Development of Novel Chemical Tools, Materials and Devices for Precise and Digital Analysis of Single Cell

• Project/Area Number: 17066005
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: HAMACHI Itaru Kyoto University, 大学院・工学研究科, 教授 (90202259)
• Co-Investigator(Kenkyū-buntansha): MIHARA Hisakazu 東京工業大学, 生命理工学研究科, 教授 (30183966) ; SUGIMOTO Naoki 甲南大学, 理工学部, 教授 (60206430) ; YOHDA Masafumi 東京農工大学, 共生科学技術研究部, 教授 (50250105) ; KINBARA Kazushi 東北大学, 多元物質科学研究所, 准教授 (30282578)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥261,000,000 (Direct Cost: ¥261,000,000); Fiscal Year 2008: ¥56,200,000 (Direct Cost: ¥56,200,000); Fiscal Year 2007: ¥56,200,000 (Direct Cost: ¥56,200,000); Fiscal Year 2006: ¥71,400,000 (Direct Cost: ¥71,400,000); Fiscal Year 2005: ¥77,200,000 (Direct Cost: ¥77,200,000)
• Keywords: バイオセンサー / DNA構造変化 / 分子クラウディング / ペプチドアレイ / 化合物ライブラリー / 分子認識 / 化学センサー / 機能性タンパク質 / 量子ドット

Research Abstract

細胞機能を制御する生体機能シグナルは、物理シグナルだけでなく分子が担う化学シグナルが重要な位置を占める。具体的には、局所的な電位や温度、pHから金属イオン、アニオン種、有機小分子、糖類や核酸、脂質、ペプチド、タンパク質などが色々な局面で生体機能のデジタル情報を担っている。細胞内外の機能情報を網羅的に解析するために、このような非常に多様で複雑かつ微量な分析対象それぞれをハイスループットに検出・分析できるセンサーやプローブ、種々の材料を、人工小分子から核酸、ペプチド、タンパク質、ナノ構造体を基盤として開発することに成功した。

Research Products

• [Journal Article] Fluorescent BODIPY-Based Zn(II)-Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer's Disease Patients. (2009)
  • Author(s): Ojida A, Sakamoto T, Inoue M, Fujishima S, Lippens G, Hamachi I.
  • Journal Title: J. Am. Chem. Soc., (ASAP Article)
  • Peer Reviewed
• [Journal Article] Ligand-directed tosyl chemistry for protein labeling in vivo. (2009)
  • Author(s): Tsukiji S, Miyagawa M, Takaoka Y, Tamura T, Hamachi I.
  • Journal Title: Nature Chemical Biology 5 Pages: 341-343
  • Peer Reviewed
• [Journal Article] MCM-Enzyme-Supramolecular Hydrogel Hybrid as a Fluorescence Sensing Material for Poly-anions of Biological Significance. (2009)
  • Author(s): Wada A, Tamaru S, Ikeda M, Hamachi I.
  • Journal Title: J.Am.Chem.Soc. 131(ASAP Article)
  • Peer Reviewed
• [Journal Article] Poly(amidoamine)dendrimermodified gold surfaces for anomalous reflection of gold (AR) method to detect biomolecular interactions. (2009)
  • Author(s): Syahir A, Tomizaki K -Y, Kajikawa K, Mihara H.
  • Journal Title: Langmuir 25 Pages: 3667-3674
  • Peer Reviewed
• [Journal Article] Hydration of Watson-Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions. (2009)
  • Author(s): Miyoshi D, Nakamura K, Tateishi-Karimata H, Ohmichi T, Sugimoto N.
  • Journal Title: J Am Chem Soc 131 Pages: 3522-3531
  • Peer Reviewed
• [Journal Article] Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer : Stabilization of Microtubules against Depolymerization. (2009)
  • Author(s): Okuro K, Kinbara K, Tsumoto, Ishii N, Aida T
  • Journal Title: J. Am. Chem. Soc. 131 Pages: 1626-1627
  • Peer Reviewed
• [Journal Article] A Tubular Biocontainer : Metal Ion-Induced 1D Assembly of a Molecularly Engineered Chaperonin (2009)
  • Author(s): Biswas S, Kinbara K, Oya N, Ishii N, Taguchi H, Aida T
  • Journal Title: J. Am. Chem. Soc. (in press)
  • Peer Reviewed
• [Journal Article] Molecular Recognition, Fluorescence Sensing, and Biological Assay of Phosphate Anion Derivatives Using Artificial Zn(II)-Dpa Complexes (2009)
  • Author(s): T. Sakamoto, A. Ojida, I. Hamachi
  • Journal Title: Chem. Commun. Feature Article Pages: 141-152
  • Peer Reviewed
• [Journal Article] MCM-Enzyme-Supramolecular Hydrogel Hybrid as a Fluorescence Sensing Material for Poly-anions of Biological Significance (2009)
  • Author(s): A. Wada, S. Tamaru, M. Ikeda, I. Hamachi
  • Journal Title: J. Am. Chem. Soc 131
  • Peer Reviewed
• [Journal Article] Ligand-directed tosyl chemistry for protein labeling in vivo (2009)
  • Author(s): S. Tsukiji, M. Miyagawa, Y. Takaoka, T. Tamura, I. Hamachi
  • Journal Title: Nature Chemical Biology 5
  • Peer Reviewed
• [Journal Article] Fluorescent BODIPY-Based Zn(II)-Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer's Disease Patients (2009)
  • Author(s): A., Ojida, T. Sakamoto, M. Inoue, S. Fujishima, G. Lippens, I. Hamachi
  • Journal Title: J. Am. Chem. Soc.
  • Peer Reviewed
• [Journal Article] Selection and structural analysis of de novo proteins from an alpha3beta3 genetic library (2009)
  • Author(s): M. T. Jumawid, T. Takahashi, T. Yamazaki, H. Ashigai, H. Mihara
  • Journal Title: Protein Science 18 Pages: 384-398
  • Peer Reviewed
• [Journal Article] Poly(amidoamine)dendrimer-modified gold surfaces for anomalous reflection of gold (AR) method to detect biomolecular interactions (2009)
  • Author(s): A. Syahir, K. Tomizaki, K. Kajikawa, H. Mihara
  • Journal Title: Langmuir 25 Pages: 3667-3674
  • Peer Reviewed
• [Journal Article] Hydration of Watson-Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions (2009)
  • Author(s): D. Miyoshi, K. Nakamura, H. Karimata, T. Ohmichi, N. Sugimoto
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 3522-3531
  • Peer Reviewed
• [Journal Article] Reversible stability switching of a hairpin DNA via a photo-responsive linker unit (2009)
  • Author(s): L. Wu, K. Koumoto, N. Sugimoto
  • Journal Title: Chem. Commun Pages: 1915-1917
  • Peer Reviewed
• [Journal Article] Molecularly imprinted nanocomposites for highly sensitive SPR detection of a non-aqueous atrazine sample (2009)
  • Author(s): J. Matsui, M. Takayose, K. Akamatsu, H. Nawafune, K. Tamaki, N. Sugimoto
  • Journal Title: Analyst 134 Pages: 80-86
  • Peer Reviewed
• [Journal Article] Designable DNA Functions toward New Nanobiotechnology (2009)
  • Author(s): N. Sugimoto
  • Journal Title: sull. Chem. Coc. Jpn. 82 Pages: 1-10
  • NAID: 10023987013
  • Peer Reviewed
• [Journal Article] 「核酸アプタマー」のケミカル・ルネサンス"知る"から"活かす"への生命化学の新しい発想 (2009)
  • Author(s): 〓原正靖・杉本直己
  • Journal Title: 化学 64 Pages: 44-49
• [Journal Article] RNAスイッチを用いた微生物のタンパク質合成技術の開発と応用 (2009)
  • Author(s): 山内隆寛・杉本直己
  • Journal Title: バイオインダストリー 82 Pages: 66-72
• [Journal Article] An approach to peptide-based ATP receptors by a combination of random selection, rational design, and molecular imprinting (2009)
  • Author(s): J. Matsui, J. Nagano, D. Miyoshi, K. Tamaki, N. Sugimoto
  • Journal Title: Biosen. Bioelectron
  • Peer Reviewed
• [Journal Article] Characterization of a sHsp of Schizosaccharomyces pombe, SpHsp15.8, and the implication of its functional mechanism by comparison with another sHsp, SpHsp16.0 (2009)
  • Author(s): Sugino, C., Hirose, M., Tohda, H., Yoshinari, Y., Abe, T., Giga-Hama, Y., Iizukai, R., Shimizu, M., Kidokoro, S., Ishii, N. Yohda, M.
  • Journal Title: Proteins 74 Pages: 6-17
  • Peer Reviewed
• [Journal Article] Crystal structure of PH1733, an aspartate racemase homologue, from Pyrococcus horikoshii OT3 (2009)
  • Author(s): Kita, A., Tasaki, S., Yohda, M. Miki, K.
  • Journal Title: Protains 74 Pages: 240-244
  • Peer Reviewed
• [Journal Article] Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer : Stabilization of Microtubules against Depolymerization (2009)
  • Author(s): Kou Okuro, Kazushi Kinbara, et.al.
  • Journal Title: Journal of the Amerincan Chemical Society 131 Pages: 1626-1627
  • Peer Reviewed
• [Journal Article] Template Sol-Gel Synthesis of Mesostructured Silica Composite, Using Metal Complexes Bearing Amphiphilic Side Chains : Immobilization of a Polythene Pd Complex Formed by a Metallophilic Interaction (2009)
  • Author(s): Wataru Otani, Kazushi Kinbara, and Takuzo Aida
  • Journal Title: Faraday Discusssions 143
  • Peer Reviewed
• [Journal Article] Turn-on Fluorescence Sensing of Nucleside Polyphosphates Using a Xanthene-Based Zn(II) ComplexChemosensor. (2008)
  • Author(s): Ojida A, Takashima I, Kohira T, Nonaka H, Hamachi I.
  • Journal Title: J.Am.Chem.Soc. 130 Pages: 12095-12101
  • Peer Reviewed
• [Journal Article] Regulation of telomerase activity by the thermodynamic stability of a DNA x RNA hybrid. (2008)
  • Author(s): Yu H.-Q, Zhang D.-H, Gu X.-B, Miyoshi D, Sugimoto N.
  • Journal Title: Angew Chem Int Ed 47 Pages: 9034-9038
  • Peer Reviewed
• [Journal Article] Structure and molecular dynamics simulation of archaeal prefoldin : the molecular mechanism for binding and recognition of nonnative substrate proteins. (2008)
  • Author(s): Ohtaki A, Kida H, Miyata Y, Ide N, Yonezawa A, Arakawa T, Iizuka R, Noguchi K, Kita A, Odaka M, Miki K, Yohda M.
