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Molecular mechanism of aluminum-activated malate transporter

Research Project

Project/Area Number 17078007
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOkayama University

Principal Investigator

SASAKI Takayuki  Okayama University, 資源生物科学研究所, 助教 (60362985)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yoko  岡山大学, 資源生物科学研究所, 教授 (50166831)
Research Collaborator FURUICHI Takuya  名古屋大学, 医学部, 博士研究員
R. RYAN PETER  CSIRO Plant Industry, Australia Principal Research Scientist
DELHAIZE Emmanuel  CSIRO Plant Industry, Australia Senior Principal Research Scientist
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥80,500,000 (Direct Cost: ¥80,500,000)
Fiscal Year 2009: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2008: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2007: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2006: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2005: ¥16,500,000 (Direct Cost: ¥16,500,000)
Keywordsアルミニウム耐性 / ALMT1 / アニオントランスポーター / 気孔閉口 / リンゴ酸トランスポーター / 電気生理学 / アルミニウム / 分子生物学
Research Abstract

The mechanisms for the expression and function of aluminum-activated malate transporter (ALMT1) of wheat were analyzed. We demonstrated that the variation of the upstream sequence of ALMT1 is strongly correlated to the aluminum sensitivity of wheat, and that three acidic amino acids within hydrophilic C-terminal domain of ALMT1 is required for the activation of transport function by aluminum. Furthermore, we found that the functions of several ALMT homologues in Arabidopsis are related to aluminum resistance and closing stomata, suggesting that ALMT proteins comprise a family of anion transporters, possessing diverse functions.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (50 results)

All 2010 2009 2008 2007 2006 2005 2003 Other

All Journal Article (25 results) (of which Peer Reviewed: 16 results) Presentation (19 results) Book (1 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 2 results)

  • [Journal Article] Closing plant stomata requires a homolog of an aluminum-activated malate transporter2010

    • Author(s)
      Sasaki T, Mori IC, Furuichi T, Munemasa S, Toyooka K, MatsuokaK, Murata Y, Yamamoto Y
    • Journal Title

      Plant Cell Physiol. 51

      Pages: 354-365

    • NAID

      10027347234

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Closing plant stomata requires a homolog of an aluminum-activated malate transporter2010

    • Author(s)
      Takayuki Sasaki., et al.
    • Journal Title

      Plant and Cell Physiology 51

      Pages: 354365-354365

    • NAID

      10027347234

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aluminum tolerance associated with enhancement of plasma membrane H+-ATPase in the root apex of soybean2010

    • Author(s)
      Yu-Seon KIM., et al.
    • Journal Title

      Soil Science and Plant Nutrition 56

      Pages: 140149-140149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterisation of the TaALMTI protein as an Al3+-activated anion channel in transformed tobacco (Nicotiana tabacum L. )cells.2008

    • Author(s)
      Zhang W-H, Ryan PR, Sasaki T, Yamamoto Y, Sullivan, W, Tyerman SD
    • Journal Title

      Plant Cell Physiol. 49

      Pages: 1316-1330

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of MALATI traces the transmission of aluminum resistance in cultivated common wheat (Triticum aestivum L. ).2008

    • Author(s)
      Raman H, Ryan PR, Raman R, Stodart BJ, Zhang K, Martin P, Wood R, Sasaki T, Yamamoto Y, Mackay M, Hebb DM, Delhaize E
    • Journal Title

      Theor. Appl. Genet. 116

      Pages: 343-354

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterisation of the TaALMT1 protein as an A 13+-activated anionchannel in transformed tobacco (Nicotiana tabacum L.) cells2008

    • Author(s)
      Zhan, et.al.
    • Journal Title

      Plant Cell Physiol 49

      Pages: 1316-1330

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of TaALMT1 traces the transmission of aluminum resistance in cultivated common wheat (Triticum aestivum L.).2008

    • Author(s)
      Ramman H, et. al.
    • Journal Title

      Theor. Appl. Genet. 116

      Pages: 343-354

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The membrane topology of ALMTI, an aluminum-activated malate transport protein in wheat (Triticum aestivum).2007

    • Author(s)
      Motoda H, Sasaki T, Kano Y, Ryan PR, Delhaize E, Matsumoto H, Yamamoto Y
    • Journal Title

      Plant Signaling Behavior 2

      Pages: 467-472

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malate enhances recovery from Al-caused inhibition of root elongation in wheat.2007

    • Author(s)
      Kikui S, Sasaki T, Matsumoto H, Osawa H, Yamamoto Y
    • Journal Title

      Plant Soil 290

      Pages: 1-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The membrane topology of ALMT1, an aluminum-activated malate transport protein in wheat (Triticum aestivum).2007

    • Author(s)
      Motoda H, et. al.
    • Journal Title

      Plant signaling Behavior 2

      Pages: 467-472

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルミニウム耐性の分子電槽:有機酸トラ;スポーターによる制得2007

    • Author(s)
      佐々木孝行、山本洋子
    • Journal Title

      蛋白質核酸酵素増刊 植物における環と生物ストレスに対する応答 52

      Pages: 619-624

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Malate enhances recovery from Al-caused inhibition of root elongation in wheat2007

