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Unified crosstalk of signal transduction, chromatin regulation, and RNA processing by transcription complexes

Research Project

Project/Area Number 17054022
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionUniversity of Toyama

Principal Investigator

OHKUMA Yoshiaki  University of Toyama, 大学院・医学薬学研究部, 教授 (70192515)

Co-Investigator(Kenkyū-buntansha) 廣瀬 豊  富山大学, 大学院医学薬学部, 助手 (00218851)
田中 亜紀  富山大学, 大学院医学薬学部, 助手 (50432109)
高野 克彦  富山大学, 薬学部, 助手 (50293303)
Co-Investigator(Renkei-kenkyūsha) HIROSE Yutaka  富山大学, 大学院・医学薬学研究部, 准教授 (00218851)
TANAKA Aki  富山大学, 大学院・医学薬学研究部, 助教 (50432109)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥77,900,000 (Direct Cost: ¥77,900,000)
Fiscal Year 2009: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2008: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2007: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2006: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2005: ¥14,500,000 (Direct Cost: ¥14,500,000)
KeywordsRNAポリメラーゼII(Pol II) / 基本転写因子TFIIH / CTD / メディエーター複合体 / リン酸化 / コファクター / TFIIE / フォークヘッドドメイン / ルディエーター複合体 / CDK19 / 酵母2ハイブリッド法 / Rpb5 / 基本転写因子 / TFIIEβ / Rpb / MED15 / KIXドメイン / CDK8 / CDK11 / TFIIH / Rpb12 / Znフィンガードメイン
Research Abstract

The applicants characterized the functions of two general transcription factors, TFIIE and TFIIH, which assist Pol II for accurate transcription, and the multisubunit Mediator complex which transduces transcriptional activation signals to Pol II in the nucleus. As for Mediator, we demonstrated that two CDK subunits play a role as a molecular switch between positive and negative regulations in transcription, and we further elucidated the molecular mechenism of TFIIH regulation by TFIIE upon binding.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (25 results) (of which Peer Reviewed: 18 results) Presentation (40 results) Book (10 results)

  • [Journal Article] メディエーター複合体によるタンパク質リン酸化がもたらす転写制御機構2010

    • Author(s)
      筒井大気、大熊芳明
    • Journal Title

      生化学 82

      Pages: 191-199

    • NAID

      10026300664

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The central forkhead domain of the small subunit of TFIIE plays a primary role in double-stranded DNA binding at transcription initiation2009

    • Author(s)
      Tanaka, A., Watanabe, T., Iida, Y., Hanaoka, F., Ohkuma, Y
    • Journal Title

      Genes Cells 14

      Pages: 395-405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells2009

    • Author(s)
      Yunokuchi, I., Fan, H., Iwamoto, Y., Araki, C., Yuda, M., Umemura, H., Harada, F., Ohkuma, Y., Hirose, Y
    • Journal Title

      Genes Cells 14

      Pages: 1105-1118

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The central forkhead domain of the small subunit of TFIIE plays a primaryrole in double-stranded DNA binding at transcription initiation.2009

    • Author(s)
      Tanaka, A., Watanabe, T., Iida, Y., Hanaoka, F., Ohkuma, Y.
    • Journal Title

      Genes Cells 14

      Pages: 395-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolylisomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells.2009

    • Author(s)
      Yunokuchi, I., Fan, H., Iwamoto, Y., Araki, C., Yuda, M., Umemura, H., Harada, F., Ohkuma, Y., Hirose, Y.
    • Journal Title

      Genes Cells 14

      Pages: 1105-1118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The central forkhead domain of the small subunit of TFIIE plays a primary role in double-stranded DNA binding at transcription initiation2009

    • Author(s)
      Tanaka, A.
    • Journal Title

      Genes Cells 14

      Pages: 395-405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural insight into the TFIIE/TFIIH: TFIIE and p53 share the binding region on TFIIH2008

