Molecular mechanism underlying Ass assembly in Alzheimer brain : pathological and therapeutic significance of an endogenous seed for amyloid

• Project/Area Number: 17025057
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Longevity Sciences,NCGG
• Principal Investigator: YANAGISAWA Katsuhiko National Institute for Longevity Sciences,NCGG, 副所長 (10230260)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥94,500,000 (Direct Cost: ¥94,500,000); Fiscal Year 2009: ¥16,700,000 (Direct Cost: ¥16,700,000); Fiscal Year 2008: ¥17,600,000 (Direct Cost: ¥17,600,000); Fiscal Year 2007: ¥19,800,000 (Direct Cost: ¥19,800,000); Fiscal Year 2006: ¥20,700,000 (Direct Cost: ¥20,700,000); Fiscal Year 2005: ¥19,700,000 (Direct Cost: ¥19,700,000)
• Keywords: アルツハイマー病 / アミロイド蛋白 / ガングリオシド / アポリポ蛋白 / シナプス / マイクロドメイン / 遺伝的変異型 / アルツヘイマー病 / アポリポ蛋白E

Research Abstract

アルツハイマー病のアミロイドss蛋白質(Ass)の重合には神経細胞膜の糖脂質であるガングリオシドに結合したAss(GAss)がアミロイドの"種"として働いていると考えられる。本研究では、GAssの形成に神経細胞内の膜輸送の障害が関わり、ガングリオシドが密集した特異な膜ドメインが形成されることが必要であることを確認した。またGAssの"種"作用の抑制により脳内におけるアミロイド形成を阻害する新しい治療法の開発を検討した。

Research Products

• [Journal Article] Surface-induced phase separation of a sphingomyelin / cholesterol / ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates As oligomerization (2010)
  • Author(s): Mao Y, Zhiguo S, Imai Y, Hoshino T, Tero R, Tanaka M, Yamamoto N, Yanagisawa K, Urisu T.
  • Journal Title: Biochim Biophys Acta (in press) Pages: 22-26
  • Peer Reviewed
• [Journal Article] Gender effect on the accumulation of hyperphosphorylated tau in the brains of locus-ceruleus-injured APP transgenic mouse (2010)
  • Author(s): Oikawa N, Ogino K, Masumoto T, Yamaguchi H, Yanagisawa K.
  • Journal Title: Neurosci. Lett. 468 Pages: 243-247
  • Peer Reviewed
• [Journal Article] Alzheimer-type tau pathology in advanced nonhuman primate brains harboring substantial amyloid depositio (2010)
  • Author(s): Oikawa N, Kimura N, Yanagisawa K.
  • Journal Title: Brain. Res. 1315 Pages: 137-149
  • Peer Reviewed
• [Journal Article] Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse. (2010)
  • Author(s): Oikawa N, (Yanagisawa K), et al.
  • Journal Title: Neuroscience letters 468 Pages: 243-247
  • Peer Reviewed
• [Journal Article] Alzheimer-type tau pathology in advanced aged nonhuman primate brainsharboring substantial amyloid deposition. (2010)
  • Author(s): Oikawa N, (Yanagisawa K), et al.
  • Journal Title: Brain research 1315 Pages: 137-149
  • Peer Reviewed
• [Journal Article] A polymerization through interaction with membrane gangliosides (2010)
  • Author(s): Matsuzaki K(Yanagisawa K), et al.
  • Journal Title: Biochim Biophys Acta (in press)
  • Peer Reviewed
• [Journal Article] Surface-induced phase sepaiation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Ass oligomerization. (2010)
  • Author(s): Mao Y(Yanagisawa K), et al.
  • Journal Title: Biochim Biophys Acta (in press)
  • Peer Reviewed
• [Journal Article] Up-and-down topological mode of amyloid s-peptide lying on hydrophilic / hydrophobic interface of ganglioside clusters (2009)
  • Author(s): Utsumi M, Yamaguchi Y, Sasakawa H, Yamamoto N, Yanagisawa K, Kato K.
