| Budget Amount *help |
¥53,500,000 (Direct Cost: ¥53,500,000)
Fiscal Year 2009: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2008: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2007: ¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2006: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2005: ¥14,700,000 (Direct Cost: ¥14,700,000)
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| Research Abstract |
Na_x channels are localized to the circumventricular organs (CVOs), the control loci for the salt and water homeostasis in mammals, where the Nax channel serves as a sodium-level sensor of body fluids. Now findings obtained in the research period are as follows.
(1) Na_x is exclusively localized to perineuronal lamellate processes extended from ependymal cells and astrocytes in CVOs.
(2) Astrocytes in the subfornical organ (SFO), one of the CVOs, sense an increase in the extracellular [Na^+] and moderate the activity of local neurons by using lactate as a signal.
(3) The information of [Na^+] increase detected by Nax does not contribute to the control of vasopressin production/release.
(4) We identified a case with clinical features of "essential hypernatremia", who was diagnosed as a paraneoplastic neurologic disorder. Anti-Na_x autoantibodies were found in the patient serum, and mice injected with the patient's Ig showed symptoms of "essential hypernatremia".
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