Efficient Carbon Skeleton Constructing Reactions by Use of Small Hydrocarbon Compounds or Carbon Monoxide

• Project/Area Number: 17065015
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: KAMBE Nobuaki Osaka University, 大学院・工学研究科, 教授 (60144432)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥26,900,000 (Direct Cost: ¥26,900,000); Fiscal Year 2008: ¥7,700,000 (Direct Cost: ¥7,700,000); Fiscal Year 2007: ¥7,700,000 (Direct Cost: ¥7,700,000); Fiscal Year 2006: ¥7,700,000 (Direct Cost: ¥7,700,000); Fiscal Year 2005: ¥3,800,000 (Direct Cost: ¥3,800,000)
• Keywords: ブタジエン / 共役エンイン / 分子内付加反応 / 銅触媒 / パラジウム触媒 / アルキン / アレン / 一酸化炭素 / メチレンシクロプロパン / グリニャール試薬 / カルボマグネシウム化反応 / ニッケル触媒 / 多成分カップリング反応 / クロロシラン / シリル化反応 / 位置選択的炭素-炭素結合開裂 / ハロゲン化アルキル / 炭素-ケイ素結合形成反応 / 炭素-炭素結合形成反応

Research Abstract

本研究では、安価で多量に供給されるブタジエンなどの小分子を用いて、有用な炭素骨格を一挙に構築する新しい手法を確立し、超効率精密分子変換法として有機合成プロセスの新しい展開を目指した。反応としては、遷移金属触媒では今まで例の少なかったアルキル化反応に焦点を当てると共に、シリル化反応についても検討した。この反応においては、アニオン性錯体を鍵活性種とする作業仮説に沿って研究を行った。その結果、ブタジエン骨格へのアルキル化を経る付加反応を種々開発した。また、C2ユニットとしてビニルグリニャール試薬を用いる炭素一炭素結合生成反応の開発を試み、ビニル基の二量化によるC4ユニットの構築とアルキル化反応を組み合わせる事により、アリル及びホモアリルグリニャール試薬の生成を経るオレフィン類の新しい合成法を開発した。更に、これらの知見をアルキンやエンインへの反応に適用し、種々のアルキル化反応を開発した。さらに、基質としてアルキルハライドのみではなく、アルキルグリニヤール試薬を用いたアルキル化反応への展開を行った。また、アレンへの分子内および分子間付加反応や一酸化炭素を利用する環化付加反応の研究では、5員環から8員環のヘテロ原子化合物の新規な合成反応を開発した。

Research Products

• [Journal Article] Transition-metal-catalyzed Regioselective Aroyl-and Trifluoro-acetylthiolation of Alkynes Using Thioesters. (2009)
  • Author(s): Minami, Y.; Kuniyasu, H.; Miyafu ji, K.; Kambe, N.
  • Journal Title: Chemical Commun. Pages: 3080-3082
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Intramolecular Se lenocarbamoylat ion of Al lenes with Carbamoselenoates: A New Entry toα, β-Unsaturated Lactams. (2009)
  • Author(s): Toyofuku, M.; Murase, E.; Nagai, H.; Fujiwara, S. -i.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Eur. J. Org. Chem. Pages: 3141-3144
  • Peer Reviewed
• [Journal Article] A new Entry toα-Alkyl idene- β-lactams by 4-Exo-dig Cyclizat ion of Carbamoyl Radicals. (2009)
  • Author(s): Fujiwara, S. -i.; Shimizu, Y.; Imahori, Y.; Toyofuku, M.; Shin-ike, T.; Kambe, N.
  • Journal Title: Tetrahedron Lett. 50 Pages: 3628-3630
  • Peer Reviewed
• [Journal Article] Structure, Bonding, and Aggregation of Selenium-Containing Organolithium Species. (2009)
  • Author(s): Pratt, L. M,; Fujiwara, S.; Kambe, N.
  • Journal Title: Tetrahedron 65 Pages: 1017-1025
  • Peer Reviewed
• [Journal Article] Structure, Bonding, and Aggregation of Selenium-Containing Organolithium Species. (2009)
  • Author(s): Pratt, L.M.; Fujiwara, S.; Kambe, N.
  • Journal Title: Tetrahedron 65 Pages: 1017-1025
  • Peer Reviewed
• [Journal Article] A new Entry to α-Alkylidene-β-lactams by 4-Exo-dig Cyclization of Carbamoyl Radicals. (2009)
  • Author(s): Fujiwara, S.-i.; Shimizu, Y.; Imahori, Y.; Toyofuku, M.; Shin-ike, T.; Kambe, N.
