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Elucidation of molecular pathomechanisms of schizophrenia

Research Project

Project/Area Number 17025016
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHIKAWA Toru  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00198441)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Naoki  東京医科歯科大学, 医学部附属病院, 講師 (70312296)
KURUMAJI Akeo  東京医科歯科大学, 医学部附属病院, 准教授 (00251504)
TAKAO Keizo  京都大学, 医学系研究科, 講師 (80420397)
柏 淳  東京医科歯科大学, 医学部附属病院, 講師 (10301227)
石井 澄和  東京医科歯科大学, 医学部, 教務職員 (20106660)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥106,600,000 (Direct Cost: ¥106,600,000)
Fiscal Year 2009: ¥20,700,000 (Direct Cost: ¥20,700,000)
Fiscal Year 2008: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2007: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2006: ¥20,400,000 (Direct Cost: ¥20,400,000)
Fiscal Year 2005: ¥24,700,000 (Direct Cost: ¥24,700,000)
Keywords統合失調症 / ドーパミン神経伝達 / グルタミン酸神経伝達 / NMDA型グルタミン酸受容体 / 内在性D-セリン / methamphetamine / phencyclidine / 脳部位 / phencyclodine / 生後発達 / 大脳新皮質 / 視床 / D-serine / 遺伝子発現 / 遺伝子改変マウス
Research Abstract

To clarify the molecular basis of schizophrenia, we have explored and detected the developmentally regulated schizophrenomimetic-inducible genes from the rat brain regions as thenovel candidates for schizophrenia-associated molecules in terms of the phenomena that schizophrenia and its pharmacological models usually occur after the specific postnatal period.Moreover, we have newly cloned and clarified the two genes and the glial regulation, respectively,which are closely related to the endogenous D-serine signal controls to get further cues for theinvestigation on the possible dysfunction of the NMDA type glutamate receptor and its co-agonistD-serine in the schizophrenia brains.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (164 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (66 results) (of which Peer Reviewed: 31 results) Presentation (78 results) Book (17 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex.2010

    • Author(s)
      Hiraoka, S., Kajii, Y., Kuroda, Y., Umino, A., Nishikawa, T.
    • Journal Title

      European Neuropsychopharmacol. 20

      Pages: 176-186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex2010

    • Author(s)
      Hiraoka S, Kajii Y, Kuroda Y, Umino A, Nishikawa T
    • Journal Title

      European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20

      Pages: 176-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-セリンの脳機能の関与. 特集「D-アミノ酸の科学」2010

    • Author(s)
      西川徹
    • Journal Title

      BIOINDUSTRY 27

      Pages: 13-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizophrenomimetic, phencyclidine2009

    • Author(s)
      Takebayashi, H., Yamamoto, N., Umino, A., Nishikawa, T.
    • Journal Title

      rat. Int. J. Neuropsychopharmacol. 12

      Pages: 1111-1126

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population. American journal of medical genetics.2009

    • Author(s)
      Hattori E, Nishikawa T (44名中19番目), Yoshikawa T, et al.
    • Journal Title

      Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics 150

      Pages: 1110-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizophrenomimetic, phencyclidine, in the rat2009

    • Author(s)
      Takebayashi H, Yamamoto N, Umino A, Nishikawa T
    • Journal Title

      The international journal of neuropsychopharmacology/official scientific journal of the Collegium Internationale Neuropsychopharmacologicum(CINP) 12

      Pages: 1111-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 150

      Pages: 1110-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coping strategies and their correlates with depression in the Japanese general population2009

    • Author(s)
      Nagase Y, Uchiyama M, Kaneita Y, Li L, Kaji T, Takahashi S, Konno M, Mishima K, Nishikawa T, Ohida T
    • Journal Title

      Psychiatry research 168

      Pages: 57-66

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Antidepressant Effect of Ketamine Anesthesia During Electroconvulsive Therapy of Treatment-Resistant Depression : Comparing Ketamine and Propofol Anesthesia2009

    • Author(s)
      Okamoto N, Nakai T, Sakamoto K, Nagafusa Y, Higuchi T, Nishikawa T
    • Journal Title

      The journal of ECT

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症とグルタミン酸伝達系2009

    • Author(s)
      西川徹
    • Journal Title

      精神神経学雑誌 111

      Pages: 859-859

    • NAID

      10026307703

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Critical period. 特集1「統合失調症は神経発達障害か、神経変性疾患か?」2009

    • Author(s)
      西川徹
    • Journal Title

      脳21 12

      Pages: 185-185

    • Related Report
      2009 Annual Research Report
  • [Journal Article] An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia.2008

    • Author(s)
      Sato, J., Shimazu, D., Yamamoto, N., Nishikawa, T.
    • Journal Title

      J. Neural Transm. 115

      Pages: 1355-1365

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of FG7142 and immobilization stress on the gene expression in the neocortex of mice.2008

    • Author(s)
      Kurumaji A, Ito T, Ishii S, Nishikawa T
    • Journal Title

      Neuroscience research 62

      Pages: 155-9

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sliding doors (but not with beans or tofu)2008