    • Author(s)
      Okuda, M., *Tanaka, A., Satoh, M., Takazawa, M., Mizuta, S., Ohkuma, Y., Nishimura, Y
    • Journal Title

      EMBO J 27

      Pages: 1161-1171

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human Mediator Kinase Subunit CDK11 Plays a Negative Role in Viral Activator VP16-dependent Transcription2008

    • Author(s)
      Tsutsui, T., Umemura, H., Tanaka, A., Mizuki, F., Hirose, Y., Ohkuma, Y
    • Journal Title

      Genes Cells 13

      Pages: 817-826

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II2008

    • Author(s)
      Hirose, Y., *Iwamoto, Y., Sakuraba, K., Yunokuchi, I., Harada, F., Ohkuma, Y
    • Journal Title

      Biochem. Biophys. Res. Comm 69

      Pages: 449-455

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural characterization of human transcription factor TFIIF in solution2008

    • Author(s)
      Akashi, S., Nagakura, S., Yamamoto, S., Ohkuma, Y., Nishimura, Y
    • Journal Title

      Protein Science 17

      Pages: 389-400

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mouse nucleolin binds to 4. 5S RNAh, a small noncoding RNA2008

    • Author(s)
      Hirose, Y., Harada, F
    • Journal Title

      Biochem. Biophys. Res. Commun 365

      Pages: 62-68

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural insight into the TFIIE/TFIIH : TFIIE and p53 share the binding region on TFIIH2008

    • Author(s)
      Okuda, M.
    • Journal Title

      EMBO J. 27

      Pages: 1161-1171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II2008

    • Author(s)
      Hirose, Y.
    • Journal Title

      Biochem. Biophys. Res. Comm. 69

      Pages: 449-455

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural characterization of human transcription factor TFIIF in solution2008

    • Author(s)
      Akashi, S.
    • Journal Title

      Protein Science 17

      Pages: 389-400

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Mediator Kinase Subunit CDK11 Plays a Negative Role in Viral Activator VP16-dependent Transcription.2008

    • Author(s)
      Ohkuma, Y.
    • Journal Title

      Genes to Cells 13

      Pages: 817-826

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A kinase subunit of the human Mediator complex, CDK8, positively regulates transcriptional activation2007

    • Author(s)
      Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F., Ohkuma, Y
    • Journal Title

      Genes Cells 12

      Pages: 119-132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eukaryotic gene expression2007

    • Author(s)
      Hirose, Y., Ohkuma, Y
    • Journal Title

      J. Biochem 122

      Pages: 481-489

    • Related Report
      2009 Final Research Report
  • [Journal Article] A kinase subunit of the human Mediator complex, CDK8, positively regulates transcriptional activation.2007

    • Author(s)
      Furumoto, T. et al.
    • Journal Title

      Genes Cells 12・1

      Pages: 119-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eukaryotic gene expression.2007

    • Author(s)
      Hirose, Y., Ohkuma, Y.
    • Journal Title

      J. Biochem. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation2005

    • Author(s)
      Hayashi, K., Watanabe, T., Tanaka, A., Furumoto, T., Sato-Tsuchiya, C., Kimura, M., Yokoi, M., Ishihama, A., Hanaoka, F., Ohkuma, Y
    • Journal Title

      Genes Cells 10

      Pages: 207-224

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEα for transcription2005

    • Author(s)
      Okuda, M., Tanaka, A., Hanaoka, F., Ohkuma, Y., Nishimura, Y
    • Journal Title

      J. Biochem 138

      Pages: 443-449

    • NAID

      10017347670

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitogenic activity of S100A9 (MRP-14). Biol2005

    • Author(s)
      Shibata, F., Ito, A., Ohkuma, Y., Mitsui, K
    • Journal Title

      Pharm. Bull 28

      Pages: 2312-2314

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Studies of Schizosaccharomyces pombe THE indicate conformational and functional changes in RNA polymerase II at transcription initiation.2005