  • Journal Title: Tetrahedron Lett. 50 Pages: 3628-3630
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Intramolecular Selenocarbamoylation of Allenes with Carbamoselenoates : A New Entry to α,β-Unsaturated Lactams. (2009)
  • Author(s): Toyofuku, M.; Murase, E.; Nagai, H.; Fujiwara, S.-i.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Eur.J.Org.Chem. 2009 Pages: 3141-3144
  • Peer Reviewed
• [Journal Article] Transition-metal-catalyzed Regioselective Aroyl- and Trifluoro-acetylthiolation of Alkynes Using Thioesters. (2009)
  • Author(s): Minami, Y.; Kuniyasu, H.; Miyafuji, K.; Kambe, N.
  • Journal Title: Chemical Commun. 2009 Pages: 3080-3082
  • Peer Reviewed
• [Journal Article] Cross-Coupling Reaction of Alkyl Halides with Grignard Reagents Catalyzed by Ni, Pd, or Cu Complexes withπ-Carbon Ligand (s). (2008)
  • Author(s): Terao, J,; Kambe, N.
  • Journal Title: Acc. Chem. Res. 41 Pages: 1545-1554
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Selenoacylation of Allenes Leading to the Regioselective Formation of Functionalized Allyl Selenides. (2008)
  • Author(s): Toyofuku, M.; Murase, E.; Fujiwara, S.; Shin-iike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Org. Lett. 10 Pages: 3957-3960
  • Peer Reviewed
• [Journal Article] Platinum-Catalyzed Intramolecular Vinylchalcogenation of Alkynes with -Phenylchalcogeno Conjugated Amides. (2008)
  • Author(s): Toyofuku, M,; Fujiwara, S.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 10504-10505
  • Peer Reviewed
• [Journal Article] One-Pot Syntheses of 2, 3-Dihydrothiopyran-4-One Derivatives by Pd/Cu-Catalyzed Reactions of α, β-Unsaturated Thioesters with Propargyl Alcohols. (2008)
  • Author(s): Minami, Y.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Org. Lett. 10 Pages: 2469-2472
  • Peer Reviewed
• [Journal Article] Cu-Catalyzed Regioselective Carbomagnesiation of Dienes and Enynes with sec-and tert-Alkyl Grignard Reagents. (2008)
  • Author(s): Todo, H.; Terao, J.; Watanabe, H.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Chem. Commun. Pages: 1332-1334
  • Peer Reviewed
• [Journal Article] Titanocene-Catalyzed Regioselective Alkylation of Styrenes with Grignard Reagents using β-Bromoethyl Ethers, Thioethers, or Amines. (2008)
  • Author(s): Terao, J.; Kato, Y.; Kambe, N.
  • Journal Title: Chem. Asian. J. 3 Pages: 1472-1478
  • Peer Reviewed
• [Journal Article] Platinum-Catalyzed Intramolecular Vinylchalcogenation of Alkynes with β-Phenylchalcogeno Conjugated Amides (2008)
  • Author(s): Toyofuku, M.; Fujiwara, S.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 10504-10505
  • Peer Reviewed
• [Journal Article] Carbon-carbon bond-forming reactions using alkyl fluorides (2008)
  • Author(s): Terao, J.; Todo, H.; Watabe, H.; Ikumi, A.; Shinohara, Y.; Kambe, N.
  • Journal Title: Pure Appl. Chem. Pages: 941-951
  • Peer Reviewed
• [Journal Article] Cu-Catalyzed Regioselective Carbomagnesiation of Dienes and Enynes with sec- and tert-Alkyl Grignard Reagents. (2008)
  • Author(s): Todo, H.; Terao, J.; Watanabe, H.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Chem.Commun. 2008 Pages: 1332-1334
  • Peer Reviewed
• [Journal Article] One-Pot Syntheses of 2,3-Dihydrothiopyran-4-one Derivatives by Pd/Cu-Catalyzed Reactions of α,β-Unsaturated Thioesters with Propargyl Alcohols. (2008)
  • Author(s): Minami, Y.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Org.Lett. 10 Pages: 2469-2472
  • Peer Reviewed
• [Journal Article] Platinum-Catalyzed Intramolecular Vinylchalcogenation of Alkynes with β-Phenylchalcogeno Conjugated Amides. (2008)
  • Author(s): Toyofuku, M.; Fujiwara, S.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: J.Am.Chem.Soc. 130 Pages: 10504-10505
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Selenoacylation of Allenes Leading to the Regioselective Formation of Functionalized Allyl Selenides. (2008)
  • Author(s): Toyofuku, M.; Murase, E.; Fujiwara, S.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Org.Lett. 10 Pages: 3957-3960
  • Peer Reviewed
• [Journal Article] Cross-Coupling Reaction of Alkyl Halides with Grignard Reagents Catalyzed by Ni, Pd, or Cu Complexes with π-Carbon Ligand(s). (2008)
  • Author(s): Terao, J.; Kambe, N.