    • Author(s)
      Yamamoto N, Tsutsui K, Yamamoto M, Arakaki H, Kurumaji A, Nishikawa T
    • Journal Title

      Lancet 372

      Pages: 1782-1782

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An association analysis of synapse-associated protein 97(SAP97) gene in schizophrenia.2008

    • Author(s)
      Sato J, Shimazu D, Yamamoto N, Nishikawa T
    • Journal Title

      Journal of neural transmission (Vienna, Austria : 1996) 115

      Pages: 1355-1365

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sliding doors (but not with beans or tofu).2008

    • Author(s)
      Yamamoto N, Tsutsui K, Yamamoto M, Arakaki H, Kurumaji A, Nishikawa T
    • Journal Title

      Lancet 372

      Pages: 1782-1782

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炭酸リチウム投与開始後19年経過して甲状腺機能低下症を発症した双極性障害の1例2008

    • Author(s)
      竹内崇, 大島一成, 柏淳, 山本直樹, 西川徹, 車地暁生
    • Journal Title

      精神科 13

      Pages: 66-69

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 脳の内在性D-セリンの代謝・機能と精神神経疾患における意義2008

    • Author(s)
      西川徹
    • Journal Title

      生化学 80

      Pages: 267-276

    • NAID

      10021191325

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神科薬物療法における将来展望-基礎的観点から-2008

    • Author(s)
      西川徹
    • Journal Title

      臨床精神薬理 11

      Pages: 547-558

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 新規抗精神病薬quetiapineの薬理作用メカニズムについて-D2以外の受容体に対する作用を中心に-2008

    • Author(s)
      竹内崇, 西川徹
    • Journal Title

      臨床精神薬理 11

      Pages: 921-928

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動物モデルを用いた統合失調症の病態進行・難治化に関与する分子の検索2008

    • Author(s)
      西川徹
    • Journal Title

      脳と精神の医学 19

      Pages: 21-29

    • NAID

      10026932751

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の分子薬理学的解析2008

    • Author(s)
      西川徹
    • Journal Title

      Schizophrenia Frontier 9

      Pages: 65-69

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Selective increase in the extracellular D-serine contents by D-cycloserine in the rat medial frontal cortex.2007

    • Author(s)
      Fujihira, T., Kanematsu, S., Umino, A., Yamamoto, N., Nishikawa, T.
    • Journal Title

      Neurochem. Int. 51

      Pages: 233-236

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of schizophrenomimetics on the expression of the CCN1 (CYR 61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat.2007

    • Author(s)
      Ito, T., Hiraoka, S., Kuroda, Y., Ishii, S., Umino, A., Kashiwa, A., Yamamoto, N., Kurumaji, A., Nishikawa, T.
    • Journal Title

      Int. J. Neuropsychopharmacol. 10

      Pages: 717-725

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine.2007

    • Author(s)
      Kaneko, Y., Kashiwa, A., Ito, T., Ishii, S., Umino, A., Nishikawa, T.
    • Journal Title

      Neuropsychopharmacol. 32

      Pages: 658-664

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization in duced by methamphetamine.2007

    • Author(s)
      Kaneko Y, et al.
    • Journal Title

      Neuropsychopharmacol 32

      Pages: 658-664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] perospirone in the treatment of patients with delirium.2007

    • Author(s)
      Takeuchi T. et al
    • Journal Title

      Psychiatry Clin Neurosci. 61

      Pages: 67-70

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of schizophrenomimetics on the expression of CCN1 (CYR61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat.2007

    • Author(s)
      Ito T, Hiraoka. et al
    • Journal Title

      Int J Neuropsychopharmacol. 10

      Pages: 717-715

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective increase in t e extracellular D-serine contents by D-cycloserine in the rat medial frontal cortex.2007

    • Author(s)
      Fujihira T. et al
    • Journal Title

      Neurochem. Int. 51

      Pages: 233-236

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered EphA5 mRNA expression in rat brain with a single methamphetamine treatment.2007

    • Author(s)
      Numachi Y. et al
    • Journal Title

      Neurosci. Lett. 424

      Pages: 116-121

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imipramineによって音楽性幻聴が生じた反復性うつ病の1症例.2007

    • Author(s)
      熱田英範, 他
    • Journal Title

      精神科 10

      Pages: 518-523

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] せん妄に対する非特定型抗精神病薬の有用性2007

    • Author(s)
      竹内崇, 他
    • Journal Title

      精神医学 49

      Pages: 821-828

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の治療薬開発研究 : 特集「新しい時代の統合失調症-研究から治療へ-」2007

    • Author(s)
      正木秀和, 他
    • Journal Title

      臨床精神医学 36

      Pages: 43-51

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 統合失調症の薬理学再発防止への展望-セロトニン作動性薬物による逆耐性消失から-2007

