscriptional level

Research Project

Project/Area Number 17024051
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKeio University

Principal Investigator

OKANO Hideyuki  Keio University, 医学部, 教授 (60160694)

Co-Investigator(Kenkyū-buntansha) OKANO James Hirotaka  慶應義塾大学, 医学部, 准教授 (90338020)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥31,600,000 (Direct Cost: ¥31,600,000)
Fiscal Year 2009: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2008: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 2007: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywords分子・細胞神経科学 / RNA結合タンパク質 / 神経幹細胞 / 翻訳調節 / 神経分化 / Hu Hzf Musashi / p21Cip1 / Hu / Hzf / 翻訳調 / Musashi / p21Cipl / IP3受容体 / RNA結合タンパク
Research Abstract

Neural RNA binding proteins play important roles in the processes of brain development and maturation. Here we show that Hu, Hzf and Musashi control neuronal differentiation, RNA transport and neural stem cell maintenance, respectively, through the post-transcriptional regulation of messenger RNA in the embryonic and adult brain.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (64 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (35 results) (of which Peer Reviewed: 30 results) Presentation (17 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 3 results)

  • [Journal Article] Kspot, a novel ubiquitin ligase, regulates synaptic activity.2010

    • Author(s)
      Tada H., Okano HJ., Takagi H., Shibata S., Matsumoto M., Yao I., Saiga T., Nakayama KI., Kashima H., Takahashi T, Setou M, Okano H.
    • Journal Title

      J.Biol.Chem. 285(6)

      Pages: 3840-3849

    • NAID

      130005449632

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stromal cell-secreted factors promote the survival of ES cell-derived early neural stem/progenitor cells via the activation of MAPK and PI3K-Akt pathways.2010

    • Author(s)
      Ishii S., Okada Y., Kadoya T., Matsuzaki Y., Shimazaki T., Okano H.
    • Journal Title

      J.Neurosci.Res. 88(4)

      Pages: 722-773

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.2009

    • Author(s)
      Oki K, Kaneko N, Kanki H Sa wamoto K, Okano H.
    • Journal Title

      Neurosci. Res. 66(4)

      Pages: 390-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors.2009

    • Author(s)
      Susaki K, Kaneko J, Yamano Y, Nakamura K, In ami W, Yoshikawa T, Ozawa Y, Shibata S, Matsuzaki O, Okano H, Chiba C
    • Journal Title

      Experimental eye research 88

      Pages: 47-55

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell types to order : Temporal specification of CNS stem cells.2009

    • Author(s)
      Okano H., Temple S.
    • Journal Title

      Current Opinion in Neurobiology 19

      Pages: 112-119

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precursor maintenance and GABAergic neuronal differentiation mediated by the PDK1-Akt pathway in mouse telencephalon.2009

    • Author(s)
      Oishi K., Watatani K., Yoshimatsu T., Masuyama N., Nakajima K., Okano H., Guillemot F., Alessi DR., Gotoh Y.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(31)

      Pages: 13064-13069

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic alopecia caused by the disruption of Sox21- mediated hair shaft cuticle differentiation.2009

    • Author(s)
      Kiso M., Tanaka S., Saba R., Matsuda S., Shimizu A., Ohyama M., James-Okano H., Shiroishi T., Okano H., Saga Y.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(23)

      Pages: 9292-9297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.2009

    • Author(s)
      Saiga T., Fukuda T., Matsumoto M., Tada H., Okano HJ., Okano H., Nakayama KI.
    • Journal Title

      Mol.Cell Biol. 29(13)

      Pages: 3529-3543

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] e ural RNA-binding protein Musashi1 Inhibits Translation Initiation by Competing with eIF4G for PABP.2008

    • Author(s)
      Kawahara H, Imai T, Imataka H, Okano H.
    • Journal Title

      J. Cell Biol. 181

      Pages: 639-653

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hzf regulates adipogenesis through translational control of C/EBPalpha.2008

    • Author(s)
      Kawagishi H, Wakoh T, Uno H, Maruyama M, Mo riya A, Morikawa S, Okano H, Sherr CJ, Takagi M, Sugimoto M
    • Journal Title

      The EMBO journal 27

      Pages: 1481-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Re quirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.2008

    • Author(s)
      Naka H, Nakamura S, Shimazaki T, Okano H
    • Journal Title

      Nature neuroscience 11

      Pages: 1014-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      Kawahara H, Yano M, Imai T, Akamatsu W, Okano HJ, Okano H, Kawahara H, Yano M, Imai T, Akamatsu W, Okano HJ, Okano H
    • Journal Title

      Kerala, India

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement for COUP-TFI and II in the temporal specification of neura I stem cells in central nervous system development2008

