| Budget Amount *help |
¥79,200,000 (Direct Cost: ¥79,200,000)
Fiscal Year 2009: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2008: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2007: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2006: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2005: ¥14,400,000 (Direct Cost: ¥14,400,000)
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| Research Abstract |
In this study, we found that orphan G protein-coupled receptor, GPR56, negatively regulates neural progenitor cell migration via G12/13 and Rho pathway, and the antibody which recognizes the orphan receptor is an useful tool for analyzing the function of the receptor. Moreover, structural basis for the specific inhibition of G proteins by YM-254890 has been revealed by biochemical and X-ray crystal structure analysis. Ubiquitination of the stimulatory G protein ・ subunit and its inhibition by Ric-8B was demonstrated. Crosstalk between G protein signaling and dioxin signaling was found by identifying AIP as a novel G protein interacting protein.
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