| Project/Area Number |
17079002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KATADA Toshiaki The University of Tokyo, 大学院・薬学系研究科, 教授 (10088859)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONTANI Kenji 東京大学, 大学院・薬学系研究科, 准教授 (30302615)
KAJIHO Hiroaki 東京大学, 大学院・薬学系研究科, 助教 (70401221)
FUKUYAMA Masamitsu 東京大学, 大学院・薬学系研究科, 助教 (20422389)
KOBAYASHI Tetsuo 東京大学, 大学院・薬学系研究科, 助教 (80433994)
SAITO Kota 東京大学, 大学院・薬学系研究科, 助教 (60549632)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥84,000,000 (Direct Cost: ¥84,000,000)
Fiscal Year 2009: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2008: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2007: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2006: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2005: ¥9,600,000 (Direct Cost: ¥9,600,000)
|
|---|
| Keywords | タンパク質 / 遺伝子 / シグナル伝達 / G蛋白質 / 小胞輸送 / リソソーム / Gサイクル / ゲノムプロジェクト / 蛋白質 / 生体分子 / 細胞・組織 / 染色体分離 / 神経細胞死 |
|---|
| Research Abstract |
G proteins, which cycle between the two different GTP- and GDP-bound conformations, play important roles as a "molecular switch" in many intracellular signaling pathways. The G protein families include the translation factors, the trimeric G proteins, and the small GTPases. Although the small GTPases are involved in the regulation of cell growth/differentiation, vesicle trafficking, and cell shape/adhesion, there are still many other GTPases, of which functions are unknown. In the Scientific Research on Priority Areas "G-protein signal", we investigated novel GTPases exhibiting unique biochemical and/or structural properties different from typical small GTPases and found that the atypical G proteins play important roles in lysosome biogenesis, cilia formation, and recycling-endosome dynamics. Thus, our findings contributed much toward an understanding of the novel functions of G proteins.
|