  • Journal Title: J Mol Biol 376 Pages: 1130-1141
  • Peer Reviewed
• [Journal Article] Structural and molecular characterization of the prefoldin beta subunit from Thermococcus strain KS-1. (2008)
  • Author(s): Kida H, Sugano Y, Iizuka R, Fujihashi M, Yohda M, Miki, K.
  • Journal Title: J Mol Biol 383 Pages: 465-474
  • Peer Reviewed
• [Journal Article] Functional characterization of recombinant prefoldin complexes from a hyperthermophilic archaeon, Thermococcus sp. strain KS-1. (2008)
  • Author(s): Iizuka R, Sugano Y, Ide N, Ohtaki A, Yoshida T, Fujiwara S, Imanaka T, Yohda M.
  • Journal Title: J Mol Biol 377 Pages: 972-983
  • Peer Reviewed
• [Journal Article] Toward Long-Distance Mechanical Communication : Studies on a Ternary Complex Interconnected by a Bridging Rotary Module. (2008)
  • Author(s): Kai H, Nara S, Kinbara K, Aida T
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 6725-6727
  • Peer Reviewed
• [Journal Article] Photo gel-sol/sol-gel transition and its patterning of a supramolecular hydrogel as stimuli-respnsive biomaterials (2008)
  • Author(s): S. Matsumoto, S. Yamaguchi, S. Ueno, H. Komatsu, M. Ikeda, K. Ishizuka, Y. Iko, K. V. Tabata, H. Aoki, S. Ito, H. Noii, I. Hamachi
  • Journal Title: Chem. -A Euro. J. 14 Pages: 3977-3986
  • Peer Reviewed
• [Journal Article] Mechanical reinforcement of supramolecular hydrogel comprising artificial glyco-lipid through supramolecular copolymerization (2008)
  • Author(s): M. Ikeda, Y. Shimizu, S. Matsumoto, H. Komatsu, S. Tamaru, T. Takigawa, I. Hamachi
  • Journal Title: Macromolecular Bioscience 8 Pages: 1019-1025
  • Peer Reviewed
• [Journal Article] Turn-on Fluorescence Sensing of Nucleside Polyphosphates Using a Xanthene-Based Zn(II) Complex Chemosensor (2008)
  • Author(s): A. Ojida, I. Takashima, T, Kohira, H. Nonaka, I. Hamachi
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 12095-12101
  • Peer Reviewed
• [Journal Article] Three-dimensional encapsulation of live cells by using a hybrid matrix of nanoparticles in a supramolecular hydrogel (2008)
  • Author(s): M. Ikeda, S. Ueno, S. Matsumoto, Y. Shimizu, H. Komatsu, K. Kusumoto, I. Hamachi
  • Journal Title: Chem. -A Euro. J. 14 Pages: 10808-10815
  • Peer Reviewed
• [Journal Article] Fluorescence Imaging of Intracellular Cadmium Using a Dualexcitation Ratiometric Chemosensor (2008)
  • Author(s): M. Taki, M. Desaki, A. Ojida, T. Hirayama, I. Hamachi, Y. Yamamoto, S. Iyoshi
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 12564-12565
  • Peer Reviewed
• [Journal Article] Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn(II)-Dpa Chemosensor (2008)
  • Author(s): T. Kohira, I. Takashima, H. Nonaka, A. Ojida, I. Hamachi
  • Journal Title: Chem. Lett. 37 Pages: 1164-1165
  • NAID: 130004424966
  • Peer Reviewed
• [Journal Article] Construction of Multi-functional Extracellular Matrix Proteins that Promote Tube Formation of Endothelial Cells (2008)
  • Author(s): M. Nakamura, M. Mie, H. Mihara, M. Nakamura, E. Kobatake
  • Journal Title: Biomaterials 29 Pages: 2977-2986
  • Peer Reviewed
• [Journal Article] Peptide and Protein Mimetics Inhibiting the Amyloid beta-Peptide Aggregation (2008)
  • Author(s): T. Takahashi, H. Mihara
  • Journal Title: Accounts of Chemical Research 41(10) Pages: 1309-1318
  • Peer Reviewed
• [Journal Article] Telomerase activity regulated by thermodynamic stability of DNA-RNA hybrid (2008)
  • Author(s): H. Yu, D. Zhang, X. Gu, D. Miyoshi, N. Sugimoto
  • Journal Title: Angew. Chem. Int. Ed. 47 Pages: 9034-9038
  • Peer Reviewed
• [Journal Article] Riboswitches for enhancing target gene expression in eukaryotes (2008)
  • Author(s): T. Yamauchi, D. Miyoshi, T. Kubodera, M. Ban, A. Nishimura, N. Sugimoto
  • Journal Title: Chem Bio Chem 9 Pages: 1040-1043
  • Peer Reviewed
• [Journal Article] Recognition of a flipped base in a hairpinloop DNA by a small peptide (2008)
  • Author(s): J. Kawakami, S. Okabe, Y. Tanabe, N. Sugimoto
  • Journal Title: Nucleosides, Nucleotides, and Nucleic Acids 27 Pages: 292-308
  • Peer Reviewed
• [Journal Article] Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media (2008)
  • Author(s): S. Nakano, L. Wu, H. Oka, H. T. Karimata, T. Kirihata, Y. Sato, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, N. Sugimoto
  • Journal Title: Mol. BioSys t. (Emerging Investigators issue) 4 Pages: 579-588
  • Peer Reviewed
• [Journal Article] Molecular crowding effects on structure and stability of DNA (2008)
  • Author(s): D. Miyoshi, N. Sugimoto
  • Journal Title: Biochimie 90 Pages: 1040-1051
  • Peer Reviewed
• [Journal Article] Design of allele-specific primers and detection of the human ABO genotyping to avoid the pseudopositive problem (2008)
  • Author(s): H. Yaku, T. Yukimasa, S. Nakano, N. Sugimoto, H. Oka
  • Journal Title: Electrophoresis 29 Pages: 4130-4140
  • Peer Reviewed
• [Journal Article] Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme (2008)
  • Author(s): S. Nakano, Y. Kitagawa, H. T. Karimata, N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 52 Pages: 519-520
• [Journal Article] Thermodynamics of DNA structures under molecular crowding conditions with neutral and positive charged cosolutes (2008)
  • Author(s): D. Miyoshi, K. Nakamura, S. Muhuli, H. T. Karimata, N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 52 Pages: 413-414
• [Journal Article] Enhanced amplification of polymerase chain reaction by addition of cosolutes derived from a cellular compatible solute (2008)
  • Author(s): K. Koumoto, H. Ochiai, N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 52 Pages: 257-258
• [Journal Article] Hydration is an important factor to regulate thermodynamic stability, of a DNA duplex under molecular crowding condtions (2008)
  • Author(s): K. Koumoto, H. Ochiai, N. Sugimoto
  • Journal Title: Chem. Lett. 37 Pages: 864-865
  • Peer Reviewed
• [Journal Article] DNAはなぜ二重らせん構造になるのか? -分子間相互作用と分子環境効果を考える- (2008)
  • Author(s): 杉本直己・中野修一
  • Journal Title: 現代化学 450 Pages: 25-30
  • NAID: 40016203606
• [Journal Article] 麹菌をタンパク質工場にする化学-いつでも好きなだけタンパク質をつくれるスイッチRNA- (2008)
  • Author(s): 山内隆寛・杉本直己
  • Journal Title: 化学 63 Pages: 36-40
  • NAID: 40016347390
• [Journal Article] 外部刺激に応答する機能性核酸-核酸ならではの機能を活用したナノバイオマテリアルの設計 (2008)
  • Author(s): 三好大輔・杉本直己
  • Journal Title: 化学工業 59 Pages: 21-27
• [Journal Article] Novel catalytic activity of nitrile hydratase from Rhodococcus sp. N771 (2008)
  • Author(s): Taniguchi, K., Murata, K., Murakami, J., Takahashi, S., Nakamura, T., Hashimoto, K., Koshino, H., Dohmae, N., Yohda, M., Hirose, T., Maeda, M. Odaka, M.
  • Journal Title: J Biosci Bioeng 106 Pages: 174-179
  • NAID: 110006873807
  • Peer Reviewed
• [Journal Article] Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin (2008)
  • Author(s): Sakono, M., Zako, T., Ueda, H., Yohda, M. Maeda, M.
  • Journal Title: FEBS J 275 Pages: 5982-5993
  • Peer Reviewed
• [Journal Article] Role of the IXI/V motif in oligomer assembly and function of StHsp14.0, a small heat shock protein from the acidothermophilic archaeon, Sulfolobus tokodaii strain 7 (2008)
  • Author(s): Saji, H., Iizuka, R., Yoshida, T., Abe, T., Kidokoro, S., Ishii, N. Hohda, M.
  • Journal Title: Proteins 71 Pages: 771-782
  • Peer Reviewed
• [Journal Article] Overexpression of prefoldin from the hyperthermophilic archaeum Pyrococcus horikoshii OT3 endowed Escherichia coli with organic soluent tolerance (2008)
  • Author(s): Okochi, M., Kanie, K., Kurimoto, M., Yohda, M. Honda, H.
  • Journal Title: Appl Microbiol Biotechnol 79 Pages: 443-449
  • Peer Reviewed
• [Journal Article] Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism (2008)
  • Author(s): Ohtaki, A., Nakano, Y., Iizuka, R., Arakawa, T., Yamada, K., Odaka, M. Yohda, M.
  • Journal Title: Proteins 70 Pages: 1167-1174
  • Peer Reviewed
• [Journal Article] Modulation of redox potential and alteration in reactivity via the peroxide shunt pathway by mutation of cytochrome P450 around the proximal heme ligand (2008)
  • Author(s): Matsumura, H., Wakatabi, M., Omi, S., Ohtaki, A., Nakamura, N., Yohda, M. Ohno, H
  • Journal Title: Biochemistry 47 Pages: 4834-4842
  • Peer Reviewed
• [Journal Article] Dynamics of group II chaperonin and prefoldin probed by 13C NMR spectroscopy (2008)
  • Author(s): Kurimoto, E., Nishi, Y., Yamaguchi, Y., Zako, T., Iizuka, R., Ide, Yohda, M. Kato, K.
  • Journal Title: Proteins 70 Pages: 1257-1263
  • Peer Reviewed
• [Journal Article] Structural and molecular characterization of the prefoldin beta subunit from Thermococcus strain KS-1 (2008)
  • Author(s): Kida, H., Sugano, Y., Iizuka, R., Fujihashi, M., Yohda, M. Miki, K.
