Analysis of immune mechanisms of Alzheimer's disease and development of a novel treatment

• Project/Area Number: 17025056
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Juntendo University (2008-2009); National Institute for Longevity Sciences,NCGG (2005-2007)
• Principal Investigator: TABIRA Takeshi Juntendo University, 大学院・医学研究科, 教授 (80112332)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Keikichi 国立長寿医療センター研究所, 血管性認知症研究部, 部長 (40117148) ; HARA Hideo 国立長寿医療センター研究所, 血管性認知症研究部, 室長 (00260381) ; SEKIYAMA Atsuo 国立長寿医療センター研究所, 血管性認知症研究部, 室長 (30403702) ; MATSUMOTO Shinei 順天堂大学, 大学院・医学研究科, 助教 (40432950)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥58,300,000 (Direct Cost: ¥58,300,000); Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2007: ¥13,600,000 (Direct Cost: ¥13,600,000); Fiscal Year 2006: ¥13,600,000 (Direct Cost: ¥13,600,000); Fiscal Year 2005: ¥13,100,000 (Direct Cost: ¥13,100,000)
• Keywords: アルツハイマー病 / アミロイド / ワクチン / 漢方薬 / ミクログリア / モノクローナル抗体 / 十全大補湯 / 免疫 / amyloid / 老人斑 / 老人班

Research Abstract

An herbal medicine Juzentaihoto activated bone marrow-derived macrophage/microglia and enhanced clearance of senile plaque amyloid. We established a new monoclonal antibody 3.4A10, which recognized a conformational structure of Aβ42, reduced senile plaque amyloid as well as Aβ oligomers, and improved cognitive functions without enhancing cerebral micro-hemorrhages. This is expected to be used as a disease modifying antibody.

Research Products

• [Journal Article] Immunization therapy for Alzheimer disease: A comprehensive review of active immunization strategies (2010)
  • Author(s): Tabira T.
  • Journal Title: Tohoku J Exp 220 Pages: 95-106
  • NAID: 10027083132
• [Journal Article] The therapeutic effects of herbal medicine, Juzen-taiho-to on the reduction of A・burden in a mouse model of Alzheimer's disease (2010)
  • Author(s): Hara H, Kataoka S, Anan M, Ueda A, Mutoh T, Tabira T.
  • Journal Title: J Alzheim (in press)
• [Journal Article] Immunization therapy for Alzheimer disease : A comprehensive review of active immunization Strategies. (2010)
  • Author(s): Tabira T
  • Journal Title: Tohokn J Exp Med 220 Pages: 95-106
  • NAID: 10027083132
  • Peer Reviewed
• [Journal Article] The therapeutic effects of herbal medicine, Juzen-taiho-to on the reduction of Aβ burden in a mouse model of Alzheimer's disease. (2010)
  • Author(s): Hara H, Kataoka S, Anan M, Ueda A, Mutoh T, Tabira T
  • Journal Title: (In press)
  • Peer Reviewed
• [Journal Article] Anxiolytic effect of a herbal medicine, yokukansan, in aged rats : Involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex. (2010)
  • Author(s): Mizoguchi K, Tanaka Y, Tabira T.
  • Journal Title: J Ethnopharmacol 127 Pages: 70-76
  • Peer Reviewed
• [Journal Article] Decorated plaques in Alzheimer's disease (2009)
  • Author(s): Tabira T.
  • Journal Title: Ann Neurology 65(1) Pages: 4-6
• [Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats. (2009)
  • Author(s): Mizoguchi K, Shoji H, Tanaka Y, Maruyama W, Tabira T
  • Journal Title: Neuroscience 162(4) Pages: 1192-201
  • Peer Reviewed
• [Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain. (2009)
  • Author(s): Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Maruyama W, Tabira T.
  • Journal Title: Neuroscience 159(1) Pages: 259-70
  • Peer Reviewed
• [Journal Article] Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : nationwide survey results over 30 years. (2009)
  • Author(s): Osoegawa M, Kira J, Fukazawa T, et al.(Tabira T)
  • Journal Title: Multiple Sclerosis 15 Pages: 159-173
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey. (2009)
  • Author(s): Ishizu T, Kira J, Osoegawa M, et al.(Tabira T)
  • Journal Title: J Neurol Sci 280 Pages: 22-28
  • Peer Reviewed
• [Journal Article] Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors (2009)
  • Author(s): Ma L, Ohyagi Y, Miyoshi K, S akae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.
