Analysis of cellular signals from cell-to-cell interactions

• Project/Area Number: 17066003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University (2007-2008); Japan Advanced Institute of Science and Technology (2005-2006)
• Principal Investigator: TAMIYA Eiichi Osaka University, 大学院・工学研究科, 教授 (60179893)
• Co-Investigator(Kenkyū-buntansha): HONDA Hiroyuki 名古屋大学, 大学院・工学研究科, 教授 (70209328) ; JINBO Yasuhiko 東京大学, 大学院・新領域創成科学研究科, 教授 (20372401) ; KONISHI Satoshi 立命館大学, 理工学部, 教授 (50288627)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥225,000,000 (Direct Cost: ¥225,000,000); Fiscal Year 2008: ¥55,000,000 (Direct Cost: ¥55,000,000); Fiscal Year 2007: ¥56,700,000 (Direct Cost: ¥56,700,000); Fiscal Year 2006: ¥55,000,000 (Direct Cost: ¥55,000,000); Fiscal Year 2005: ¥58,300,000 (Direct Cost: ¥58,300,000)
• Keywords: 細胞チップ / シグナル応答 / ニューロン / 神経回路 / ensemble recording / 電極アレイ / ペプチドアレイ / バイオセンサー / バイオチップ / 細胞チッブ / 表面プラズモン

Research Abstract

バイオセンサー、チップ集積化技術、一細胞マニピュレーション技術などを駆使して、網羅的に且つ高感度に細胞シグナルなどを解析するバイオセンシングツールの開発に関する研究を行った。疫一細胞刺激応答や、磁気液滴操作によるガン1細胞遺伝子発現解析、神経細胞ネットワーク形成、マイクロチャネルアレイ(MCA)による神経細胞シグナル計測など様々な機能を備えた各種一細胞情報解析チップの開発と応用に成果をあげた。

Research Products

• [Journal Article] 幹細胞由来培養神経回路の構築と電気活動計測 (2009)
  • Author(s): 高山祐三、斎藤淳史、森口裕之、小谷潔、神保泰彦
  • Journal Title: 電気学会論文誌 C129 Pages: 8-16
  • NAID: 10023999096
• [Journal Article] Label-free Electrochemical Detection for Food Allergen using Screen Printed Carbon Electrode (2009)
  • Author(s): M. Saito, M. Kitsunai, M.U. Ahmed, S. Sugiyama, E. Tamiya
  • Journal Title: Electrochemistry 76 Pages: 606-606
  • NAID: 130002150745
  • Peer Reviewed
• [Journal Article] An Interference Localized Surface Plasmon Resonance Biosens or Based on the Photonic Structure of Au Nanoparticles and SiO2/Si Multilayers (2009)
  • Author(s): H. M. Hiep, H. Yoshikawa, M. Saito, and E. Tamiya
  • Journal Title: ACS Nano (In press)
  • Peer Reviewed
• [Journal Article] Detection of Alzheimer's Amyloid Beta Aggregation by Capturing Molecular Trails of Individual Assemblies (2009)
  • Author(s): M. Vestergaard, T. Hamada, M. Saito, Y. Yajima, M. Kudou, E. Tamiya, M. Takagi
  • Journal Title: Biochemical and Biophysical Research Com munications
  • Peer Reviewed
• [Journal Article] Sensors (2009)
  • Author(s): M. Saito, H.M. Hiep, N. Nagatani, E. Tamiya
  • Journal Title: ADVANCES IN BIOCHEMICAL ENGINEE RING/BIOTECHNOLOGY : Nano/Micro Biotechnology (In press)
• [Journal Article] Label-Free Detection of Melittin Binding to a Membrane Using Electrochemical-Localized Surface Plasmon Resonance (2008)
  • Author(s): H.M. Hiep, T. Endo, M. Saito, M. Chikae, D.K. Kim, S. Yamamura, Y. Takamura, E. Tamiya
  • Journal Title: Anal. Chem. 80 Pages: 1859-1864
  • Peer Reviewed
• [Journal Article] Nanomaterial-based electrochemical biosensors for medical applications (2008)
  • Author(s): K. Kerman, M. Saito, S. Yamamura, Y. Takamura, E. Tamiya
  • Journal Title: TrAC 27 Pages: 585-592
  • Peer Reviewed
• [Journal Article] Cell culture arrays using magnetic force-based cell patterning for dynamic single cell analysis (2008)
  • Author(s): K. Ino, M. Okochi, N. Konishi, M. Nakatochi, R. Imai, M. Shikida, A. Ito, H. Honda
  • Journal Title: Lob on a Chip 8 Pages: 134-142
  • Peer Reviewed
• [Journal Article] Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variations - insight from respiratory-phase domain analysis (2008)
  • Author(s): K. Kotani, K. Takamasu, Y. Jimbo, Y. Yamamoto
  • Journal Title: Am. J.Physiol. 294
  • Peer Reviewed
• [Journal Article] Aptamer-Functionalized Au Nanoparticles for the Electrochemical Detection of Thrombin (2008)
  • Author(s): K. Kerman, E. Tamiya
  • Journal Title: The United States of America Journal of Biomedical Nanotechnology 4 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Nanomaterial-based electrochemical biosensors for medical application (2008)
  • Author(s): K. Kerman, M. Saito, S. Yamamura, Y. Takamura, E. Tamiya
  • Journal Title: TrAC Trends in Analytical Chemistry 27 Pages: 585-592
  • Peer Reviewed
• [Journal Article] Electroactive chitosan nanoparticles for the detection of single -nucleotide polymorphisms using peptide nucleic acids (2008)
  • Author(s): K. Kerman, M. Saito, E. Tamiya
