| Budget Amount *help |
¥58,300,000 (Direct Cost: ¥58,300,000)
Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2007: ¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2006: ¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2005: ¥13,100,000 (Direct Cost: ¥13,100,000)
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| Research Abstract |
An herbal medicine Juzentaihoto activated bone marrow-derived macrophage/microglia and enhanced clearance of senile plaque amyloid. We established a new monoclonal antibody 3.4A10, which recognized a conformational structure of Aβ42, reduced senile plaque amyloid as well as Aβ oligomers, and improved cognitive functions without enhancing cerebral micro-hemorrhages. This is expected to be used as a disease modifying antibody.
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