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Analysis of the mechanism of cell cycle-dependent virus infection and cellular response

Research Project

Project/Area Number 17076017
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionHosei University

Principal Investigator

HONDA Ayae  Hosei University, 生命科学部, 教授 (80343747)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tadashi  東京大学, 医科学研究所, 教授 (40134621)
SAKAGUCHI Takemasa  広島大学, 医歯薬大学院, 教授 (70196070)
YASUDA Jiro  学警察研究所, 法科学第一部, 室長 (10282518)
SHIMIZU Kazufumi  日本大学, 医学部, 教授 (50004677)
IWATA Akira  日本生物科学研究所, 研究部, 主任研究員 (70193745)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥95,700,000 (Direct Cost: ¥95,700,000)
Fiscal Year 2009: ¥16,700,000 (Direct Cost: ¥16,700,000)
Fiscal Year 2008: ¥19,700,000 (Direct Cost: ¥19,700,000)
Fiscal Year 2007: ¥20,300,000 (Direct Cost: ¥20,300,000)
Fiscal Year 2006: ¥19,400,000 (Direct Cost: ¥19,400,000)
Fiscal Year 2005: ¥19,600,000 (Direct Cost: ¥19,600,000)
Keywordsインフルエンザウイルス / 光ピンセット / 宿主タンパク質 / Ebp1 / シアル酸 / RNAポリメラーゼ / 細胞周期 / 宿主因子 / 単一ウイルス / プロモーター / GFP / ErbB3 / 遺伝子発現誘導 / 宿主蛋白質 / 仙台ウイルス / 蛋白質修飾 / RNAi / 感染応答 / 単一細胞
Research Abstract

1. To understand whether influenza virus infection is cell cycle dependent or not, we developed the microchip chamber system combined with optical trapping of single virus. Using this system, the fluorescently labeled influenza virus was successfully trapped under the lens using 1064 nm laser. The trapped influenza virus was transported on the dividing cell and released on it, but influenza virus did not attached. The same unattached virus on the dividing cell was trapped again and transported to the resting cell and released on it, the virus was attached on the resting cell. This result encouraged us to identify the difference between the resting and dividing cells. At first, we tried to compare the ・ 2,3-sialic acid contents between both cells. The result indicated that the content of ・ 2,3-sialic acid is higher in the resting cells than in the dividing cells.
2. Host protein Ebp1, ErbB3 binding protein, interacted with PB1 subunit of influenza virus RNA dependent RNA polymerase, and inhibited the RNA synthesis in vitro but not endonuclease associated with RNA dependent RNA polymerase. Interestingly Ebp1 expression was induced by influenza virus infection. To understand the induction mechanism of Ebp1 expression by influenza virus infection, the different combination among the eight viral protein expression plasmids and viral RNA (vRNA) expression plasmid were transfected into the cell and assayed the Ebp1 expression level using RT-PCR. The result indicated that the expression of vRNP complex, vRNA, influenza virus RNA dependent RNA polymerase and NP, influenced the Ebp1 expression. 3. Influenza virus infection induced changing of the cellular membrane strength.

Report

(7 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Products Report
  • Research Products

    (86 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (41 results) (of which Peer Reviewed: 17 results) Presentation (45 results)

  • [Journal Article] Host factor Ebp1 inhibits rinderpest virus transcription in vivo.2010

    • Author(s)
      Gopinath, M., Raju, S., Honda, A., Shaila, M.S.
    • Journal Title

      Arch. Virol. 155

      Pages: 455-462

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host factor Ebp1 inhibits Rinderpest virus transcription in vivo2010

    • Author(s)
      Gopinath, M^*., Raju, S^*., Honda, A^†., Shaila, M.S.^<$*>
    • Journal Title

      Arch,Virol. 155

      Pages: 455-562

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tadao Sugiura and Ayae Honda: Analysis of cellular membrane changing induced by influenza virus infection.2009

    • Author(s)
      Tatsuro Takahata, Shinichiro Kume, Hideaki Miyoshi
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 267-270