  • Journal Title: Anal Bioanal Chem 391 Pages: 2759-2767
  • Peer Reviewed
• [Journal Article] Label-free optical detection of aptamer-protein interactions using gold-capped oxide nanostructures (2008)
  • Author(s): D.K. Kim, K. Kerman, H.M. Hiep, M. Saito, S. Yamamura, Y. Takamura, Y.S. Kwon, E. Tamiya
  • Journal Title: Analytical Biochemistry 379 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Electrochemical genosensor for the rapid detection of GMO using loop-mediated isothermal amplification (2008)
  • Author(s): M. U. Ahmed, M. Saito, M. M. Hossain, S. R. Rao, S. Furui, A. Hino, Y. Takamura, M. Takagi and E Tamiya
  • Journal Title: Analyst
  • Peer Reviewed
• [Journal Article] Electrochemical biosensors for medical and food applications (2008)
  • Author(s): M.U. Ahmed, M.M. Hossain, E. Tamiya
  • Journal Title: Electroanalysis 20 Pages: 616-626
  • Peer Reviewed
• [Journal Article] Electrochemical DNA biosensors : Protocols for intercalator-based detection of hybridization in solution and at the surface (2008)
  • Author(s): K. Kerman, M. Vestergaard, E. Tamiya
  • Journal Title: Methods in Molecular Biology 504, Biosensors and Biodetection volume 2, Chapeter 7
• [Journal Article] バイオセンサー研究から見えるナノ空間の制御、化学、物理、バイオの統合 (2008)
  • Author(s): 民谷栄一
  • Journal Title: 化学と工業 61 Pages: 1145-1145
  • NAID: 10024483707
• [Journal Article] Detection of Alzheimer's tau protein using localized surface plasmon resonance-based immunochip (2008)
  • Author(s): Mun'delanji, Vestergaard・Kagan, Kerman・Do-Kyun, Kim・Ha Minh, Hiep・Eiichi, Tamiya
  • Journal Title: Talanta 74 Pages: 1038-1042
  • Peer Reviewed
• [Journal Article] Label-Free Detection of Melittin Binding to a Membrane Using Electroc hemical Localized Surface Plasmon Resonance (2008)
  • Author(s): Ha Minh, Hiep・Tatsuro, Endo・Masato, Saito・Miyuki, Chikae・Do, Kyun Kim・Shohei, Yamamura・Yuzuru, Takamura・Eiichi, Tamiya
  • Journal Title: Anal.Chem. (In press)
  • Peer Reviewed
• [Journal Article] AFM Picking-up manipulation of the metaphase chromosome fragment by using the tweezers-type probe (2008)
  • Author(s): Keiichiro, Yamanaka
  • Journal Title: Ultramicroscopy (In press)
  • Peer Reviewed
• [Journal Article] Cell culture arrays using magnetic force-based cell patterning for dynamic single cell analysis (2008)
  • Author(s): Kosuke, Ino・Mina, Okochi・Nao, Konishi・Masahiro, Nakatochi・Rentaro, Imai・Mitsuhiro, Shikida・Akira, Ito・Hiroyuki, Honda
  • Journal Title: Lob on a Chip 8 Pages: 134-142
  • Peer Reviewed
• [Journal Article] Microsystems technology and biosensing,Advances in Biochemical Engineering/Biotechnology (2008)
  • Author(s): Ramachandra, Rao Sathuluri・Shohei, Yamamura・Eiichi, Tamiya
  • Journal Title: Biosensing for the 21st Century(Advances in Biochemical Engineering/biotechnology), Fred Lisdat, Reinhard Renneberg, Springer publishers 109 Pages: 285-350
  • Peer Reviewed
• [Journal Article] マイクロチャンネルアレイ構造を有した細胞間ネットワーク解析用デバイス (2007)
  • Author(s): 殿村渉、倉島利明、高山祐三、森口裕之、神保泰彦、小西聡
  • Journal Title: 電気学会論文誌C 127 Pages: 1575-1580
  • NAID: 10019958319
  • Peer Reviewed
• [Journal Article] Transparent Biosensor with Micro Channel Array for Optical and Electrophysiological Detection of Luciferin-Luciferase Reaction (2007)
  • Author(s): W. Tonomura, H. Okamura, S. Konishi
  • Journal Title: IEEJ Transactions on Electrical and Electronic Engineering 2 Pages: 372-377
  • NAID: 10025772102
  • Peer Reviewed
• [Journal Article] An Overview of Label-free Electrochemical Protein Sensors (2007)
  • Author(s): Mun'delanji, Vestergaard・Kagan, Kerman・Eiichi, Tamiya
  • Journal Title: Sensors 7 Pages: 3442-3458
• [Journal Article] Application of an Ultra-Water-Repellent Surface to Cell Culture (2007)
  • Author(s): Kosuke, Ino・Akira, Ito・Yunying, Wu・Nagahiro, Saito・Eri, Hibino・Osamu, Takai・Hiroyuki, Honda
  • Journal Title: Journal of Bioscience and Bioengineering 104(5) Pages: 420-423
  • NAID: 110006402614
  • Peer Reviewed
• [Journal Article] Cell patterning using magnetite nanoparticles and magnetic force (2007)
  • Author(s): Kosuke, Ino・Akira, Ito・Hiroyuki, Honda
  • Journal Title: Biotechnology and Bioengineering 97(5) Pages: 1309-1317
  • Peer Reviewed
• [Journal Article] MEA-based recording of neurnal activity in vitro (2007)
  • Author(s): Jimbo, Y.
