Biomechanical force-sensing and response mechanisms in vascular cells and its application to tissue engineering
| Project/Area Number |
17076002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
ANDO Joji The University of Tokyo, 医学部, 特任教授 (20159528)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kimiko 東京大学, 大学院・医学系研究科, 講師 (00323618)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥98,500,000 (Direct Cost: ¥98,500,000)
Fiscal Year 2009: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2008: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2007: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2006: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2005: ¥19,700,000 (Direct Cost: ¥19,700,000)
|
|---|
| Keywords | 血管 / 剪断応力 / 伸展張力 / ES細胞 / 内皮細胞 / 平滑筋細胞 / 再生医療 / 血流 / 勇断応力 / 内皮前駆細胞 / 動静脈分化 / 転写因子 / 細胞分化 / 血管内非細胞 / 流れずり応力 / 胚性幹細胞 / 血管内皮増殖因子 / 血管平滑筋細胞 / 力学刺激 / 人工血管 / 血管内皮細胞 |
|---|
| Research Abstract |
Embryonic stem cells (ES cells) are attracting interests as a promising source of cells for use in regenerative medicine. The aim of the present study was to investigate whether biomechanical forces such as shear stress and cyclic strain affect ES cell differentiation. Fluid shear stress induced differentiation of cultured murine ES cell-derived VEGF receptor 2-positive (VEGFR2^+) cells into endothelial cells (ECs), whereas cyclic strain promoted the differentiation of the cells into smooth muscle cells (SMCs). Thus, it seems likely that biomechanical forces act as key regulators of early vascular development in the embryo. Moreover, biomechanical force may provide an invaluable tool to directly control ES cell differentiation in the field of tissue engineering.
|
Report
(6 results)
Research Products
(90 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.2006
Author(s)
K. Yamamoto, T. Sokabe, T. Matsumoto, K. Yoshimura, M. Shibata, N. Ohura, T. Fukuda, K. Sekine, S. Kato, M. Isshiki, T. Fujita, M. Kobayashi, K. Kawamura, H. Masuda, A. Kamiya, J. Ando
-
Journal Title
Nat. Med. 12
Pages: 133-137
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading.2005
Author(s)
H. Huang, Y. Nakayama, K. Qin, K. Yamamoto, J. Ando, J. Yamashita, H. Itoh, K. Kanda, H. Yaku, Y. Okamoto, Y. Nemoto
-
Journal Title
J. Artif. Organs 8
Pages: 110-118
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 循環器科2006
Author(s)
安藤譲二, 曽我部隆影, 山本稀美子
Total Pages
671
Publisher
科学評論社
Related Report
-
-