    • Related Report
      2009 Final Research Report
  • [Journal Article] Analysis of Promoter Binding proteins of Ebp1 that is Inhibitor Protein of Influenza Virus RNA polymerase.2009

    • Author(s)
      Masahiro Mukai, Ayae Honda
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 271-274

    • Related Report
      2009 Final Research Report
  • [Journal Article] Analysis of promoter binding proteins of Ebp1 that is Inhibitor protein of Influenza Virus RNA Polymerase2009

    • Author(s)
      Mukai, M., Honda, A.
    • Journal Title

      Micro-Nano Mechatronics anf Human Science, IEEE

      Pages: 271-274

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Analysis of cellular membrane changing induced by influenza virusinfection2009

    • Author(s)
      Takahata, T., Kume, S., Miyoshi, M., Sugiura, T., Honda, A.
    • Journal Title

      Micro-Nano Mechatronics anf Human Science, IEEE

      Pages: 267-270

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Role of host protein Ebp1 in influenza virus growth: intercellular Localization of Ebp1 in virus-infected and uninfected cells.2008

    • Author(s)
      Ayae Honda
    • Journal Title

      J. Biotechnology

      Pages: 208-212

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ebp1 expression is induced by influenza virus infection.2008

    • Author(s)
      Miho Ejima、Ryuta Ueda, Shinichiro Kume, Daisuke Okazaki, Takefumi, Yamkawa, Hitoshi Shiku, Ayae Honda
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 214-218

    • Related Report
      2009 Final Research Report
  • [Journal Article] Kid-mediated chromosome compaction ensures proper nuclear envelop formation.2008

    • Author(s)
      Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, Yamamoto T
    • Journal Title

      Cell 132

      Pages: 771-782

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.2008

    • Author(s)
      Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S, Imamoto N
    • Journal Title

      J Cell Biol 180

      Pages: 493-506

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paramyxovirus Sendai virus C proteins are essential for maintenance of negative- sense RNA genome in virus particles.2008

    • Author(s)
      Irie, T., Nagata, N., Yoshida, T., Sakaguchi, T
    • Journal Title

      Virology 374(2)

      Pages: 495-505

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recruitment of Alix/AIP1 to the plasma membrane by the Sendai virus C protein facilitates budding of virus-like particles.2008

    • Author(s)
      Irie, T., Nagata, N., Yoshida, T., Sakaguchi, T.
    • Journal Title

      Virology 371(1)

      Pages: 108-120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of host protein Ebpl in influenza virus growth : intercellular Locali zation of Ebpl in virus-infected and uninfected cells2008

    • Author(s)
      Ayae Honda
    • Journal Title

      J. Biotechnology 133

      Pages: 208-212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ebp1 expression is induced by influenza virus infection2008

    • Author(s)
      Miho Ejima, Ryuta Ueda, Shinichiro Kume, Daisuke Okazaki, Takefumi, Yamkawa, Hitoshi Shiku and Avae Honda
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 214-218

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role of host protein Ebp1 in Influenza virus Growth:Intercellular localization of Ebp1 in Virus-infected and uninfected cells2008

    • Author(s)
      Honda, A.
    • Journal Title

      J. Biotechnology 133

      Pages: 208-212

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of host protein Ebp 1 in influenza virus growth : intercellular Localization of Ebp! in virus-infected and uninfected cells2008

    • Author(s)
      Ayae Honda
    • Journal Title

      J. Biotechnology

      Volume: 133 Pages: 208-212

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] Ebp1 expression is induced by influenza virus infection.2008

    • Author(s)
      Miho Ejima、 Ryuta Ueda, Shinichiro Kume, Daisuke Okazaki, Takefumi, Yamkawa, Hitoshi Shiku and Ayae Honda
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 214-218

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] Ebp1: Selective inhibitor of Influenza virus transcriptase.2007

    • Author(s)
      Honda, A. Okamoto, T, Ishihama, A. Host Factor Ebp1
    • Journal Title

      Genes to Cells 12

      Pages: 133-142

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influenza virus selects cell phase for infection.2007