  • Journal Title: Arch.Ita.Biol 145 Pages: 289-297
  • Peer Reviewed
• [Journal Article] スプレーパターニングと稼動式微小電極による小規模神経回路の一選択的自発活動記録 (2007)
  • Author(s): 森口裕之、玉井暢洋、高山祐三、倉島利明、神保泰彦
  • Journal Title: 電気学会論文誌C 127 Pages: 1562-1567
  • Peer Reviewed
• [Journal Article] カオトロピックエッチング法による細胞培養用マイクロウェルの作成 (2007)
  • Author(s): 玉井暢洋、森口裕之、高山祐三、神保泰彦、鈴木郁郎、安田賢二、
  • Journal Title: 電気学会論文誌C 127 Pages: 1568-1574
  • NAID: 10019958299
  • Peer Reviewed
• [Journal Article] Light-addressable electrode with hydrogenated amorphous silicon and low-conductivepassivation layer for stimulation of cultured neurons (2007)
  • Author(s): Suzurikzwa, J・Takahashib, H.・Kanzaki, R.・Nakao, M.・Takayama, Y.・Jimbo, Y.
  • Journal Title: Appl.Phys.Lett 90 Pages: 9390-9390
  • Peer Reviewed
• [Journal Article] 低導電性保護膜を有する光アドレス電極の光電気特性と同電極を用いた電気刺激の空間分解能 (2007)
  • Author(s): 硯川 潤、高橋宏知、神崎亮平、中尾政之、神保泰彦
  • Journal Title: 電気学会論文誌C 127 Pages: 1581-1587
  • NAID: 10019958334
  • Peer Reviewed
• [Journal Article] 時空間刺激による神経回路活動変化の誘導 (2007)
  • Author(s): 高山祐三、森口裕之、神保泰彦
  • Journal Title: 電気学会論文誌C 127 Pages: 1619-1624
  • NAID: 10019958465
  • Peer Reviewed
• [Journal Article] マイクロチャンネルアレイ構造を有した細胞間ネットワーク解析用デバイス (2007)
  • Author(s): 殿村 渉, 倉島 利明, 高山 祐三, 森口 裕之, 神保 泰彦, 小西 聡
  • Journal Title: 電気学会論文誌 Vol.127,No.10 Pages: 1575-1580
  • NAID: 10019958319
  • Peer Reviewed
• [Journal Article] Transparent Biosensor with Micro Channel Array for Optical and Electrophysiological Detection of Luciferin-Luciferase Reaction (2007)
  • Author(s): W., Tonomura・H., Okamura・S., Konishi
  • Journal Title: IEEJ Transactions on Electrical and Electronic Engingeering Vol.2,No.3 Pages: 372-377
  • NAID: 10025772102
  • Peer Reviewed
• [Journal Article] ナノ・マイクロ技術を用いた細胞間ネットワークシグナルの解析 (2007)
  • Author(s): 山村昌平、民谷栄-
  • Journal Title: 表面科学 28(4) Pages: 211-217
  • NAID: 10019506806
• [Journal Article] ナノバイオテクノロジーとバイオデバイス (2007)
  • Author(s): 民谷栄一
  • Journal Title: BIONICS 2 Pages: 48-52
• [Journal Article] ナノバイオテクノロジーを用いた先進バイオセンサーの開発 (2007)
  • Author(s): 民谷栄一
  • Journal Title: 生産と技術 59(4) Pages: 26-31
  • NAID: 40015647824
• [Journal Article] Pico/nano-liter chamber array chips for single-cell,DNA,and protein analyses (2007)
  • Author(s): S., Yamamura・S., Ramachandra Rao・E., Tamiya
  • Journal Title: Nanotechnology for the Life Fciences Vol.8.Nanomaterials for Biosensors(ed.) Kumar, C., Wiley-VCH pulishers, Weinheim Pages: 368-397
  • Peer Reviewed
• [Journal Article] Construction of multi-layered cardiomyocyte sheets using magnetite nanoparticles and magnetic force (2007)
  • Author(s): Kazunori Shimizu, Akira Ito, Jong-kook Lee, Tatsuro Yoshida, Keiko Miwa, Hisaaki Ishiguro, Yasushi Numaguchi, Toyoaki Murohara, Itsuo Kodama, Hiroyuki Honda
  • Journal Title: Biotechnology and Bioengineering 96(4) Pages: 803-809
• [Journal Article] MEA-based recording of neuronal activity in vitro (2007)
  • Author(s): Y.Jimbo
  • Journal Title: Arch. Ita. Biol. 127(in press)
• [Journal Article] Light-addressable electrode with hydrogenated amorphous silicon and low-conductive passivation layer for stimulation of cultured neurons (2007)
  • Author(s): Suzurikawa J, Takahashib H., Kanzaki R., Nakao M., Takayama Y., Jimbo Y
  • Journal Title: Appl. Phys. Lett 90 Pages: 9390-9390
• [Journal Article] Transparent Biosensor with Micro Channel Array for Optical and Electrophysiological Detection of Luciferin-Luciferase Reaction (2007)
  • Author(s): W.Tonomura, H.Okamura, S.Konishi
  • Journal Title: IEEJ Transactions of Electrical and Electronic Engineering Vol. 2・No. 3 Pages: 372-377
  • NAID: 10025772102
• [Journal Article] Multiple label-free detection of antigen-antibody reaction using localized surface plasmon resonance based core-shell structured nanoparticle layer nanochip (2006)
  • Author(s): T. Endo, K. Kerman, H.M. Hiep, D.K. Kim, Y. Yonezawa, K. Nakano, E. Tamiya
  • Journal Title: Anal. Chem. 78 Pages: 6465-6475
  • Peer Reviewed
• [Journal Article] High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence (2006)
  • Author(s): M. Okochi, M. Nakanishi, R. Kato, T. Kobayashi, H. Honda
  • Journal Title: FEBS Letter 580 Pages: 885-889
  • Peer Reviewed
• [Journal Article] Peptide array based interaction assay of solid-bound peptide and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design (2006)
  • Author(s): Ryuji Kato, Chiaki Kaga, Mitoshi Kunimatsu, Takeshi Kobayashi, Hiroyuki Honda
  • Journal Title: Journal of Bioscience and Bioengineering 101(6) Pages: 485-495
  • NAID: 110004758121
• [Journal Article] Incorporating of capillary-lake structures into dermal cell sheets constructed by magnetic force-bases tissue engineering (2006)
  • Author(s): Kousuke Ino, Akira Ito, Hirohito Kumazawa, Hideaki Kagami, Minoru Ueda, Hiroyuki Honda
  • Journal Title: Journal of Chemical Engineering Japan 40(1) Pages: 51-58