  • Journal Title: Acc.Chem.Res. 41 Pages: 1545-1554
  • Peer Reviewed
• [Journal Article] Free Radical Tandem Addition/Cyclization of Te-Phenyl N,N-Dimethyl-carbamotelluroate to 1,6-Enynes (2008)
  • Author(s): Shin-ichi Fujiwara, Yoshihiko Shimizu, Yoshimasa Makita, Tsutomu Shin-ike, Nobuaki Kambe
  • Journal Title: Heterocycles (印刷中)
  • Peer Reviewed
• [Journal Article] One-Pot Syntheses of 2,3-Dihydrothiopyran-4-one Derivatives by Pd/Cu-Catalyzed Reactions of α,β-Unsaturated Thioesters with Propargyl Alcohols (2008)
  • Author(s): Yasunori Minami, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Org. Lett. 10 Pages: 2469-2472
  • Peer Reviewed
• [Journal Article] Cu-Catalyzed Regioselective Carbomagnesiation of Dienes and Enynes with sec- and tert-Alkyl Grignard Reagents (2008)
  • Author(s): Hirohisa Todo, Jun Terao, Hideyuki Watanabe, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Chem. Commun. Pages: 1332-1334
  • Peer Reviewed
• [Journal Article] Platinum-Catalyzed Regio- and Stereoselective Arylthiolation of Internal Alkynes (2008)
  • Author(s): Yamashita, Fumikazu ; Kuniyasu, Hitoshi ; Terao, Jun ; Kambe, Nobuaki
  • Journal Title: Org. Lett. 10 Pages: 101-104
  • Peer Reviewed
• [Journal Article] Transition Metal Catalyzed Carbon-Silicon Bond Forming Reactions Using Chlorosilanes Promoted by Grignard Reagents (2007)
  • Author(s): Terao, J.; Kambe, N.
  • Journal Title: Chem, Rec. 7 Pages: 57-67
  • Peer Reviewed
• [Journal Article] Copper-catalyzed Cross-coupling Reaction of Grignard Reagents with Primary-alkyl Halides: Remarkable Effect of 1-Phenylpropyne (2007)
  • Author(s): Terao, J.; Todo, H.; Begum, S.A.; Kuniyasu, H.; Kambe, N.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 2086-2089
  • Peer Reviewed
• [Journal Article] Copper(I)-catalyzed Highly Efficient Synthesis of Benzoselenazoles and Benzotellurazoles (2007)
  • Author(s): Fujiwara, Shin-ichi ; Asanuma,Yoshiaki ; Shin-ike, Tsutomu ; Kambe, Nobuaki
  • Journal Title: J. Org. Chem. 72 Pages: 8087-8090
  • Peer Reviewed
• [Journal Article] Nickel-catalyzed dimerization coupling reactions of vinyl Grignard reagents with 3,4-membered cyclic ethers and chlorosilanes (2007)
  • Author(s): Fujii, Yuuki ; Terao, Jun ; Watabe, Hiroyasu ; Watanabe, Hiroyuki ; Kambe, Nobuaki
  • Journal Title: Tetrahedron 63 Pages: 6635-6641
  • Peer Reviewed
• [Journal Article] Definitive Evidence for the Insertion of Terminal Alkynes into Ary1S-Pt Bonds : "o-Halogen Effect" in Stoichiometric and Catalytic Reactions (2007)
  • Author(s): Kuniyasu, Hitoshi ; Yamashita, Fumikazu ; Terao, Jun ; Kambe, Nobuaki
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 5229-5933
  • Peer Reviewed
• [Journal Article] Transition Metal Catalyzed Carbon-Silicon Bond Forming Reactions Using Chlorosilanes Promoted by Grignard Reagents (2007)
  • Author(s): Jun Terao, Nobuaki Kambe
  • Journal Title: Chem. Record. 7・1 Pages: 57-57
• [Journal Article] Conversion of a(sp3)C-F bond of alkyl fluorides to(sp3)C-X(X=Cl, C, H, O, S, Se, Te, N)bonds using organoaluminium reagents (2007)
  • Author(s): Jun Terao, Shameem Ara Begum, Yoshiaki Shinohara, Masahiro Tomita, Yoshitaka Naitoh, Nobuaki Kambe
  • Journal Title: Chem. Commun. 8 Pages: 855-855
• [Journal Article] Cu-Catalyzed Cross-Coupling Reaction of Grignard Reagents with primary-Alkyl Chlorides:Remerkable Effect of 1-Phenylpropyne (2007)
  • Author(s): Jun Terao, Hirohisa Todo, Shameem Ara Begum, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 2086-2086
• [Journal Article] Transition Metal-Catalyzed C-C Bond Formation Reactions Using Alkyl Halides. (2006)
  • Author(s): Terao, J.; Kambe, N.