  • Journal Title: J Alzheim Dis 16 Pages: 565-75
  • Peer Reviewed
• [Journal Article] Developmentand characterization of a TAPIR-like mouse monoclonal antibody to Aβ (2008)
  • Author(s): Wang, J., Hara, H., Makifuchi, T., TabiT.
  • Journal Title: J Alzheim Dis 14 Pages: 161-73
• [Journal Article] Juzen-taiho-to, an herbal medicine, activates and enhances phagocytosis in microglia/macrophages (2008)
  • Author(s): Liu, H., Wang, J., Sekiyama, A., Tabira T.
  • Journal Title: Tohoku J Exp Med 215 Pages: 43-54
  • NAID: 10024167860
  • Peer Reviewed
• [Journal Article] Development and characterization of a TAPIR-like mouse monoclonal antibody to Aβ (2008)
  • Author(s): Wang, J., Hara, H., Makifuchi, T., Tabira, T.
  • Journal Title: J Alzheim Dis 14 Pages: 161-73
  • Peer Reviewed
• [Journal Article] A family of membrane proteins associated with presenilin expression and gamma-secretase function (2008)
  • Author(s): Araki, W., Takahashi-Sasaki, N., Chui, D. H., Saito, S., Takeda, K., Shirotani, K., Takahashi, K., Murayama, K. S., Kametani, F., Shiraishi, H., Komano, H. & Tabira. T.
  • Journal Title: FASEB J. 22 Pages: 819-827
  • Peer Reviewed
• [Journal Article] Oral vaccination with a recombinant adeno-associated viral vector attenuates age-related Abeta accumulation and memory deficits without lymphocytic infiltration in Tg2576 mice (2007)
  • Author(s): Mouri, A., Noda, Y., Hara, H., Mizoguchi, H., Tabira, T., Nabeshima, T.
  • Journal Title: FASEB J. 21 Pages: 2135-48
• [Journal Article] Amyloid beta protein-related death-Inducing Protein Induces G2/M arrest: Implications for neurodegeneration in Alzheimer's diseasa. (2007)
  • Author(s): Lakshmana, M. K., Hara, H. & Tabira, T.
  • Journal Title: J. Neurosci. Res. 85 Pages: 2262-71
  • Peer Reviewed
• [Journal Article] A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation (2007)
  • Author(s): Tanahashi, H. & Tabira, T.
  • Journal Title: Neuroscience Letteers 428 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Molecular chaperone inducer protects neurons from ER stress (2007)
  • Author(s): Kudo, T., Kanemoto, s., Hara, H., Morimoto, N., Morihara, T., Kimura, R., Tabira, T., Imaizumi, K. & Takeda M. A.
  • Journal Title: Cell Death Differentiation 30 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Novel mutation of the Notch3 gene in a Japanese patient with CADASIL (2007)
  • Author(s): Oki K, Nagata E, Ishiko A, Shimizu A, Tanaka K, Takahashi K, Tabira T, Katayama T, Suzuki N.
  • Journal Title: Eur. J. Neurol. 14(4) Pages: 464-466
  • Peer Reviewed
• [Journal Article] Oral vaccination with a recombinant adeno-associated viral vector attenuates age-related Abeta accumulation and memory deficits without lymphocytic infiltration in Tg2576 mice. (2007)
  • Author(s): Mouri A, Noda Y, Hara H, Mizoguchi S, Tabira T, Nabeshima T
  • Journal Title: FASEB J
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress. (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
  • Journal Title: Biocnem Biopnys Res Commun 344 Pages: 525-530
• [Journal Article] CADASIL-causing mutations do not alter Notch3 receptor processing and activation. (2006)
  • Author(s): Low W C, Santa Y, Takahashi K, Tabira T, Kalaria R N
  • Journal Title: NueroReort 17 Pages: 945-949
• [Journal Article] Intracellular amyloid β-protein and its associated molecules in the pathoaenesis of Alzheimer's disease. (2006)
  • Author(s): Ohyagi Y, Tabira T
  • Journal Title: Mini-Reviews in Medicinal Chemistry 6 Pages: 1075-1080
• [Journal Article] Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL. (2006)
  • Author(s): Ishiko A, Shimizu A, Nagata E, Takahashi K, Tabira T, Suzuki N
  • Journal Title: Acta Neuropathol 112 Pages: 333-339
• [Journal Article] Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. (2005)
  • Author(s): Lakshmana MK, Araki W, Tabira T.