• [Journal Article] The state-of art of NanobioScience in Japan (2006)
  • Author(s): S.Ueno, J.Ando, H.Fujita, T.Sugawara, Y.Jimbo, K..Itaka, K.Kataoka, T.Ushida
  • Journal Title: IEEE Trans. Nanobiosci 5 Pages: 54-65
• [Journal Article] Electrochemical Genosensor Based on Peptide Nucleic Acid-Mediated PCR and Asymmetric PCR Techniques : Electrostatic Interactions with a Metal Cation (2006)
  • Author(s): Kagan Kerman, Mun'delanji Vestergaard, Naoki Nagatani, Yuzuru Takamura, Eiichi Tamiya
  • Journal Title: Anal. Chem. 78,7 Pages: 2182-2189
• [Journal Article] Multiple label-free detection of antigen-antibody reaction using localized surface plasmon resonance based core-shell structured nanoparticle layer nanochip (2006)
  • Author(s): Tatsuro Endo, Kagan Kerman, Yuji Yonezawa, Koichi Nakano, Eiichi Tamiya
  • Journal Title: Anal. Chem. 78,18 Pages: 6465-6475
• [Journal Article] Constraining the connectivity of neuronal networks cultured on microelectrode arrays with microfluidic techniques : A step towards neuron-based functional chips (2006)
  • Author(s): Fabrice Morin, Naoki Nishimura, Laurent Griscom, Bruno Lepioufle, Hiroyuki Fujita, Yuzuru Takamura, Eiichi Tamiya
  • Journal Title: Biosensors and Bioelectronics 21, 7 Pages: 1093-1100
• [Journal Article] Circumventing the air-bubbles for microfluidic systems and quantitative continuous-flow PCR applications (2006)
  • Author(s): Tsuyoshi Nakayama, Yasunori Kurosawa, Satoshi Furui, Kagan Kerman, Masaaki Kobayashi, S.Ramachandra Rao, Yuji Yonezawa, Kouichi Nakano, Akihiro Hino, Shouhei Yamamura, Yuzuru Takamura, Eiichi Tamiya
  • Journal Title: Anal Bioanal. Chem. 386 Pages: 1327-1333
• [Journal Article] Development of a novel DNA detection system for real-time detection of DNA hybridization (2006)
  • Author(s): Do-Kyun Kim, Eiichi Tamiya, Young-Soo Kwon
  • Journal Title: Current Applied Physics 6, 4 Pages: 669-674
• [Journal Article] 電気化学会編集委員会 (2006)
  • Author(s): 山村昌平, 民谷栄一
  • Journal Title: 細胞解析を目指したオンチップバイオデバイス、 Electrochemistry(電気化学および工業物理化学)誌 74(11) Pages: 890-894
• [Journal Article] High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence (2006)
  • Author(s): Mina Okochi, Mari Nakanishi, Ryuji Kato, Takeshi Kobayashi, Hiroyuki Honda
  • Journal Title: FEBS Letter 580(3) Pages: 885-889
• [Journal Article] Prediction of peptide binding to major histocompatibility complex class II molecules through use of boosted fussy classfier with SWEEP operator method (2006)
  • Author(s): Hiro Takahashi, Hiroyuki Honda
  • Journal Title: Journal of Bioscience and Bioengineering 101(2) Pages: 137-141
• [Journal Article] Pentamer peptide from Fas antigen ligand inhibits tumor-growth with solid-bound form found by peptide array (2006)
  • Author(s): Ryuji Kato, Yukako Okuno, Chiaki Kaga, Mitoshi Kunimatsu, Takeshi Kobayashi, Hiroyuki Honda
  • Journal Title: Journal of Peptide Research 66(Suppl 1) Pages: 146-153
• [Journal Article] The state-of art of NanobioScience in Japan (2006)
  • Author(s): S.Ueno, J.Ando, H.Fujita, T.Sugawara, Y.Jimbo, K.Itaka, K.Kataoka, T.Ushida
  • Journal Title: IEEE Trans.Nanobioscience 5 Pages: 54-65
• [Journal Article] Single-cell microarray for analyzing cellular response (2005)
  • Author(s): S. Yamamura, H. Kishi, Y. Tokimitsu, S. Kondo, R. Honda, S. R. Rao, M. Omori, E. Tamiya and A. Muraguchi
  • Journal Title: Anal. Chem. 77 Pages: 8050-8056
  • Peer Reviewed
• [Journal Article] A rapid label-free electrochemical detection and kinetic study of Alzheimer's Amyloid-beta aggregation (2005)
  • Author(s): M.Vestergaard, K.Kerman, M.Saito, M.Nagatani, Y.Takamura, E.Tamiya
  • Journal Title: J.Am.Chem.Soc. 127 Pages: 11892-11893
  • Peer Reviewed
• [Journal Article] Spatio-temporal cholinergic modulation in cultured networks of rat cortical neurons : evoked activity (2005)
  • Author(s): T.Tateno, Y.Jimbo, H.P.C.Robinson
  • Journal Title: Neuroscience 134 Pages: 439-448
• [Journal Article] Spatio-temporal cholinergic modulation in cultured networks of rat cortical neurons : spontaneous activity (2005)
  • Author(s): T.Tateno, Y.Jimbo, H.P.C.Robinson
  • Journal Title: Neuroscience 134 Pages: 425-437
• [Journal Article] Stepwise pattern modification of neuronal network in photo-thermally-etched agarose architecture on multi-electrode array chip for single-cell-based electrophysiological measurement (2005)
  • Author(s): I.Suzuki, Y.Sugio, Y.Jimbo, K.Yasuda
  • Journal Title: Lab on Chip 5 Pages: 241-247
• [Journal Article] 大脳皮質神経回路形成過程における細胞内Caダイナミクス (2005)
  • Author(s): 高山, 森本, 郷, 佐久間, 小林, 神保
  • Journal Title: 豊田研究報告 58 Pages: 71-77
• [Journal Article] A rapid label-free electrochemical detection kinetic study of Alzheimer's Amyloid-beta aggregation, (2005)
  • Author(s): M.Vestergaard et al.