    • Author(s)
      Hayashi, K.et al.
    • Journal Title

      Genes Cells 10・3

      Pages: 207-224

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mitogenic activity of S100A9 (MRP-14).2005

    • Author(s)
      Shibata, F.et al.
    • Journal Title

      Biol.Pharm.Bull. 28・12

      Pages: 2312-2314

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEα for transcription.2005

    • Author(s)
      Okuda, M., et al.
    • Journal Title

      J.Biochem. 138・4

      Pages: 443-449

    • Related Report
      2005 Annual Research Report
  • [Presentation] 転写活性化シグナルはいかにしてRNAポリメラーゼIIへと伝達されるのか?2009

    • Author(s)
      大熊芳明
    • Organizer
      日本生化学会北海道支部,日本薬学会北海道支部共催,北海道大学大学院薬学研究院特別セミナー
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mediator complexes play various roles in transcription2009

    • Author(s)
      Ohkuma, Y., Tsutsui, T., Umemura, H., Nakatsubo, T
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA [II]
    • Place of Presentation
      Chateraise Gateaux Kingdom Sapporo, Sapporo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Mediator MED15 and general transcription factor TFIIE interact to regulate RNA polymerase II transcription2009

    • Author(s)
      Nakatsubo, T., Tanaka, A., Tsutsui, T., Mizuki, F., Ohkuma, Y
    • Organizer
      The 2009 CSH Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional characterization of the vertebrate phosphorylated CTD-interacting protein PCIF12009

    • Author(s)
      Hirose, Y., Iwamoto, Y., Yunokuchi, I., Araki, C., Harada, H., Ho, K., Shuman, S., Mizuta, S., Ohkuma, Y
    • Organizer
      The 2009 CSH Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 基本転写因子TFIIEによる2種のRNAポリメラーゼIICTDキナーゼ複合体の制御. シンポジウム1S14pタンパク質修飾による遺伝子発現制御のクロストーク2009

    • Author(s)
      大熊芳明, 中坪拓也, 後藤さやか, 筒井大気, 田中亜紀
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊椎動物リン酸化RNAポリメラーゼII制御因子の機能解析2009

    • Author(s)
      広瀬豊, 岩本悠, 山本真也, 荒木千里, 河野隆英, 水口峰之, 原田文夫, 大熊芳明
    • Organizer
      遺伝情報DECODE・冬のワークショップ(転写研究会共催)
    • Place of Presentation
      湯沢
    • Related Report
      2009 Final Research Report
  • [Presentation] Mediator complexes play various roles in transcription.2009

    • Author(s)
      Ohkuma Y.
    • Organizer
      The 24th Naito Conference on Nuclear Dynamics and RNA [II]
    • Place of Presentation
      Chateraise Gateaux Kingdom Sapporo, Sapporo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mediator MED15 and general transcription factor TFIIE interact to regulate RNA polymerase II transcription.2009

    • Author(s)
      Ohkuma Y.
    • Organizer
      The 2009 CSH Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor, NY, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional characterization of the vertebrate phosphorylated CTD-interacting protein PCIF1.2009

    • Author(s)
      Hirose Y.
    • Organizer
      The 2009 CSH Meeting on Mechanisms of Eukaryotic Transcription
    • Place of Presentation
      Cold Spring Harbor, NY, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 基本転写因子TFIIEによる2種のRNAポリメラーゼIICTDキナーゼ複合体の制御2009

    • Author(s)
      大熊芳明
    • Organizer
      第82回日本生化学会大会 シンポジウム「タンパク質修飾による遺伝子発現制御のクロストーク」
    • Place of Presentation
      神戸ポートピアホテル、神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] メディエーターの2つのCDKサブユニットCDK8とCDK11は転写において正反対に機能する2008

