| Budget Amount *help |
¥105,200,000 (Direct Cost: ¥105,200,000)
Fiscal Year 2009: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2008: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2007: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2006: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2005: ¥21,200,000 (Direct Cost: ¥21,200,000)
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| Research Abstract |
We notice the nuclear receptors as factors that connect DECODE networks with DECODE complex, and tried to analyze the transcriptional regulations.
We have found that CHIP, a U-box-type ubiquitin ligase, is implicated in degradation of estrogen receptor (ER), and that CHIP has tumor suppressive role. Moreover, we found that ER promotes Smad degradation by recruiting unknown ubiqutin ligase(s) to Smad complex. We also identified Nucleomethylin (NML),a novel nucleolar protein, and eNoSC, a novel protein complex that connect energy signal with DECODE network..
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