| Project/Area Number |
17054022
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Toyama |
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Principal Investigator |
OHKUMA Yoshiaki University of Toyama, 大学院・医学薬学研究部, 教授 (70192515)
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| Co-Investigator(Kenkyū-buntansha) |
廣瀬 豊 富山大学, 大学院医学薬学部, 助手 (00218851)
田中 亜紀 富山大学, 大学院医学薬学部, 助手 (50432109)
高野 克彦 富山大学, 薬学部, 助手 (50293303)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSE Yutaka 富山大学, 大学院・医学薬学研究部, 准教授 (00218851)
TANAKA Aki 富山大学, 大学院・医学薬学研究部, 助教 (50432109)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥77,900,000 (Direct Cost: ¥77,900,000)
Fiscal Year 2009: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2008: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2007: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2006: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2005: ¥14,500,000 (Direct Cost: ¥14,500,000)
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| Keywords | RNAポリメラーゼII(Pol II) / 基本転写因子TFIIH / CTD / メディエーター複合体 / リン酸化 / コファクター / TFIIE / フォークヘッドドメイン / ルディエーター複合体 / CDK19 / 酵母2ハイブリッド法 / Rpb5 / 基本転写因子 / TFIIEβ / Rpb / MED15 / KIXドメイン / CDK8 / CDK11 / TFIIH / Rpb12 / Znフィンガードメイン |
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| Research Abstract |
The applicants characterized the functions of two general transcription factors, TFIIE and TFIIH, which assist Pol II for accurate transcription, and the multisubunit Mediator complex which transduces transcriptional activation signals to Pol II in the nucleus. As for Mediator, we demonstrated that two CDK subunits play a role as a molecular switch between positive and negative regulations in transcription, and we further elucidated the molecular mechenism of TFIIH regulation by TFIIE upon binding.
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