  • Journal Title: J.Am.Chem.Soc., 127 Pages: 11892-11893
• [Journal Article] Microfabrication of encoded microparticle array for multiplexed DNA hybridization detection, (2005)
  • Author(s): Z.Zhi, et al.
  • Journal Title: Chemical Communications Pages: 2448-2450
• [Journal Article] Single-cell microarray for analyzing cellular response (2005)
  • Author(s): Yamamura Shouhei et al.
  • Journal Title: Analytical Chemistry 77 Pages: 8050-8056
• [Journal Article] Light-addressed stimulation under Ca2+ imaging of cultured neurons,
  • Author(s): J. Suzurikawa, M. Nakao, Y. Jimbo, R. Kanzaki, H. Takahashi
  • Journal Title: IEEE Trans. BME in press
  • Peer Reviewed
• [Journal Article] Ensemble Stimulation of Embryoid Bodies using Substrate- Embedded Electrodes
  • Author(s): Y. Takayama, A. Saito, H. Moriguchi., Y. Jimbo.
  • Journal Title: IEEJ Trans. in press
  • Peer Reviewed
• [Presentation] Spatially Arranged Microelectrodes Using Wire Bonding Technology for Spatially Distributed Chemical Information Acquision (2009)
  • Author(s): W.Tonomura, K. Shimizu, and S. Konishi
  • Organizer: Proc. Of.22^<nd> IEEE International Conference on Micro Electro Mechanical Systems (MEMS'09)
  • Place of Presentation: Sorrento, Italy
  • Year and Date: 2009-01-26
• [Presentation] 磁気細胞パターニング法を用いた3 次元がん細胞挙動評価モデルの構築 (2009)
  • Author(s): 高野翔、大河内美奈、千賀威、本多裕之
  • Organizer: 化学工学会第74年会
  • Place of Presentation: 横浜国立大
• [Presentation] ナノ構造フォトニクスデバイスを用いたバイオセンシング (2008)
  • Author(s): 民谷栄一
  • Organizer: 大阪大学フォトニクス先端融合研究センター第3回シンポジウム「光とナノが創る科学と産業」
  • Place of Presentation: 大手町サンケイブラザ、東京
  • Year and Date: 2008-12-12
• [Presentation] 先端バイオセンサーを用いた安全安心計測への展開 (2008)
  • Author(s): 民谷栄一
  • Organizer: 第4回バイオ計測プロジェクト「食の安全・安心のバイオ計測」発表交流会
  • Place of Presentation: 京都大学
  • Year and Date: 2008-11-14
• [Presentation] ナノ構造デバイスとインターフェース分子を連携したバイオチップ (2008)
  • Author(s): 民谷栄一
  • Organizer: 第26回医用高分子研究会講座-検査・診断を支える高分子-
  • Place of Presentation: 産業技術総合研究所臨海副都心センター、東京
  • Year and Date: 2008-11-11
• [Presentation] バイオセンシングテクノロジーとPOC対応型バイオセンサー (2008)
  • Author(s): 民谷栄一
  • Organizer: 日本臨床検査自動化学会第40回大会
  • Place of Presentation: パシフィコ横浜会議センター、神奈川
  • Year and Date: 2008-10-10
• [Presentation] ナノインターフェース制御と光バイオセンシング (2008)
  • Author(s): 民谷栄一
  • Organizer: 第4回集積光デバイス技術研究会
  • Place of Presentation: 芝浦工大、東京
  • Year and Date: 2008-07-30
• [Presentation] Conductive biocompatible polymer pattering inside microfluidic channel for cellular investigation (2008)
  • Author(s): Mohammad, Mosharraf, Hossain、斉藤真人、Minhaz, Uddin, Ahmed、民谷栄一
  • Organizer: 日本電気化学会 (第75大会)
  • Place of Presentation: 山梨大学
  • Year and Date: 2008-03-31
• [Presentation] 一細胞マイクロアレイチッブを用いた抗原感作マウス牌B細胞の発現解析 (2008)
  • Author(s): 清水 良純、山村 昌平、奥山亮、高村 禅、中野秀雄、民谷 栄一
  • Organizer: 日本化学会第88春季年会(2008)
  • Place of Presentation: 千葉、
  • Year and Date: 2008-03-29
• [Presentation] Addressable Fluidic Gate Arrays for Layer-to-Layor Parallel Fluidic Transportation System (2008)
  • Author(s): T., Morimoto・S., Konishi
  • Organizer: Proc of the 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS'8)
  • Place of Presentation: Tucson, Arizona, USA
  • Year and Date: 2008-01-17
• [Presentation] Both Pneumatic and Magnetic Induction of Scattered Cells on Micro Channel Array for Cellular Analysis (2008)
  • Author(s): T. Hiranishi, W. Tonomura, K. Ino, M. Okochi, H. Honda and S. Konishi
  • Organizer: Proc. of the 21^<st> IEEE International Conference on Micro Electro Mechanical Systems (MEMS'08)
  • Place of Presentation: Tucson, Arizona, USA
  • Year and Date: 2008-01-15
• [Presentation] Both Pneumatic and Magnetic Induction of Scattered Cells on Micro Channel Array for Cellular Analysis (2008)
  • Author(s): T., Hiranishi・W., Tonomura・K., Ino・M., Okochi・H., Honda・S., Konishi
  • Organizer: Proc of the 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS'08)
  • Place of Presentation: Tucson, Arizona, USA
  • Year and Date: 2008-01-15
• [Presentation] Single-Cell Based Microchips for Cellular Signal Analyses (2008)
  • Author(s): E. Tamiya
  • Organizer: PRiME 2008, 214th ECS Meeting
  • Place of Presentation: Honolulu