  • Journal Title: FASEB J. 19 Pages: 1362-1364
• [Journal Article] Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis. (2005)
  • Author(s): Stadelmann C, Ludwin S, Tabira T, Guseo A, Lucchinetti CF, Leel-OssyL, Ordinario AT, BruckW, Lassmann H.
  • Journal Title: Brain 128 Pages: 979-987
• [Journal Article] Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomvelitis. (2005)
  • Author(s): Xu W, Fazekas G, Hara H, Tabira T.
  • Journal Title: J Neuroimmunol. 163 Pages: 24-30
• [Journal Article] Functional redundancy of the Notch gene family during mouse embryogenesis : Analysis of Notch gene expression in Notch3-deficient mice. (2005)
  • Author(s): Kitamoto T, Takahashi K, Takimoto H, Tomizuka K, Hayasaka M, Tabira T, Hanaoka K.
  • Journal Title: Biochem.Biophys.Res.Commun. 331 Pages: 1154-1162
• [Journal Article] Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk. stable transfectants expressing presenilin 1 protein. (2005)
  • Author(s): Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
  • Journal Title: Brain Res Mol Brain Res. 137 Pages: 70-76
• [Journal Article] Development and characterization of a TAPIR-like mouse monoclonal antibody to Aβ
  • Author(s): Wang, J., Hara, H., Makifuchi, T. & Tabira, T.
  • Journal Title: J.Alzheim. in press
  • Peer Reviewed
• [Journal Article] Juzen-taiho-to, an Herbal Medicine, Activates and Enhances Phagocytosis in Microglia/Macrophages
  • Author(s): Liu, H., Wang, J., Sekiyama, A. & Tabira T.
  • Journal Title: Tohoku J. Exp. in press
  • NAID: 10024167860
  • Peer Reviewed
• [Presentation] ストレスは万病のもと (2010)
  • Author(s): 田平武
  • Organizer: 朝日カルチャーセンター朝日JTB-交流文化塾
  • Place of Presentation: 朝日カルチャーセンター、新宿
  • Year and Date: 2010-03-30
• [Presentation] (特別講演)アルツハイマー病治療薬開発最近の話題 (2010)
  • Author(s): 田平武
  • Organizer: 第8回大阪アルツハイマー病研究会
  • Place of Presentation: ヒルトン大阪、大阪
  • Year and Date: 2010-03-13
• [Presentation] (特別講演)アルツハイマー病:免疫療法の開発状況と展望 (2010)
  • Author(s): 田平武
  • Organizer: 第74回石川県神経科精神科医会学術講演会
  • Place of Presentation: 金沢ニューグランドホテル、金沢
  • Year and Date: 2010-02-26
• [Presentation] アルツハイマー病の免疫療法:現状と展望 (2009)
  • Author(s): 田平武
  • Organizer: 科学技術交流財団主催第3回アルツハイマー病の早期診断・治療・予防法の開発研究会
  • Place of Presentation: 名城大学名駅サテライト、名古屋
  • Year and Date: 2009-12-22
• [Presentation] アルツハイマー病のワクチン療法開発と今後の展望、 (2009)
  • Author(s): 田平武
  • Organizer: 技術情報協会セミナー臨床ニーズ、標的分子の現状と展望をふまえた「これからのアルツハイマー病治療薬開発戦略」
  • Place of Presentation: 中央大学駿河台記念館、東京
  • Year and Date: 2009-12-16
• [Presentation] (イブニングセミナー)アルツハイマー病のワクチン療法について (2009)
  • Author(s): 田平武
  • Organizer: 日本精神病院協会主催第16回認知症高齢者に関する研修会、
  • Place of Presentation: JALシティ田町、東京
  • Year and Date: 2009-12-03
• [Presentation] (特別講演)アルツハイマー病の予防・治療最近の話題 (2009)
  • Author(s): 田平武
  • Organizer: 出雲クリニカルカンファレンス
  • Place of Presentation: ウエルシティ島根、出雲
  • Year and Date: 2009-11-30
• [Presentation] N末端構造に着目した野生型および変異Aβの物性解析 (2009)
  • Author(s): 武田和也、國本正子、足立香代、渡邊淳、脇田英明、高橋慶吉、田平武
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念館、仙台