    • Author(s)
      Naka H., Nakamura S., Shimazaki T., Okano H.
    • Journal Title

      Nature Neurosci 11(9)

      Pages: 1014-1023

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal recapitulation of central nervous system development by ES cell-derived neural stem/progenitor cells2008

    • Author(s)
      Okada Y., Matsumoto A., Shimazaki T., Enoki R., Koizumi A., Ishii S., Itoyama Y., Sobue G., Okano H.
    • Journal Title

      Stem Cells 26

      Pages: 3086-3098

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging in humanized mice2008

    • Author(s)
      Masuda H., Okano HJ., Maruya ma T., Yoshimura Y., Okano H., Matsuzaki Y
    • Journal Title

      Curr Top Microbiol Immunol 324

      Pages: 179-196

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hzf regulates adipogenesis through translational control of C/EBPa2008

    • Author(s)
      Kawagishi H., Wakoh T., Uno H Maruyama M., Moriya A., Morikawa S., Okano H., Sherr C J., Takagi M., Sugimoto M.
    • Journal Title

      EMBO J 27

      Pages: 1481-1490

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stage/Cell cycle phase specific nestin gene expression coordinated with the morphological alteration of embryonic cortical neural progenitor cells2008

    • Author(s)
      Sunabori T., Tokunaga A., Nagai T., Sawamoto K., Okabe M., Miyawaki A., Matsuzaki Y., Miyata T., Okano H
    • Journal Title

      J. Cell Sci 121

      Pages: 1204-1212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural RNA-binding protein Musashil inhibits translation initiation bycompeting with eIF4G for PABP.2008

    • Author(s)
      Kawahara, N., et al.
    • Journal Title

      J.Cell.Biol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of neural RNA binding protein, Musashi1 in pediatric brain tumors.2007

    • Author(s)
      Nakano A, Kanemura Y, Mori K, Kodama E, Ya mamoto A, Sakamoto H, Nakamura Y, Okano H, Yamasaki M, Arita N.
    • Journal Title

      Pediatric Neurosurgery 43

      Pages: 279-283

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated Expression of HuD and GAP-43 in Hippocampal Dentate Granule Cells During Developmental and Adult Plasticity.2007

    • Author(s)
      Bolognani F, Tanner DC, Nixon S, Okano HJ, Okano H, Perrone-Bizzozero NI.
    • Journal Title

      eurochem Res. 32

      Pages: 2142-2151

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Motor Functions in Mice Lacking the RNA-binding Protein Hzf.2007

    • Author(s)
      Iijima T, Ogura H, Takatsuki K, Shigenori Ka wahara S, Wakabayashi K, Nakayama D, Fujioka M, Kimura Y, Bernstein A, Okano HJ, Kirino Y, Okano H.
    • Journal Title

      Neurosci Res 58

      Pages: 183-189

    • NAID

      10024415208

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Musashi-1 expression in postnatal mouse olfactory epithelium.2007

    • Author(s)
      Watanabe K, Kondo K, Takeuchi N, Okano H, Yam asoba T
    • Journal Title

      Neuroreort 18

      Pages: 641-644

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Motor Functions in Mice Lacking the RNA-biading Protein Hzf.2007

    • Author(s)
      Iijima, T., et al.
    • Journal Title

      Neurosci Res. 58

      Pages: 183-189

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated Expression of HuD and GAP-43 in Hippocampal Dentate Granule Cells During Developmental and Adult Plasticity.2007

    • Author(s)
      Bolognani, F., et al.
    • Journal Title

      Neurochem Res. 32

      Pages: 2142-2151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.2006

    • Author(s)
      Sakaguchi M, Shingo T, S himazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H.
    • Journal Title

      Proc Natl Acad Sci USA. 103(18)

      Pages: 7112-7117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Musashi1 antigen expression in human fetal germinal matrix development.2006

    • Author(s)
      Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG
    • Journal Title

      Exp Neurol. 201

      Pages: 515-518

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A carbohydrate binding protein, Galectin-1, promotes proliferation of adult neural stem cells2006

    • Author(s)
      Sakaguchi M. et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 103

      Pages: 7112-7117

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.2005

    • Author(s)
      Yano M, Okano HJ, Oka no H
    • Journal Title

      The Journal of biological chemistry 280

      Pages: 12690-12699

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RNA-binding protein HuD regulates neuronal cell identity and maturation.2005

    • Author(s)
      Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, Okano HJ, Sakakibara S, Takano H, Takano T, Takahashi T, Noda T, Okano H
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 102

      Pages: 4625-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Function of RNA-binding protein Musashi-1 in stem cells.2005

    • Author(s)
      Okano H, Kawahara H, Toriya M, Nakao K, Shibata S, Imai T
    • Journal Title