  • Journal Title: Bull. Chem. Soc. Jpn. 79 Pages: 663-672
  • Peer Reviewed
• [Journal Article] Transition Metal-Catalyzed C-C Bond Formation Reactions Using Alkyl Halides (2006)
  • Author(s): Terao, J.; Kambe, N.
  • Journal Title: Bull. Chem. Soc. Jpn. 79・5 Pages: 663-672
• [Journal Article] Generation of Carbamoyl-and Thiocarbamoyllithium Synthons Having a Hydrogen(s)or an Aryl Group on the Nitrogen and Their Trapping with Carbonyl Electrophiles (2006)
  • Author(s): Nobuaki Kambe, Toru Inoue, Takanobu Takeda, Shin-ichi Fujiwara, Noboru Sonoda
  • Journal Title: J. Am. Chem. Soc. 128・39 Pages: 12650-12651
• [Journal Article] Transition Metal-catalyzed Carbochalcogenation of Alkynes (2006)
  • Author(s): Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Chem. Lett. 35・12 Pages: 1320-1321
• [Journal Article] The first definitive example of oxidative addition of acyclic vinyl selenide to M(0)complex (2006)
  • Author(s): Hitoshi Kuniyasu, Tomohiro Kato, Masafumi Inoue, Jun Terao, Nobuaki Kambe
  • Journal Title: J. Organomet. Chem. 691・9 Pages: 1873-1878
• [Journal Article] Silylation and alkylation of allenes using chlorosilanes and alkyl halides in the presence of palladium catalyst and Grignard reagents (2006)
  • Author(s): Yuuki Fujii, Jun Terao, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: J. Organomett. Chem. 692・1-3 Pages: 375-381
• [Journal Article] β-cis-SAr effect on decarbonylation from α, β-unsaturated acyl and aroyl complexes (2006)
  • Author(s): Tomohiro Kato, Hitoshi Kuniyasu, Takamichi Kajiura, Yasunori Minami, Atsushi Ohtaka, Masanori Kinomoto, Jun Terao, Hideo Kurosawa, Nobuaki Kambe
  • Journal Title: Chem Commun. 12 Pages: 868-870
• [Journal Article] Pd-catalyzed thiocarbamoylation of terminal alkynes with sulfenamide and carbon monoxide (2006)
  • Author(s): Hitoshi Kuniyasu, Tomohiro Kato, Shigehito Asano, Jia-Hai Ye, Ohmori Takumi, Masaski Morita, Hiroshi Hiraike, Shin-ichi Fujiwara, Jun Terao, Hideo Kurosawa, Nobuaki Kambe
  • Journal Title: Tetrahedron Lett. 47・7 Pages: 1141-1144
• [Journal Article] Pd-Catalyzed Coupling Reaction of Allyl and Propargyl Ethers with Chlorosilanes (2006)
  • Author(s): Yoshitaka Naitoh, Fumiaki Bando, Jun Terao, Kazutaka Otsuki, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Chem. Lett. 36・1 Pages: 236-237
• [Journal Article] Palladium-Catalyzed Intramolecular Selenocarbamoylation of Alkynes with Carbamoselenoates: Formation of α-Alkylidene- β-lactam Framework. (2005)
  • Author(s): Toyofuku, M.; Fujiwara, S. -i.; Shin-ike, T.; Kuniyasu, H.; Kambe, N.