    • Author(s)
      Satoshi Kikui, et al.
    • Journal Title

      Plant Soil 290

      Pages: 1-15

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sequence upstream of the wheat (Triticum aestivum L. ) ALATI gene and its relationship to aluminum resistance.2006

    • Author(s)
      Sasaki T, Ryan PR, Delhaize E, Hebb DM, Ogihara Y, Kawaura K, Noda K, Kojima T, Toyoda A, Matsumoto H, Yamamoto Y
    • Journal Title

      Plant Cell Physiol. 47

      Pages: 1343-1354

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] AtALMTI, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis.2006

    • Author(s)
      Hoekenga OA, Maron LG, Pineros MA, Cancado GM, Shaff J, Kobayashi Y, Ryan PR, Dong B, Delhaize E, Sasaki T, Matsumoto H, Yamamoto Y, Koyama H, Kochian LV
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 9738-9743

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis2006

    • Author(s)
      Owen A.Hoekenga, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 9738-9743

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sequence upstream of the wheat (Triticum aestivum L.) ALMT1 gene and its relationship to aluminum resistance2006

    • Author(s)
      Takayuki Sasaki, et al.
    • Journal Title

      Plant Cell Physiol. 47

      Pages: 1343-1354

    • NAID

      10018331345

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Root plasma membrane H+-ATPase is involved in the adaptation of soybean to phosphorus starvation2006

    • Author(s)
      Hong Shen, et al.
    • Journal Title

      J.Exp.Bot. 57

      Pages: 1353-1362

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evidence for the plasma membrane localization of Al-activated malate transporter (ALMTI).2005

    • Author(s)
      Yamaguchi M, Sasaki T, Sivaguru M, Yamamoto Y, Osawa H, Ahn SJ, Matsumoto H
    • Journal Title

      Plant Cell Physiol. 46

      Pages: 812-816

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Citrate secretion coupled with the modulation of soybean root tip under aluminum stress: Up-regulation of transcription, translation and threonined-oriented phosphorylation of plasma membrane H+-ATPase.2005

    • Author(s)
      Shen H, He LF, Sasaki T, Yamamoto Y, Zheng SJ, Ligaba A, Yan XL, Ahn SJ, Yamaguchi M, Sasakawa H, Matsumoto H
    • Journal Title

      Plant Physiol. 138

      Pages: 287-296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological and genetic analyses of aluminium tolerance in rice, focusing on root growth during germination.2005

    • Author(s)
      Kikui S, Sasaki T, Maekawa M, Miyao A, Hirochika H, Matsumoto H, Yamamoto Y
    • Journal Title

      J. Inorganic Biochem. 99

      Pages: 1837-1844

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization and mapping of ALMTI, the aluminium-tolerance gene of bread wheat (Triticum aestivum L. ).2005

    • Author(s)
      Raman H, Zhang K, Cakir M, Appels R, Garvin DF, Maron LG, Kochian LV, Moroni JS, Raman R, Imtiaz M, Drake-Brockman F, Waters I, Martin P, Sasaki T, Yamamoto Y, Matsumoto H, Hebb DM, Delhaize E, Ryan PR.
    • Journal Title

      Genome 48

      Pages: 781-791

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for the plasma membrane localization of Al-activated malate transporter (ALMT1).2005

    • Author(s)
      Mineo Yamaguchi, et al.
    • Journal Title

      Plant and Cell Physiology 46

      Pages: 812-816

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular characterization and mapping of ALMT1,the aluminium-tolerance gene of bread wheat (Triticum aestivum L.)2005

    • Author(s)
      Harsh Raman, et al.
    • Journal Title

      Genome 48

      Pages: 781-791

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アルミニウム毒性の多様性と作物にみられる耐性の分子メカニズム2005

    • Author(s)
      佐々木孝行 ら
    • Journal Title

      化学と生物 43

      Pages: 569-578

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アルミニウム毒性の多様性と作物にみられる耐性の分子

    • Author(s)
      佐々木孝行, 山本洋子
    • Journal Title

      メカニズム化学と生物 Vol.43

      Pages: 569-578

    • Related Report
      2009 Final Research Report
  • [Presentation] Functional diversity of plant specific ALMT-type anion transporter.2010

    • Author(s)
      Takayuki Sasaki
    • Organizer
      International symposium on plant membrane transport
    • Place of Presentation
      The University of Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギのALMTI活性調節に関与する新奇遺伝子の探索2010

    • Author(s)
      氷見英子、佐々木孝行、土屋善幸、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Final Research Report
  • [Presentation] アルミニウムによるコムギALMTIの活性制御機構2010

    • Author(s)
      古市卓也、佐々木孝行、土屋善幸、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional diversity of plant specific ALMT-type anion transporter2010

    • Author(s)
      Takayuki Sasaki
    • Organizer
      International Symposium on Plant Membrane Transport
    • Place of Presentation
      東京大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルミニウムによるコムギALMT1の活性制御機構2010