• [Presentation] Screening of adhesion peptide for mesencymal stem cell (2008)
  • Author(s): M. Okochi
  • Organizer: 3rd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: Zurich, Swiss
• [Presentation] Hierarchical oscillatory patterns observed in the spontaneous and evoked activity in cultured small recurrent networks (2008)
  • Author(s): Moriguchi H., Tamai N., Takayama Y., Kotani K., Jimbo Y
  • Organizer: 6th FENS Forum
  • Place of Presentation: Geneva
• [Presentation] Neurons derived from P19 embryonal carcinoma cells establish functional neuronal network (2008)
  • Author(s): Takayama Y., Saito A., Moriguchi H., Kotani K., Jimbo Y
  • Organizer: 6th Int. Meeting on Substrate-Integrated Microelectrodes
  • Place of Presentation: Reutlingen
• [Presentation] ナノ・マイクロバイオデバイスの開発と安全安心社会への応用 (2008)
  • Author(s): 斉藤真人、吉川裕之、民谷栄一
  • Organizer: 日本分光学会高感度表面・界面部会第1回シンポジウム
  • Place of Presentation: 産業技術総合研究所つくばセンター
• [Presentation] ナノ構造デバイスとインターフェース分子を連携したバイオチップ (2008)
  • Author(s): 民谷栄一
  • Organizer: 第26 回医用高分子研究会講座-検査・診断を支える高分子-
  • Place of Presentation: 産業技術総合研究所臨海副都心センター、東京
• [Presentation] 細胞接着ペプチドの探索法の開発とペプチド固定化基盤上での細胞 (2008)
  • Author(s): 大河内美奈
  • Organizer: 第17回日本バイオイメージング学会
  • Place of Presentation: 千葉
• [Presentation] 接着ペプチド修飾基盤における間葉系幹細胞の分化誘導 (2008)
  • Author(s): 大河内美奈
  • Organizer: 日本生物工学会平成20年度大会
  • Place of Presentation: 仙台
• [Presentation] 磁性微粒子を用いた液滴ハンドリングによる細胞計測 (2008)
  • Author(s): 本多裕之
  • Organizer: 第6回ライフサーベイヤシンポジウム
  • Place of Presentation: 大阪大学
• [Presentation] 一細胞マイクロアレイチップを用いた抗原感作マウス脾B 細胞の発現解析 (2008)
  • Author(s): 清水良純、山村昌平、奥山亮、高村禅、中野秀雄、民谷栄一
  • Organizer: 日本化学会第88 春季年会
  • Place of Presentation: 千葉
• [Presentation] 微小神経回路アレイのネットワーク活動の電気的・光学的計測 (2008)
  • Author(s): 森口裕之, 高山祐三, 小谷 潔, 神保泰彦
  • Organizer: 電気学会電子・情報・システム部門大会
  • Place of Presentation: 函館
• [Presentation] Toward ultra-high sensitive detection approaches in nanosensors based on gold-capped nanoparticles structure (2008)
  • Author(s): H. M. Hiep, M. Saito, E. Tamiya
  • Organizer: 8th International Conference on Nano-Molecular Electronics(ICNME 2008)
  • Place of Presentation: Kobe
• [Presentation] Electro - active cells on. Microfluidic cell chips : Culture, Stimulation and Manipulation (2008)
  • Author(s): M.M. Hossain, S.R. Rao, E. Tamiya
  • Organizer: 5th International Stemcell School Regenerative Medicine 2008
  • Place of Presentation: Berlin and Rostock, Germany
• [Presentation] Microfluidics Flow-chip PCR-electrochemical Sensor for the Rapid Detection of Pathogen (2008)
  • Author(s): M. U. Ahmed, M. Saito, E. Tamiya
  • Organizer: PRiME 2008, 214th ECS Meeting
  • Place of Presentation: Honolulu
• [Presentation] Microfluidic system for on-chip high-throughput antigen-speciic single B-lymphocyte screening and cell functional analysis (2008)
  • Author(s): S. R. Rao, M. Saito and E. Tamiya
  • Organizer: PRiME 2008, 214th ECS Meeting
  • Place of Presentation: Honolulu
• [Presentation] An efficient optical biosensor based on core-shell nanoparticle array for biomolecular Interactions (2008)
  • Author(s): H.M. Ha, T. Endo, M. Saito, Y. Takamura, T. Asahi, E. Tamiya
  • Organizer: The 10th World Congress on Biosensors 2008
  • Place of Presentation: Shanghai, China
• [Presentation] Electrochemical patterning of conductive polymer inside micro fluidic channel for biosensor application (2008)
  • Author(s): M.M. Hossain, M. Saito, E. Tamiya
  • Organizer: The 10th World Congress on Biosensors 2008
  • Place of Presentation: Shanghai, China
• [Presentation] A rapid electrochemical sensor based on DNA-hoechst 33258 interaction for the detection of unpurified LAMP and PCR amplicons (2008)
  • Author(s): M.U. Ahmed, M. Saito, S. Yamamura, Y. Takamura, E. Tamiya
  • Organizer: The 10th World Congress on Biosensors 2008
  • Place of Presentation: Shanghai, China
• [Presentation] Label-free Electrochemical-optical Detection of Peptide Toxins Binding to a Membrane Based on Core-Shell Nanoparticles Substrates (2008)
  • Author(s): H. M. Ha, M. Saito, T. End o and E. Tamiya
  • Organizer: PRiME 2008, 214th ECS Meeting
  • Place of Presentation: Honolulu
• [Presentation] Biofuel Cells with Cellulose Nano-Particles (2008)