    • Author(s)
      大熊芳明
    • Organizer
      北海道大学大学院薬学研究院特別講演会(共催:日本薬学会北海道支部, 日本生化学会北海道支部, 北海道分子生物学研究会)
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-16
    • Related Report
      2009 Final Research Report
  • [Presentation] メディエーターの2つのCDKサブユニットCDK8とCDK11は転写において正反対に機能する.2008

    • Author(s)
      大熊芳明
    • Organizer
      日本生化学会北海道支部
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 転写とDNA修復のスイッチモデルーp53と基本転写因子TFIIEによるTFIIHの受渡し2008

    • Author(s)
      大熊芳明
    • Organizer
      「特定領域研究」2領域合同公開シンポジウム「クロマチンシグナリングの分子機構」
    • Place of Presentation
      東京
    • Year and Date
      2008-01-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Studies on the Mechanisms of Nuclear Signaling via Transcription Apparatus2008

    • Author(s)
      Ohkuma, Y
    • Organizer
      The 21st Naito Conference on Nuclear Dynamics and RNA [I]
    • Place of Presentation
      Yatsugatake Royal Hotel, Yamanashi, Japan
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Functional study of novel Mediator kinase subunit CDK11 in transcriptional regulation2008

    • Author(s)
      Tsutsui T., Umemura H., Tanaka A., Mizuki F., Hirose Y., Ohkuma Y
    • Organizer
      The 21st Naito Conference on Nuclear Dynamics and RNA [I]
    • Place of Presentation
      Yatsugatake Royal Hotel, Yamanashi, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Two CDK subunits of Mediator complex play opposite roles each other in transcriptional repression2008

    • Author(s)
      Ohkuma, Y
    • Organizer
      8th EMBL Transcription Meeting
    • Place of Presentation
      EMBL, Heidelberg, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] Specific interaction of TFIIEα acidic domain with TFIIH p62 PH domain in regulation of initiation transcription2008

    • Author(s)
      Tanaka, A., Mizuta, S., Takazawa, M., Okuda, M., Nishimura, Y., Ohkuma, Y
    • Organizer
      8th EMBL Transcription Meeting
    • Place of Presentation
      EMBL, Heidelberg, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional study on novel Mediator subunit CDK11 in transcriptional regulation2008

    • Author(s)
      Tsutsui, T., Umemura, H., Tanaka, A., Mizuki, F., Hirose, Y., Ohkuma, Y
    • Organizer
      8th EMBL Transcription Meeting
    • Place of Presentation
      EMBL, Heidelberg, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] メディエーター複合体の新規キナーゼサブユニットの機能解析2008

    • Author(s)
      梅村啓靖, 筒井大気, 田中亜紀, 廣瀬豊, 大熊芳明
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写制御におけるメディエーター複合体サブユニットMED15の機能解析2008

    • Author(s)
      大熊芳明
    • Organizer
      第81回日本生化学学会大会、合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Two CDK subunits of Mediator complex play opposite roles each other in transcriptional repression.2008

    • Author(s)
      Ohkuma Y.
    • Organizer
      8th EMBL Transcription Meeting
    • Place of Presentation
      EMBL, Heidelberg, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Roles of Conformational Changes in Transcription Complexes2007

    • Author(s)
      Ohkuma, Y
    • Organizer
      International Symposium on Systems Biology Initiative at University of Tokyo
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional studies on TFIIE and its mediated changes of RNA polymerase II in association with TFIIH and Mediator2007

    • Author(s)
      Nakatsubo, T., Goto, S., Iida, Y., Tanaka, A., Ohkuma, Y
    • Organizer
      10th Cold Spring Harbor Meeting on Cancer Cells: mechanisms of eukaryotic transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] hCDK8, a kinase subunit of human Mediator complex, plays a positive role in transcription2007

    • Author(s)
      Umemura, H., Tsutsui, T., Nakatsubo, T., Tanaka, A., Hirose, Y., Ohkuma, Y
    • Organizer
      10th Cold Spring Harbor Meeting on Cancer Cells
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子発現におけるRNAポリメラーゼIIの制御2007