  • Year and Date: 2009-11-20
• [Presentation] (特別講演)アルツハイマー病の免疫療法開発の現状と課題 (2009)
  • Author(s): 田平武
  • Organizer: 札幌臨床薬理研究会
  • Place of Presentation: JRホテル日航札幌、札幌
  • Year and Date: 2009-11-05
• [Presentation] (特別講演)アルツハイマー病の予防:ワクチンと生活習慣 (2009)
  • Author(s): 田平武
  • Organizer: 第8回鹿屋肝属地区認知症研究会
  • Place of Presentation: ホテルさつき苑、鹿屋
  • Year and Date: 2009-11-02
• [Presentation] 生活習慣と認知症:オーバービュー (2009)
  • Author(s): 田平武
  • Organizer: 第6回アルミニウムと健康フォーラム
  • Place of Presentation: 星陵会館、東京
  • Year and Date: 2009-10-17
• [Presentation] (特別講演)アルツハイマー病の抗体療法 (2009)
  • Author(s): 田平武
  • Organizer: 第4回佐賀県認知症研究会
  • Place of Presentation: ホテルニューオータニ佐賀、佐賀
  • Year and Date: 2009-10-14
• [Presentation] 認知症を防ぐ暮らし方 (2009)
  • Author(s): 田平武
  • Organizer: 朝日カルチャーセンター朝日JTB・交流文化塾
  • Place of Presentation: 朝日カルチャーセンター、新宿
  • Year and Date: 2009-10-06
• [Presentation] (特別講演)近未来の認知症治療の可能性を探る:Aβワクチン療法の現状と課 (2009)
  • Author(s): 田平武
  • Organizer: 第16回沖縄認知症研究会
  • Place of Presentation: 沖縄ハーバービューホテルクラウンプラザ、那覇
  • Year and Date: 2009-10-03
• [Presentation] アルツハイマー病の予防:ワクチンと生活習慣の改善 (2009)
  • Author(s): 田平武
  • Organizer: 順天堂大学脳神経内科市民公開講座「認知症克服への挑戦:認知症を治す時代の到来を信じて」
  • Place of Presentation: 順天堂大学有山記念講堂、東京
  • Year and Date: 2009-09-05
• [Presentation] アルツハイマー病の治療法開発 (2009)
  • Author(s): 田平武
  • Organizer: 第1回お茶の水Neuroimaging Conference
  • Place of Presentation: 泉ガーデンタワー、東京
  • Year and Date: 2009-09-05
• [Presentation] Alzheimer's disease vaccine (2009)
  • Author(s): Tabira T
  • Organizer: 2ND German-Japanese Neuroimmunology Symposium
  • Place of Presentation: Eibsee, Gremany
  • Year and Date: 2009-07-11
• [Presentation] Alzheimer's disease vaccine. (2009)
  • Author(s): Tabira T.
  • Organizer: 2^<nd> German-Japanese Neuroimmunology Symposium.
  • Place of Presentation: Eibsee, Germany
  • Year and Date: 2009-07-11
• [Presentation] アルツハイマー病の予防・治療ワクチンの開発 (2009)
  • Author(s): 田平武
  • Organizer: 第46回薬剤学懇談会研究討論会
  • Place of Presentation: 神戸ポートピアホテル、神戸
  • Year and Date: 2009-06-25
• [Presentation] (特別講演)アルツハイマー病:免疫療法の開発状況 (2009)
  • Author(s): 田平武
  • Organizer: 第34回多摩核医学技術検討会
  • Place of Presentation: 立川グランドホテル、立川
  • Year and Date: 2009-06-23
• [Presentation] (特別講演)アルツハイマー・ワクチン開発の現状 (2009)
  • Author(s): 田平武
  • Organizer: 第560回新潟医学会
  • Place of Presentation: 新潟大学有壬記念館、新潟
  • Year and Date: 2009-06-20
• [Presentation] カレントコンセプト 高齢者の認知機能低下、座長のことば。東京、東京 (2009)
  • Author(s): 田平武
  • Organizer: 第9回日本抗加齢医学会総会
  • Place of Presentation: ホテル日航、東京
  • Year and Date: 2009-05-28
• [Presentation] Abeta vaccine for prevention and treatment of Alzheimer's disease : monkey studies (2009)
  • Author(s): Tabira T
  • Organizer: 9^<th> ADPD
  • Place of Presentation: Prague
  • Year and Date: 2009-03-14
• [Presentation] ウイルスベクターを用いたアルツハイマー・ワクチン (2008)
  • Author(s): 田平 武
  • Organizer: 日本薬学会大128回年会シヒポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Immunotherapy of Alzheimer's disease (2008)
  • Author(s): Tabira T