  • Journal Title: J. Am. Chem. Soc. 127 Pages: 9706-9707
  • Peer Reviewed
• [Journal Article] Ni-Catalyzed Alkylative Dimerization of Vinyl Grignard Reagents Using Alkyl Fluorides (2005)
  • Author(s): Terao, J.; Watabe, H.; Kambe, N.
  • Journal Title: 5. Am. Chem. Sec. 127 Pages: 3656-3657
  • Peer Reviewed
• [Journal Article] Zr-Catalyzed Coupling Reaction of Alkyl Halides, Tosylates, and Sulfates with β-Phenethyl Grignard Reagents via Styrene-Zirconate Intermediates (2005)
  • Author(s): J.Terao, S.A.Begum, A.Oda, Nobuaki Kambe
  • Journal Title: Synlett 11 Pages: 1783-1783
• [Journal Article] Palladium-Catalyzed Intramolecular Selenocarbamoylation of Alkynes with Carbamoselenoates : Formation of a-Alkylidene-β-lactam Frameworks (2005)
  • Author(s): M.Toyofuku, S.Fujiwara, T.Shin-ike, H.Kuniyasu, N.Kambe
  • Journal Title: J.Am.Chem.Soc. 127/27 Pages: 9706-9706
• [Journal Article] Carbonylation of Lithium Enolates of Esters and Amides with Carbon Monoxide and Selenium (2005)
  • Author(s): N.Kambe, A.Nishiyama, S.Fujiwara, T.Shin-ike, N.Sonoda
  • Journal Title: Phosphorus Sulfur Silicon Relat.Elem. 180/3 Pages: 1001-1001
• [Journal Article] Thio-, Seleno-, and Telluro-Carboxylic Acid Esters (2005)
  • Author(s): S.Fujiwara, N.Kambe
  • Journal Title: Toppics in Current Chemistry : Chalcogen Carboxylic Acid Derivatives 251 Pages: 87-87
• [Journal Article] Ni-Catalyzed Alkylative Dimerization of Vinyl Grignard Reagents Using Alkyl Fluorides (2005)
  • Author(s): J.Terao, H.Watabe, N.Kambe
  • Journal Title: J.Am.Chem.Soc. 127/11 Pages: 3656-3656
• [Journal Article] Pt-catalyzed regio- and stereoselective pyridylthiolation of terminal alkynes (2005)
  • Author(s): Takayoshi Hirai, Hitoshi Kuniyasu, Nobuaki Kambe
  • Journal Title: Tetrahedron Lett. 46/1 Pages: 117-117
• [Presentation] 銀触媒存在下、アルキルハライドを用いたアルキンのカルボマグネシウム化反応 (2009)
  • Author(s): 森脇悠介・藤井佑樹・神戸宣明
  • Organizer: 日本化学会第89春季年会(2009)
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] Pd触媒存在下、アルキンへのイミノチオレーション (2009)
  • Author(s): 南安規・国安均・神戸宣明
  • Organizer: 日本化学会第89春季年会(2009)
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] パラジウム触媒を用いるアレンの分子内ビニルカルコゲノ化による2-ピリドン骨格の構築 (2009)
  • Author(s): 奥山麻依子・豊福昌志・藤原眞一・新池孜・国安均・神戸宣明
  • Organizer: 日本化学会第89春季年会(2009)
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] パラジウム触媒を用いるアルキン類の分子内テルロカルバモイル化によるα-アルキリデンラクタム類の合成 (2009)
  • Author(s): 永井裕之・豊福昌志・藤原眞一・新池孜・国安均・神戸宣明
  • Organizer: 日本化学会第89春季年会(2009)
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] 酸ハライド誘導体のゼロ価白金への酸化的付加:予想外の反応速度と配位子交換を利用する熱力学の評価 (2009)
  • Author(s): 中根大輔・国安均・神戸宣明
  • Organizer: 日本化学会第89春季年会(2009)
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-27
• [Presentation] 遷移金属触媒を用いるアルキル化およびシリル化の新手法. (2009)
  • Author(s): 神戸宣明
  • Organizer: ファインケミカルズ研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-04
• [Presentation] Transition Metal Catalyzed Introduction of Alkyl Groups into Alkenes, Alkynes, and Dienes. (2009)
  • Author(s): Kambe, N.; Terao, J.; Iwasaki, T.; Fujii, Y.; Todo, H.; Watanabe, H.; Miyamoto, M.