    • Author(s)
      大熊芳明
    • Organizer
      第7回転写研究会冬のワークショップ
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトメディエーター複合体のキナーゼサブユニットCDK8は転写活性化を正に制御する2007

    • Author(s)
      大熊芳明, 古元義, 田中亜紀, 花岡文雄
    • Organizer
      日本薬学会第127年会 シンポジウム「核内情報受容から遺伝子発現への機構-その分子レベルでのアプローチ」
    • Place of Presentation
      富山
    • Related Report
      2009 Final Research Report
  • [Presentation] リン酸化RNAポリメラーゼII結合因子PCIF1による脊椎動物遺伝子発現調節2007

    • Author(s)
      廣瀬豊, 荒木千里, 范紅, 湯の口いずみ, 湯田昌道, 原田文夫, 大熊芳明
    • Organizer
      日本薬学会第127年会 シンポジウム「核内情報受容から遺伝子発現への機構-その分子レベルでのアプローチ」
    • Place of Presentation
      富山
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写メディエーターから基本転写装置へのシグナリング2007

    • Author(s)
      田中亜紀, 古元義, 廣瀬豊, 花岡文雄, 大熊芳明
    • Organizer
      BMB2007ワークショップ「遺伝子発現に向けた核内シグナリング」
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Two opposed transcriptional roles of human Mediator complexes are supported by distinct subunits2006

    • Author(s)
      Ohkuma, Y
    • Organizer
      German Science Foundation
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2006-08-31
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional studies of human Mediator subunits2006

    • Author(s)
      Furumoto, T., Ito, M., Roeder, R.G., Hanaoka, F., Ohkuma, Y
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] The winged helix regions of human TFIIE are essential for transcription of RNA polymerase II2006

    • Author(s)
      Tanaka, A., Watanabe, T., Hanaoka, F., Ohkuma, Y
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional characterization of the phosphorylated RNA polymerase II interacting factor PCIF12006

    • Author(s)
      Hirose, Y., Yuda, M., Yunokuchi, I., Fan, H., Ho, K., Shuman, S., Harada, F
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] A kinase subunit of human Mediator complex CDK8 plays a positive role in transcription2006

    • Author(s)
      Furumoto, T., Tanaka, A., Malik, S., Roeder, R.G., Hanaoka, F., Ohkuma, Y
    • Organizer
      7th EMBL Transcription Meeting
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional characterization of the phosphorylated RNA polymerase II interacting factor PCIF12006

    • Author(s)
      Hirose, Y., Araki, C., Yuda, M., Yunokuchi, I., Fan, H., Harada, F., Ohkuma, Y
    • Organizer
      RNA 2006 Izu "Functional RNAs and Regulatory Machinery"
    • Place of Presentation
      Izunokuni, Japan1
    • Related Report
      2009 Final Research Report
  • [Presentation] リン酸化RNAポリメラーゼII-CTD結合蛋白質PCIF1の機能解析2006

    • Author(s)
      廣瀬豊, 湯田昌道, 湯の口いずみ, 范紅, 原田文夫, 大熊芳明
    • Organizer
      第8回RNAミーティング
    • Place of Presentation
      淡路島
    • Related Report
      2009 Final Research Report
  • [Presentation] TFIIE induces conformational and functional changes in RNA polymerase II during transcription initiation2005

    • Author(s)
      Hayashi, K., Watanabe, T., Tanaka, A., Furumoto, T., Sato-Tsuchiya, C., Yokoi, M., Hanaoka, F., Ohkuma, Y
    • Organizer
      9th Cold Spring Harbor Meeting on Cancer Cells: mechanisms of eukaryotic transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional studies of human Mediator subunit Med18/p28b2005