  • Journal Title: J Mol Biol 383 Pages: 465-474
  • Peer Reviewed
• [Journal Article] Sequential action of ATP-dependent subunit conformational change and interaction between helical protrusions in the closure of the built-in lid of group II chaperonins (2008)
  • Author(s): Kanzaki, T., Iizuka, R., Takahashi, K., Maki, K., Masuda, R., Sahlan, M., Yebenes, H., Valpuesta, J. M., Oka, T., Furutani, M., Ishii, N., Kuwajima, K. Yohda, M.
  • Journal Title: J Biol Chem 283 Pages: 34773-34784
  • Peer Reviewed
• [Journal Article] Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines (2008)
  • Author(s): Islam, M. M., Sohya, S., Noguchi, K., Yohda, M. Kuroda, Y.
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 15334-15339
  • Peer Reviewed
• [Journal Article] Functional characterization of recombinant prefoldin complexes from a hyperthermophilic archaeon, Thermococcus sp. strain KS-1 (2008)
  • Author(s): Iizuka, R., Sugano, Y., Ide, N., Ohtaki, A., Yoshida, T., Fujiwara, S., Imanaka, T. Yohda, M.
  • Journal Title: J Mol Biol 377 Pages: 972-983
  • Peer Reviewed
• [Journal Article] Catalytic mechanism of nitrile hydratase proposed by time-resolved X-ray crystallography using a novel substrate, tart-butysionitrile (2008)
  • Author(s): Hashimoto, K., Suzuki, H., Taniguchi, K., Noguchi, T., Yohda, M. Odaka, M.
  • Journal Title: J Biol Chem 283 Pages: 36617-36623
  • Peer Reviewed
• [Journal Article] Toward Autonomously Operating Molecular Machines Driven by Transition-Metal Catalyst (2008)
  • Author(s): Kenichi Tanaka and Kazushi Kinbara
  • Journal Title: Molecular BioSystems 4 Pages: 512-514
  • Peer Reviewed
• [Journal Article] Toward Long-Distance Mechanical Communication : Studies on a Ternary Complex Interconnected by a Bridging Rotary Module (2008)
  • Author(s): Hiroyuki Kai, Shinji Nara, Kazushi Kinbara, and Takuzo Aida
  • Journal Title: Journal of the Amerincan Chemical Society 130 Pages: 6725-6727
  • Peer Reviewed
• [Journal Article] Thermally responsive supramolecular nano-meshes for on/off switching of the rotary motion of F1-ATPase at a single molecular level (2008)
  • Author(s): Satoshi Yamaguchi, Shinji Matsumoto, Koji Ishizuka. Yuko Iko, Kazuhito V. Tabata, Hideyuki Arata, Hiroyuki Fujita, Hiroyuki Noji, Itaru Hamachi
  • Journal Title: Chemistry-A European Journal 14 Pages: 1891-1896
  • Peer Reviewed
• [Journal Article] Artificial Receptors Designed for Intracellular Delivery of Anionic Phosphate Derivatices (2008)
  • Author(s): Takahiro Kohira, Kei Honda, Akio Ojida, Itaru Hamachi
  • Journal Title: ChemBioChem 9 Pages: 698-701
  • Peer Reviewed
• [Journal Article] Target-Specific Chemical Acylation of Lectins by Ligand-Tethered DMAP Catalysts (2008)
  • Author(s): Yoichiro Koshi, Eiji Nakata, Masayoshi Miyagawa, Shinya Tsukiji, Tomohisa Ogawa, and Itaru Hamachi
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 245-251
  • Peer Reviewed
• [Journal Article] Ratiometric Fluorescent Biosensor for Real-time and Label-free Monitoring of Fine Saccharide Metabolic Pathways (2008)
  • Author(s): Eiji Nakata, Hangxiang Wang, and Itaru Hamachi
  • Journal Title: ChemBioChem 9,1 Pages: 25-28
  • Peer Reviewed
• [Journal Article] Photo-responsive gel droplet as a nano-or pico-liter container comprising a supramolecular hydrogel (2008)
  • Author(s): Shinji Matsumoto, Satoshi Yamaguchi, Atsuhiko Wada, Toshihiro Matsui, Masato Ikeda, and Itaru Hamachi
  • Journal Title: Chem. Commun. Pages: 1545-1547
  • Peer Reviewed
• [Journal Article] Functional characterization of recombinant prefoldin complexes from a hyperthermophi1ic archaeon, Thermococcus sp. strain KS-1 (2008)
  • Author(s): Iizuka R, Sugano Y, Ide N, Ohtaki A, Yoshida T, Fujiwara S, Imanaka T, Yohda M
  • Journal Title: J Mol Biol. 28;377(3) Pages: 972-83
  • Peer Reviewed
• [Journal Article] Structure and molecular dynamics simulation of archaeal prefoldin: the molecular mechanism for binding and recognition of nonnative substrate proteins (2008)
  • Author(s): Ohtaki A, Kida H, Miyata Y, Ide N, Yonezawa A, Arakawa T, Iizuka R, Noguchi K, Kita A, Odaka M, Miki K, Yohda M
  • Journal Title: J Mol Biol. 29;376(4)
  • Peer Reviewed
• [Journal Article] Dynamics of group II chaperonin and prefoldin probed by 13C NMR spectroscopy (2008)
  • Author(s): Kurimoto E, Nishi Y, Yamaguchi Y, Zako T, Iizuka R, Ide N, Yohda M, Kato k
  • Journal Title: Proteins. 70(4) Pages: 1257-63
  • Peer Reviewed
• [Journal Article] Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism (2008)
  • Author(s): Ohtaki A, Nakano Y, Iizuka R, Arakawa T, Yamada K, Odaka M, Yohda M
  • Journal Title: Proteins. 70(4) Pages: 1167-74
  • Peer Reviewed
• [Journal Article] Toward Autonomously Operating Molecular Machines Driven by Transition-metal Catalyst (2008)
  • Author(s): K. Tanaka, K. Kinbara
  • Journal Title: Molecular Biosystems 4(印刷中)
  • Peer Reviewed
• [Journal Article] Ferrocenes as Novel Rotary Modules for Synthetic Molecular Machines (2008)
  • Author(s): K. Kinbara, T. Muraoka, T. Aida
  • Journal Title: Organic & Biomolecular Chemistry 6(印刷中)
  • Peer Reviewed
• [Journal Article] Phosphate-Mediated Molecular Memory Driven by Two Different Protein Kinases as Information Input Elements. (2007)
  • Author(s): Tomizaki K -Y, Mihara H.
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 8345-8352
  • Peer Reviewed
• [Journal Article] Localization of prefoldin interaction sites in the hyperthermophilic group II chaperonin and correlations between binding rate and protein transfer rate. (2007)
  • Author(s): Zako T, Murase Y, Iizuka R, Yoshida T, Kanzaki T, Ide N, Maeda M, Funatsu T, Yohda M.
  • Journal Title: J Mol Biol 364 Pages: 110-120
  • Peer Reviewed
• [Journal Article] (2007)
  • Author(s): Horiuchi H, Iwamia N, Tachibana F, Ohtaki A, Iizuka R, Zako T, Oda M, Yohda M, Tani T. Yohda M, Tani T.
  • Journal Title: J Luminescence 127 Pages: 192-197
  • Peer Reviewed
• [Journal Article] Design of a Hybrid Biosensor for Enhanced Phosphopeptide Recognition Based on a Phosphoprotein Binding Domain Coupled with a Fluorescent Chemosensor (2007)
  • Author(s): Takahiro Anai, Eiji Nakata, Yoichiro Koshi, Akio Ojida, and Itaru Hamachi
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 6232-6239
  • Peer Reviewed
• [Journal Article] Pyrene Excimer Based Dual-Emission detection of a Oligo-Aspartate Tag Fused Protein using Zn(II)-DpaTyr Probe (2007)
  • Author(s): Kei Honda, Sho-hei Fujishima, Akio Ojida, and Itaru Hamachi
  • Journal Title: ChemBioChem 8,12 Pages: 1370-1372
  • Peer Reviewed
• [Journal Article] Non-enzymatic Covalent Protein Labeling Using a Reactive Tag (2007)
  • Author(s): Hiroshi Nonaka, Shinya Tsukiji, Akio Ojida, Itaru Hamachi
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 15777-15779
  • Peer Reviewed
• [Journal Article] Screening of α-Helical Peptide Ligands Controlling a Calcineurin-Phosphatase Activity (2007)
  • Author(s): Usui K, Tomizaki K-Y, Mihara H
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 167-171
  • Peer Reviewed
• [Journal Article] Interactions Between Peptides Containing Nucleobase Amino Acids and T7 Phages Displaying S. cerevisiae Proteins (2007)
  • Author(s): Watanabe S, Tomizaki K-Y, Takahashi T, UsuiK, Kajikawa K, Mihara H
  • Journal Title: Biopolymer 88 Pages: 131-140
  • Peer Reviewed
• [Journal Article] Phosphate-Mediated Molecular Memory Driven by Two Different Protein・Kinases as Information Input Elements (2007)
  • Author(s): Tomizaki K-Y, Mihara H
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 8345-8352
  • Peer Reviewed
• [Journal Article] Embedding the Amyloid β-Peptide Sequence in Green Fluorescent Protein Inhibits A β 0ligomerization (2007)
  • Author(s): Takahashi T, Ohta K, Mihara H
  • Journal Title: ChemBioChem 8 Pages: 985-988
  • Peer Reviewed
• [Journal Article] Design of Peptides That Form Amyloid-like Fibrils Capturing Amyloid a β1-42 Peptides (2007)
  • Author(s): Sato J, Takahashi T, 0shima H, Matsumura S, Mihara H
  • Journal Title: Chem. Eur. J. 13 Pages: 7745-7752
  • Peer Reviewed
• [Journal Article] Artificial G-wire switch with 2,2'-bipyridine units responsive to divalent metal ions. (2007)
  • Author(s): D. Miyoshi, H. Karimata, Z.-M. Wang, K. Koumoto, and N. Sugimoto
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 5919-5925
  • Peer Reviewed
• [Journal Article] Consecutive GC base pairs determine the energy barrier of DNA duplex formation under molecularly crowded conditions. (2007)
  • Author(s): X. Gu, S. Nakano, and N. Sugimoto
  • Journal Title: Chem. Commun. Pages: 2750-2752
  • Peer Reviewed
• [Journal Article] Molecular imprinting under molecular crowding conditions:an aid to the synthesis of a high-capacity polymeric sorbent fortriazine herbicides. (2007)
  • Author(s): J. Matsui, S. Goji, T. Murashima, D. Miyoshi, S. Komai, A. Shigeyasu, T. Kushida, T. T, Miyazawa, T. Yamada, K. Tamaki, and N. Sugimoto
  • Journal Title: Anal. Chem. 79 Pages: 1749-1757
  • Peer Reviewed
• [Journal Article] Synthesis, structure and thermal stability of fully hydrophobicporphyrin-DNA conjugates. (2007)
  • Author(s): T. Murashima, K. Hayata, Y. Saiki, J. Matsui, D. Miyoshi, T. Yamada, T. Miyazawa, and N. Sugimoto
  • Journal Title: Tetrahedron Lett. 48 Pages: 8514-8517
  • Peer Reviewed
• [Journal Article] Effects of polyethylene glycol on a DNA duplex stability differed by the NaCl concentration. (2007)
  • Author(s): H. Karimata, S. Nakano, and N. Sugimoto
  • Journal Title: Bull. Chem. Soc. Jpn. 80 Pages: 1987-1994
  • NAID: 10019825196
  • Peer Reviewed
• [Journal Article] Hydration regulates thermodynamic stability of DNA structuresunder molecular crowding conditions. (2007)
  • Author(s): D. Miyoshi, H. Karimata, and N. Sugimoto
  • Journal Title: Nucleosides, Nucleotides and Nucleic Acids 26 Pages: 589-595
  • Peer Reviewed
• [Journal Article] Regulation of DNA nucleases by molecular crowding. (2007)
  • Author(s): Y. Sasaki, D. Miyoshi, and N. Sugimoto
  • Journal Title: Nucleic Acids Res. 35 Pages: 4086-4093
  • Peer Reviewed
• [Journal Article] The base-pairing ability of the base pair-mimic nucleosides. (2007)
  • Author(s): S. Nakano, K. Uenishi, M. Fujii, and N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 51 Pages: 71-72
• [Journal Article] Functionalization of DNA by the base pair-mimic nucleosides. (2007)
  • Author(s): H. Oka, S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 51 Pages: 151-152
• [Journal Article] Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex. (2007)
  • Author(s): K. Nakamura, H. Karimata, T. Ohmichi, D. Miyoshi, and N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 51 Pages: 167-168
• [Journal Article] Conformational switch of a functional nanowire based on the DNAG-quadruplex. (2007)
  • Author(s): H. Karimata, D. Miyoshi, T. Fujimoto, K. Koumoto, Z.-M. Wang, and N. Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 51 Pages: 251-252
• [Journal Article] Structure of thiocyanate hydrolase: a new nitrile hydratase family protein with a novel five-coordinate cobalt (III) center (2007)
  • Author(s): Arakawa T, Kawano Y, Kataoka S, Katayama Y, Kamiya N, Yohda M, Odaka M
  • Journal Title: J Mol Biol. 9;366(5) Pages: 1497-509
  • Peer Reviewed
• [Journal Article] Influence of cationic molecules on the hairpin to duplex equilibria of self-complementary DNA and RNA oligonucleotides (2007)
  • Author(s): S.Nakano, T.Kirihata, S.Fujii, H.Sakai, M.Kuwahara, H.Sawai, N.Sugimoto
  • Journal Title: Nucleic Acids Research 35 Pages: 486-494
• [Journal Article] Reversible Operation of Chiral Molecular Scissors by Redox and UV Light (2007)
  • Author(s): Muraoka, T., Kinbara, K., Aida, T.