    • Author(s)
      柏淳, 他
    • Journal Title

      脳と精神の医学 18

      Pages: 197-203

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine2007

    • Author(s)
      Kaneko Y et al.
    • Journal Title

      Neuropsychopharmacol 32

      Pages: 658-664

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Perospirone in the treatment of patients with delirium2007

    • Author(s)
      Takeuchi T et al.
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 67-70

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain.2006

    • Author(s)
      Kanematsu, S., Ishii, S., Umino, A., Fujihira, T., Kashiwa, A., Yamamoto, N., Kurumaji, A., Nishikawa T
    • Journal Title

      J. Neural Transm. 113

      Pages: 1717-1721

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of D-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as D-serine modulator-1.2006

    • Author(s)
      Shimazu, D., Yamamoto, N., Umino, A., Ishii, S., Sakurai, S., Nishikawa, T.
    • Journal Title

      J. Neurochem. 96

      Pages: 30-42

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative magnetic resonance spectroscopy of schizophrenia : relationship between decreased N-acetylaspartate and frontal lobe dysfunction2006

    • Author(s)
      Tanaka Y et al.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 365-372

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of repetitive transcranial magnetic stimulation on [^<11>C] raclopride binding and cognitive function in patients with depression2006

    • Author(s)
      Kuroda Y et al.
    • Journal Title

      J. Affect. Disorder 95

      Pages: 35-42

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain2006

    • Author(s)
      Kanematsu S et al.
    • Journal Title

      J Neural Transm 113

      Pages: 1717-1721

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurobiological and molecular bases of methamphetamine-induced behavioral sensitization and spontaneous recurrence of methamphetamine psychosis, and its implication in schizophrenia2006

    • Author(s)
      Yui K et al.
    • Journal Title

      Current Psychiatry Reviews 2

      Pages: 381-393

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 修正型電気けいれん療法(m-ECT)が著効した両心室ペースメーカーを植込まれたうつ病の1症例;特集 電気けいれん療法(ECT)の治療経験-症例を中心に-2006

    • Author(s)
      光定博生 他
    • Journal Title

      臨床精神医学 35

      Pages: 1207-1212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 経過中にせん妄を呈した血管性うつ病の1症例2006

    • Author(s)
      横溝美緒 他
    • Journal Title

      精神科 8

      Pages: 165-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の分子機構研究の最前線;疾患解明Overview2006

    • Author(s)
      西川徹
    • Journal Title

      実験医学 24

      Pages: 2663-2671

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脳の発達障害としての統合失調症2006

    • Author(s)
      西川徹
    • Journal Title

      日本薬理学雑誌 128

      Pages: 13-18

    • NAID

      10018333470

    • Related Report
      2006 Annual Research Report
  • [Journal Article] アシル化アミノ酸の行動薬理学的評価-脂質による高次脳機能異常改善作用の機序を中心に-2006

    • Author(s)
      日比野英彦 他
    • Journal Title

      オレオサイエンス 6

      Pages: 93-105

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 違法ドラッグと依存性薬物による精神障害の分子病態2006

    • Author(s)
      山本直樹 他
    • Journal Title

      医学のあゆみ 217

      Pages: 1147-1151

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の薬理学的発展;特集「統合失調症解明へのアプローチ」2006

    • Author(s)
      熱田英範 他
    • Journal Title

      精神科 8

      Pages: 257-263

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新規抗精神病薬-急性期に対する使い方;特集「統合失調症-診断と治療の今日」 治療薬解説2006

    • Author(s)
      熱田英範 他
    • Journal Title

      Current Therapy 24

      Pages: 640-644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of d-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as d-serine modulator-12006

    • Author(s)
      Shimazu D et al.
    • Journal Title

      J Neurochem 96

      Pages: 30-42

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 違法ドラッグと依存性薬物による精神障害の分子病態2006

    • Author(s)
      山本直樹 他
    • Journal Title

      医学のあゆみ 217(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] セロトニン作動性薬物によるメタンフェタミン逆耐性の減弱-統合失調症の再発予防にむけて-2006

    • Author(s)
      柏 淳 他
    • Journal Title

      精神薬療研究年報 37(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.2005

    • Author(s)
      Fujii R, Okabe S, Urushido T, Inoue K, Yoshimura A, Tachibana T, Nishikawa T, Hicks GG, Takumi T
    • Journal Title

      Current Biology 15

      Pages: 587-593

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning of a D-serine-regulated transcript dsr-2 from rat cerebral neocortex.2005

    • Author(s)
      Taniguchi, G., Yamamoto, N., Tsuchida, H., Umino, A., Shimazu, D., Sakurai, S., Takebayashi, H., Nishikawa, T.
    • Journal Title

      J. Neurochem. 95

      Pages: 1541-1549

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolism and functional roles of endogenous D-serine in mammalian brains.2005

    • Author(s)
      Nishikawa T
    • Journal Title

      Biological & pharmaceutical bulletin 28

      Pages: 1561-1565

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolism and Functional Roles of Endogenous D-Serine in Mammalian Brains2005

