| Budget Amount *help |
¥98,500,000 (Direct Cost: ¥98,500,000)
Fiscal Year 2009: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2008: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2007: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2006: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2005: ¥19,700,000 (Direct Cost: ¥19,700,000)
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| Research Abstract |
Embryonic stem cells (ES cells) are attracting interests as a promising source of cells for use in regenerative medicine. The aim of the present study was to investigate whether biomechanical forces such as shear stress and cyclic strain affect ES cell differentiation. Fluid shear stress induced differentiation of cultured murine ES cell-derived VEGF receptor 2-positive (VEGFR2^+) cells into endothelial cells (ECs), whereas cyclic strain promoted the differentiation of the cells into smooth muscle cells (SMCs). Thus, it seems likely that biomechanical forces act as key regulators of early vascular development in the embryo. Moreover, biomechanical force may provide an invaluable tool to directly control ES cell differentiation in the field of tissue engineering.
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