  • Journal Title: Chem.Common. Pages: 1441-1443
• [Journal Article] Crystallographic and Chiroptical Studies on Tetraarylferrocenes for Use as Chiral Rotary Modules for Molecular Machines (2007)
  • Author(s): Muraoka, T., Kinbara, K., Wakamiya, A., Yamaguchi, S., Aida, T.
  • Journal Title: Chem.Eur.J. 13 Pages: 1724-1730
• [Journal Article] A Novel Peptide Microarray for Protein Detection and Analysis Utilizing a Dry Peptide Array System. (2006)
  • Author(s): Usui K, Tomizaki K -Y, Ohyama T, Nokihara K, Mihara H.
  • Journal Title: Mol. BioSyst. 2 Pages: 113-121
  • Peer Reviewed
• [Journal Article] Protein-fingerprint data mining of a designed a-helical peptide array (2006)
  • Author(s): Usui K, Tomizaki K -Y, Mihara H.
  • Journal Title: Mol. BioSyst. 2 Pages: 417-420
  • Peer Reviewed
• [Journal Article] DNA Logic Gates Based on Structural Polymorphism of Telomere DNA Molecules Responding to Chemical Input Signals. (2006)
  • Author(s): Miyoshi D, Inoue M, Sugimoto N.
  • Journal Title: Angew Chem Int Ed 45 Pages: 7716-7719
  • Peer Reviewed
• [Journal Article] Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions. (2006)
  • Author(s): Miyoshi D, Karimata H, Sugimoto N.
  • Journal Title: J Am Chem Soc 128 Pages: 7957-7963
  • Peer Reviewed
• [Journal Article] Mechanical Twisting of a Guest by a Photoresponsive Host. (2006)
  • Author(s): Muraoka T, Kinbara K, Aida T
  • Journal Title: Nature 440 Pages: 512-515
  • Peer Reviewed
• [Journal Article] Semibiological Molecular Machine with an Implemented "AND" Logic Gate for Regulation of Protein Folding. (2006)
  • Author(s): Muramatsu S, Kinbara K, Taguchi, H, Ishii N, Aida T
  • Journal Title: J. Am. Chem. Soc. 128 Pages: 3764-3769
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Bis(Zn(II)Dipicolylamine)-Based Fluorescent Artificial Chemosensors for Phosphorylated Proteins/Peptides (2006)
  • Author(s): Akio Ojida, Itaru Hamachi
  • Journal Title: Bull.Chem.Soc.Japan. 1 Pages: 35-46
  • NAID: 10017169809
• [Journal Article] Label-Free, Real-Time Glycosyltransferase Assay Based on a Fluorescent Artificial Chemosensor (2006)
  • Author(s): Jirarut Wongkongkatep, Yoshifumi Miyahara, Akio Ojida, Itaru Hamachi
  • Journal Title: Angew.Chem., Int.Ed. 45 Pages: 665-668
• [Journal Article] Effective Disruption of Phosphoprotein-Protein Surface Interaction Using Zn(II) Dipicolylamine-Based Artificial Receptors via Two-Point Interaction (2006)
  • Author(s): Akio Ojida, Masa-aki Inoue, Yasuko Mito-oka, Hiroshi Tsutsumi, Kazuki Sada, Itaru Hamachi
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 2052-2058
• [Journal Article] Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure (2006)
  • Author(s): H.Tamamura, A.Ojida, T.Ogawa, H.Tsutsumi, H.Masuno, Nakashima, N.Yamamoto, I.Hamachi, N.Fujii
  • Journal Title: J.Med.Chem. 49 Pages: 3412-3415
• [Journal Article] A Fluorescent Lectin Array Using Supramolecular Hydrogel for Simple Detection and Pattern Profiling for Various Glyco-conjugates (2006)
  • Author(s): Yoichiro Koshi, Eiji Nakata, Hiroki Yamane, Itaru Hamachi
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 10413-10422
• [Journal Article] Ratiometric fluorescence detection of a tag fused protein using the dual-emission artificial molecular probe (2006)
  • Author(s): Kei Honda, Eiji Nakata, Akio Ojida, Itaru Hamachi
  • Journal Title: Chem.Commun. 38 Pages: 4024-4026
• [Journal Article] Design of Dual-Emission Chemosensors for Ratiometric Detection of ATP Derivatives (2006)
  • Author(s): A.Ojida, Y.Miyahara, J.Wongkongkatep, S.Tamaru, K.Sada, I.Hamachi
  • Journal Title: Chem.Asian J 1(4) Pages: 555-563
• [Journal Article] A Novel Peptide Microarray for Protein Detection and Analysis Utilizing a Dry Peptide Array System (2006)
  • Author(s): Kenji Usui, Hisakazu Mihara
  • Journal Title: Mol.BioSyst. 2 Pages: 113-121
• [Journal Article] Protein-fingerprint data mining of a designed α-helical peptide array (2006)
  • Author(s): Kenji Usui, Hisakazu Mihara
  • Journal Title: Mol.BioSyst. 2 Pages: 417-420
• [Journal Article] Rational design of homogenous protein kinase assay platforms that allow both fluorometric and colorimetric signal readouts (2006)
  • Author(s): Kin-ya Tomizaki, Hisakazu Mihara
  • Journal Title: Mol.BioSyst. 2 Pages: 580-589
• [Journal Article] A PNA-DNA Hybridization Chip Approach for the Detection of b-Secretase Activity (2006)
  • Author(s): Shusuke Sano, Hisakazu Mihara
  • Journal Title: Bioorg.Med.Chem.Lett. 16 Pages: 503-506
• [Journal Article] Molecular imprinting within a single peptide molecule for synthesizing a water-soluble ATP receptor (2006)
  • Author(s): J.Matsui, Y.Kamitakahara, J.Nagano, Y.Ono, S.Komai, D.Miyoshi, K.Tamaki, N.Sugimoto
  • Journal Title: Proceedings of the International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting Pages: 396-397
  • NAID: 10020530519
• [Journal Article] Development of molecular logic gates using the structural switch of telomere DNAs (2006)
  • Author(s): M.Inoue, D.Miyoshi, N.Sugimoto
  • Journal Title: Nucleic Acids Symp. Ser. 50 Pages: 315-316
• [Journal Article] Functional role of the cofactor on activation process of L-histidine dependent ribozyme (2006)
  • Author(s): J.Kawakami, C.Maiya, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 241-242
• [Journal Article] Properties of long telomeric DNAs under cell-mimicking conditions (2006)
  • Author(s): H.-Q.Yu, D.Miyoshi, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 207-208
• [Journal Article] The effect of the structure of cosolutes on the DNA duplex formation (2006)
  • Author(s): X.-B.Gu, S.Nakano, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 205-206
• [Journal Article] Factors regulating thermodynamic stability of DNA structures under molecular crowding conditions (2006)
  • Author(s): D.Miyoshi, H.Karimata, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 203-204
• [Journal Article] Recognition of the base pair-mimic nucleosides by DNA polymerases (2006)
  • Author(s): S.Nakano, Y.Uotani, Y.Sato, H.Oka, K.Uenishi, M.Fujii, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 201-202
• [Journal Article] The roles of cosolutes on the hammerhead ribozyme activity (2006)
  • Author(s): H.Karimata, S.Nakano, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 50 Pages: 81-82
• [Journal Article] Use of the polymorphic nature of high-order DNA structures for the design of dynamic and functional nanodevices (2006)
  • Author(s): D.Miyoshi, N.Sugimoto
  • Journal Title: Recent Devel.Nucleic Acids Res. 2 Pages: 49-70
• [Journal Article] Effect of molecular crowding on DNA polymerase activity (2006)
  • Author(s): Y.Sasaki, D.Miyoshi, N.Sugimoto
  • Journal Title: Biotech.J 1 Pages: 440-446
• [Journal Article] Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions (2006)
  • Author(s): D.Miyoshi, H.Karimata, N.Sugimoto
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 7957-7963
• [Journal Article] A novel stable RNA pentaloop that interacts specifically with a motif peptide of lambda-N protein (2006)
  • Author(s): J.awakami, H.Tokitoh, Y.Tanabe, N.Sugimoto
  • Journal Title: Nucleosides, Nucleotides, and Nucleic Acids 25 Pages: 397-416
• [Journal Article] DNA logic gates based on structural polymorphism of telomere DNA molecules responding to chemical input signals (2006)
  • Author(s): D.Miyoshi, M.Inoue, N.Sugimoto
  • Journal Title: Angew.Chem.Int.Ed. 45 Pages: 15461-15468
• [Journal Article] Functional expression of thiocyanate hydrolase is promoted by its activator protein, P15K. (2006)
  • Author(s): Kataoka S, Arakawa T, Hori S, Katayama Y, Hara Y, Matsushita Y, Nakayama H, Yohda M, Nyunoya H, Dohmae N, Maeda M, Odaka M
  • Journal Title: FEBS Lett 580・19 Pages: 4667-4672
• [Journal Article] Thiocyanate hydrolase is a cobalt-containing metalloenzyme with a cysteine-sulfinic acid ligand. (2006)
  • Author(s): Katayama Y, Hashimoto K, Nakayama H, Mino H, Nojiri M, Ono TA, Nyunoya H, Yohda M, Takio K, Odaka M
  • Journal Title: J Am Chem Soc 128・3 Pages: 728-729
• [Journal Article] Contribution of the C-terminal region to the thermostability of the archaeal group II chaperonin from Thermococcus sp. strain KS-1. (2006)
  • Author(s): Yoshida T, Kanzaki, Iizuka R, Komada T, Zako T, Suzuki R, Maruyama T, Yohda M
  • Journal Title: Extremophiles 10・5 Pages: 451-459
• [Journal Article] Roles of conserved basic amino acid residues and activation mechanism of the hyperthermophilic aspartate racemase at high temperature. (2006)
  • Author(s): Yoshida T, Seko T, Okada O, Iwata K, Liu L, Miki K, Yohda M
  • Journal Title: Proteins 64・2 Pages: 502-512
• [Journal Article] Localization of prefoldin interaction sites in the hyperthermophilic group II chaperonin and correlations between binding rate and protein transfer rate. (2006)
  • Author(s): Zako T, Murase Y, Iizuka R, Yoshida T, Kanzaki T, Ide N, Maeda M, Funatsu T, Yohda M
  • Journal Title: J Mol Biol 364・1 Pages: 110-120
• [Journal Article] A Self-locking Molecule Operative with a Photoresponsive Key (2006)
  • Author(s): Muraoka, T., Kinbara, K., Aida, T.
