| Budget Amount *help |
¥141,200,000 (Direct Cost: ¥141,200,000)
Fiscal Year 2009: ¥28,400,000 (Direct Cost: ¥28,400,000)
Fiscal Year 2008: ¥28,400,000 (Direct Cost: ¥28,400,000)
Fiscal Year 2007: ¥28,400,000 (Direct Cost: ¥28,400,000)
Fiscal Year 2006: ¥28,400,000 (Direct Cost: ¥28,400,000)
Fiscal Year 2005: ¥27,600,000 (Direct Cost: ¥27,600,000)
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| Research Abstract |
DECODE complexes of Bach1, Bach2, and MafK were purified and characterized by using mass spectrometry analysis. Bach1 was found to interact with the tumor suppressor p53 and to inhibit cellular senescence induced by oxidative stress. Bach1 recruits histone deacetylase 1 to some of the p53 target genes and promotes histone deacetylation. In addition, a DECODE gene circuit for the class switch recombination of antibody genes has been identified.
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