      Experimental cell research 306

      Pages: 349-56

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1, 4, 5-trisphosphate receptor mRNA.2005

    • Author(s)
      Iijima T, Imai T, Kimura Y, Bernstein A, Okano HJ, Yuzaki M, Okano H
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 102

      Pages: 17190-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Hu and hnRNP K in neuronal differentiation through p21 mRNA post-transcriptional regulation2005

    • Author(s)
      Yano M.et al.
    • Journal Title

      J.Biol.Chem 280

      Pages: 12690-12699

    • Related Report
      2005 Annual Research Report
  • [Journal Article] RNA-binding protein HuD regulates neuronal cell identity and maturation.2005

    • Author(s)
      Akamatsu W. et al.
    • Journal Title

      Proc Natl Acad Sci USA. 102

      Pages: 4625-4630

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hzf Protein Regulates Dendritic Localization and BDNF-induced Translation of Type 1 Inositol 1,4,5-Trisphosphate Receptor mRNA.2005

    • Author(s)
      Iijima T. et al.
    • Journal Title

      Proc Natl Acad Sci USA. 102

      Pages: 17190-17195

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impaired Motor Functions in Mice Lacking the RNA-binding Protein Hzf

    • Author(s)
      Iijima T. et al.
    • Journal Title

      Neurosci Res. (In press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Sensory neural network formation with RNA binding protein Musashi-2 deficient mice.2009

    • Author(s)
      Shinsuke Shibata
    • Organizer
      36th International Congress Of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of RNA Binding Protein Hu in Developing and Mature Neurons.2009

    • Author(s)
      Hirotaka James Okano
    • Organizer
      36th Intemational Congress Of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Axonal degeneration in HuC-deficient Cerebellum.2009

    • Author(s)
      Kyoko Kakumoto
    • Organizer
      36th International Congress Of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of RN A Binding Protein Hu in Developing and Mature Neurons.2009

    • Author(s)
      Okano HJ.
    • Organizer
      36th International Congress Of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural differentiation of pluripotent stem cells based therapy for spinal cord injury2008

    • Author(s)
      Okano H.
    • Organizer
      the National Centre for Adult Stem Cell Research conference, Adult Stem Cells - Biology and Clinical Applications Meeting
    • Place of Presentation
      Griffith University, Queensland, Australia
    • Year and Date
      2008-11-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural differentiation of pluripotent stem cells based therapy for spinal cord injury, the National Centre for Adult Stem Cell Research conference2008

    • Author(s)
      H. Okano
    • Organizer
      Adult Stem Cells - Biology and Clinical Applications Meeting
    • Place of Presentation
      Griffith University, Queensland, Australia
    • Year and Date
      2008-11-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural differentiation of pluripotent stem cells based therapy for spinal cord injury2008

    • Author(s)
      Hideyuki Okano
    • Organizer
      the National Centre for Adult Stem Cell Research conference, Adult Stem Cells-Biology and Clinical Applications Meeting
    • Place of Presentation
      Griffith University, Que ensland, Australia
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regeneration of the damaged CNS using stem cells2008

    • Author(s)
      Okano H.
    • Organizer
      Neural Stem Cells & Regenarative Neuroscience Workshop
    • Place of Presentation
      Scientia Building, UNSW, Sydney Australia
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Neural differentiation and cell therapy using pluripotent stem cells2008

    • Author(s)
      Okano H.
    • Organizer
      2nd Symposium on Brain and Mind Research in the Asia / Pacific (BMAP)
    • Place of Presentation
      the Matrix, Biopolis, Singapore.
    • Year and Date
      2008-09-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural differentiation and cell therapy using pluripotent stem cells2008

    • Author(s)
      Hideyuki Okano
    • Organizer
      2^<nd> Symposium on Brain and Mind Research in the Asia / Pacific (BMAP)
    • Place of Presentation
      the Matrix, Biopolis, Si ngapore
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Strategies for the regeneration of damaged CNS2008

    • Author(s)
      Okano H.
    • Organizer
      The 17th Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Asilomar, CA, U.S.A.
    • Year and Date
      2008-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Strategies for the regeneration of damaged CNS2008

    • Author(s)
      Hideyuki Okano
    • Organizer
      The 17^<th> Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Asilomar, CA, U.S.A.
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular Identification of Neural Stem Cell Self-renewing Factor2007

    • Author(s)
      Okano, H.
    • Organizer
      4th Annual Christopher Reeve "HOT TOPICS" IN STEM CELL BIOLOGY, Satellite Symposium at the 2007 Annual Meeting of the Society For Nuroscience
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2007-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural Stem Cells: their involvement in adult neurogenesis and CNS-repair2007

