Development of Highly Stereocontrolled Oxidation and Reduction Systems

• Project/Area Number: 17065017
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyushu University
• Principal Investigator: INANAGA Junji Kyushu University, 先導物質化学研究所, 教授 (50091244)
• Co-Investigator(Kenkyū-buntansha): FURUNO Hiroshi 九州大学, 先導物質化学研究所, 助教 (90335993)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥26,500,000 (Direct Cost: ¥26,500,000); Fiscal Year 2008: ¥5,700,000 (Direct Cost: ¥5,700,000); Fiscal Year 2007: ¥5,700,000 (Direct Cost: ¥5,700,000); Fiscal Year 2006: ¥6,600,000 (Direct Cost: ¥6,600,000); Fiscal Year 2005: ¥8,500,000 (Direct Cost: ¥8,500,000)
• Keywords: 反応 / 触媒設計 / 誘導適合 / 不斉触媒 / キラル希土類触媒 / キラル不均一触媒 / 不斉エポキシ化 / 不斉マイケル付加 / フロー反応系 / グリーンケミストリー / 自己組織化型低原子価錯体 / 分子間ラジカル反応 / 還元的二量化 / 触媒的不斉Evans-Tishchenko 反応 / キラル多孔質固体触媒 / フロー反応システム / 回収再使用 / ピナコールカップリング / 低原子価二核錯体 / 動的軸不斉 / 還元的二重化 / キラル金属二核錯体 / 電子移動 / Induced-fit

Research Abstract

電子移動プロセスを経る還元的炭素-炭素結合形成反応における不斉制御や、不斉酸化反応のための再使用可能な高性能・高実用的固体触媒の開発、従来困難とされている酸化反応を可能とする新触媒系の開拓、さらには分子内酸化還元型反応の触媒による不斉制御などに取組むとともに、酸化還元を伴わない触媒反応系の展開研究も行い、物質の精密合成を効率的かつ環境調和型で行うことのできる新手法の開発に成功した。

Research Products

• [Journal Article] Tamdem Catalysis Strategy for Direct Glycosylation of 1-Hydroxy Sugars. Methoxyacetic Acid as an Effective Catalytic Mediator (2009)
  • Author(s): Yasuo Yokoyama, Hiroshi Furuno, Junji Inanaga他3名(6番目)
  • Journal Title: Heterocycles 79 Pages: 967-983
  • Peer Reviewed
• [Journal Article] Heterogeneous Lewis Acid Catalysis with Self-Organized Polymeric Rare Earth Arylsulfonates under Solvent-Free Conditions, Heterocycles (2009)
  • Author(s): Hiroshi Furuno, Junji Inanaga他3名(5番目)
  • Journal Title: 77 Pages: 1007-1018
  • Peer Reviewed
• [Journal Article] Heterogeneous Lewis Acid Catalysis with Self-Organized Polymeric Rare Earth Arylsulfonates under Solvent-Free Conditions (2009)
  • Author(s): Hiroshi Furuno, et.al.
  • Journal Title: Heterocycles 77 Pages: 1007-1018
  • NAID: 40016454340
  • Peer Reviewed
• [Journal Article] Tamdem Catalysis Strategy for Direct Glycosylation of 1-Hydroxy Sugars. Methoxyacetic Acid as an Effective Catalytic Mediator (2009)
  • Author(s): Yasuo Yokoyama, et.al.
  • Journal Title: Heterocycles 79 Pages: 967-983
  • Peer Reviewed
• [Journal Article] 誘導適合型の不斉識別・不斉制御/Induced-Fit Type Chiral Discrimination and Control (2008)
  • Author(s): 稲永純二、古野裕史
  • Journal Title: ファインケミカル 37 Pages: 33-40
• [Journal Article] 高性能・高実用的キラル希土類錯体触媒の開発と利用 (2008)
  • Author(s): 古野裕史、鬼束聡明、稲永純二
  • Journal Title: 化学工業 59 Pages: 318-322
  • NAID: 40015922137
• [Journal Article] Reaction of N-Methyl-5-tributylstannyl-4-fluoro-1H-pyrazole and Its Application to N-Methyl-chromeno[2,3-d]pyrazol-9-one Synthesis (2008)
  • Author(s): Takeshi Hanamoto, Hiroshi Furuno, Junji Inanaga他2名(5番目)
  • Journal Title: J. Org. Chem 73 Pages: 4736-4739
  • Peer Reviewed
• [Journal Article] Reaction of N-Methyl-5-tributylstanny1-4-fluoro-1H-pyrazole and Its Application to N-Methyl-chromeno[2, 3-dlpyrazol-9-one Synthesis (2008)
  • Author(s): Takeshi Hanamoto, et.al.