    • Author(s)
      Ryuta Ueda, Akihiko Ichikawa, Mariko Kusunoki, Miho Ejima, Fumihito Arai, Toshio Fukuda, Ayae Honda
    • Journal Title

      Micro-Nano Mechanics and Human Science

      Pages: 28-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] In-situ formation of a gel microbead for laser micromanipulation of microorganisms, DNA and virus.2007

    • Author(s)
      Akihiko Ichikawa, Ayae Honda, Miho Ejima, Tamio Tanikawa, Fumihito Arai, Toshio Fukuda
    • Journal Title

      J. Robotics and Mechatronics 19

      Pages: 569-576

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host factor Ebp1:Selective Inhibitor of influenza virus transcriptase.2007

    • Author(s)
      Honda, A., Okamoto, T., Ishihama, A.
    • Journal Title

      Genes Cells 12

      Pages: 133-142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-situ formation of a gel microbead for laser micromanipulation of microorganisms, DNA and virus.2007

    • Author(s)
      Ichikawa, A. Honda, A., et. al.
    • Journal Title

      J. Robotics and Mechatronics 19

      Pages: 1-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza virus selects cell phase for infection2007

    • Author(s)
      Ueda, R., Honda, A., et. al.
    • Journal Title

      Micro-Nano Mechanics and HumanScience, IEEE (In press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Focal adhesion kinase regulates laminin-induced oligodendroglial process2007

    • Author(s)
      Hoshina, N., et. al.
    • Journal Title

      Genes to Cells 12

      Pages: 1245-1254

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depletion of mammalian CCR4b deadenylase triggers incement of the p2 7^kip1 mRNA and impaires cell growth.2007

    • Author(s)
      Morita, M., et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 4980-4990

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host Factor Ebpl : Selective Inhibitor of Influenza virus transcriptase2007

    • Author(s)
      Honda, A., Ukamoto, T., Ishihama, A.
    • Journal Title

      Genes to Cells 12

      Pages: 133-142

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Localization of Ebpl in the Influenza virus infected cells2007

    • Author(s)
      Honda, A.
    • Journal Title

      J.Biotechnology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of PBlc45 on Influenza virus replication2007

    • Author(s)
      Ejima, M., Haraguchi, K., Yamamoto, T., Honda, A.
    • Journal Title

      Micro-Nano Mechatronics and Human Science(Fukuda, T.,ed) (IEEE) (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In situ Formation of Gel Microbead tor laser Micromanipulation of Microorganisms, DNA and Virus2007

    • Author(s)
      Ichikawa, A., Honda, A., Ejima, M., Tanikawa, T., Arai, F., Fukuda, T.
    • Journal Title

      Micro-Nano Mechatronics and Human Science(Fukuda, T.,ed) (IEEE) (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of PB1c45 on Influenza Virus Replication.2006

    • Author(s)
      Ejima, Miho, Haraguchi, Keiko, Yamamoto, T., Honda, Ayae
    • Journal Title

      Micro-Nano Mechanics and human Science

      Pages: 382-385

    • Related Report
      2009 Final Research Report
  • [Journal Article] Role of the kinesin-2 family protein, KIF 3, during mitosis2006

    • Author(s)
      Haraguchi, K. et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 4094-4099

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Unique role ot SNT-2/FRS2b/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathway2006

    • Author(s)
      Huang, L. et al.
    • Journal Title

      Oncogene 25

      Pages: 6457-6466

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NR2B tyrosine phosphorulation modulates fear learning as well as Amygdaloid aynaptic plasticity2006

    • Author(s)
      Nakazawa, T. et al.
    • Journal Title

      EMBO J. 25

      Pages: 2867-2877

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LATS-Ajuba complex regulates g-tubulin recruitment to centrosomes and spindle organization during mitosis2006

    • Author(s)
      Abe, Y.et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 782-788

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Detection of 5' side subgenome of hepatitis C virus terminating at nucleotide 384 in patients' plasma and liver tissues2006