  • Journal Title: Glycoconjugate J. 26 Pages: 999-1006
  • Peer Reviewed
• [Journal Article] Gangliosides determine the amyloid pathology of Alzheimer disease (2009)
  • Author(s): Oikawa N, Yamaguchi H, Ogino K, Taki T, Yuyama K, Yamamoto N, Shin R-W., Furukawa K, Yanagisawa K.
  • Journal Title: Neuroreport 20 Pages: 143-1046
  • Peer Reviewed
• [Journal Article] ate endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease (2009)
  • Author(s): Yuyama K, Yanagisawa K.
  • Journal Title: J. Neurochem 109 Pages: 1250-1260
  • Peer Reviewed
• [Journal Article] ate endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease (2009)
  • Author(s): Yuyama., Yanagisawa K.
  • Journal Title: J. Neurochem 109 Pages: 1250-1260
  • Peer Reviewed
• [Journal Article] Gangliosides determine the amyloid pathology of Alzheimer's disease. (2009)
  • Author(s): Oikawa N, (Yanagisawa K), et al.
  • Journal Title: Neuroreport 20 Pages: 1043-1046
  • Peer Reviewed
• [Journal Article] Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters. (2009)
  • Author(s): Utsumi M, (Yanagisawa K), et al.
  • Journal Title: Glycoconjugate journal 26 Pages: 999-1006
  • Peer Reviewed
• [Journal Article] Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease. (2009)
  • Author(s): Yuyama K, (Yanagisawa K)
  • Journal Title: Journal of neurochemistry 109 Pages: 1250-1260
  • Peer Reviewed
• [Journal Article] Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. (2009)
  • Author(s): Tesseur I, (Yanagisawa K), et al.
  • Journal Title: Journai of neurochemistry 110 Pages: 1254-1262
  • Peer Reviewed
• [Journal Article] Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. (2009)
  • Author(s): Nishida Y, (Yanagisawa K), et al.
  • Journal Title: The Journal of biological chemistry 284 Pages: 33400-33408
  • Peer Reviewed
• [Journal Article] Up-and-down topological mode of amyloid β-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters. (2009)
  • Author(s): Utsumi M, (Yanagisawa K), et al.
  • Journal Title: Glycoconjugate J (in press)
  • Peer Reviewed
• [Journal Article] Gangliosides determine the amyloid pathology of Alzheimer disease. (2009)
  • Author(s): Oikawa N, (Yanagisawa K), et al.
  • Journal Title: Neuroreport (in press)
  • Peer Reviewed
• [Journal Article] Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease. (2009)
  • Author(s): Yuyama K, Yanagisawa K.
  • Journal Title: J Neurochem (in press)
  • Peer Reviewed
• [Journal Article] ccelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation (2008)
  • Author(s): Yuyama K, Yamamoto N, Yanagisawa K.
  • Journal Title: J. Neurochem 105 Pages: 217-224
  • Peer Reviewed
• [Journal Article] Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid s-protein fibrillogenesis (2008)
  • Author(s): Yamamoto N, Matusbara T, Sato T. Yanagisawa K.
  • Journal Title: Biochim. Biophys. Acta 1778 Pages: 2717-2726
  • Peer Reviewed
• [Journal Article] Novel role of presenilins in maturation and transport of integrin β1. (2008)
  • Author(s): Zou K, (Yanagisawa K), et al.
  • Journal Title: Biochemistry 47 Pages: 3370-3378
  • Peer Reviewed
• [Journal Article] Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis. (2008)
  • Author(s): Yamamoto N, (Yanagisawa K), et al.
  • Journal Title: Biochim Biophys Acta 1778 Pages: 2717-2726
  • Peer Reviewed
• [Journal Article] Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality : another putative pathway for GM1-induced amyloid fibril formation. (2008)
  • Author(s): Yuyama K, (Yanagisawa K) et al.
