Analysis of the ubiquitin ligase complexes that regulates the transcription of nuclear receptors.
Project/Area Number |
17054005
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | University of Tsukuba |
Principal Investigator |
YANAGISAWA Junn University of Tsukuba, 大学院・生命環境科学研究科, 教授 (50301114)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥105,200,000 (Direct Cost: ¥105,200,000)
Fiscal Year 2009: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2008: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2007: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2006: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 2005: ¥21,200,000 (Direct Cost: ¥21,200,000)
|
Keywords | ゲノム / 蛋白質 / 発現制御 / プロテオーム / 核内レセプター / ユビキチンリガーゼ / 蛋白質分解 / 乳癌 / 転移 / 転写因子 / 転写 / 核内受容体 / ユビキチン化 / プロテアソーム |
Research Abstract |
We notice the nuclear receptors as factors that connect DECODE networks with DECODE complex, and tried to analyze the transcriptional regulations. We have found that CHIP, a U-box-type ubiquitin ligase, is implicated in degradation of estrogen receptor (ER), and that CHIP has tumor suppressive role. Moreover, we found that ER promotes Smad degradation by recruiting unknown ubiqutin ligase(s) to Smad complex. We also identified Nucleomethylin (NML),a novel nucleolar protein, and eNoSC, a novel protein complex that connect energy signal with DECODE network..
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Report
(6 results)
Research Products
(117 results)
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[Journal Article] Estrogen inhibits TGF-{beta} signaling by promoting Smad2/3 degradation2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J
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Journal Title
The Journal of biological chemistry (In press)
Related Report
Peer Reviewed
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[Journal Article] Estrogen inhibits TGF-{beta} signaling by promoting Smad2/3 degradation2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.
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Journal Title
The Journal of biological chemistry (In press)
Related Report
Peer Reviewed
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[Journal Article] Estrogen inhibits TGF-{beta} signaling by promoting Smad2/3 degradation.2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.
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Journal Title
The Journal of biological chemistry. (印刷中)(In press)
Related Report
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[Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A2009
Author(s)
akemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, Kimura K
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Journal Title
Nature Structural & Molecular Biology Vol.16,No.12
Pages: 1302-1308
Related Report
Peer Reviewed
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[Journal Article] The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways2009
Author(s)
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie S, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J
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Journal Title
Nature Cell Biol Vol.11,No3
Pages: 312-319
Related Report
Peer Reviewed
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[Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A2009
Author(s)
Takemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, Kimura K.
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Journal Title
Nature Structural & Molecular Biology 16
Pages: 1302-1308
Related Report
Peer Reviewed
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[Journal Article] The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways2009
Author(s)
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie S, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J.
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Journal Title
Nature Cell Biol. 11
Pages: 312-319
Related Report
Peer Reviewed
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[Journal Article] The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.2009
Author(s)
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie S, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J.
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Journal Title
Nature Cell Biol. 11
Pages: 312-219
Related Report
Peer Reviewed
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[Journal Article] The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.2009
Author(s)
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie S, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J.
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Journal Title
Nature Cell Biol. 11(3)
Pages: 312-319
Related Report
Peer Reviewed
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[Journal Article] Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs2008
Author(s)
Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y
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Journal Title
Cell Stem Cell Vol.3,No5
Pages: 555-567
Related Report
Peer Reviewed
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[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status2008
Author(s)
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Simizu T, Yanagisawa J
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] PPARy ligands suppress the feedback loop between E2F2 and cyclin-El2008
Author(s)
Komatsu Y, Ito I, Wayama M, Fujimura A, Akaogi K, Machida H, Nakajima Y, Kuroda T, Ohmori K, Murayama A, Kimura K, Yanagisawa J
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Journal Title
Biochem Biophys Res Commun Vol.370,No.1
Pages: 145-148
Related Report
Peer Reviewed
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[Journal Article] Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.2008
Author(s)
Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y.
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Journal Title
Cell Stem Cell. 3(5)
Pages: 555-567
Related Report
Peer Reviewed
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[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status.2008
Author(s)
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Simizu T, Yanagisawa J.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status2008
Author(s)
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, Yanagisawa J.
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Journal Title
Related Report
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[Journal Article] PPARγ ligands suppress the feedback loop between E2F2 and cyclin-E1.2008
Author(s)
Komatsu Y, Ito I, Wayama M, Fujimura A, Akaogi K, Machida H, Nakajima Y, Kuroda T, Ohmori K, Murayama A, Kimura K, Yanagisawa J.
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Journal Title
Biochem Biophys Res Commun. (in press)
Related Report
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[Journal Article] Turning Off Estrogen Receptor β-Mediated Transcription Requires Estrogen-Dependent Receptor Proteolysis2006
Author(s)
Tateishi Y, Sonoo R, Sekiya Y, Sunahara N, Kawano M, Wayama M, Hirota R, Kawabe Y, Murayama A, Kato S, Kimura K, Yanagisawa J
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Journal Title
MoL Cell. Biol 26
Pages: 7966-7976
Related Report
Peer Reviewed
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[Journal Article] A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory2006
Author(s)
Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Shibuya K, Kawabe Y, Yanagisawa J
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Journal Title
EMBO J 25
Pages: 1081-1092
Related Report
Peer Reviewed
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[Journal Article] Turning Off Estrogen Receptor β-Mediated Transcription Requires Estrogen-Dependent Receptor Proteolysis.2006
Author(s)
Tateishi Y, Sonoo R, Sekiya Y, Sunahara N, Kawano M, Wayama M, Hirota R, Kawabe Y, Murayama A, Kato S, Kimura K, Yanagisawa J.
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Journal Title
Mol. Cell. Biol. 26
Pages: 7966-7976
Related Report
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[Journal Article] A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.2006
Author(s)
Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Shibuya K, Kawabe Y, Yanagisawa J.
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Journal Title
Related Report
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[Journal Article] Repressive domain of unliganded human estrogen receptor alpha associates with Hsc702005
Author(s)
Ogawa S, Oishi H, Mezaki Y, Kouzu-Fujita M, Matsuyama R, Nakagomi M, Mori E, Murayama E, Nagasawa H, Kitagawa H, Yanagisawa J, Yano T, Kato S
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Journal Title
Genes Cells 10
Pages: 1095-1102
Related Report
Peer Reviewed
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[Journal Article] Repressive domain of unliganded human estrogen receptor alpha associates with Hsc70.2005
Author(s)
Ogawa S, Oishi H, Mezaki Y, Kouzu-Fujita M, Matsuyama R, Nakagomi M, Mori E, Murayama E, Nagasawa H, Kitagawa H, Yanagisawa J, Yano T, Kato S.
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Journal Title
Genes Cells 10・12
Pages: 1095-1102
Related Report
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[Presentation]2009
Author(s)
柳澤純
Organizer
第9回TCカンファレンス(興和製薬株式会社)
Place of Presentation
興和製薬株式会社東京
Year and Date
2009-06-06
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