  • Journal Title: The Journal of Organic Chemistry 73 Pages: 4736-4739
  • Peer Reviewed
• [Journal Article] 高性能・高実用的キラル希土類錯体触媒の開発と利用 (2008)
  • Author(s): 古野裕史, ら
  • Journal Title: 化学工業 59 Pages: 318-322
  • NAID: 40015922137
• [Journal Article] 誘導適合型の不斉識別・不斉制御/Induced-Fit Type Chiral Discrimination and Control (2008)
  • Author(s): 稲永純二, ら
  • Journal Title: ファインケミカル 37 Pages: 33-40
• [Journal Article] 2〜4族元素を活用する不斉反応設計: 動的要素の積極利用 (2008)
  • Author(s): 稲永純二
  • Journal Title: Organo Metallic News Pages: 20-24
• [Journal Article] 新規なキラル希土類金属錯体触媒を用いるエナンチオ選択的反応の開発 (2007)
  • Author(s): 古野裕史、鬼束聡明、稲永純二
  • Journal Title: 有機合成化学協会誌 65 Pages: 977-988
  • NAID: 10019836357
  • Peer Reviewed
• [Journal Article] Synthesis and Reactions of 5-TributyIstannyl-4-trifluoro-1H-pyrazole (2007)
  • Author(s): T., Hanamoto, et. al.
  • Journal Title: Tetrahedron 63 Pages: 5062-5070
  • Peer Reviewed
• [Journal Article] 新規なキラル希土類金属錯体触媒を用いるエナンチオ選択的反応の開発 (2007)
  • Author(s): 古野裕史, ら
  • Journal Title: 有機合成化学協会誌 65 Pages: 977-988
  • NAID: 10019836357
  • Peer Reviewed
• [Journal Article] Asymmetric Fluorination of β-Keto Esters Catalyzed by Chiral Rare Earth Perfluorinated Organophosphates (2006)
  • Author(s): Shoko Suzuki, Hiroshi Furuno, Yasuo Yokoyama, Junji Inanaga
  • Journal Title: Tetrahedron : Asymmetry 17 Pages: 504-507
  • Peer Reviewed
• [Journal Article] Heterogeneous Catalysis of Novel Polymeric Rare Earth Complexes under Solvent-Free Conditions : Zero-Emission Synthesis of β-Amino Alcohols (2006)
  • Author(s): Shuichi Ishida, Shoko Suzuki, Tetsuji Hayano, Hiroshi Furuno, Junji Inanaga
  • Journal Title: J. Alloys Compd 408-412 Pages: 441-443
  • Peer Reviewed
• [Journal Article] (2006)
  • Author(s): Ikki Yonemura, Hiroshi Furuno, Junji Inanaga他3名(6番目)
  • Journal Title: Heterocycles 67 Pages: 433-436
  • Peer Reviewed
• [Journal Article] Heterogeneous Catalysis of Novel Polymeric Rare Earth Complexes under Solvent-Free Conditions : Zero-Emission Synthesis of β-Amino Alcohols (2006)
  • Author(s): Shoko Suzuki et al.
  • Journal Title: Journal of Alloys and Compounds 408-412 Pages: 441-443
• [Journal Article] Asymmetric Fluorination of β-Keto Esters Catalyzed by Chiral Rare Earth Perfluorinated Organophosphates (2006)
  • Author(s): Shoko Suzuki et al.