    • Author(s)
      Nishikawa T
    • Journal Title

      Biol Pharm Bul 28

      Pages: 1561-1565

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology2005

    • Author(s)
      Fujii R et al.
    • Journal Title

      Curr Biol 15

      Pages: 587-593

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia2005

    • Author(s)
      Aoki-Suzuki M et al.
    • Journal Title

      Biol Psychiatry 57

      Pages: 382-393

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cloning of a d-serine-regulated transcript dsr-2from rat cerebral neocortex2005

    • Author(s)
      Taniguchi C et al.
    • Journal Title

      J Neurochem 95

      Pages: 1541-1549

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヒトの脳に存在する遊離型D-セリンの機能と病態-精神神経疾患の治療への応用-2005

    • Author(s)
      西川 徹
    • Journal Title

      ファルマシア 41

      Pages: 863-868

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 統合失調症の分子薬理学的解析-ドーパミン受容体およびNMDA受容体作用薬を用いたアプローチ-.特集1 統合失調症:分子から治療まで2005

    • Author(s)
      西川 徹
    • Journal Title

      脳21 8

      Pages: 9-15

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 統合失調症 標準治療と最新治療-メリットとデメリット法-2005

    • Author(s)
      古田 光 他
    • Journal Title

      Clin Neurosci 23

      Pages: 106-107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] モノアミン障害・アンフェタミンモデル 統合失調症の仮説とそのモデル検証2005

    • Author(s)
      嶋津 奈 他
    • Journal Title

      分子精神医学 5

      Pages: 25-63

    • Related Report
      2005 Annual Research Report
  • [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging.

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Journal Title

      American journal of geriatric psychiatry (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Journal Title

      American journal of geriatric psychiatry (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] メトアンフェタミンを用いた統合失調症の分子病態への発達薬理学的アプローチ2010

    • Author(s)
      海野真一、山本直樹、荒木誠、海野麻未、上里章仁、車地暁生、西川徹
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 向精神薬はなぜ効くのか2010

    • Author(s)
      西川徹
    • Organizer
      第24回皮膚科心身医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMDA受容体-D-セリン系に作用する既認可薬の難治性精神神経症状治療への応用2009

    • Author(s)
      西川徹
    • Organizer
      第二回創薬シンポジウム-温故知新創薬研究への挑戦-
    • Place of Presentation
      熊本
    • Year and Date
      2009-12-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 手術前の精神科介入は術後せん妄の発症予防になりうるか2009

    • Author(s)
      竹内崇, 上里彰仁, 藤田宗久, 筒井啓太, 片岡宗子, 白井聖子, 周山祐大, 熱田英範, 西多昌規, 行実知昭, 成島健二, 大島一成, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第22回日本総合病院精神医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症の病因論2009

    • Author(s)
      西川徹
    • Organizer
      第18回地域精神保健学講座
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Presentation] Adult-onset citrullinemia with repeated stereotyped behavior : a pitfall for antiepileptic drug usage2009

    • Author(s)
      Yamamoto N, Tsutsui K, Yamamoto M, Arakaki H, Kurumaji A, Nishikawa T
    • Organizer
      First Meeting of the Asian College of Neuropsychopharmacology(AsCNP), 第19回日本臨床精神神経薬理学会, 第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMDA受容体-D-セリン系を標的とした新規統合失調症治療薬の開発2009

    • Author(s)
      西川徹
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気分障害入院患者の退院時における向精神薬に関する研究2009

    • Author(s)
      車地暁生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 吉池卓也, 柏淳, 西川徹
    • Organizer
      第19回日本臨床精神神経薬理学会、第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気分障害入院患者の精神診断学的研究. 第29回日本精神科診断学会2009

    • Author(s)
      車地暁生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 吉池卓也, 西多昌規, 藤田宗久, 上里彰仁, 西川徹
    • Organizer
      第29回日本精神診断学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] An association study on synapse-associated protein 97(SAP97) gene in schizophrenia.2009

    • Author(s)
      Yamamoto N, Sato J, Shimazu D, Nishikawa T.
    • Organizer
      XVIth World Congress on Psychiatric Genetics.
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Japanese version of bonn scale for the assessment of basic symptoms, its reliability and its validity2009

    • Author(s)
      Oshima K, Okimura T, Yukizane T, Yasumi K, Iwawaki A, Nishikawa T, Hanamura S.
    • Organizer
      The 14^<th> World Congress of Psychiatry
    • Place of Presentation
      Prague
    • Year and Date
      2009-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMDA receptor-D-serine system targeted treatment development for schizophrenia, "Drug development for schizophrenia"2009

    • Author(s)
      Nishikawa T.
    • Organizer
      51st Annual Meeting of JSNC
    • Place of Presentation
      Toyama
    • Year and Date
      2009-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経発達から見た統合失調症思春期発症の分子機構2009

    • Author(s)
      西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自殺関連行動によりERセンター救急科に入院した患者の抗うつ薬の服薬状況2009