  • Journal Title: J. Neurochem 105 Pages: 217-214
  • Peer Reviewed
• [Journal Article] Novel role of presenilins in maturation and transport of integrin β1. (2008)
  • Author(s): Zou K, (Yanagisawa K) et al.
  • Journal Title: Biochemistry 47 Pages: 3370-3378
  • Peer Reviewed
• [Journal Article] A ganglioside -induced toxic soluble As assembly: Its enhanced formation from As bearing theArctic mutation (2007)
  • Author(s): amamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M, Yanagisawa, K.
  • Journal Title: J. Biol. Chem 282 Pages: 2646-2656
  • Peer Reviewed
• [Journal Article] GM1-ganglioside-induced As assembly on synaptic membranes of cultured neurons (2007)
  • Author(s): Yamamoto N, Fukata Y, Fukata M, Yanagisawa K.
  • Journal Title: Biochim. Biophys. Acta 1768 Pages: 1128-1137
  • Peer Reviewed
• [Journal Article] GM1-ganglioside-induced Aβ assembly on synaptic membranes of cultured neurons. (2007)
  • Author(s): Yamamoto N, (Yanagisawa K) et al.
  • Journal Title: Biochim. Biophys. Acta 1768 Pages: 1128-1137
  • Peer Reviewed
• [Journal Article] Novel action of apolipoprotein E (ApoE) : ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons. (2007)
  • Author(s): Gong J, (Yanagisawa K) et al.
  • Journal Title: Molecular Neurodegeneration 2
  • Peer Reviewed
• [Journal Article] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition. (2007)
  • Author(s): Zou K, (Yanagisawa K) et al,
  • Journal Title: J. Neurosci. 27 Pages: 8628-8635
  • Peer Reviewed
• [Journal Article] Endosomal accumulation of GM1-ganglioside-bound amyloid β-protein inneurons of aged monkey brains. (2007)
  • Author(s): Kimura N & Yanagisawa K.
  • Journal Title: Neuroreport 18 Pages: 1669-1673
  • Peer Reviewed
• [Journal Article] Role of gangliosides in Alzheimer's disease. (2007)
  • Author(s): Yanagisawa K.
  • Journal Title: Biochim. Biophys. Acta 1768 Pages: 1943-1951
  • Peer Reviewed
• [Journal Article] A ganglioside-induced toxic soluble Aβ assembly: Its enhanced formation from Aβ bearing the Arctic mutation. (2007)
  • Author(s): Yamamoto N, (Yanagisawa K), et. al.
  • Journal Title: J Biol Chem 282 Pages: 2646-2655
• [Journal Article] GM1-ganglioside-induced Aβ assembly on synaptic membranes of culturedneurons. (2007)
  • Author(s): Yamamoto N, (Yanagisawa K), et. al.
  • Journal Title: Biochim Biophys Acta 1768 Pages: 1128-1137
• [Journal Article] Chloroquine-induced endocytic pathway abnormalities: cellular model of GM1 -ganglioside-induced As fibrillogenesis in Alzheimer's disease (2006)
  • Author(s): Yuyama K, Yamamoto N, Yanagisawa K.
  • Journal Title: FEBS Lett 580 Pages: 6972-6976
  • Peer Reviewed
• [Journal Article] Further evidence of local ganglioside-dependent amyloid β-protein assembly in brain. (2006)
  • Author(s): Yamamoto N, (Yanagisawa K), et. al.
  • Journal Title: Neuroreport 17 Pages: 1735-1737
• [Journal Article] Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Aβ fibrillogenesis in Alzheimer's disease. (2006)
  • Author(s): Yuyama K, (Yanagisawa K), et. al.
  • Journal Title: FEBS Lett 580 Pages: 6972-6976
• [Journal Article] Assembly of hereditary amyloid s-protein variants in the presence of favorable gangliosides (2005)
  • Author(s): Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Van Nostr, W.E., Yanagisawa K.