  • Journal Title: Tetrahedron : Asymmetry 17・4 Pages: 504-507
• [Journal Article] 不斉合成で活躍するキラル希土類錯体触媒 (2006)
  • Author(s): 稲永純二
  • Journal Title: マテリアルインテグレーション 19・1 Pages: 43-46
• [Journal Article] 無機物ナノ結晶表面上での不斉触媒反応 (2006)
  • Author(s): 鬼束聡明ら
  • Journal Title: 化学 62・1 Pages: 72-73
• [Journal Article] Hetero-Diels-Alder Reaction Catalyzed by Self-Organized Polymeric Rare Earth Complexes under Solvent-Free Conditions (2005)
  • Author(s): Shuichi Ishida, Tetsuji Hayano, Hiroshi Furuno, Junji Inanaga
  • Journal Title: Heterocycles 66 Pages: 645-649
  • NAID: 40007080658
  • Peer Reviewed
• [Presentation] 電子移動を引き金とする炭素一炭素結合形成反応の不斉制御 (2009)
  • Author(s): 稲永純二
  • Organizer: 電気化学会第76回大会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-30
• [Presentation] Self-Organized Approach to One-Pot Preparation of Chiral Rare Earth Complex Catalysts: Highly Enantioselective Scandium Complex-Catalyzed Michael Reaction (2009)
  • Author(s): Yoriko Tsutsumi et.al.
  • Organizer: Kyudai International Symposium on Photo and Supramolecular Chemistry
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-07
• [Presentation] La-BINOL-R_3P=O錯体の構造活性相関に基づく高性能不斉エポキシ化触媒の開発 (2009)
  • Author(s): 鬼束聡明, ら
  • Organizer: 第4回物質合成シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-23
• [Presentation] 自己組織化型アリ-ルスルホン酸スカンジウムを触媒とする無溶媒反応 (2009)
  • Author(s): 古野裕史, ら
  • Organizer: 第4回物質合成シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-23
• [Presentation] New Use of (R, R)-BiBINOL Having Dynamic Axial Chirality. Highly Enantioselective Bronsted Acid-Base Bifunctional Catalysis of Michael Reactions (2008)
  • Author(s): Junji Inanaga
  • Organizer: The 9^<th> International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
  • Year and Date: 2008-11-22
• [Presentation] Heterogeneous Catalysis with Reusable Rare Earth Coordination Polymers (2008)
  • Author(s): Junji Inanaga
  • Organizer: International Symposium on Advanced Green Catalysis and Materials
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2008-11-18
• [Presentation] Heterogeneous Catalysis with Reusable Rare Earth Coordination Polymers (2008)
  • Author(s): Junji Inanaga
  • Organizer: International Symposium on Advanced Green Catalysis and Materials
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-11-18
• [Presentation] 自己組織化型希土類金属錯体触媒を用いる無溶媒不均一反応 (2008)
  • Author(s): 古野裕史, ら
  • Organizer: 2008年日本化学会西日本大会
  • Place of Presentation: 長崎
  • Year and Date: 2008-11-15
• [Presentation] Rare Earth Coodination Polymer Catalysts for Fine Chemicals Synthesis (2008)
  • Author(s): Junji Inanaga
  • Organizer: 2nd Symposium on Applied Chemistry of Chinese Academy of Sciences
  • Place of Presentation: Changchun (China)
  • Year and Date: 2008-09-24
• [Presentation] Rare Earth Coordination Polymer Catalysts for Fine Chemicals Synthesis (2008)
  • Author(s): Junji Inanaga
  • Organizer: 2^<nd> Symposium on Applied Chemistry of Chinese Academy of Sciences
  • Place of Presentation: Changchun, China
  • Year and Date: 2008-09-24
• [Presentation] 希土類錯体 : 未踏配位科学の探求と機能創成 (2008)
  • Author(s): 稲永純二
  • Organizer: 第58回錯体科学討論会
  • Place of Presentation: 金沢
  • Year and Date: 2008-09-20
• [Presentation] 共役エノン類の不斉エポキシ化におけるLa-BINOL-R_3P=O錯体触媒の構造活性相関 (2008)
  • Author(s): 鬼束聡明, ら
  • Organizer: 第25回有機合成化学セミナー
  • Place of Presentation: 熊本、阿蘇
  • Year and Date: 2008-09-08
• [Presentation] 自己組織化型高分子希土類ルイス酸触媒を用いる無溶媒不均一反応 (2008)
  • Author(s): 古野裕史, ら
  • Organizer: 第25回有機合成化学セミナー
  • Place of Presentation: 熊本、阿蘇
  • Year and Date: 2008-09-08
• [Presentation] Chiral Lanthanum Complex Catalyzed Asymmetric Epoxidation of Enones. Mechanistic Investigation and Application to Flow Reaction System (2008)
  • Author(s): Satoaki Onitsuka, et.al.