    • Author(s)
      竹内崇, 石川洋世, 吉池卓也, 藤田宗久, 上里彰仁, 行実知昭, 熱田英範, 西多昌規, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 難治性のうつ状態を呈する患者に対する外来小集団精神療法の試み. 第105回日本精神神経学会学術総会2009

    • Author(s)
      大島一成, 岡泰央, 吉池卓也, 石川洋世, 奥住祥子, 治徳大介, 光定博生, 稲垣美里, 森岡あすか, 正木秀和, 車地暁生, 西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい抗精神病薬開発戦略とその現状2009

    • Author(s)
      西川徹
    • Organizer
      第12回東北臨床精神薬理研究会
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression and characterization of D-serine-regulated genes in the rat cerebral cortex2009

    • Author(s)
      Yamamoto N, Taniguchi G, Umino M, Umino A, Nishikawa T
    • Organizer
      The 1^<st> International Conference of D-Amino Acid Research
    • Place of Presentation
      Awaji
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of extracrllular D-Serine contents in the rat brain2009

    • Author(s)
      Nishikawa T, Yamamoto N, Umino A, Kanematsu S, Fujihira T, Iwama H, Shimadu D, Hashimoto A, Kurumaji A
    • Organizer
      The 1^<st> International Conference of D-Amino Acid Research
    • Place of Presentation
      Awaji
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス海馬における新環境ストレスに反応する分子機構の生後発達2009

    • Author(s)
      車地暁生, 西川徹
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳のはたらきとこころの病2009

    • Author(s)
      西川徹
    • Organizer
      第12回市民フォーラム~医学講座とピアノ演奏会~, 東京医科歯科大学ピアノの会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] グルタミン酸伝達系からみた統合失調症の病態と治療薬開発2009

    • Author(s)
      西川徹
    • Organizer
      ジプレキサ米子学術講演会
    • Place of Presentation
      米子
    • Year and Date
      2009-04-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical period,シンポジウム「統合失調症は神経発達障害か、神経変性疾患か?」2009

    • Author(s)
      西川徹
    • Organizer
      第4回統合失調症学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] The postnatal development of stress-responsive molecular system in the hippocampus of mice.2009

    • Author(s)
      Kurumaji A, Ito T, Ishii S, Nishikawa T.
    • Organizer
      World Federation of Society of Biological Psychiatry 2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      Toyama
    • Related Report
      2008 Annual Research Report
  • [Presentation] White matter abnormalities as a risk factor of postoperative delirium revealed by DTI.2009

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Organizer
      World Federation of Society of Biological Psychiatry 2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      Toyama
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自殺関連行動でERセンター救急科に入院した患者の抗うつ薬の服薬状況2008

    • Author(s)
      竹内宗, 石川洋世, 吉池卓也, 藤田宗久, 児玉知之, 細田益之, 行実知昭, 熱田英範, 西多昌規, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹, 大友康裕, 登坂直規
    • Organizer
      第21回日本総合病院精神医学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 短パルス矩形波治療器によるECTの認知機能への影響~けいれん閾値と認知機能2008

    • Author(s)
      石川洋世, 藤田宗久, 吉池卓也, 熱田英範, 西多昌規, 行実知昭, 竹内崇, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第21回日本総合病院精神医学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 薬物依存の発達による変化から見た快・不快情動生成機構の障害2008

    • Author(s)
      西川徹
    • Organizer
      平成20年度生理学研究所研究会「感覚刺激・薬物による快・不快情動生成機構とその破綻」
    • Place of Presentation
      岡崎
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症の分子メカニズムへのアプローチ-新しい治療法の開発を目指して-2008

    • Author(s)
      西川徹
    • Organizer
      日本青年心理学会第16回大会 大会記念講演
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] セロトニン神経と精神行動2008

    • Author(s)
      西川徹
    • Organizer
      第14回「性と生殖」公開シンポジウム「セロトニンと人間」
    • Place of Presentation
      東京
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dysfunction of NMDA receptor- D-serine system and schizophrenia, Symposium "Disturbed glutamate neurotransmission in schizophrenia as a target for development of novel antipsychotics"2008

    • Author(s)
      Nishikawa T.
    • Organizer
      13th Pacific Rim College of Psychiatrists Scientific Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Dysfunction of NMDA receptor-D-serine system and schizophrenia, Symposium "Disturbed glutamate neurotransmission in schizophrenia as a target for development of novel antipsychotics"2008

    • Author(s)
      Nishikawa T.
    • Organizer
      13^<th> Pacific Rim College of Psychiatrists Scientific Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] てんかん発作群発後に躁状態の増悪がみられた双極性障害の1例2008

    • Author(s)
      熱田英範, 田村紀郎, 谷顕, 行実知昭, 車地暁生, 西川徹
    • Organizer
      東京精神医学会第84回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院ERセンター救急科に入院した過量服薬患者の実態-希死念慮の発現時期や受診状況についての検討-2008

    • Author(s)
      竹内崇, 石川洋世, 吉池卓也, 藤田宗久, 児玉知之, 細田益宏, 行実知昭, 熱田英範, 西多昌規, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹, 大友康裕, 登坂直規
    • Organizer
      第16回日本精神科救急学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類で機能しているD-アミノ酸-D-セリンと脳疾患-2008