  • Organizer: The International Symposium on Catalysis and Fine Chemicals (CFC 2009)
  • Place of Presentation: Seoul (Korea)
• [Presentation] Reactions and Synthetic Application of Transition Metal Ate Complexes. (2009)
  • Author(s): Nobuaki Kambe.
  • Organizer: The Sixth International Forum on Chemistry of Functional Organic Chemicals (IFOC-6)
  • Place of Presentation: Tokyo
• [Presentation] Transition Metal Catalyzed Reaction of Alkyl Halides and Organochalcogen Compounds. (2009)
  • Author(s): Nobuaki Kambe
  • Organizer: The 9th International Conference on Heteroatom Chemistry (ICHAC-9)
  • Place of Presentation: Oviedo (Spain)
• [Presentation] 有機アルミニウム試薬(R_3Al)による芳香環上のCF_2およびCF_3基のCR_2およびCR_3基への変換反応 (2008)
  • Author(s): 中村美咲・寺尾潤・神戸宣明
  • Organizer: 第35回有機典型元素化学討論会
  • Place of Presentation: 首都大学東京南大沢キャンパス講堂
  • Year and Date: 2008-12-13
• [Presentation] Ni触媒存在下、末端アルキン、ハロゲン化アルキル及び有機金属試薬との位置選択的3成分カップリング反応 (2008)
  • Author(s): 坂東文明・寺尾潤・神戸宣明
  • Organizer: 社団法人石油学会関西支部第17回研究発表会 社団法人日本エネルギー学会関西支部第53回研究発表会 合同研究発表会
  • Place of Presentation: 京都大学桂キャンパス
  • Year and Date: 2008-12-05
• [Presentation] パラジウム触媒を用いるベイリス・ヒルマン反応付加体のカルボニル化による5-メチレン-2-(5H)-フラノン骨格の構築 (2008)
  • Author(s): 岡田篤・豊福昌志・藤原眞一・新池孜・国安均・神戸宣明
  • Organizer: 第38回複素環化学討論会
  • Place of Presentation: 広島県民文化センターふくやま
  • Year and Date: 2008-11-21
• [Presentation] 遷移金属触媒を用いる炭素-カルコゲン結合のアルキンおよびアレンへの位置および立体選択的付加反応を利用した炭素骨格構築手法の開発 (2008)
  • Author(s): 豊福昌志, 村瀬恵里香, 岡田篤, 藤原眞一, 新池孜, 国安均, 神戸宣明
  • Organizer: 第55回有機金属化学討論会
  • Place of Presentation: 大阪府立大学中百舌鳥キャンパス
  • Year and Date: 2008-09-28
• [Presentation] Transition Metal Catalyzed Coupling Reactions Using Alkyl Halides and/or Silyl Chlorides. (2008)
  • Author(s): Kambe, N.
  • Place of Presentation: Cardiff University, UK
  • Year and Date: 2008-09-05
• [Presentation] Transition Metal Catalyzed Alkylation and Silylation Reactions via Ate Complex Intermediates. (2008)
  • Author(s): Kambe N
  • Organizer: 2nd RSC/CSJ Joint Meeting on Green Chemistry and Sustainability
  • Place of Presentation: Belfast, UK
  • Year and Date: 2008-09-04
• [Presentation] Transition Metal Catalyzed Alkylation and Silylation Reactions via Ate Complex Intermediates (2008)
  • Author(s): Nobuaki Kambe
  • Organizer: 2nd RSC/CSJ Joint Meeting on Green Chemistry and Sustainability
  • Place of Presentation: Belfast (UK)
  • Year and Date: 2008-09-04
• [Presentation] Transition-Metal-Catalyzed Reactions of Thioesters with Alkynes : Construction of Cyclic and Acyclic VinylSulfide Derivatives (2008)
  • Author(s): Yasunori Minami, Hitoshi Kuniyasu, Nobuaki Kambe
  • Organizer: IUPAC 17^<th> International Conference on Organic Synthesis (ICOS-17)
  • Place of Presentation: Daejeon (Korea)
  • Year and Date: 2008-06-24
• [Presentation] Synthesis of an Insulated Molecular Wire Using [1-1]Rotaxane as a Monomer Unit (2008)
  • Author(s): Susumu Tsuda, Keisuke Tsurui, Jun Terao, Nobuaki Kambe
  • Organizer: IUPAC 17^<th> International Conference on Organic Synthesis (ICOS-17)
  • Place of Presentation: Daejeon (Korea)
  • Year and Date: 2008-06-24
• [Presentation] Transition Metal Catalyzed Alkylation Reactions Using Alkyl Chlorides and Fluorides (2008)