  • Author(s): Y. Sugano, M. Saito and E. Tamiya
  • Organizer: PRiME 2008, 214th ECS Meeting
  • Place of Presentation: Honolulu
• [Presentation] 磁気細胞アレイを用いた1細胞解析 (2008)
  • Author(s): 伊野浩介、大河内美奈、小西奈緒、今井連太郎、式田光宏、本多裕之
  • Organizer: 化学工学会第73年会
  • Place of Presentation: 静岡大学
• [Presentation] Transparent Biosensor with Micro Channel Array for Optical and Electrophysiological Cell Signal Detection (2007)
  • Author(s): W., Tonomura・M., Sato・H., Okamura・S., Konishi
  • Organizer: Proc of the 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS'08)
  • Place of Presentation: Tucson, Arizona, USA
  • Year and Date: 2007-11-12
• [Presentation] 細胞ネットワーク定量解析用MEMSデバイスとその応用 (2007)
  • Author(s): 殿村 渉, 小西 聡, 森口 裕之, 高山 祐三, 神保 泰彦
  • Organizer: 第24回「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2007-10-17
• [Presentation] 曲面構造を用いた空圧駆動ダイヤフラム型バルブの性能向上 (2007)
  • Author(s): 森本 孝、Ok, Chan, Jeong, 小西 聡
  • Organizer: 第24回「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2007-10-16
• [Presentation] 化学的細胞膜穿孔のための試薬灌流型チャネル/試薬固定プローブを有するマイクロデバイス (2007)
  • Author(s): 山本 貴宏, 磯 圭祐, 小西 聡, 齋藤敬, 六車 仁志, 田畑 仁
  • Organizer: 第24回「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2007-10-16
• [Presentation] 一細胞マイクロアレイチッブを用いた抗原特異的Bリンパ球細胞の発現解析 (2007)
  • Author(s): 清水 良純、山村 昌平、高村 禅、民谷 栄一
  • Organizer: 日本化学会第22回生体機能関連化学シンボジウム
  • Place of Presentation: 宮城
  • Year and Date: 2007-09-28
• [Presentation] 超集積・高機能型一細胞チッブを用いた細胞シグナルけ寧析システムの開発 (2007)
  • Author(s): 山村 昌平
  • Organizer: 日本生物工学会2007シンボジウム
  • Place of Presentation: 広島
  • Year and Date: 2007-09-26
• [Presentation] Sinultaneous Multipoint Measurement of Cellular Network by Isolated Micro Channel Array with Pt-Black Electrodes (2007)
  • Author(s): W., Tonomura・S., Konishi
  • Organizer: The 2nd International Workshop on Approaches to Single-cell Analysis
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-09-06
• [Presentation] 細胞信号計測用マイクロチャネルアレイデバイスと神経ネットワーク解析への応用 (2007)
  • Author(s): 殿村 渉, 守口 裕之, 高山 祐三, 神保 泰彦, 小西 聡
  • Organizer: 平成19年電気学会電子・情報システム部門大会
  • Place of Presentation: 大阪府立大学中百舌鳥キャンパス
  • Year and Date: 2007-09-04
• [Presentation] Simultaneous Multipoint Measurement of Cellular Network by Isolated Micro Channel Array with Pt-Black Electrode (2007)
  • Author(s): W. Tonomura, T. Kurashima, Y. Takayama, H. Moriguchi, Y. Jimbo and S. Konishi
  • Organizer: Proc. of the 14^<th> International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'07)
  • Place of Presentation: Lyon, France
  • Year and Date: 2007-06-13
• [Presentation] Simultaneous Multipoint Measurement of Cellular Network by Isolated Micro Channel Array with Pt-Black Electrode (2007)
  • Author(s): W., Tonomura・T., Kurashima・Y., Takayama・H., Moriguchi・Y., Jimbo・S., Konishi
  • Organizer: Proc of the 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'07)
  • Place of Presentation: Lyon, France
  • Year and Date: 2007-06-13
• [Presentation] 集積型一細胞チップを用いた細胞シグナル解析システムの開発、特定領域研究生体分子分のデジタル精密計測に基づいた細胞機能解析 (2007)
  • Author(s): 山村昌平
  • Organizer: ライフサーペイヤ若手の会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-05
• [Presentation] 光学的・電気的観察機能を有した細胞信号計測用MEMSデバイス (2007)
  • Author(s): 殿村 渉, 岡村 均, 小西 聡
  • Organizer: 日本機械学会ロボティクス・メカトロニクス部門ロボテイクス・メカトロニクス講演会
  • Place of Presentation: 秋田拠点センターALVE
  • Year and Date: 2007-05-12
• [Presentation] Magnetic force-based cell patterning for tissue engineering (2007)
  • Author(s): K. Ino, A. Ito, M. Okochi, H. Honda
  • Organizer: International Conference on Cellular & Molecular Biology
  • Place of Presentation: シンガポール
• [Presentation] A cell patterning technique using magnetic force (2007)
  • Author(s): K. Ino, A. Ito, M. Okochi, H. Honda
  • Organizer: The 2nd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: Waseda Univ., Tokyo
• [Presentation] New technologies and materials (2007)
  • Author(s): E. Tamiya
  • Organizer: The 2nd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: Tokyo
• [Presentation] Single-cell picoliter microfluidic chip system for high-throughput screening and analysis of antigen-specific B-cells form bulk suspensions (2007)
  • Author(s): R.R. Sathuluri, M. Kitamura, S. Yamamura, Y. Takamura, E. Tamiya