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 11600-11605
• [Journal Article] Label-Free Real-Time Glycosyltransferase Assay Based on a Fluorescent Artificial Chemosensor, (2006)
  • Author(s): J.WONGKONGKATEP, Y.MIYAHARA, A.OJIDDA, I.HAMACHI
  • Journal Title: Angew.Chem., Int.Ed., 45 Pages: 665-668
• [Journal Article] Mechanical twisting of a guest by a synthetic molecular machine (2006)
  • Author(s): T.Muraoka, K.Kinbara, T.Aida
  • Journal Title: Nature (印刷中)
• [Journal Article] Semibiological Molecular Machine with an Implemented "AND" Logic Gate for Regulation of Protein Folding (2006)
  • Author(s): S.Muramatsu, K.Kinbara, H.Taguchi, N.Ishii, T.Aida
  • Journal Title: J.Am.Chem.Soc. 128(印刷中)
• [Journal Article] Effective Disruption of Phosphoprotein-Protein Surface Interaction Using Zn(II)Dipicolylamine-Based Artificial Receptors via Two-Point Interaction, (2006)
  • Author(s): A.OJIDA, M.INOUE, Y.MITO-OKA, H.TSUTUMI, K.SADA, I.HAMACHI
  • Journal Title: J.Am.Chem.Soc., 128 Pages: 2052-2058
• [Journal Article] Design and Synthesis of Bis(Zn(II)-dipicolylamine)-based Fluorescent Artificial Chemosensors for Phosphorylated Proteins/peptides, (2006)
  • Author(s): A.OJIDA, I.HAMACHI
  • Journal Title: Bull.Chem.Soc.Japan., 1 Pages: 35-46
  • NAID: 10017169809
• [Journal Article] One-pot and Sequential Organic Chemistry on an Enzyme Surface to Tether a Fluorescent Probe at the Proximity of the Active Site with Restoring Enzyme Activity, (2006)
  • Author(s): Y.TAKAOKA, H.TSUTSUMI, N.KASAGI, E.NAKATA, I.HAMACHI
  • Journal Title: J.Am.Chem.Soc., 128 Pages: 3273-3280
• [Journal Article] A DNA duplex with Extremely Enhanced Thermal Stability Based on Controlled Immobilization on Gold Nanoparticles (2006)
  • Author(s): K.Akamatsu, M.Kimura, Y.Shibata, S.Nakano, D.Miyoshi, H.Nawafune, N.Sugimoto
  • Journal Title: Nano Lett. 6(印刷中)
• [Journal Article] Double-Modification of Lectin Using Two Distinct Chemistries for Fluorescent Ratiometric Sensing and Imaging Saccharides in Test Tube or in Cell. (2005)
  • Author(s): Nakata E, Kosh Y, Koga E, Katayama Y, Hamachi I.
  • Journal Title: J.Am.Chem.Soc. 127(38) Pages: 13253-13261
  • Peer Reviewed
• [Journal Article] Protein-Detecting Microarrays : Current Accomplishments and Requirements. (2005)
  • Author(s): Tomizaki K -Y, Usui K, Mihara H.
  • Journal Title: ChemBioChem 6 Pages: 782-799
  • Peer Reviewed
• [Journal Article] Site-selective RNA Cleavage by DNA Bearing a Base Pair-Mimic Nucleoside. (2005)
  • Author(s): Nakano S, Uotani Y, Uenishi K, Fujii M, Sugimoto N.
  • Journal Title: J Am Chem Soc 127 Pages: 4350-4353
  • Peer Reviewed
• [Journal Article] Simple and Practical Semi-wet Protein/Peptide Array Utilizing a Micelle-mixed Agarose Hydrogel, (2005)
  • Author(s): S.TAMARU, S.YAMAGUCHI, I.HAMACHI
  • Journal Title: Chem.Lett. 34 Pages: 294-295
  • NAID: 10014463937
• [Journal Article] Luminescent Saccharide Biosensor by Using Lanthanide-Bound Lectin Labeled with Fluorescein, (2005)
  • Author(s): Y.KOSHI, E.NAKATA, I.HAMACHI
  • Journal Title: Chem Bio Chem, 6(8) Pages: 1349-1352
• [Journal Article] Cooperation between Artificial Receptor and Supramolecular Hydrogel for Sensing and Discriminating Phosphate Derivatives, (2005)
  • Author(s): S.YAMAGUCHI, I.YOSHEIMURA, T.KOHIRA, S.TAMARU, I.HAMACHI
  • Journal Title: J.Am.Chem.Soc., 127 Pages: 11835-11841
• [Journal Article] Three Distinct Reading-out Modes for Enzyme Acticity can be Operated in Semi-wet Supramolecular Hydrogel, (2005)
  • Author(s): S.TAMARU, S.KIYONAKA, I.HAMACHI
  • Journal Title: Chem.Eur.J., 11 Pages: 7294-7304
• [Journal Article] Double-Modification of Lectin Using Two Distinct Chemistries for Fluorescent Ratiometric Sensing and Imaging Saccharides in Test Tube or in Cell, (2005)
  • Author(s): E.NAKATA, Y.KOSHI, E.KOGA, Y.KATAYAMA, I.HAMACHI
  • Journal Title: J.Am.Chem.Soc., 127(38), Pages: 13253-13261
• [Journal Article] Roles of Mg^<2+> in TPP-dependent riboswitch (2005)
  • Author(s): T.Yamauchi, D.Miyoshi, T.Kubodera, A.Nishimura, S.Nakai, N.Sugimoto
  • Journal Title: FEBS Lett. 579 Pages: 2583-2588
• [Journal Article] Drastic Effect of a Single Base Difference between Human and Tetrahymena Telomere Sequences on Their Structures under Molecular Crowding Conditions (2005)
  • Author(s): D.Miyoshi, H.Karimata, N.Sugimoto
  • Journal Title: Angew.Chem.Int.Ed.Engl. 44 Pages: 3740-3744
• [Journal Article] Towards Intelligent Molecular Machines : Directed Motions of Biological and Artificial Molecules and Assemblies (2005)
  • Author(s): K.Kinbara, T.Aida
  • Journal Title: Chem.Rev. 105 Pages: 1377-1377
• [Journal Article] シャペロニンを利用した動的機能材料 (2005)
  • Author(s): 金原 数
  • Journal Title: 高分子 54 Pages: 82-82
  • NAID: 10014320225
• [Journal Article] A Designed Glycopeptide Array for Characterization of Sugar-Binding Proteins Toward a Glycopeptide Chip Technology (2005)
  • Author(s): Kenji Usui, Hisakazu.Mihara
  • Journal Title: NanoBiotechnology 1 Pages: 191-200
• [Journal Article] Anomalous Reflection of Gold Applicable for a Practical Protein-detecting Chip Platform (2005)
  • Author(s): Shinya Watanabe, Hisakazu.Mihara
  • Journal Title: Molecular BioSystems 1 Pages: 363-365
• [Journal Article] Facilitated release of substrate protein from prefoldin by chaperonin (2005)
  • Author(s): Zako, T., R.Iizuka, M.Okochi, T.Nomura, T.Ueno, H.Tadakuma, M.Yohda, T.Funatsu.
  • Journal Title: FEBS Lett 579 Pages: 3718-3724
• [Journal Article] Interaction of a small heat shock protein of the fission yeast, Schizosaccharomyces pombe, with a denatured protein at elevated temperature (2005)
  • Author(s): Hirose,.M., H.Tohda, Y.Giga-Hama, R.Tsushima, T.Zako, R.Iizuka, C.Pack, M.Kinjo, N.Ishii, M.Yohda.
