| Co-Investigator(Kenkyū-buntansha) |
SASAKI Keiichi 東北大学, 大学院・歯学研究科, 教授 (30178644)
KAMAKURA Shinji 東北大学, 大学院・医工学研究科, 教授 (80224640)
TAKAHASHI Ichiro 九州大学, 大学院・歯学研究院, 教授 (70241643)
NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394)
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
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| Budget Amount *help |
¥95,900,000 (Direct Cost: ¥95,900,000)
Fiscal Year 2009: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2007: ¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2005: ¥39,400,000 (Direct Cost: ¥39,400,000)
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| Research Abstract |
The present study demonstrated that local environments, such as mechanical stress, control quantitatively osteoclastic cell-mediated biodegradability of apatite precursor (synthetic octacalcium phosphate, OCP), resulting in the loss of bone regenerative capability of this material through strain-dependent stimulation of the osteoblasts around the implanted OCP with collagen matrix. The mechanical stress could be a key factor controlling the morphology of the calcified tissue regeneration during bone and cartilage formation.
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