  • Journal Title: FEBS Lett 579 Pages: 2185-2190
  • Peer Reviewed
• [Journal Article] Cross seeding of wild- and hereditary variant-type amyloid s-proteins in the presence of gangliosides (2005)
  • Author(s): Yamamoto N, Matsuzaki K, Yanagisawa K.
  • Journal Title: J. Neurochem. 95 Pages: 1167-1176
  • Peer Reviewed
• [Journal Article] Suppression of As deposition in brain by peripheral administration of Fab fragments of anti-seed antibody (2005)
  • Author(s): Yamamoto N, Yokoseki T, Shibata M, Yamaguchi H, Yanagisawa K.
  • Journal Title: Biochem. Biophys. Res. Commun. 335 Pages: 45-47
  • Peer Reviewed
• [Journal Article] Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides. (2005)
  • Author(s): Yamamoto N, (Yanagisawa K) et al.
  • Journal Title: FEBS Lett 579 Pages: 2185-2190
• [Journal Article] Suppression of Aβ deposition in brain by peripharal administration of Fab fragments of anti-seed antibody. (2005)
  • Author(s): Yamamoto N, (Yanagisawa K) et al.
  • Journal Title: Biochem Biophys Res Commun 335 Pages: 45-47
• [Journal Article] Cross-seeding of wild- and hereditary variant-type amyloid β-proteins in the presence of gangliosides. (2005)
  • Author(s): Yamamoto N, (Yanagisawa K) et al.
  • Journal Title: J Neurochem 95 Pages: 1167-1176
• [Journal Article] Altered cholesterol metabolism in Niemann-Pick type C mouse brains affectsmitochondrial function. (2005)
  • Author(s): Yu W, (Yanagisawa K) et al.
  • Journal Title: J Biol Chem 280 Pages: 11731-11739
• [Journal Article] Neurodegeneration in heterogenous Niemann-Pick type C1 (NPC1) mouse : implication of heterogenous NPC1 mutations being a risk for tauopathy. (2005)
  • Author(s): Yu W, (Yanagisawa K) et al.
  • Journal Title: J Biol Chem 280 Pages: 27296-27302
• [Presentation] NMR法を用いたアミロイドβとガングリオシドクラスターの相互作用解析 (2010)
  • Author(s): 矢木真穂,(柳澤勝彦)
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] NMR analyses of interaction mode of amyloid -peptide with GM1 ganglioside clusters (2009)
  • Author(s): Yagi-Utsumi M,(Yanagisawa K)
  • Organizer: 3rd Asia-Pacific NMR Symposium
  • Place of Presentation: 韓国チェジュ島
  • Year and Date: 2009-10-26
• [Presentation] NMR法によるアミロイドペプチドとGM1ガングリオシドクラスターとの相互作用解析 (2009)
  • Author(s): 矢木-内海真穂,(柳澤勝彦)
  • Organizer: 第7回「若手の力」フォーラムおよび拠点共同研究報告会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-30
• [Presentation] Lipid metabolism and its pathophysiology in CNS (2009)
  • Author(s): シンポジウム
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-30
• [Presentation] Pathological significance of ganglioside cluster in Alzheimer disease. (2009)
  • Author(s): 柳澤勝彦
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-30
• [Presentation] Seed形成の細胞生物学的基礎:ガングリオシドマイクロドメインの役割 (2009)
  • Author(s): 柳澤勝彦
  • Organizer: 大阪大学蛋白質研究所セミナー「蛋白質立体構造を基盤とするプリオン現象の解明と制御」