    • Author(s)
      Shimizu, Y.K. et al.
    • Journal Title

      J. Viral. Hepatitis 13

      Pages: 746-755

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An inhibitory effect of A20 on NF-kB activation in airway epithelium upon influenza virus2006

    • Author(s)
      Onose, A. et al.
    • Journal Title

      Eur. J.Pharmacol. 541

      Pages: 198-204

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Control of Influenza virus growth by cellular proteins.2005

    • Author(s)
      Honda, A, Fukuda, T., ed
    • Journal Title

      Micro-Nano Mechatronics and Human Science

      Pages: 171-174

    • Related Report
      2009 Final Research Report
  • [Journal Article] Control of Influenza virus growth by cellular proteins2005

    • Author(s)
      Honda, A.
    • Journal Title

      Micro-Nano mechanics and Human Science

      Pages: 171-174

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The combined effects of anti-TNF alpha antibody an IL-1 receptor antagonist in human rheumatoid arthritis synovial membrane2005

    • Author(s)
      Hosaka, K., et al.
    • Journal Title

      Cytokine 32

      Pages: 263-269

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Removal of hepatitis C virus by G-1 beads in sera from patients with chronic hepatitis C2005

    • Author(s)
      Moriyama, M., et al.
    • Journal Title

      Intervirology 48

      Pages: 84-88

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 人工抗体テクノロジー:その基礎と応用2005

    • Author(s)
      田中寅彦, 渡辺則幸, 清水一史
    • Journal Title

      日大医誌 64

    • NAID

      10016785167

    • Related Report
      2005 Annual Research Report
  • [Presentation] インフルエンザウイルス感染細胞と非感染細胞における膜強度解析2010

    • Author(s)
      高畑辰郎、本田文江
    • Organizer
      第23回桂門会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-03-14
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルス感染細胞と非感染細胞における膜強度解析2010

    • Author(s)
      高畑辰郎、本田文江
    • Organizer
      第23回桂門会シンポジウム
    • Place of Presentation
      エスエス製薬会議室(東京)
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス感染によるEbp1発現誘導機構2010

    • Author(s)
      川口徹也、門井浩二、本田文江
    • Organizer
      バイオ操作第8回シンポジウム
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス感染に伴う細胞膜変化の解析2010

    • Author(s)
      高畑辰郎、三好秀明、杉浦忠男、本田文江
    • Organizer
      バイオ操作第8回シンポジウム
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス感染による宿主蛋白質の発現誘導2009

    • Author(s)
      門井浩二、粂慎一郎、江島美穂、本田文江
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      パシフイコ横浜(横浜)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Influenza virus selects the cell to bind2009

    • Author(s)
      Honda, A., Arai, F., Fukuda, T.
    • Organizer
      BIT The 3^<rd> World Congress of GENE
    • Place of Presentation
      Foshan,China
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibitory effect of Ebp1 on the influenza virus RNA polymerase function2009

    • Author(s)
      Ayae Honda
    • Organizer
      Japan biophysics annual meeting
    • Place of Presentation
      Tokushima
    • Year and Date
      2009-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Inhibitory Effect of Ebp1 on the influenza virus RNA polymerase function2009

    • Author(s)
      Honda, A.
    • Organizer
      Japan Biophisics Annual meeting
    • Place of Presentation
      Asty-Tokushima
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内環境計測のための機能性ナノツールの作製2009

    • Author(s)
      丸山久峰, 港谷恭輔, 飯塚龍, 本田文江, 江島美穂, 新井史人
    • Organizer
      第27回日本ロボット学会学術講演会
    • Place of Presentation
      横浜国立大学
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞内環境計測のための機能性ナノッールの作製2009

    • Author(s)
      丸山央峰、港谷恭輔、飯塚龍、本田文江、江島美穂、新井史人
    • Organizer
      第27回日本ロボット学会学術講演会
    • Place of Presentation
      横浜国立大学(横浜)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウイルス感染・非感染細胞の膜強度解析2009