  • Author(s): N.Kambe, J.Terao, H.Todo, H.Watabe, S.A.Begum, Y.Shinohara, H.Kuniyasu
  • Organizer: Frontiers in Chemistry and Interface with Biology and Physics
  • Place of Presentation: Osaka
  • Year and Date: 2008-06-03
• [Presentation] Transition Metal Catalyzed Coupling Reactions Using Vinyl Grignard Reagents (2008)
  • Author(s): Nobuaki Kambe, Jun Terao
  • Organizer: 5^<th> Asian-European Symposium
  • Place of Presentation: Obernai (France)
  • Year and Date: 2008-05-26
• [Presentation] Transition Metal Catalyzed Addition of Organosulfur and Organoselenium Compounds to Carbon-Carbon Unsaturated Bonds. (2008)
  • Author(s): Kambe, N. Osaka
  • Organizer: University Forum 2008
  • Place of Presentation: San Francisco, USA
• [Presentation] Transition Metal Catalyzed Alkylation Reactions Using Alkyl Chlorides and Fluorides. (2008)
  • Author(s): Kambe, N.; Terao, J.; Todo, H.; Watabe, H.; Begum, S.A. Shinohara, Y.; Kuniyasu, H.
  • Organizer: Frontiers in Chemistry and Interface with Biology and Physics
  • Place of Presentation: Osaka
• [Presentation] Coupling Reactions Using Alkyl Halides and Chlorosilanes Promoted by Transition Metal Ate Complexes. (2008)
  • Author(s): Kambe, N.
  • Organizer: Georg-August-Universitaet Goettingen
  • Place of Presentation: Germany
• [Presentation] Transition Metal Catalyzed Coupling Reactions Using Vinyl Grignard Reagents (2008)
  • Author(s): Kambe, N.; Terao, J.
  • Organizer: The 5th Asian-European Symposium
  • Place of Presentation: Obernai, France
• [Presentation] Carbon-Carbon Bond Forming Reactions via Cleavage of (sp3)C-F or (sp3)C-C1 Bonds (2008)
  • Author(s): Kambe, N.; Terao, J.
  • Organizer: 1 Japan-Singapore Bilateral Symposium on Catalysis
  • Place of Presentation: National University of Singapore, Singapore
• [Presentation] Inter-and Intramolecular Carboselenation of Alkynes and Allenes Catalyzed by Palladium (2008)
  • Author(s): Kambe, N.; Murase, E.; Toyofuku, M.; Kuniyasu, H.; Fujiwara, S. -I.; Shinike, T.
  • Organizer: International Symposium on Catalysis and Fine Chemicals
  • Place of Presentation: Nanyang Technological University, Singapore
• [Presentation] Pt触媒存在下、種々のチオエステルを用いるアルキンへのカーボチオレーション (2008)
  • Author(s): 南 安規・国安 均・寺尾 潤・神戸 宣明
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京都豊島区(立教大学 池袋キャンパス)
• [Presentation] Ni触媒存在下、有機ジハロゲン化物とグリニャール試薬との反応による連続的な炭素-炭素結合形成手法の開発 (2007)
  • Author(s): 坂東 文明・寺尾 潤・神戸 宣明
  • Organizer: 社団法人石油学会関西支部第16回研究発表会 社団法人日本エネルギー学会関西支部第52回研究発表会合同研究発表会
  • Place of Presentation: 大阪府吹田市(関西大学千里山キャンパス)
  • Year and Date: 2007-12-07
• [Presentation] Fluoroalkanes as Promising Alkylating Reagents. (2007)
  • Author(s): Kambe, N.
  • Organizer: International Mini-Symposium for Celebration of Prof. Oneyama's ACS Award for Creative Work in Fluorine Chemistry
  • Place of Presentation: Okayama University, Okayama
  • Year and Date: 2007-09-15
• [Presentation] グリニャール試薬および有機亜鉛試薬を用いる新しいカップリング反応. (2007)
  • Author(s): 神戸宣明
  • Organizer: 有機合成化学協会秋季講習会, 日本薬学会永井記念ホール
  • Place of Presentation: 東京
• [Presentation] Palladium Catalyzed Inter-and Intramolecular Carboselenation of Alkynes and Allenes. (2007)
  • Author(s): Kambe, N.