  • Place of Presentation: 吹田
  • Year and Date: 2009-07-13
• [Presentation] アルツハイマー病におけるGM1ガングリオシド誘導性アミロイドs蛋白質重合に関与する後期エンドサイトーシス障害 (2009)
  • Author(s): 湯山耕平, 柳澤勝彦
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川
  • Year and Date: 2009-06-22
• [Presentation] アルツハイマー病におけるGM1ガングリオシド誘導性アミロイドβ蛋白質重合に関与する後期エンドサイトーシス障害 (2009)
  • Author(s): 湯山耕平,(柳澤勝彦)
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川
  • Year and Date: 2009-06-22
• [Presentation] カニクイザル脳におけるアルツハイマー病関連蛋白(As、タウ)の解析 (2008)
  • Author(s): 及川尚人, 木村展之, 柳澤勝彦
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] カニクイザル脳におけるアルツハイマー病関連蛋白(Aβ、タウ)の解析 (2008)
  • Author(s): 及川尚人、(柳澤勝彦)
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] As線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス経路障害 (2008)
  • Author(s): 湯山耕平, 山本直樹, 柳澤勝彦
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-21
• [Presentation] シナプス前膜の年齢依存的なGM1 ganglioisde集積ドメイン形成はAs線維化を促す (2008)
  • Author(s): 山本直樹, 松原輝彦, 湯山耕平, 佐藤智典, 柳澤勝彦
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Aβ重合開始の分子機構 (2008)
  • Author(s): 柳澤勝彦
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] シナプス前膜の年齢依存的なGM1 ganglioside集積ドメイン形成はAβ線維化を促す (2008)
  • Author(s): 山本直樹、(柳澤勝彦)
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Aβ線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス経路障害 (2008)
  • Author(s): 湯山耕平、(柳澤勝彦)
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Aβ線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス径路傷害 (2008)
  • Author(s): 柳澤勝彦
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] GM1ガングリオシドのエンドサイトーシス制御によるアルツハイマー病細胞モデルの構築 (2008)
  • Author(s): 湯山耕平、(柳澤勝彦)
  • Organizer: 糖鎖機能研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2008-05-22
• [Presentation] Ganglioside-induced Aβ assembly as an early event of Alzheimer's disease. (2008)
  • Author(s): Yanagisawa K.
  • Organizer: 10th International Hong Kong/Spreingfield Pan-Asian Symposium on Advances on Alzheimer Therapy
  • Place of Presentation: Hong Kong
  • Year and Date: 2008-03-01
• [Presentation] A ganglioside-induced toxic soluble Aβ assembly. (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第257回東北大学薬学研究科セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-09
• [Presentation] A ganglioside-induced soluble As assembly causes neuronal death through NGF receptors (2007)
  • Author(s): Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Michikawa M, Yanagisawa K.
  • Organizer: 37th Society for Neuroscience Annual Meeting
  • Place of Presentation: サンディエゴ, アメリカ
  • Year and Date: 2007-11-05
• [Presentation] A ganglioside-induced soluble Aβ assembly causes neuronal death through NGF receptors. (2007)
  • Author(s): Yamamoto N, (Yanagisawa K) et al.
  • Organizer: 37th Society for Neuroscience Annual Meeting
  • Place of Presentation: San Diego, U. S. A.
