| Budget Amount *help |
¥54,500,000 (Direct Cost: ¥54,500,000)
Fiscal Year 2009: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2008: ¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2007: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥8,800,000 (Direct Cost: ¥8,800,000)
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| Research Abstract |
Using fluorescence single-molecule imaging which directly visualizes remodeling processes of the actin cytoskeleton, this research project has revealed a novel actin polymer regeneration mechanism by which an increase in the cellular monomeric actin concentration provokes rapid actin nucleation by Formin homology proteins. This project has also quantitatively proved the frequent actin filament disruption in the cell. In addition, through various types of cell imaging analysis, the roles of Rho family GTPases in cell migration and inhibitor-induced conformational regulation of a protein kinase, Abl, have been elucidated.
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