  • Journal Title: J Biol Chem 280 Pages: 32586-32593
• [Journal Article] Characterization of archaeal group II chaperonin-ADP-metal fluoride complexes : implications that group II chaperonins operate as a "two-stroke engine" (2005)
  • Author(s): Iizuka, R., T.Yoshida, N.Ishii, T.Zako, K.Takahashi, K.Maki, T.Inobe, K.Kuwajima, M.Yohda.
  • Journal Title: J Biol Chem 280 Pages: 40375-40383
• [Journal Article] Molecular characterization of the group II chaperonin from the hyperthermophilic archaeum Pyrococcus horikoshii OT3 (2005)
  • Author(s): Okochi, M, H.Matsuzaki, T.Nomura, N.Ishii, M.Yohda.
  • Journal Title: Extremophiles 9 Pages: 127-134
• [Journal Article] DNA Base Flipping by a Base Pair-Mimic Nucleoside (2005)
  • Author(s): S.Nakano, Y.Uotani, K.Uenishi, M.Fujii, N.Sugimoto
  • Journal Title: Nucleic Acids Research 33 Pages: 7111-7119
• [Journal Article] Nucleic acid with guanidinum modification exhibits efficient cellular uptake (2005)
  • Author(s): T.Ohmichi, M.Kuwahara, N.Sasaki, M.Hasegawa, T.Nishikata, H.Sawai, N.Sugimoto
  • Journal Title: Angew.Chem.Int.Ed.Engl. 44 Pages: 6682-6685
• [Journal Article] Structural switch of telomere DNA by pH and monovalent cation (2005)
  • Author(s): M.Inoue, D.Miyoshi, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 49 Pages: 243-244
• [Journal Article] Conformational switch of oligonucleotides induced by spermine (2005)
  • Author(s): T.Kirihata, S.Nakano, S.Fujii, M.Matsumoto, M.Kuwahara, H.Sawai, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 49 Pages: 241-242
• [Journal Article] Structure and stability of DNA quadruplexes under molecular crowding conditions (2005)
  • Author(s): H.Karimata, D.Miyoshi, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 49 Pages: 239-240
• [Journal Article] DNA nanowire sensitive to the surrounding condition (2005)
  • Author(s): D.Miyoshi, Z.-M.Wang, H.Karimata, N.Sugimoto
  • Journal Title: Nucleic Acids Symp.Ser. 49 Pages: 43-44
• [Journal Article] An SPR Sensor Chip for sensitive Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticle (2005)
  • Author(s): J.Matsui, K.Akamatsu, N.Hara, D.Miyoshi, H.Nawafune, K.Tamaki, N.Sugimoto
  • Journal Title: Anal.Chem. 77 Pages: 4282-4285
• [Journal Article] DNA-Based Biosensor for Monitoring pH In Vitro and Living Cells (2005)
  • Author(s): T.Ohmichi, Y.Kawamoto, P.Wu, D.Miyoshi, H.Karimata, N.Sugimoto
  • Journal Title: Biochemistry 44 Pages: 7125-7130
• [Presentation] NanoBioNow(17)麹菌由来リボスイッチの機能改変 (2009)
  • Author(s): 山内隆寛、三好大輔、徳井美里、神谷久弥、松永將義、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-30
• [Presentation] NanoBioNow(18)DNAのリン酸負電荷とカチオンのクーロン相互作用に対する定量的アプローチ (2009)
  • Author(s): 北川雄一、中野修一、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-30
• [Presentation] NanoBioNow(15)安定なペンタループ形成の熱力学的パラメータの算出 (2009)
  • Author(s): 田中裕子、岸本加恵、川上純司、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(16)ヘアピンRNAの二次構造変化に及ぼすカチオンの静電相互作用の影響 (2009)
  • Author(s): 平山英伸、中野修一、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(19)テロメアDNAの構造安定性とテロメラーゼ活性の相関 (2009)
  • Author(s): 三村健太、Hai-Quing Yu、Dong-Hao Zhang、三好大輔、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(20)DNA四重鎖構造の熱力学的安定性に及ぼすループ領域の役割 (2009)
  • Author(s): 藤本健史、三好大輔、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(21)DNAの構造安定性に及ぼすヒストン模倣ペプチドの効果 (2009)
  • Author(s): 三好大輔、中村かおり、Muhuri Sanjukta、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(23)紫外線照射サケ白子DNAの紫外線吸収スペクトル (2009)
  • Author(s): 佐々木義晴、三好大輔、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] Nucleic acid interaction revisited : Cation and water binding to nucleotides (2009)
  • Author(s): 中野修一
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] モレキュラーグルー(分子糊)を用いたタンパク質の超分子的修飾 (2009)
  • Author(s): 大黒耕ら
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] キラルなアミノ酸、4-アミノピペリジンー4-カルボン酸、からなる新規なオリゴペプチドの分子設計と性質 (2009)
  • Author(s): 田中雅洋ら
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学理工学部船橋キャンパス
  • Year and Date: 2009-03-29
• [Presentation] NanoBioNow(22)適合溶質の酵素活性に及ぼす影響 (2009)
  • Author(s): 出口瑛介、甲元一也、杉本直己
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-27
• [Presentation] 核酸の高次構造を活かした新機能性材料の創製 (2009)
  • Author(s): 杉本直己
  • Organizer: 有機材料研究会九州支部
  • Place of Presentation: 北九州市
  • Year and Date: 2009-02-28
• [Presentation] 体シグナル解析用分子として活用できる機能性核酸センサーの定量的デザイン (2009)
  • Author(s): 杉本直己
  • Organizer: 第7回ライフサーベイヤシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-01-10
• [Presentation] フォトクロミック配位子を有する遷移金属錯体触媒の設計と重合反応の可変立体制御 (2008)
  • Author(s): 宮村泰直、金原数、相田卓三
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-25
• [Presentation] シャペロニンナノチューブの構築と拡張 (2008)
  • Author(s): ビスワス シュヴェンドゥら
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-25
• [Presentation] アキラルなアミノ酸「4-アミノピペリジンー4-カルボン酸」からなる新規なオリゴペプチドの設計 (2008)
  • Author(s): 趙〓一、金原数、相田卓三
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-25
• [Presentation] タンパク質の超分子的な修飾を可能にするモレキュラーグルーの開拓と性質 (2008)
  • Author(s): 大黒耕、金原数、津本浩平、相田卓三
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-25
• [Presentation] Artificial DNA forming metal-responding nanowire (2008)
  • Author(s): D. Miyoshi, H. T. Karimata, Z. -M. Wang, K. Koumoto, N. Sugimoto
  • Organizer: RSC Conference ; Chemistry in the New World of Bioengineering and Synthetic Biology
  • Place of Presentation: Oxford(イギリス)
  • Year and Date: 2008-09-22
• [Presentation] 分子クラウディング環境によってもたらされる核酸とカチオンの結合性の向上とその生物学的意義 (2008)
  • Author(s): 中野修一・桐畑俊正・平山英伸・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] ハンマーヘッドリボザイムの切断活性変化を利用したカチオンと共存核酸の結合の評価 (2008)
  • Author(s): 北川雄一・中野修一・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] 分子クラウディング環境下におけるテロメラーゼ活性の検討 (2008)
  • Author(s): Zhang Dong-Hao・Yu Hai-Qing, 三好大輔, ・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] DNA四重鎖の構造形成におけるカチオンと水分子の役割 (2008)
  • Author(s): 藤本健史・三好大輔・三村健太・狩俣寿枝・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] ラショナル・ランダム融合設計によるATPセンサーペプチドの構築 (2008)
  • Author(s): 畠山智之・松井淳・玉置克之・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] Trlple Helix Bundle構造をとるペプチドジチオカルバメート鉄錯体においてペプチド長がBundle構造安定性に及ぼす効果 (2008)
  • Author(s): 山中敏志・西村宗十・藤井敏司・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] 核酸の構造安定性に及ぼす分子クラウディングとヒストン模倣ペプチドの影響 (2008)
  • Author(s): 三好大輔・中村かおり・Muhuri Sanjukta・狩俣寿枝・杉本直己
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-18
• [Presentation] Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme (2008)
  • Author(s): S. Nakano, Y. Kitagawa, H. T. Karimata, N. Sugimoto
  • Organizer: Joint Symposium of the 18th International Roundtable on Nucleosides, nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2008-09-11
• [Presentation] Enhanced amplification of polymerase chain reaction by addition of cosolutes derived from a cellular compatible solute (2008)
  • Author(s): K. Koumoto, H. Ochiai, N. Sugimoto
  • Organizer: Joint Symposium of the 18th International Roundtable on Nucleosides, nucleotides and Nucleic Acids and the 35th International Synposium on Nucleic Acids Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2008-09-10
• [Presentation] Thermodynamics of DNA structures under molecular crowding conditions with neutral and positive charged cosolutes (2008)
  • Author(s): D. Miyoshi, K. Nakamura, S. Muhuli, H. T. Karimata, N. Sugimoto
  • Organizer: Joint Symposium of the 18th International Roundtable on Nucleosides, nucleotides and,Nucleic Acids and the 35th International Synposium on Nucleic Acids Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2008-09-10
• [Presentation] Phosphorescent Mesostructured Silica Templated by an Amphiphilic Columnar Assembly of Trinuclear Au(I) Pyrazolate Complex (2008)
  • Author(s): Hendrik O. Lintang, et.al.
  • Organizer: IMMS 2008 6th International Mesostructured Materials Symposium
  • Place of Presentation: Namur, Belgium
  • Year and Date: 2008-09-09
• [Presentation] 生命科学を加速する分子ツールの開発 (2008)
  • Author(s): 浜地格
  • Organizer: 第4回バイオ機器研究会
  • Place of Presentation: 産業医科大(北九州)
  • Year and Date: 2008-08-08
• [Presentation] DNA nanostructures that respond to chemical stimuli (2008)
  • Author(s): 三好大輔・狩俣寿枝・Z. -M. Wang・甲元一也・杉本直己
  • Organizer: ICOMC2008
  • Place of Presentation: Rennes(フランス)
  • Year and Date: 2008-07-14
• [Presentation] 核酸の高次構造変化を利用した機能性ナノバイオマテリアルの開発 (2008)
  • Author(s): 三好大輔・Hai-Qing Yu・狩俣寿枝・杉本直己
  • Organizer: ナノバイオ若手ネットワーキングシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2008-06-13
• [Presentation] Designed peptide chips for protein analyses (2008)
  • Author(s): Hisakazu Mihara
  • Organizer: Korean Biochio Conference
  • Place of Presentation: Daejon, Korea
  • Year and Date: 2008-06-12
• [Presentation] スマートバイオマテリアルとしての超分子ヒドロゲル (2008)
  • Author(s): 浜地格
  • Organizer: 08-2ポリマーフロンティア
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-06-05
• [Presentation] DNA and RNA structures in the presence of a neutral cosolute (2008)
  • Author(s): 中野修一・Lei Wu・岡裕人・狩俣寿枝・桐畑俊正・佐藤雄一・藤井敏司・酒井宏・桑原正靖・澤井宏明・杉本直己
  • Organizer: Gordon Research Conference (Nucleic Acids)
  • Place of Presentation: Newport(アメリカ)
  • Year and Date: 2008-06-01
• [Presentation] シャペロニンをユニットとした刺激応答性超分子構造体の構築 (2008)
  • Author(s): ビスワス シュヴェンドゥら
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-29
• [Presentation] モレキュラーグルー(分子糊)を用いたタンパク質修飾 (2008)
  • Author(s): 大黒耕・金原数・津本浩平・相田卓三
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-28
• [Presentation] Phosphorescent Mesostructured Silica Templated by a Columnar Assembly of Trinuclear, Au(I) Pyrazolate Complex Formed via a Metallophilic Interaction (2008)
  • Author(s): Hendrik O. Lintang, et.al.