  • Year and Date: 2007-11-05
• [Presentation] 脳内Aβ蓄積の時空間的特性の基盤:細胞膜脂質環境の重要性 (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第26回日本認知症学会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-17
• [Presentation] アルツハイマー病 - Up date. (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第22回日本老年精神医学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-16
• [Presentation] エンドサイトーシス経路異常によるGM1ガングリオシドの細胞外放出の促進 (2007)
  • Author(s): 湯山耕平, 山本直樹, 柳澤勝彦
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 老齢マウス脳シナプス膜中の特異なGM1 ganglioside集積ドメイン (2007)
  • Author(s): 山本直樹, 湯山耕平, 柳澤勝彦
  • Organizer: 50回日本神経化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 安定同位体利用NMR法によるGM1ミセル結合型アミロイドβの構造解析 (2007)
  • Author(s): 内海真穂、(柳澤勝彦)、その他
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 老齢マウス脳シナプス膜中の特異なGM1 ganglioside 集積ドメイン (2007)
  • Author(s): 山本直樹、(柳澤勝彦)、その他
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] エンドサイトーシス径路異常によるGM1ガングリオシドの細胞外放出の促進 (2007)
  • Author(s): 湯山耕平、(柳澤勝彦)、その他
  • Organizer: 第50回日本神経化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] アルツハイマー病発祥と神経細胞膜脂質 (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第16回日本脂質栄養学会シンポジウム
  • Place of Presentation: 島根
  • Year and Date: 2007-08-31
• [Presentation] PC12細胞エンドーシス径路障害時におけるGM1ガングリオシドの細胞外放出 (2007)
  • Author(s): 湯山耕平、(柳澤勝彦)、その他
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2007-08-02
• [Presentation] アミロイドβペプチド・GM1ガングリオシド相互作用系のNMR解析 (2007)
  • Author(s): 内海真穂、(柳澤勝彦)、その他
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2007-08-02
• [Presentation] アルツハイマー病の分子病理と治療戦略 (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第23回創薬セミナー
  • Place of Presentation: 長野
  • Year and Date: 2007-07-25
• [Presentation] 細胞膜脂質とアルツハイマー病 (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第29回 日本フリーラジカル学会・第31回 日本過酸化脂質フリーラジカル学会合同大会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-09
• [Presentation] アミロイドβ蛋白の構造変化とアルツハイマー病 (2007)
  • Author(s): 柳澤勝彦
  • Organizer: 第7回日本タンパク質科学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25
• [Presentation] Ganglioside-induced Aβ assembly in Alzheimer disease. (2007)
  • Author(s): Yanagisawa K.
  • Organizer: Inangural Meeting of the Korea Society for Neuro degenerative Disorder.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-04-14
• [Presentation] A ganglioside-induced toxic soluble As assemblycauses neuronal death (2006)
  • Author(s): 山本直樹, 松原悦朗, 前田純裕, 高島明彦, 丸山和佳子, 道川誠, 柳澤勝彦
  • Organizer: 第29回日本分子生物学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-06
• [Presentation] GM1-ganglioside-induced As assembly at neuritic terminals of nerve growth factor-treated PC12 cells (2006)
  • Author(s): 山本直樹, 湯山耕平, 柳澤勝彦
  • Organizer: 第49回日本神経化学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
• [Presentation] GM1 ganglioside accumulation in PC12 cells treated with chloroquine: a cellular model of As assembly (2006)
  • Author(s): 湯山耕平, 山本直樹, 柳澤勝彦
  • Organizer: 第49回日本神経化学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
• [Presentation] 膜マイクロドメインとアルツハイマー病:GM1ガングリオシド集積の意味 (2005)
  • Author(s): 柳澤勝彦
  • Organizer: 第28回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2005-12-10
• [Presentation] Assembly of hereditary variant amyloid s-protein in the presence of gangliosides (2005)
  • Author(s): Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Nostr, W, Yanagisawa K.
  • Organizer: 第48回日本神経化学会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
• [Presentation] アミロイドs蛋白重合とガングリオシド (2005)
  • Author(s): 柳澤勝彦
  • Organizer: 第28回日本神経科学大会シンポジウム「糖鎖科学と神経科学の融合による新展開」
  • Place of Presentation: 横浜
  • Year and Date: 2005-07-27
• [Presentation] Pivotal roles of lipids in generating an endogenous seed for Alzheimer amyloid (2005)
  • Author(s): Yanagisawa K.
  • Organizer: 7th International Conference on Alzheimer's Disease and Parkinson Disease. Sorrento
  • Place of Presentation: イタリア
• [Presentation] Pathological significance of ganglioside cluster in Alzheimer disesse
  • Author(s): 柳澤勝彦
• [Book] Research Progress in Alzheimer's Disease(edited by Miao-Kun Sun, Pivotal roles of cholesterol and gangliosides in aggregation of amyloid β-protein.) (2010)
  • Author(s): Yanagisawa K.