  • Organizer: Engineering cell biology II
  • Place of Presentation: Massachusetts
• [Presentation] Nanotechnology- Oriented Biosensors and Biochips (2007)
  • Author(s): E. Tamiya
  • Organizer: Asia Sense 2007
  • Place of Presentation: マニラ(Invited)
• [Presentation] New technologies and materials (2007)
  • Author(s): Eiichi, Tamiya
  • Organizer: The 2nd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: 東京
• [Presentation] High-throughput Single-cell analysis systems for antigen-specific B-cells (2007)
  • Author(s): Shohei, Yamamura・Yoshizumi, Shimizu・Ramachandra, Rao, Sathuluri・Yuzuru, Takamura・Eiichi, Tamiya
  • Organizer: The 2nd International Workshop on Approaches to Single-cell Analysis
  • Place of Presentation: Tokyo
• [Presentation] Single-cell microarray for high-throughput analysis of dioxin-specific B-cells, (2007)
  • Author(s): Shohei, Yamamura・Yoshizumi, Shimizu・Ramachandra, Rao, Sathuluri・Yuzuru, Takamura・Eiichi, Tamiya
  • Organizer: Engineering cell biology II
  • Place of Presentation: Massachusetts
• [Presentation] Nanotechnology-Oriented Biosensors and Biochips (2007)
  • Author(s): Eiichi, Tamiya
  • Organizer: Asia Sense 2007
  • Place of Presentation: マニラ
• [Presentation] Nanobiotechnology and Biosensor Innovation (2007)
  • Author(s): Eiichi, Tamiya
  • Organizer: International Conference on Biotechnology Engineering 2007
  • Place of Presentation: マレーシア
• [Presentation] 磁石を駆動力とした微小液滴操作による遺伝子解析用マイクロデバイスの開発 (2007)
  • Author(s): 大河内美奈、土屋裕義、長尾宣洋、式田光宏、本多裕之
  • Organizer: 第80回日本分子生物学会生化学会合同大会
  • Place of Presentation: 静岡大学
• [Presentation] A cell patterning technique using magnetic force (2007)
  • Author(s): Kosuke, Ino・Akira, Ito・Mina, Okochi・Hiroyuki, Honda
  • Organizer: The 2nd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: 早稲田大学
• [Presentation] 磁気細胞パターニング法を用いた細胞アレイの作成 (2007)
  • Author(s): 伊野浩介、大河内美奈、小西奈緒、今井連太郎、式田光宏、本多裕之
  • Organizer: 日本生物工学会平成19年度大会
  • Place of Presentation: 広島大学
• [Presentation] 探索したペプチドの問葉系幹細胞接着・形態制御 (2007)
  • Author(s): 野村茂幸、加賀千晶、加藤竜司、大河内美奈、紀ノ岡正博、本多裕之
  • Organizer: 日本生物工学会平成19年度大会
  • Place of Presentation: 広島大学
• [Presentation] A single human chromosome manipulation and gene detection via trace volume PCR amplification using microtweezer probe and microchamber array (2006)
  • Author(s): M. Saito, K. Nakagawa, T. Takekawa, K. Yamanaka, Y. Takamura, G. Hashiguchi, E. Tamiya
  • Organizer: Micro Total Analysis System 2006
  • Place of Presentation: Tokyo
• [Presentation] A new design of knife edged-AFM probe for chromosome precision manipulating (2005)
  • Author(s): M. Saito, K. Nakagawa, K. Yamanaka, Y. Takamura, E. Tamiya
  • Organizer: The 13th international conference on solid-state sensors, actuators and Microsystems (Transducers05)
  • Place of Presentation: KOREA
• [Book] 神経回路活動の計測,分担執筆(合原,神崎編 理工学系からの脳科学入門 (2008)
  • Author(s): 神保泰彦
  • Publisher: 東京大学出版会
• [Book] "Pico/Nanoliter Chamber Array Chips for Single-cell, DNA and Protein Analyses", Nanomaterials for Biosensors (2007)
  • Author(s): S. Yamamura, S.R. Rao, E. Tamiya
  • Publisher: Wiley-VCH Publishers, USA
• [Book] 動物実験代替のためのバイオマテリアル・デバイス (2007)
  • Author(s): 酒井康行、民谷栄一他57名
  • Total Pages: 324
  • Publisher: シーエムシー出版
• [Book] バイオセンサーの先端化学技術と応用 (2007)
  • Author(s): 民谷栄一
  • Total Pages: 320
  • Publisher: シーエムシー出版
• [Book] 動物実験代替のためのバイオマテリアル・デバイス (2007)
  • Author(s): 酒井 康行、民谷 栄一, 他57名
  • Total Pages: 324
  • Publisher: 株式会社シーエムシー出版
• [Book] バイオセンサーの先端化学技術と応用 (2007)
  • Author(s): 民谷 栄一, 他40名
  • Total Pages: 320
  • Publisher: 株式会社シーエムシー出版
• [Book] Frontiers in Biochip Technology (2006)
  • Author(s): Y.Jimbo, N.Kasai, K.Torimitsu, T.Tateno
  • Publisher: Springer-Verlag(分担執筆)
• [Book] Frontiers in Biochip Technology(分担執筆) (2006)
  • Author(s): Y.Jimbo
  • Publisher: Springer-Verlag(in press)
• [Book] 第5版 実験化学講座 25 触媒化学、電気化学(分担執筆) (2006)
  • Author(s): 民谷栄一
  • Total Pages: 413
  • Publisher: 丸善
• [Remarks]
  • URL: http://www.tuat.ac.jp/~surveyor/
• [Remarks] 山村昌平、民谷栄一、ナノ・マイクロ技術を用いた細胞間ネットワークシグナルの解析、表面科学 28, 211-217 (2007)
• [Remarks] 山村昌平、民谷栄一、細胞機能解析をめざしたオンチップバイオデバイス、電気化学および工業物理化学 74, 890-894 (2006)ほか3件