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-05-28
• [Presentation] 分子クラウディング状態における長鎖テロメアDNAの構造と安定性 (2008)
  • Author(s): 三好大輔・Hai-Qing Yu・Dong-Hao Zhang・杉本直己
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-20
• [Presentation] Development of Functional Molecules Based on Nucleic Acids (2008)
  • Author(s): 三好大輔・中野修一・狩俣寿枝・井上真美子・中村かおり・岡裕人・Zhong-Ming Wnag・甲元一也・杉本直己
  • Organizer: 2008 Medical Chemistry and Developmental Therapeutics Symposium
  • Place of Presentation: Tucson(アメリカ)
  • Year and Date: 2008-04-17
• [Presentation] NanoBioNow(1) NDA結合分子によるDNA二重鎖中の擬塩基対型人工ヌクレオシドの構造制御 (2008)
  • Author(s): 中野修一・岡裕人・魚谷有希・上西和也・藤井政幸・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(2) 擬塩基対型人工ヌクレオシドによる塩基の認識 (2008)
  • Author(s): 岡裕人・中野修一・魚谷有希・上西和也・藤井政幸・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(3)共存溶質の分子クラウディングによるフーグスティーン塩基対からなるDNA構造の安定化 (2008)
  • Author(s): 中村かおり・狩俣寿枝・三好大輔・大道達雄・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(4)DNA四重鎖の熱力学的安定性に及ぼすカルテットとループの安定性の寄与 (2008)
  • Author(s): 藤本健史・狩俣寿枝・三好大輔・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(5) DNA二重鎖による機能性DNA四重鎖の配向化 (2008)
  • Author(s): 三好大輔・Kakoli Dutta・Sanjukta Muhuri・井上真美子・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(6) ポルフィリン修飾核酸を含むDNA二重鎖の構造と安定性 (2008)
  • Author(s): 佐伯裕美・村嶋貴之・松井淳・三好大輔・宮澤敏文・山田 隆己・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(7)カチオン性ポルフィリンによるDNA四重鎖の構造制御 (2008)
  • Author(s): 村嶋貴之・三好大輔・松井淳・宮澤敏文・山田隆己・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(13)一酸化窒素感受性を有するThree Helix Bundle型ペプチドー鉄ジチオカルバメート錯体の合成と性質 (2008)
  • Author(s): 矢口真由美・西村宗十・藤井敏司・酒井宏・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(14) 可逆的架橋により構築された分子インプリントペプチドによるATPの認識 (2008)
  • Author(s): 松井淳・駒居諭・玉置克之・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] NanoBioNow(8) 二価金属イオン非存在下で起こるハンマーヘッドリボザイムの切断反応に対するPEGの分子クラウディングの影響 (2008)
  • Author(s): 北川雄一・狩俣寿枝・中野修一・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] NanoBioNow (9) The structure of G-quadruplex for 5'-UTR mRNA of bc1-2 under molecular crowing condition (2008)
  • Author(s): Dong-Hao Zhang・三好大輔・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] NanoBioNow(10)周辺の分子環境に応答するDNAナノスイッチの構築 (2008)
  • Author(s): 狩俣寿枝・三好大輔・藤本健史・甲元一也・Zhong-Ming, Wang・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] NanoBioNow(11)新規光応答性モレキュラービーコンの開発 (2008)
  • Author(s): Li Wu・甲元一也・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] NanoBioNow(12) ポリメラーゼ連鎖反応による高GC領域のDNA増幅を促進する低分子添加剤の開発 (2008)
  • Author(s): 甲元一也・杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-28
• [Presentation] 核酸の安定性及び新しい機能に関する定量的研究 (2008)
  • Author(s): 杉本直己
  • Organizer: 日本化学会第88回春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] Design of Functional Nanomaterials with DNAs (2008)
  • Author(s): 三好大輔・中野修一・狩俣寿枝・井上真美子・中村かおり・魚谷有希・岡裕人・Z.-M. Wang・甲元一也・杉本直己
  • Organizer: International Conference on Functional Materials-Synthesis, applications and characterizations
  • Place of Presentation: Taiwan
  • Year and Date: 2008-03-13
• [Presentation] 生体シグナル解析用分子として活用できる機能性核酸センサーの定量的デザイン (2008)
  • Author(s): 杉本直己
  • Organizer: 第5回ライフサーベイヤシンポジム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-02-01
• [Presentation] DNAからDBへ-核酸(DNA)を活用するデザイナブルナノバイオ(DNB)エンジニアリング- (2008)
  • Author(s): 杉本直己
  • Organizer: 第26回医用高分子研究会講座
  • Place of Presentation: 東京
  • Year and Date: 2008-01-11
• [Presentation] Self-assembled semi-wet materials for nano-biotechnology (2008)
  • Author(s): Itaru Hamachi
  • Organizer: 2008 Bionano-sympo in Tokyo Tech
  • Place of Presentation: Yokohama
• [Presentation] 人工小分子によるタンパク質認識と反応 (2007)
  • Author(s): 浜地 格
  • Organizer: 第3回バイオミメティクスシンポジウム(BMRC)
  • Place of Presentation: 京都
  • Year and Date: 2007-12-08
• [Presentation] 「物理+化学+生物の学問は何を生み出すか?」 (2007)
  • Author(s): 杉本直己
  • Organizer: BMCシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2007-12-03
• [Presentation] Functionalization of DNA by the base pair-mimic nucleosides (2007)
  • Author(s): 岡裕人・中野修一・魚谷有希・上西和也・藤井政幸・杉本直己
  • Organizer: 第5回国際核酸化学シンポジウム(第34回核酸化学シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Conformational switch of a functional nanowire based on the DNA G-quadruplex (2007)
  • Author(s): 狩俣寿枝・三好大輔・藤本健史・甲元一也・Z.-M. Wang・杉本直己
  • Organizer: 第5回国際核酸化学シンポジウム(第34回核酸化学シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] The base-pairing ability of the base pair-mimic nucleosides、2007年11月 東京大学 (2007)
  • Author(s): 中野修一・上西和也・藤井政幸・杉本直己
  • Organizer: 第5回国際核酸化学シンポジウム(第34回核酸化学シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex (2007)
  • Author(s): 中村かおり・狩俣寿枝・大道達雄・三好大輔・杉本直己
  • Organizer: 第5回国際核酸化学シンポジウム(第34回核酸化学シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] 設計ペプチドを利用したタンパク質分析チップ (2007)
  • Author(s): 三原久和
  • Organizer: 第4回コンビナトリアル・バイオエンジニアリング会議
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2007-11-09
• [Presentation] Functional DNA materials controlled by surrounding conditions (2007)
  • Author(s): 杉本直己・三好大輔・中野修一・甲元一也・Z.-M. Wang・井上真美子・狩俣寿枝
  • Organizer: IUPAC 3rd International Symposium on Novel Materials and Synthesis (NMS-III)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2007-10-18
• [Presentation] ナノコンポジット材料を用いる内分泌撹乱化学物質のSPRセンシング、2007年9月 東北大学 (2007)
  • Author(s): 高寄めぐみ・松井淳・赤松謙祐・縄舟秀美・玉置克之・杉本直己
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-29
• [Presentation] 可逆的架橋反応を用いるペプチド分子内インプリンティングによるATPレセプターの構築 (2007)
  • Author(s): 駒居諭・松井淳・玉置克之・杉本直己
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-29
• [Presentation] 擬似細胞環境下における長鎖テロメア核酸の構造と熱力学的安定性 (2007)
  • Author(s): 三好大輔・Hai-Qing Yu・狩俣寿枝・杉本直己
  • Organizer: 第22回日本化学会生体関連化学部会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-28
• [Presentation] 銅イオン結合部位を有するペプチドによるアミロイドβ線維化制御 (2007)
  • Author(s): 藤井敏司・阿部準・三好大輔・赤松謙佑・縄舟秀美・酒井宏・杉本直己
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-28
• [Presentation] 化学入力に応答するユニバーサルDNA論理素子の開発 (2007)
  • Author(s): 三好大輔・井上真美子・杉本直己
  • Organizer: 日本化学会バイオテクノロジー部会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-08
• [Presentation] Telomere DNA-based logic gates (2007)
  • Author(s): 三好大輔・井上真美子・杉本直己
  • Organizer: The 2nd International Workshop on Approaches to Single-Cell Analysis
  • Place of Presentation: 東京
  • Year and Date: 2007-09-06
• [Presentation] Development of functional nanobiodevices with DNAs (2007)
  • Author(s): 三好大輔・中野修一・狩俣寿枝・井上真美子・中村かおり・魚谷有希・岡裕人・Z.-M. Wang・甲元一也・杉本直己
  • Organizer: 2nd European Conference on Chemistry for Life Sciences
  • Place of Presentation: Wroclaw, Poland
  • Year and Date: 2007-09-05
• [Presentation] 「生体機能性高分子ナノコンポジットによる神経伝達物質のセンシング」 (2007)
  • Author(s): 松井 淳・高寄めぐみ・赤松謙祐・縄舟秀美・玉置克之・杉本直己
  • Organizer: 第17回バイオ・高分子シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-07-31
• [Presentation] Regulation of Function and Structure of DNAs by Molecular Environments toward New Chemical Sensors" (2007)
  • Author(s): 中野修一・三好大輔・魚谷有希・岡裕人・狩俣寿枝・井上真美子・Z.-M. Wang・K.甲元一也.上西和也・藤井政幸・杉本直己
  • Organizer: Gordon Research Conference (Chemical Sensors Interfacial Design)
  • Place of Presentation: Newport, RI, USA
  • Year and Date: 2007-07-30
• [Presentation] Self-assembly for Biological Materials (2007)
  • Author(s): 浜地 格
  • Organizer: Crete Symposium on Self-assembly of Peptide and Proteins