    • Author(s)
      西川徹
    • Organizer
      第15回血液の分子病態研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症における情報処理障害の分子科学的理解は可能か2008

    • Author(s)
      西川徹
    • Organizer
      第15回 九州大学 こころと脳のセミナー
    • Place of Presentation
      福岡
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 内側前頭葉皮質におけるAsc-1阻害薬の細胞外D-セリン濃度増加作用2008

    • Author(s)
      西川徹, 小方茂弘, 海野麻未, 白久博史, 山本直樹
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] D-セリン含有細胞に関する研究.ミニシンポジウム「脳内D-セリン」2008

    • Author(s)
      西川徹, 海野麻未, 小柄渚, 嶋津奈, 小方茂弘, 白久博史, 窪田哲朗, 仙波禮治, 山本直樹
    • Organizer
      第4回D-アミノ酸研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット脳内在性D-serine代謝関連遺伝子の発現,局在と発達依存性変化2008

    • Author(s)
      山本直樹, 嶋津奈, 兼松宗太郎, 谷口豪, 海野麻未, 西川徹
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMDA receptor dysfunction in schizophrenia : the possible involvement of D-serine system, "NMDA Receptor and Molecular Pathology of Schizophrenia"2008

    • Author(s)
      Nishikawa T.
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット内側前頭葉皮質における組織中・細胞外液中D-セリン濃度に与える影響2008

    • Author(s)
      西川徹, 海野麻未, 岩間久行, 嶋津奈, 小方茂弘, 山本直樹
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院ERセンター救急科に入院した過量服薬患者の実態-希死念慮の発現時期や受診状況についての検討-2008

    • Author(s)
      竹内崇, 佐々木健至, 石川洋世, 吉池卓也, 行実知昭, 正木秀和, 熱田英範, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] PTSDに対するPE療法(長時間曝露法)の有効性2008

    • Author(s)
      飛鳥井望, 鶴田信子, 齋藤梓, 西川徹, 山上皓
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症とグルタミン酸伝達系(教育講演)2008

    • Author(s)
      西川徹
    • Organizer
      第104回日本精神神経学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 併用薬quetiapineの投与中止を契機として発症したセロトニン症候群の一例2008

    • Author(s)
      熱田英範、車地暁生、大島一成、西川徹
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 単極性うつ病における電気けいれん療法後の薬物療法2008

    • Author(s)
      石川洋世, 熱田英範, 竹内崇, 吉池卓也, 佐々木健至, 行実知昭, 正木秀和, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] せん妄に対するaripiprazoleの使用経験2008

    • Author(s)
      吉池卓也, 竹内崇, 佐々木健至, 石川洋世, 熱田英範, 正木秀和, 行実知昭, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第104回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症の新しい治療法開発の可能性と展望2008

    • Author(s)
      西川徹
    • Organizer
      第55回今堀フォーラム『統合失調症治療薬の創薬を考える』
    • Place of Presentation
      東京
    • Year and Date
      2008-05-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規抗精神病薬の薬理作用メカニズムについて-D2以外の受容体に対する作用を中心に-2008

    • Author(s)
      西川徹
    • Organizer
      第3回日本統合失調症学会ランチョンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-03-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗精神病薬のD2受容体以外の作用と統合失調症状との関連2008

    • Author(s)
      西川徹
    • Organizer
      第10回新潟統合失調症研究会
    • Place of Presentation
      新潟
    • Year and Date
      2008-02-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の分子病態2008

    • Author(s)
      西川徹
    • Organizer
      福井大学医学部特別講義
    • Place of Presentation
      福井
    • Year and Date
      2008-01-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳のD-セリンと統合失調症2008

    • Author(s)
      西川徹
    • Organizer
      福井大学医学部セミナー
    • Place of Presentation
      福井
    • Year and Date
      2008-01-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症はなぜ思春期以降に発症するのか2007

    • Author(s)
      西川徹
    • Organizer
      文部科学省特定領域研究「統合脳」5領域冬の公開シンポジウム,合同領域班会議
    • Place of Presentation
      東京
    • Year and Date
      2007-12-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] molecular and cellular mechanisms of extracellular release of cerebral D-serine in the rat.2007

    • Author(s)
      西川徹
    • Organizer
      第30回日本分子生物学会年会,第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 単極性うつ病性障害患者の入院治療における気分安定薬の併用について : 第2報2007

    • Author(s)
      車地暁生, 他
    • Organizer
      第6回Biopolar Disorder研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の病因論2007

    • Author(s)
      西川徹
    • Organizer
      第17回地域精神保健講座
    • Place of Presentation
      東京
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院に入院となった自殺関連行動のみられた患者の実態2007

    • Author(s)
      竹内崇, 他
    • Organizer
      第20回日本総合病院精神医学会総会-がん診療と精神科医療の連携-
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 短パルス短形波治療器によるECTの認知機能への影響2007