  • Organizer: 2nd Aachen-Osaka Joint Symposium
  • Place of Presentation: Osaka University, Suita
• [Presentation] 遷移金属触媒を用いるアルキル化及びシリル化の新方法論. (2007)
  • Author(s): 神戸宣明
  • Organizer: 第3回触媒相模セミナー
  • Place of Presentation: 相模中央化学研究所, (神奈川県)綾瀬市
• [Presentation] Carbon-Carbon Bond Forming Reactions Using Alkyl Fluorides. (2007)
  • Author(s): Kambe, N.
  • Organizer: 14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-14)
  • Place of Presentation: Nara Central Hall, Nara
• [Presentation] パラジウム触媒を用いるアレン類の分子内セレノカルバモイル比によるα,β-不飽和ラクタム類の合成 (2007)
  • Author(s): 村瀬 恵里香・豊福昌志・藤原眞一・新池 孜・国安 均・神戸宣明
  • Organizer: 第37回複素環化学討論会
  • Place of Presentation: 長野県 長野市 (長野市若里市民文化ホール)
• [Presentation] 白金-硫黄結合間へのアルキン挿入反応 (2007)
  • Author(s): 山下史一、国安 均、神戸宣明
  • Organizer: 第54回有機金化学属討論会
  • Place of Presentation: 広島県 東広島市 (広島大学東広島キャンパス)
• [Presentation] 白金触媒を用いるアルキン類の分子内ビニルチオおよびセレノ化反応 (2007)
  • Author(s): 豊福昌志・藤原眞一・新池 孜・国安 均・神戸宣明
  • Organizer: 第54回有機金属化学討論会
  • Place of Presentation: 広島県 東広島市 (広島大学東広島キャンパス)
• [Presentation] パラジウム触媒を用いるアレン類の分子内セレノカルバモイル化によるα,β-不飽和ラクタム類の合成 (2007)
  • Author(s): 永井裕之・村瀬恵里香・豊福昌志・藤原眞一・新池 孜・国安 均・神戸宣明
  • Organizer: 第34回有機典型元素化学討論会
  • Place of Presentation: 大阪府吹田市(大阪大学吹田キャンパス)
• [Presentation] C-C and C-Si Bond Forming Reactions Catalyzed by Transition Metal Ate Complexes. (2006)
  • Author(s): Kambe, N.
  • Organizer: Ludwing-Maximilian-Universitat Munchen
  • Place of Presentation: Germany
  • Year and Date: 2006-05-15
• [Presentation] Transition Metal Catalyzed Alkylation and Silylation Reactions Using Alkyl Halides and Chlorosilanes. (2006)
  • Author(s): Kambe, N.
  • Organizer: The First Aachen-Osaka Joint Symposium
  • Place of Presentation: RWTH Aachen University, Germany
  • Year and Date: 2006-05-12
• [Presentation] ビスアリル金属錯体を触媒活性種とするクロスカップリング反応. (2006)
  • Author(s): 神戸宣明
  • Organizer: 日本化学会第86春期年会
  • Year and Date: 2006-03-29
• [Presentation] 触媒的炭素-炭素結合および炭素-ケイ素結合生成の新手法. (2006)
  • Author(s): 神戸宣明
  • Organizer: ネカ講演会
  • Year and Date: 2006-02-28
• [Presentation] Construction of β-Lactam Frameworks by Cyclization of Organoselenium and -tellurium Compounds. (2006)
  • Author(s): Kambe, N.
  • Organizer: 16th IUPAC' s International Conference on Organic Synthesis (ICOS-16)
  • Place of Presentation: Yucatan, Mexico
• [Presentation] Metal-catalyzed carbon -carbon bond forming reactions using alkyl chlorides or fluorides. (2005)
  • Author(s): Kambe, N.; Kuniyasu, H.; Terao, J.
  • Organizer: Pacifichem 2005
  • Place of Presentation: Honolulu
  • Year and Date: 2005-12-17
• [Presentation] Coupling Reactions Using Alkyl Halides and/or Chlorosilanes Catalyzed by Transition Metal Ate Complexes. (2005)
  • Author(s): Kambe, N.
  • Organizer: Fourth Asian-European Symposium
  • Place of Presentation: 長崎
  • Year and Date: 2005-11-06
• [Book] 現代化学増刊 最新有機合成化学(分筆) (2005)
  • Author(s): 寺尾 潤, 神戸宣明
  • Total Pages: 250
  • Publisher: 東京化学同人