    • Author(s)
      Okano, H.
    • Organizer
      8th World Congress on Inflammation
    • Place of Presentation
      Copenhagen, Denmark.
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural Stem Cells: their involvement in adult neurogenesis and CNS-repair2007

    • Author(s)
      Okano, H.
    • Organizer
      Stem Cells and CNS Regeneration (Symposium by biosymposia, Inc. )
    • Place of Presentation
      Boston, USA.
    • Related Report
      2009 Final Research Report
  • [Presentation] Neural Stem Cells: their involvement in adult neurogenesis and CNS-repair.2007

    • Author(s)
      Okano. H.
    • Organizer
      8th World Congress on Inflammation
    • Place of Presentation
      Copenhagen, Denmark.
    • Related Report
      2007 Annual Research Report
  • [Presentation] A rol of neuronal RNA binding protein Hu and NF45/90 in the nervous system.2007

    • Author(s)
      Okano, HJ., Igarashi, M., Yano, M.& Okano, H.
    • Organizer
      2007 Annual Meeting of the Society For Nuroscience
    • Place of Presentation
      San Diego, USA.
    • Related Report
      2007 Annual Research Report
  • [Book] Functions of neural RNA-binding proteins Musashi and Hu in stem cells and neuronal differentiation. RNA Binding Proteins in Development and Disease. (Edited by Robert B. Denman)2008

    • Author(s)
      Kawahara, H., Yano, M., Imai, T., Akamatsu, W., Okano, HJ., Okano, H.
    • Publisher
      Research Signpost, Kerala
    • Related Report
      2009 Final Research Report
  • [Book] Functions of neural RNA-binding proteins Musashi and Hu in stem cells and neuronal differentiation.2008

    • Author(s)
      Kawahara, H., et al.
    • Publisher
      RNA Binding Proteins in Development and Disease. (Edited by Robert B. Denman), Research Signpost, Kerala, India.
    • Related Report
      2007 Annual Research Report
  • [Book] RNA Binding Proteins in Development and Disease

    • Author(s)
      Kawahara H. et al.
    • Publisher
      Research Signpost(In press)
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.okano-lab.com/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 神経幹細胞の増殖抑制剤2010

    • Inventor(s)
      岡野栄之, 他
    • Industrial Property Rights Holder
      学校法人慶應義塾、独立行政法人産業技術総合研究所
    • Acquisition Date
      2010-02-16
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 神経幹細胞の増殖抑制剤2010

    • Inventor(s)
      岡野栄之、坂口昌徳、澤本和延、平林淳
    • Industrial Property Rights Holder
      学校法人慶應義塾,(独)産業技術総合研究所
    • Acquisition Date
      2010-02-16
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経損傷治療剤及び神経損傷治療方法2008

    • Inventor(s)
      岡野栄之, 他
    • Industrial Property Rights Holder
      学校法人慶應義塾、国立大学法人京都大学
    • Industrial Property Number
      2008-005844
    • Filing Date
      2008-03-07
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 脊髄損傷治療藥剤2008

    • Inventor(s)
      岡野栄之, 他
    • Industrial Property Rights Holder
      学校法人慶應義塾、国立大学法人大阪大学、クリングルファーマ株式会社
    • Filing Date
      2008-02-08
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 神経損傷治療剤及び神経損傷治療方法2008

    • Inventor(s)
      岡野栄之、中村雅也、辻収彦、山中伸弥、三浦恭子
    • Industrial Property Rights Holder
      学校法人慶応義塾大学、国立大学法人京都大学
    • Filing Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 神経損傷治療剤及び神経損傷治療方法2008

    • Inventor(s)
      (慶應)岡野栄之、中村雅也、辻収彦(共願先), 山中伸弥、三浦恭子
    • Industrial Property Rights Holder
      学校法人慶應義塾、国立大学法人京都大学
    • Industrial Property Number
      2008-058447
    • Filing Date
      2008-03-07
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD FOR TREATING THENEURAL INJURY2008

    • Inventor(s)
      (慶應)岡野栄之、中村雅也、辻収彦(共願先), 山中伸弥、三浦恭子
    • Industrial Property Rights Holder
      学校法人慶應義塾、国立大学法人京都大学
    • Filing Date
      2008-02-15
    • Related Report
      2007 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] AGENT FOR TREATMENT OF NEURAL INJURY ADN METHOD OF THE SAME2008

    • Inventor(s)
      (慶應)岡野栄之、中村雅也、辻収彦(共願先), 山中伸弥、三浦恭子
    • Industrial Property Rights Holder
      学校法人慶應義塾、国立大学法人京都大学
    • Filing Date
      2008-03-07
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2005-04-01   Modified: 2018-03-28  

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