  • Organizer: Update in Treatment of Alzheimer's disease, Busan-Gyeongnam Dementia Association Meeting
  • Place of Presentation: Busan,Korea
  • Year and Date: 2008-03-22
• [Presentation] アルツハイマー病のワクチン療法と今後の展望 (2008)
  • Author(s): 田平 武
  • Organizer: 技術情報協会主催アルツハイマー病治療薬の最新開発動向
  • Place of Presentation: 東京
  • Year and Date: 2008-03-18
• [Presentation] 特別講演アルツハイマー病の免疫療法 (2008)
  • Author(s): 田平 武
  • Organizer: 第40回摩耶神経カンファレンス
  • Place of Presentation: 神戸
  • Year and Date: 2008-03-14
• [Presentation] 基調講演認知症のこれから-予防・治療・ケアー (2008)
  • Author(s): 田平 武
  • Organizer: 第3回大府センター認知症フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] 特別講演アルツハイマー病の免疫療法 (2008)
  • Author(s): 田平 武
  • Organizer: 第18回日本老年医学会九州地方会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-01
• [Presentation] ストレスと脳 (2007)
  • Author(s): 田平 武
  • Organizer: 岐阜市生涯学習センター主催講座
  • Place of Presentation: 岐阜
  • Year and Date: 2007-12-15
• [Presentation] 高齢サルを用いたアルツハイマー病遺伝子治療研究と将来展望 (2007)
  • Author(s): 田平 武
  • Organizer: 第16回サル類疾病国際ワークショップ霊長類における長寿科学研究と動物福祉環境
  • Place of Presentation: つくば
  • Year and Date: 2007-12-07
• [Presentation] アルツハイマー病のワクチン療法最近の話題 (2007)
  • Author(s): 田平 武
  • Organizer: 第14回 New Horizon for Neurosciences
  • Place of Presentation: 東京
  • Year and Date: 2007-12-01
• [Presentation] 神経・免疫・内分泌相関と年齢軸恒常性 (2007)
  • Author(s): 田平 武
  • Organizer: 第1回年齢軸生体恒常性研究会シンポジウム生命の統合的理解にむけて
  • Place of Presentation: 東京
  • Year and Date: 2007-11-30
• [Presentation] 先端医療セッションアルツハイマー病のワクチン療法 (2007)
  • Author(s): 田平 武
  • Organizer: かわさきサイエンス&テクノロジーフォーラム
  • Place of Presentation: 川崎
  • Year and Date: 2007-11-21
• [Presentation] Alzhemer's disease: Immune response and immunotherapy (2007)
  • Author(s): Tabira T
  • Organizer: Abeta vaccine using vial vectors for Alzheimer's disease. The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics
  • Place of Presentation: Beijing
  • Year and Date: 2007-10-22
• [Presentation] Alzhemer's disease vaccine. R&D技術「次世代ワクチン・アルツハイマー病、肥満、がん」 (2007)
  • Author(s): 田平 武
  • Organizer: BioJapan2007-World Business Forum-
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-21
• [Presentation] アルツハイマー病とアンチエイジング医学 (2007)
  • Author(s): 田平 武
  • Organizer: 抗加齢医学会主催抗加齢医学の実際
  • Place of Presentation: 東京
  • Year and Date: 2007-09-17
• [Presentation] 特別講演「アルツハイマー病の免疫療法-最近の話題-」 (2007)
  • Author(s): 田平 武
  • Organizer: 第21回老年期痴呆研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-28
• [Presentation] Prevention of Dementia (2007)
  • Author(s): Tabira T
  • Organizer: International Symposium [Challenge: Functional Aging and Well-being] Sponsored by Busan City and Busan National University
  • Place of Presentation: Busan,Krea
  • Year and Date: 2007-07-23
• [Presentation] 免疫・内分泌と認知機能 (2007)
  • Author(s): 田平 武
  • Organizer: シンポジウム神経年齢-認知機能とアンチエイジング.第7回日本坑加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-21
• [Presentation] Oral Abeta Vaccine using Adeno-associated Virus Vector for Alzheimer Disease (2007)
  • Author(s): Tabira T.