    • Author(s)
      石川洋世, 他
    • Organizer
      第20回日本総合病院精神医学会総会-がん診療と精神科医療の連携-
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大うつ病性障害患者の入院治療における気分安定薬の併用に関する研究2007

    • Author(s)
      車地暁生, 他
    • Organizer
      第17回に本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院ERセンター救急科に入院となった自殺関連行動のみられた患者の実態2007

    • Author(s)
      竹内崇, 他
    • Organizer
      第15回日本精神科救急学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2007-09-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の分子病態と薬物療法2007

    • Author(s)
      西川徹
    • Organizer
      創薬薬理フォーラム第15回シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症治療薬の前頭葉細胞外液中D-セリン濃度に対する影響2007

    • Author(s)
      西川徹, 他
    • Organizer
      第3回D-アミノ酸研究会学術講演会
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット脳methamphetamine応用性mrt3およびas-mrt3遺伝子の構造と発送2007

    • Author(s)
      山本直樹, 他
    • Organizer
      Neuro2007第3回日本神経科学大会,第50回日本神経化学会大会,第17回日本神経回路学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット大脳新皮質由来培養アストロサイト及び神経細胞におけるD-セリン局在の解明2007

    • Author(s)
      小柄渚, 他
    • Organizer
      Neuro2007第30回日本神経科学大会,第50回日本神経化学会大会,第17回日本神経回路学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 海馬におけるストレス反応の分子構造に関する研究2007

    • Author(s)
      車地暁生, 他
    • Organizer
      Neuro2007第30回日本神経科学大会,第50回日本神経化学会大会,第17回日本神経回路学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳内D-セリンの代謝・機能と精神神経疾患2007

    • Author(s)
      西川徹
    • Organizer
      疾患酵素学研究の最前線と新展開
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の病態と治療-脳科学の進歩により統合失調症はどこまで解明されたか?-2007

    • Author(s)
      西川徹
    • Organizer
      針生ヶ丘病院夏期特別講義
    • Place of Presentation
      郡山
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 薬理学的モデルを用いた統合失調症の分子病態の解析.特定領域研究『統合脳』夏のワークショップ2007

    • Author(s)
      西川徹
    • Organizer
      病態脳シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 精神科薬物療法における将来展望-基礎的観点から.抗精神病薬50年を振り返る2007

    • Author(s)
      西川徹
    • Organizer
      諏訪・佐野メモリアルシンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗精神病薬のD2受容体以外の作用メカニズム.ランチョンセミナー62007

    • Author(s)
      西川徹
    • Organizer
      第29回日本生物学的精神医学会.第37回日本神経薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 動物モデルを用いた統合失調症の病態進行と難知化に関する分子の検索.シンポジウム1 統合失調症の病態進行・難知化と動物モデル2007

    • Author(s)
      西川徹
    • Organizer
      第29回日本生物学的精神医学会,第37回日本神経薬理学会合同年会,
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] MMSEとFrontal Assessment Batteryにより、認知機能障害改善を簡便に評価し得た間歇型一酸化炭素中毒の1症例2007

    • Author(s)
      玉井眞一郎, 他
    • Organizer
      東京精神医学会第30回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院救急科に入院となった自殺関連行動のみられた患者の実態2007

    • Author(s)
      竹内崇, 他
    • Organizer
      第103回日本精神神経学会総会
    • Place of Presentation
      高知
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] うつ状態を対象とした力動的小集団精神療法における喪失体験にみられる集団力動の検討2007

    • Author(s)
      森岡あすか, 他
    • Organizer
      日本集団精神療法学会第24回大会
    • Place of Presentation
      広島
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 外来治療中にリチウム中毒を反復した高齢者の双極性障害の1症例2007

    • Author(s)
      沖村宰, 他
    • Organizer
      第27回リチウム研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 炭酸リチウム投与開始後19年経過して甲状腺機能低下症を発症した双極性障害の1例2007

    • Author(s)
      竹内崇, 他
    • Organizer
      第27回リチウム研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の分子機序への発達神経薬理学的アプローチ : こころの障害を分子から解く-新たなアプローチで理解するこころの問題-2007

    • Author(s)
      西川徹
    • Organizer
      第27回日本医学総会(いのち ひと 夢)
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] NMDA receptor, D-serine and Schizophrenia.2005

    • Author(s)
      Nishikawa, T.
    • Organizer
      8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna
    • Year and Date
      2005-07-01
    • Related Report
      2009 Final Research Report
  • [Presentation] A molecular pharmacological approach to the vulnerability to schizophrenia.2005

    • Author(s)
      Nishikawa, T.
    • Organizer
      Society of Biological Psychiatry 60th Annual Scientific Convention
    • Place of Presentation
      Atlanta
    • Year and Date
      2005-05-26
    • Related Report
      2009 Final Research Report
  • [Book] 分子神経科学の視点から. 統合失調症生物学的背景(松下正明, 加藤敏, 神庭重信 編集, 精神医学対話)2008