  • Place of Presentation: Crete (Greek)
  • Year and Date: 2007-07-12
• [Presentation] Design and Development of Functional Molecules Based on Nucleic Acids (2007)
  • Author(s): 三好大輔・中野修一・狩俣寿枝・井上真美子・中村かおり・魚谷有希・岡裕人・Z.-M. Wang・甲元一也・杉本直己
  • Organizer: Gordon Research Conference (Nucleosides, Nucleotides & Oligonucleotides)
  • Place of Presentation: Newport, RI, USA
  • Year and Date: 2007-07-02
• [Presentation] タンパク質認識と変換のための有機化学 (2007)
  • Author(s): 浜地 格
  • Organizer: 万有仙台シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-23
• [Presentation] DNAマテリアル-新材料としての核酸の才能- (2007)
  • Author(s): 杉本直己
  • Organizer: 「生命をはかる」研究会 第21回研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-22
• [Presentation] 細胞内環境因子に応答するユニバーサルDNAロジックゲートの構築 (2007)
  • Author(s): 三好大輔・井上真美子・杉本直己
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-10
• [Presentation] DNAとRNAの選択的フリップアウトを引き起こす擬塩基対型人工ヌクレオシド (2007)
  • Author(s): 中野修一・岡裕人・魚谷看希・上西和也・藤井政幸・杉本直己
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] ナノバイオチップによる生体関連物質の高感度検出 (2007)
  • Author(s): 松井淳・高寄めぐみ・玉置克之・杉本直己
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] Development of Functional DNAs Based on G-Quadruplexes (2007)
  • Author(s): 三好大輔・Hai-Qing Yu・狩俣寿枝・杉本直己
  • Organizer: First International Meeting of Quadruplex DNA
  • Place of Presentation: Louisville, KY, USA
  • Year and Date: 2007-04-22
• [Presentation] Molecular Recognition to Anionic Species of Biological Signigicanc (2007)
  • Author(s): 浜地 格
  • Organizer: 2nd Korean-Japan Summit
  • Place of Presentation: Toya (Japan)
• [Presentation] Chemistry-based Protein Labeling (2007)
  • Author(s): 浜地 格
  • Organizer: 1st Japan-Swiss Chemical Biology Symposium
  • Place of Presentation: Lausanne (Swiss)
• [Presentation] Semi-wet Self-assembled Materials for Nanobio-science and technology (2007)
  • Author(s): 浜地 格
  • Organizer: 6th JSPS France symposium
  • Place of Presentation: Strasbourg (France)
• [Presentation] Novel Biosensors for Analyzing Substrates of Biological Significance (2007)
  • Author(s): 浜地 格
  • Organizer: 2007 Material Research Society (MRS) Fall meeting
  • Place of Presentation: Boston (USA)
• [Presentation] 生体機能を探るナノバイオセンサー (2007)
  • Author(s): 浜地 格
  • Organizer: 第56回分析科学討論会
  • Place of Presentation: 徳島
• [Presentation] 超分子ヒドロゲルファイバーのバイオ機能 (2007)
  • Author(s): 浜地 格
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋
• [Presentation] 自己組織化超分子ゲルの構築と機能 (2007)
  • Author(s): 浜地 格
  • Organizer: 第9回リング・チューブ超分子研究会シンポジウム
  • Place of Presentation: 京都
• [Presentation] Peptide microarrays for protein and cell analyses (2007)
  • Author(s): Mihara H
  • Organizer: HITS Bionanotechnology Symposium
  • Place of Presentation: Hanyang University, Ansan, Korea
• [Presentation] Control of Amyloid Formation by designed Peptides and Proteins (2007)
  • Author(s): Takahashi T, Mihara H
  • Organizer: Japanese-Swiss Symposium on Chemical Biology(ISCB2007)
  • Place of Presentation: Lausanne, Swiss (invited)
• [Presentation] Desiged pepttide for protein and cell analyess using peptide libraries (2007)
  • Author(s): Mihara
  • Organizer: Modern Soid Phase Peptide synthesis&it's a pplication
  • Place of Presentation: Port Douglas Australia (invited)
• [Presentation] Highly sensitive anomalous reflection of gold applicable for protein detection (2007)
  • Author(s): Amir S, Tomizaki K-Y, Kajikawa K, Mihara H
  • Organizer: 4th International Peptide Symposium, Cairns
  • Place of Presentation: Australia
• [Presentation] 金の異常反射(AR)を利用したタンパク質検出の感度向上 (2007)
  • Author(s): Amir Syahir、富崎 欣也、梶川 浩太郎、三原 久和
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
• [Presentation] ペプチドの設計とバイオチップ応用 (2007)
  • Author(s): 三原久和
  • Organizer: 第20回生物無機化学夏季セミナー
  • Place of Presentation: 湯河原
• [Presentation] 光切断型ペプチドアレイと細胞アッセイ (2007)
  • Author(s): 柿山 喬、富崎欣也、臼井健二、小畠英理、三原久和
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋
• [Book] バイオ研究のフロンティア2、酵素・タンパク質をはかる・とらえる・利用する (2009)
  • Author(s): 岡畑恵雄・三原久和
  • Total Pages: 188
  • Publisher: 工学図書
• [Book] 超分子サイエンス〜基礎から材料への展開〜 (2009)
  • Author(s): 杉本直己、三好大輔
  • Publisher: 機能性核酸のテーラーメード設計
• [Book] 核酸医薬の最前線 (2009)
  • Author(s): 三好大輔、杉本直己
  • Publisher: 核酸医薬の分子設計
• [Book] 最新 分子マシンガイド:ナノで働く"高度な機械"を目指して化学同人 (2008)
  • Author(s): 金原 数 (分担執筆)
  • Total Pages: 160
  • Publisher: 化学同人
• [Book] とことんやさしい タンパク質の本 (2007)
  • Author(s): 三原久和、高橋剛、富崎欣也
  • Total Pages: 8
  • Publisher: 日本工業新聞社
• [Book] ナノバイオ計測の実際 (2007)
  • Author(s): 三原久和、小畠英理、馬場嘉信
  • Publisher: 講談社
• [Book] 「新しいDNAチップの科学と応用」 プロテインチップの開発 (2007)
  • Author(s): 富崎欣也、三原久和
  • Total Pages: 13
  • Publisher: 講談社サイエンティフィック
• [Book] 「マイクロアレイ・バイオチップの最新技術」ペプチドチップ (2007)
  • Author(s): 富崎欣也、三原久和
  • Total Pages: 13
  • Publisher: シーエムシー
• [Book] 生物物理学ハンドブック (2007)
  • Author(s): 杉本直己・大道達雄
  • Total Pages: 4
  • Publisher: 朝倉書店
• [Book] 未来材料 (2007)
  • Author(s): 三好大輔・杉本直己
  • Total Pages: 9
  • Publisher: (株)エヌ・ティー・エス
• [Book] 化学 (2007)
  • Author(s): 杉本直己・三好大輔
  • Total Pages: 5
  • Publisher: 化学同人
• [Book] 絵で見てわかるナノDDS (2007)
  • Author(s): 杉本直己・甲元一也
  • Total Pages: 7
  • Publisher: メディカルドゥ
• [Book] 分子認識と超分子 (2007)
  • Author(s): 杉本直己・松井淳
  • Total Pages: 18
  • Publisher: 三共出版
• [Book] 生命化学-Biochemistry- (2007)
  • Author(s): 杉本直己
  • Total Pages: 192
  • Publisher: 丸善株式会社
• [Book] 一細胞定量解析の最前線-ライフサーベイヤ構築に向けて- 第2章生体シグナル解析用分子材料群の創製、4.ペプチドチップテクノロジーによるシグナル解析 (2006)
  • Author(s): 富崎欣也, 三原久和
  • Publisher: シーエムシー出版
• [Book] 細胞定量解析の最前線 -ライフサーベイヤ構築に向けて(題:シグナル解析を目指した機能性核酸の構築) (2006)
  • Author(s): 杉本直己, 三好大輔
  • Total Pages: 15
  • Publisher: シーエムシー出版
• [Book] 生物物理(題:分子クラウディング環境は生命分子の物性と機能をいかに変えるか) (2006)
  • Author(s): 中野修一, 杉本直己
  • Total Pages: 6
  • Publisher: 日本生物物理学会
• [Book] 現代化学(題:細胞の分子クラウディング効果) (2006)
  • Author(s): 杉本直己, 中野修一
  • Total Pages: 6
  • Publisher: 東京化学同人
• [Book] 遺伝子医学MOOK5 先端生物医学研究・医療のため遺伝子導入テクノロジーウイルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開(11章デザイナブル核酸修飾) (2006)
  • Author(s): 杉本直己, 中野修一, 大道達雄
  • Total Pages: 7
  • Publisher: メディカルドゥ
• [Book] 高分子(題:生命を制御するのは遺伝子か環境か-細胞内環境に左右される遺伝子の構造と機能-) (2006)
  • Author(s): 杉本直己, 三好大輔
  • Total Pages: 4
  • Publisher: 高分子学会
• [Book] 生物物理(タイトル:分子クラウディング環境は生命分子の物性と機能をいかに変えるか) (2006)
  • Author(s): 中野修一, 杉本直己
  • Publisher: 生物理学会誌(印刷中)
• [Book] 細胞工学(タイトル:量子ドット(Q-dot)の基礎とナノバイオエンジニアリング) (2005)
  • Author(s): 赤松謙祐, 鶴岡孝章, 縄舟秀美, 杉本直己
  • Total Pages: 6
  • Publisher: 秀潤社
• [Remarks] 学部・大学院ホームページ
  • URL: http://www.konan-first.jp
• [Remarks] 研究所ホームページ
  • URL: http://www.konan-fiber.jp
• [Remarks]
  • URL: http://fiber.konan-u.ac.jp/
• [Patent(Industrial Property Rights)] 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法 (2007)
  • Inventor(s): 甲元一也、杉本直己
  • Industrial Property Rights Holder: 甲南学園
  • Industrial Property Number: 2007-270700
  • Filing Date: 2007-10-17
• [Patent(Industrial Property Rights)] 修飾核酸・金属イオン多量体 (2006)
  • Inventor(s): 杉本 直己他2名
  • Industrial Property Rights Holder: 富士フイルムホールディングス株式会社
  • Filing Date: 2006-03-06
  • Acquisition Date: 2006-11-24
• [Patent(Industrial Property Rights)] 修飾核酸鎖化合物 (2006)
  • Inventor(s): 杉本 直己他2名
  • Industrial Property Rights Holder: 富士フイルムホールディングス株式会社
  • Filing Date: 2006-03-06
  • Acquisition Date: 2006-11-24