  • Organizer: ICC 14 Pre-Symposium
  • Place of Presentation: 京都
  • Year and Date: 2008-07-09
• [Presentation] ランタン-BINOL-トリアリ-ルホスフィンオキサイド錯体を触媒に用いる共役エノン類の不斉エポキシ化反応の機構 (2008)
  • Author(s): 鬼束聡明, ら
  • Organizer: 第25回希土類討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Presentation] Chiral Discrimination and Catalysis Utilizing the Cooperative Effect of Dynamic and Axial Chiralities (2008)
  • Author(s): Kalluri Venkata Sri Ranganath, et.al.
  • Organizer: シンポジウム「モレキュラー・キラリティー2008」
  • Place of Presentation: 岡山
  • Year and Date: 2008-05-22
• [Presentation] Induced-Fit Type Asymmetric Complexation, Reaction, and Catalysis (2007)
  • Author(s): Junji Inanaga
  • Organizer: The 2007 International Symposium on Catalysis and Fine Chemicals
  • Place of Presentation: Singapore
  • Year and Date: 2007-12-19
• [Presentation] Development of Highly Practical Chiral Catalysts for Asymmetric Reactions : Self-Organization Strategy (2007)
  • Author(s): Junji Inanaga
  • Organizer: 3rd Taiwan-Japan Bilateral Symposium on Architecture of Functional Organic Molecules
  • Place of Presentation: Chiayi (Taiwan)
  • Year and Date: 2007-11-18
• [Presentation] Ca-(R,R)-BisBINOL Complex as a Novel Bronsted Acid-Base Bifunctional Catalyst with Dynamic Chirality (2007)
  • Author(s): Junji Inanaga
  • Organizer: The 2nd International Conference of Cutting-Edge Organic Chemistry in Asia
  • Place of Presentation: Busan (Korea)
  • Year and Date: 2007-09-03
• [Presentation] Induced-Fit Type Intermolecular Asymmetric Pinacol Coupling Reactions Promoted by Low-Valent Dinuclear Metal Complexes with Dynamic Chirality (2007)
  • Author(s): Junji Inanaga
  • Organizer: International Symposium on Organic Electron Transfer Chemistry directed toward Organic Synthesis
  • Place of Presentation: 横浜
  • Year and Date: 2007-01-09
• [Presentation] Highly Enantioselective Radical Coupling Reactions Promoted by Low-Valent Chiral Metal Complexes, 8th International Symposium on Biotechnology (2006)
  • Author(s): Junji Inanaga
  • Organizer: Metal Complexes and Catalysis
  • Place of Presentation: Haikou (China)
  • Year and Date: 2006-11-06
• [Presentation] Chiral Sensing, Helical Assembly, and Asymmetric Induction Caused by the Dynamic Chirality of (R)-BINOL Oligomers (2006)
  • Author(s): Junji Inanaga
  • Organizer: 2nd Taiwan-Japan Conference on Molecular Architecture of Organic Compounds for Functional Designs
  • Place of Presentation: 福岡
  • Year and Date: 2006-03-24
• [Presentation] Highly Efficient Chiral Sensing, Enantioselective Reaction, and Asymmetric Catalysis Utilizing Novel BINOL Derivatives (2005)
  • Author(s): Junji Inanaga
  • Organizer: 2nd Symposium on Chemical Approaches to Chirality
  • Place of Presentation: 東京
  • Year and Date: 2005-11-11
• [Presentation] Development of Self-Organized Polymeric Lewis Acid-Catalysts for the Zero-Emission Synthesis of 2-Amino Alcohols (2005)
  • Author(s): Junji Inanaga
  • Organizer: 15th International Symposium on Fine and Functional Polymers & IUPAC 1st International Symposium on Novel Materials and Synthesis
  • Place of Presentation: Shanghai (China)
  • Year and Date: 2005-10-18
• [Book] 触媒便覧 (2008)
  • Author(s): 稲永純二
  • Publisher: 講談社
• [Book] 希土類の材料技術ハンドブック (2008)
  • Author(s): 稲永純二
  • Publisher: エヌ・ティー・エス
• [Remarks]
  • URL: http://www.cm.kyushu-u.ac.jp/winanaga/