    • Author(s)
      西川徹
    • Publisher
      弘文堂
    • Related Report
      2009 Final Research Report
  • [Book] 精神医学対話(分子神経科学の視点から.統合失調症 生物学的背景)2008

    • Author(s)
      西川徹
    • Publisher
      弘文堂
    • Related Report
      2008 Annual Research Report
  • [Book] 病期・病態・重症度からみた疾患別看護過程+病態関連図(69 抑うつ(うつ病))2008

    • Author(s)
      竹内崇, 西川徹
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Book] A systematic approach to the brain d-serine system. Fujii N, Homma H, Bruecker H, Fisher GH, Konno R (eds.) A New Frontier in Amino Adid and Protein Research.2008

    • Author(s)
      Nishikawa T. et al
    • Publisher
      Nova Science Publishers
    • Related Report
      2007 Annual Research Report
  • [Book] 2ストレスに対する生体の応答,2.7発達,ストレスの科学と健康2008

    • Author(s)
      西川徹
    • Publisher
      共立出版株式会社
    • Related Report
      2007 Annual Research Report
  • [Book] A systematic approach to the brain d-serine system.(Fujii N, Homma H, Bruecker H, Fisher GH, Konno R (eds. ), A New Frontier in Amino Acid and Protein Research.)2007

    • Author(s)
      Nishikawa T.
    • Publisher
      Nova Science Publishers
    • Related Report
      2009 Final Research Report
  • [Book] 脳神経疾病研究の成果と課題.実験医学増刊『脳神経疾患の分子病態と治療への展開』2007

    • Author(s)
      貫名信行, 他
    • Publisher
      羊土社
    • Related Report
      2007 Annual Research Report
  • [Book] ドーパミン・興奮性アミノ酸仮説-3.原因と病態モデル-.統合失調症の概念-統合失調症の治療-臨床と基礎-2007

    • Author(s)
      山本直樹, 他
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Book] A New Frontier in Amino Acid and Protein Research. A systematic approach to the brain d-serine system.(Fujii N, Homma H, Bruecker H, Fisher GH, Konno R (eds.))2007

    • Author(s)
      Nishikawa T
    • Publisher
      Nova Science Publishers(in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Neuroanatomical and Molecular Changes in Stress Responses During Early Life: Implications for Stress Disorders,(Kato N, Kawata M Pitman RK (Eds. ), PTSD: Brain Mechanisms and Clinical Implications)2006

    • Author(s)
      Nishikawa T, Kurumaji A, Ito T, Umino A, Ishii S
    • Publisher
      Springer-Verlag
    • Related Report
      2009 Final Research Report
  • [Book] 1.統合失調症. 第7章神経・精神疾患の分子機構. 脳神経科学イラストレイテッド(改訂第2版)(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛編)2006

    • Author(s)
      西川 徹 他
    • Publisher
      羊土社
    • Related Report
      2006 Annual Research Report
  • [Book] 精神科薬物療法研究会編.統合失調症の薬物治療アルゴリズム2006

    • Author(s)
      濱村貴史 他
    • Publisher
      医学書院
    • Related Report
      2006 Annual Research Report
  • [Book] 3.グルタミン酸-D-セリンシステムと統合失調症.V.「グルタミン酸」と「てんかん、統合失調症」.脳とこころの科学(鶴紀子編)2006

    • Author(s)
      谷口 豪 他
    • Publisher
      新興医学出版
    • Related Report
      2006 Annual Research Report
  • [Book] 身体表現性障害を経過中にBipolarII Disorderを呈し、炭酸リチウム投与によって寛解に至った1症例.Bipolar Disorder 4(Bipolar Disorder研究会編)2006

    • Author(s)
      車地暁生
    • Publisher
      アルタ出版
    • Related Report
      2006 Annual Research Report
  • [Book] PTSD brain mechanisms and clinical implications (Kato N, Kawata M and Pitman RK eds.)2006

    • Author(s)
      Nishikawa T
    • Total Pages
      9
    • Publisher
      Springer-Verlag
    • Related Report
      2005 Annual Research Report
  • [Book] 心の科学セレクション 統合失調症(風祭元,山下格 編)2006

    • Author(s)
      西川 徹
    • Total Pages
      18
    • Publisher
      日本評論社
    • Related Report
      2005 Annual Research Report
  • [Book] 23.不安「緊急度・重症度からみた 症状別看護過程+病態関連図」

    • Author(s)
      西多昌規、西川徹
    • Publisher
      医学書院(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Remarks] 受賞日本油化学会第6回オレオサイエンス賞受賞受賞者西川徹 平成19年9月

    • Related Report
      2009 Final Research Report
  • [Remarks] プレス発表 読売新聞平成20年12月7日版 『Dアミノ酸ー陰の存在実は「主役」?ー』 西川 徹

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 高速液体クロマトグラフィーによるアミノ酸の分析方法2008

    • Inventor(s)
      酒井芳博・太田鈴枝・西川徹 権利者:東京医科歯科大学
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2008-05-30
    • Acquisition Date
      2008-05-30
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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