    • Author(s)
      本田文江
    • Organizer
      特定領域"女性シンポジウム"
    • Place of Presentation
      東京
    • Year and Date
      2009-08-18
    • Related Report
      2009 Final Research Report
  • [Presentation] ウイルス感染細胞と非感染細胞における膜強度解析2009

    • Author(s)
      本田文江
    • Organizer
      特定領域"女性シンポジウム"
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2009-08-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] On-Chip Robotics for Biomedical Innovation: Manipulation of Single Virus on a Chip2009

    • Author(s)
      Fumihito Arai, Kyouke Kotani, Hisataka Maruyama, Ayae Honda, Miho Ejima
    • Organizer
      2009 9th IEEE Conference on Nanotechnology
    • Place of Presentation
      Italy
    • Year and Date
      2009-07-28
    • Related Report
      2009 Final Research Report
  • [Presentation] On-Chip Robotics for Biomedical Innovation : Manipulation of Single Virus on a Chip2009

    • Author(s)
      Arai, F., Kotani, K., Maruyama, H., Honda, A., Ejima, M.
    • Organizer
      9^<th> IEEE Conference on Nanotechnology
    • Place of Presentation
      Italy Jenora
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス感染細胞と非感染細胞における宿主蛋白質発現量の違い2009

    • Author(s)
      本田文江
    • Organizer
      桂門会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-03-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] インフルエンザウイルスが好む細胞について2009

    • Author(s)
      本田文江
    • Organizer
      理化学研究所シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2009-01-30
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルスが好む細胞について2009

    • Author(s)
      本田文江
    • Organizer
      理科学研究所シンポジウム
    • Place of Presentation
      理化学研究所横浜研究所
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Influenza virus selects the cell to bind.2009

    • Author(s)
      Ayae Honda、Fumihito Arai, Toshio Fukuda
    • Organizer
      BIT The 3rd World Congress of GENE
    • Place of Presentation
      Foshan, China
    • Related Report
      2009 Final Research Report
  • [Presentation] 光ピンセットを利用したウイルス搬送・付着から見えてくる細胞の特徴CRSET光で拓く細胞から染色体の世界2009

    • Author(s)
      本田文江
    • Organizer
      第2回シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 単一ウイルスの特定細胞への感染及び定量解析を可能とするバイオ操作システムの提案2008

    • Author(s)
      港谷恭輔、丸山央峰、本田文江、江島美穂、新井史人
    • Organizer
      第18回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report Products Report
  • [Presentation] 宿主蛋白質Ebp1のインフルエンザウイルス感染による発現誘導機構解析2008

    • Author(s)
      江島美穂、栗原卓也、本田文江
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Ebp1タンパク質によるインフルエンザウイルス増殖抑制機構の解析2008

    • Author(s)
      三林正樹、本田文江
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      倉敷
    • Year and Date
      2008-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Ebp1タンパク質によるインフルエンザウイルス増殖抑制機構の解析2008

    • Author(s)
      三林正樹、本田文江
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report Products Report
  • [Presentation] インフルエンザウイルス増殖を抑制する因子Ebp1の作用機序の解析2008

    • Author(s)
      三林正樹、本田文江
    • Organizer
      湯河原ウイルスキャンプ
    • Year and Date
      2008-07-29
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 宿主蛋白質Ebp1のインフルエンザウイルス感染による発言誘導機構解析2008

    • Author(s)
      江島美穂、上田竜太、栗原卓也、本田文江
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Influenza virus infection and cellular response.2008

    • Author(s)
      Ayae Honda
    • Organizer
      Beijing Institute for Neuroscience
    • Place of Presentation
      Capital Medical University
    • Related Report
      2009 Final Research Report
  • [Presentation] Influenza virus selects the cell phase for infection. Department of Microbiology2008

    • Author(s)
      Ayae Honda
    • Organizer
      New York City Medical School
    • Related Report
      2009 Final Research Report
  • [Presentation] Ebp1 Expression is induced by influenza virus infection. Department of Microbiology2008

    • Author(s)
      Ayae Honda
    • Organizer
      Mount Sinai Medical School
    • Place of Presentation
      New York
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルス感染と細胞周期:桂門会シンポジウム2008