  • Publisher: Nova Science Pulishers, Inc.(in press)
• [Book] Comprehensive Glycoscience(edited by Kamerling J.P., Boons G-J., Lee Y.C.,Suzuki A. and Taniguchi N., Glycoconjugates and neurological diseases.) (2007)
  • Author(s): Yanagisawa K, Yuki N.
  • Publisher: Elsevier
• [Book] Comprehensive Glycoscience (2007)
  • Author(s): Yuki N & Yanagisawa K.
  • Publisher: Elsevier
• [Book] Sphingolipid Biology.(edited by Hirabayashi Y, Igarashi Y and Merill AH, Ganglioside and Alzheimer's disease.) (2006)
  • Author(s): Yanagisawa K.
  • Publisher: Springer
• [Book] Ganglioside and Alzheimer's Disease. In: Sphingolipid Biology (2006)
  • Author(s): Yanagisawa K.
  • Publisher: Springer-Verlag, Tokyo
• [Book] Recent Progress in Alzheimer's and Parkinsons's Diseases(edited by Hanin I,Casabelos R and Fisher A, Cholesterol and Aβ cascade:pathological implication of apolipoprotein E in Alzheimer's disease.) (2005)
  • Author(s): Yanagisawa K.
  • Publisher: Taylor & Francis
• [Book] Cholesterol and amyloid β fibrillogenesisIn: Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid β(edited by Robin Harris and Falk Fahrenholz) (2005)
  • Author(s): Yanagisawa, K.
  • Publisher: Springer-Verlag
• [Book] Cholesterol and amyloid β fibrillogenesis. In : Alzheimer's Disease : Cellular and Molecular Aspects of Amyloid β. (2005)
  • Author(s): Yanagisawa K.
  • Total Pages: 409
  • Publisher: Springer-Verlag, Heidelberg, Germany
• [Book] Cholesterol and Aβ fibrillogenesis. In : SubcelluIar Biochemistry : Alzheimer's disease-Cellular and moleculer aspects of amyloid. (2005)
  • Author(s): Yanagisawa K.
  • Publisher: Springer-Vierlag
• [Book] Possible link between cholesterol and dementia, depression. In : Cognition and Mood. (2005)
  • Author(s): Yanagisawa K.
  • Publisher: Nova Science Publishers, Inc. New York, U.S.A
• [Book] Cholesterol and Aβ cascade : pathological implication of apolipoprotein E in Alzheimer's and Parkinson's disease. (2005)
  • Author(s): Yanagisawa K.
  • Publisher: The Patherson Publishing Group
• [Patent(Industrial Property Rights)] Antibody Having Inhibitory Effect on AmyloidFibri Formation. (2008)
  • Inventor(s): 柳澤勝彦, 柴田昌夫
  • Industrial Property Rights Holder: 柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
  • Acquisition Date: 2008-03-08
  • Overseas
• [Patent(Industrial Property Rights)] Antibody Recognizing GM1 Ganglioside-Bound Amyloid β-Protein and DNA Encoding The Antibody (2008)
  • Inventor(s): 柳澤勝彦, 柴田昌夫
  • Industrial Property Rights Holder: 柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
  • Acquisition Date: 2008-03-04
  • Overseas
• [Patent(Industrial Property Rights)] GM1ガングリオシド結合型アミロイドタンパク質を認識する抗体を含有するアミロイド繊維形成抑制剤 (2008)
  • Inventor(s): 柳澤勝彦, 柴田昌夫
  • Industrial Property Rights Holder: 柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
  • Acquisition Date: 2008-03-28
• [Patent(Industrial Property Rights)] 可溶性アミロイドs蛋白重合体の調整法ならびに毒性評価法 (2006)
  • Inventor(s): 柳澤勝彦、山本直樹
  • Industrial Property Rights Holder: ヒューマンサイエンス振興財団
  • Filing Date: 2006-06-05