  • Organizer: Keynote Lecture at the Annual Meeting of Geriatric Society of Taiwan, National Taiwan University Hospital International Conference Hall
  • Place of Presentation: Taipei
  • Year and Date: 2007-07-01
• [Presentation] Oral Abeta Vaccine using Adeno-associated Virus Vector for Alzheimer Disease (2007)
  • Author(s): Tabira T
  • Organizer: Seminar at the National Health Research Institute Zhu-Nan Campus
  • Place of Presentation: Taipei
  • Year and Date: 2007-06-29
• [Presentation] アルツハイマー・ワクチン開発 (2007)
  • Author(s): 田平 武
  • Organizer: 第192回中部産業活性化センター(CIAC)フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-28
• [Presentation] 認知症の臨床 (2007)
  • Author(s): 田平 武
  • Organizer: 教育企画Meet the Expert.第49回老年医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-21
• [Presentation] 基調講演 認知症予防のポイント (2007)
  • Author(s): 田平 武
  • Organizer: 毎日新聞社、(財)ぼけ予防協会主催ミッドランドホール開設記念シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-04-28
• [Presentation] 老化とアルツハイマー病-オーバービュー (2007)
  • Author(s): 田平 武
  • Organizer: 「アルミニウムと健康」連絡協議会主催第5回アルミニウムと健康フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2007-04-21
• [Presentation] アルツハイマー病のワクチン療法 (2007)
  • Author(s): 原 英夫、田平 武
  • Organizer: 第19回日本神経免疫学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-13
• [Presentation] シンポジウム認知障害を理解する-発症機序の解明と薬剤治療の進展-アルツハイマー病のワクチン療法 (2007)
  • Author(s): 田平 武
  • Organizer: 第27回日本医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-07
• [Book] アルツハイマー病に克つ (2009)
  • Author(s): 田平武
  • Total Pages: 255
  • Publisher: 朝日新書
• [Book] 浦上克哉編集、大内尉義監修 老年医学の基礎と臨床II(分担執筆) (2009)
  • Author(s): 田平武
  • Total Pages: 4
  • Publisher: ワールドプランニング
• [Book] 老化・老年病研究のための動物実験ガイドブック (2008)
  • Author(s): 武田和也、吉崎嘉一、田平武
  • Total Pages: 6
  • Publisher: アドスリー
• [Book] Current Topics in Neuroimmunology (2007)
  • Author(s): Tabira, T., Yamamura, T. & Kira
  • Publisher: Medimond,Bologna,Italy
• [Book] アルツハイマー・ワクチン (2007)
  • Author(s): 田平 武
  • Publisher: 中央法規出版,東京
• [Book] アルツハイマー病の神経細胞死を誘導する因子の解析と抑止法の開発 (2007)
  • Author(s): 田平 武
  • Publisher: 財団法人精神・神経科学振興財団監修こころの健康科学研究の現状と課題,東京
• [Book] 脳いきいき特攻法 (2007)
  • Author(s): 田平 武
  • Publisher: 主婦と生活社,東京
• [Book] 近い将来登場する有望なワクチン療法とは.認知症アルツハイマー病治療・ケア最前線 (2007)
  • Author(s): 田平 武
  • Total Pages: 14
  • Publisher: 主婦の友生活シリーズ 主婦の友社,東京
• [Book] 認知症を防ぐ-免疫反応利用根治療へ期待 (2007)
  • Author(s): 田平 武
  • Publisher: 北海道新聞編集北海道百科,北海道
• [Book] 8th Intemational Congress Neuroimmunology Free Papers (2007)
  • Author(s): Tabira, T., Yamamura, T. & Kira
  • Publisher: Medimond, Bologna, Italy
• [Patent(Industrial Property Rights)] アルツハイマー病治療の為のタピール様抗体 (2008)
  • Inventor(s): 田平武、王軍
  • Industrial Property Rights Holder: 田平武、王軍
  • Filing Date: 2008-02-22
• [Patent(Industrial Property Rights)] 組織アミロイドプラーク親和性抗体及びそれを用いた医薬組成物 (2008)
  • Inventor(s): 王軍、田平武
  • Industrial Property Rights Holder: 王軍、田平武
  • Industrial Property Number: 2008-042116
  • Filing Date: 2008-02-22
• [Patent(Industrial Property Rights)] 組織アミロイドプラーク親和性抗体及びそれを用いた医薬組成物 (2008)
  • Inventor(s): 王軍、田平 武
  • Industrial Property Rights Holder: 国立長寿医療センター総長大島伸一
  • Industrial Property Number: 2008-042116
  • Filing Date: 2008-02-22