    • Author(s)
      上田竜太、斉藤朋子、本田文江
    • Organizer
      日本大学歯学会館
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルスの感染細胞変化の総合的解析2008

    • Author(s)
      本田文江
    • Organizer
      招待講演
    • Place of Presentation
      奈良女子大学
    • Related Report
      2009 Final Research Report
  • [Presentation] Induction Mechanism of host protein Ebp1 by Influenza virus infection. ACTX IISC2008

    • Author(s)
      Ayae Honda
    • Organizer
      Bangalore
    • Place of Presentation
      India Jan
    • Related Report
      2009 Final Research Report
  • [Presentation] Influenza Virus selects cell phase for infection.2008

    • Author(s)
      Ueda R., Ichikawa, A., Kusunoki, M., Ejima, M., Arai, F., Fukuda, T., Honda, A.
    • Organizer
      International Meeting of MHS
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルス感染によるEbp1発現誘導機構解析2008

    • Author(s)
      江島美穂、栗原卓也、上田竜太、本田文江
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report Products Report
  • [Presentation] インフルエンザウイルス感染細胞変化の総合的解析2008

    • Author(s)
      本田 文江
    • Organizer
      招待講演
    • Place of Presentation
      奈良女子大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction mechanism of host protein Ebpl by influenza virus infection2008

    • Author(s)
      Honda, A.
    • Organizer
      ACT X
    • Place of Presentation
      IISC, India
    • Related Report
      2007 Annual Research Report
  • [Presentation] インフルエンザウイルス感染と細胞周期2008

    • Author(s)
      上田竜太、 斎藤朋子、本田 文江
    • Organizer
      桂門会
    • Place of Presentation
      日本大学歯学会館
    • Related Report
      2007 Annual Research Report
  • [Presentation] インフルエンザウイルス感染によるEbp1発現誘導の解析:単一細胞系2008

    • Author(s)
      上田竜太、本田 文江
    • Organizer
      MHSシンポジウム
    • Place of Presentation
      法政大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] インフルエンザウイルスが結合する細胞膜蛋白質の探索と精製2008

    • Author(s)
      縫田 瑞貴、本田 文江
    • Organizer
      MHSシンポジウム
    • Place of Presentation
      法政大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] Host Factor Ebpl: Selective inhibitor of influenza virus RNA polymerase2008

    • Author(s)
      Honda, A.
    • Organizer
      Invited seminar
    • Place of Presentation
      New York City Medical College
    • Related Report
      2007 Annual Research Report
  • [Presentation] Host Factor Ebp1:Selective inhibitor of influenza virus RNA polymerase2008

    • Author(s)
      Honda, A.
    • Organizer
      Invited seminar
    • Place of Presentation
      Mount Sinai School of Medicine
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction mechanism of host protein Ebp 1 by influenza virus infection.2007

    • Author(s)
      Ayae Honda
    • Organizer
      ACT X
    • Place of Presentation
      インド科学研究所
    • Year and Date
      2007-12-31
    • Related Report
      Products Report
  • [Presentation] インフルエンザウイルス感染の細胞周期特異性について2007

    • Author(s)
      本田文江、市川明彦、新井史人、福田 敏男
    • Organizer
      農芸化学会
    • Place of Presentation
      東京農大
    • Related Report
      2009 Final Research Report
  • [Presentation] インフルエンザウイルス感染の細胞周期特異性について2007

    • Author(s)
      本田 文江
    • Organizer
      特定女性研究者によるシンポジウム
    • Place of Presentation
      法政大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] Replication Mechanism of Influenza Virus2007

    • Author(s)
      Honda, A.
    • Organizer
      Invited Seminar
    • Place of Presentation
      Jiangsu University
    • Related Report
      2007 Annual Research Report
  • [Presentation] Influenza virus selects cell phase for infection2007

    • Author(s)
      Honda, A.
    • Organizer
      MHS International Meeting
    • Place of Presentation
      名古屋大学
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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