    • Author(s)
      Furumoto, T., Tanaka, A., Malik, S., Ito, M., Roeder, R.G., Hanaoka, F., Ohkuma, Y
    • Organizer
      9th Cold Spring Harbor Meeting on Cancer Cells: mechanisms of eukaryotic transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional elucidations of the subdomains of the small subunit of TFIIE2005

    • Author(s)
      Tanaka, A., Hanaoka, F., Ohkuma, Y
    • Organizer
      9th Cold Spring Harbor Meeting on Cancer Cells: mechanisms of eukaryotic transcription
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Coordinated regulation for gene expression - From the studies of the general transcription factors and the Mediator2005

    • Author(s)
      Ohkuma, Y
    • Organizer
      Nagasaki Symposium on the Nuclear System to Decipher Operation Code for Biological Responses
    • Place of Presentation
      Nagasaki, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] 真核生物細胞核内の遺伝子発現ネットワーク:基本転写因子TFIIEは転写のスイッチである2005

    • Author(s)
      林和洋、田中亜紀、古元義、佐藤-土屋千晶、花岡文雄、大熊芳明
    • Organizer
      第28回日本分子生物学会年会, ワークショップ「蛋白質・核酸の修飾による転写制御を中心とした核内クロストーク」
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Book] 2章 遺伝情報の保持と伝達:2(編集:田村隆明,山本 雅, 改訂第3版 分子生物学イラストレイテッド)2009

    • Author(s)
      大熊芳明
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] 7章 真核生物の転写の分子機構(編集:菊池 洋, ノーベル賞の生命科学入門RNAが拓く新世界)2009

    • Author(s)
      大熊芳明
    • Publisher
      講談社
    • Related Report
      2009 Final Research Report
  • [Book] III.RNAのプロセシングと編集:mRNAポリメラーゼII-CTDリン酸化制御による転写とmRNAプロセシングの共役「mRNAプログラム-多様性と非対称の獲得戦略」(編集:稲田利文,大野睦人, 蛋白質・核酸・酵素, 12月号増刊)2009

    • Author(s)
      廣瀬豊
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 著書名「ノーベル賞の生命科学入門RNAが拓く新世界」、編集:菊池洋、第7章 真核生物の転写の分子機構2009

    • Author(s)
      大熊芳明
    • Total Pages
      180
    • Publisher
      講談社
    • Related Report
      2009 Annual Research Report
  • [Book] IV.転写制御にかかわる分子群 第12章 基本転写因子による転写開始の分子機構(編集:加藤茂明, 転写制御の分子生物学-ゲノムデコードに向けて-)2008

    • Author(s)
      大熊芳明
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 分子細胞生物学辞典 第2版(TFIIE、TFIIH、TFIIK、PC4、プロモータークリアランス)2008

    • Author(s)
      大熊芳明
    • Publisher
      東京化学同人
    • Related Report
      2009 Final Research Report
  • [Book] 著書名「改訂第3版分子生物学イラストレイテッド」, 編集 : 田村隆明, 山本雅, 2章遺伝情報の保持と伝達第2項転写機構2008

    • Author(s)
      大熊芳明
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Book] 著書名「転写制御の分子生物学-ゲノムデコードに向けて-」, 編集 : 加藤茂明, IV.転写制御にかかわる分子群第12章基本転写因子による転写開始の分子機構2008

    • Author(s)
      大熊芳明
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Book] 著書名「分子細胞生物学辞典」担当用語TFIIE, TFIIH, TFIIK, PC4, プロモータークリアランス2008

    • Author(s)
      大熊芳明
    • Publisher
      東京化学同人
    • Related Report
      2008 Annual Research Report
  • [Book] 転写装置シグナリング、「転写因子による生命現象解明の最前線-クロマチン制御機構・エピジェネティクスと転写因子複合体ネットワークの包括的解明-」(編集:五十嵐和彦,深水昭吉,大熊芳明,山本雅之, 実験医学6月号増刊, 25巻)2007

    • Author(s)
      大熊芳明
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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