    • Author(s)
      古市卓也, 他
    • Organizer
      日本植物生理学会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] コムギのALMT1活性調節に関与する新奇遺伝子の探索2010

    • Author(s)
      氷見英子, 他
    • Organizer
      日本植物生理学会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 異種発現系を用いたコムギALMTIタンパク質の精製2009

    • Author(s)
      佐々木孝行、古市卓也、源治尚久、戸澤譲、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギALMTIの電気生理学的機能解析2009

    • Author(s)
      古市卓也、佐々木孝行、土屋善幸、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 異種発現系を用いたコムギALMT 1タンパク質の精製2009

    • Author(s)
      佐々木孝行, 他
    • Organizer
      日本植物生理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] コムギALMT 1の電気生理学的機能解析2009

    • Author(s)
      古市卓也, 他
    • Organizer
      日本植物生理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] コムギにおけるアルミニウム活性化型リンゴ酸トランスポーター(ALMTI)の転写後発現調節の解析2008

    • Author(s)
      菊井聖士、佐々木孝行、土屋善幸、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギにおけるアルミニウム活性化型リンゴ酸トランスポーター(ALMTI)の転写後発現調節の解析2008

    • Author(s)
      菊井聖土、他
    • Organizer
      日本植物生理学会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2007 Annual Research Report
  • [Presentation] コムギALMTI上流配列とアルミニウム耐性2007

    • Author(s)
      佐々木孝行、Peter R. Ryan、Emmanuel Delhaize、松本英明、山本洋子
    • Organizer
      日本植物生理学会
    • Place of Presentation
      愛媛
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギALMTIタンパク質の構造解析2007

    • Author(s)
      佐々木孝行、元田弘敏、山本洋子
    • Organizer
      日本土壌肥料学会
    • Place of Presentation
      東京農業大学
    • Related Report
      2009 Final Research Report
  • [Presentation] Aluminum-activated malate transporter in plants.2007

    • Author(s)
      Takayuki Sasaki, Yamamoto Yamamoto.
    • Organizer
      Aluminum-activated malate transporter in plants. Joint International Symposium 'Membrane Transport as a Universal Biological Mechanism '
    • Place of Presentation
      Kyoto University
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギALMT1タンパク質の構造解析2007

    • Author(s)
      佐々木孝行、他
    • Organizer
      日本土壌肥料学会
    • Place of Presentation
      東京農業大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] コムギALMT1のアルミニウム活性化機構の解析2007

    • Author(s)
      菊井聖土、他
    • Organizer
      日本土壌肥料学会
    • Place of Presentation
      東京農業大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] コムギにおけるアルミニウム耐性形質とALMTI上流配列の解析2006

    • Author(s)
      佐々木孝行、菊井聖士、松本英明、山本洋子
    • Organizer
      日本土壌肥料学会
    • Place of Presentation
      秋田県立大学
    • Related Report
      2009 Final Research Report
  • [Presentation] コムギALMTI形質転換植物のアルミニウム耐性2005

    • Author(s)
      佐々木孝行、山本洋子、Emmanuel Delhaize、Peter R. Ryan、有吉美智代、松本英明
    • Organizer
      日本植物生理学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Book] アルミニウム耐性の分子機構:有機酸トランスポーターによる制御(蛋白質核酸酵素2007年5月号増刊植物における環境と生物ストレスに対する応答)2007

    • Author(s)
      佐々木孝行, 山本洋子
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] GENE OF ALUMINUM-ACTIVATED MALATE TRANSPORTER OF A PLANT AND A PROTEIN ENCODED BY THE GENE2010

    • Inventor(s)
      松本英明、佐々木孝行、山本洋子、江崎文一、且原真木
    • Industrial Property Rights Holder
      岡山大学長河野伊一郎
    • Filing Date
      2010
    • Related Report
      2009 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 植物のアルミニウム応答性リンゴ酸輸送体の遺伝子及び当該遺伝子がコードする蛋白質2006

    • Inventor(s)
      松本英明、佐々木孝行、山本洋子、江崎文一、且原真木
    • Industrial Property Rights Holder
      岡山大学長河野伊一郎
    • Acquisition Date
      2006-09-08
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] GENE OF ALUMINUM-ACTIVATED MALATE TRANSPORTER OF APLANT AND A PROTEIN ENCODED BY THE GENE2006

    • Inventor(s)
      松本英明、佐々木孝行、山本洋子、江崎文一、且原真木
    • Industrial Property Rights Holder
      岡山大学長河野伊一郎
    • Acquisition Date
      2006-11-21
    • Related Report
      2009 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 植物のアルミニウム応答性リンゴ酸輸送体の遺伝子及び当該遺伝子がコードする蛋白質2003

    • Inventor(s)
      松本英明, 佐々木孝行, 山本洋子 他2名
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2003-03-04
    • Acquisition Date
      2006-09-08
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 植物のアルミニウム応答性リンゴ酸輸送体の遺伝子及び当該遺伝子がコードする蛋白質2003

    • Inventor(s)
      松本英明, 佐々木孝行, 山本洋子 他2名
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2003-03-20
    • Acquisition Date
      2006-11-21
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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