Molecular mechanisms of phospholipid metabolism and cell morphology regulated by small G protein signaling
| Project/Area Number |
17079008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KANAHO Yasunori University of Tsukuba, 大学院・人間総合科学研究科, 教授 (00214437)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOZEKI Takeaki 筑波大学, 大学院・人間総合科学研究科, 講師 (80373405)
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| Co-Investigator(Renkei-kenkyūsha) |
FUNAKOSHI Yuji 筑波大学, 大学院・人間総合科学研究科, 助教 (30415286)
HASEGAWA Hiroshi 筑波大学, 大学院・人間総合科学研究科, 教授 (88928814)
SUGIMOTO Rika 筑波大学, 大学院・人間総合科学研究科, 研究員 (40455936)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥84,900,000 (Direct Cost: ¥84,900,000)
Fiscal Year 2009: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2008: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2007: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 2006: ¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2005: ¥10,200,000 (Direct Cost: ¥10,200,000)
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| Keywords | 低分子量G蛋白質 / Arf6 / リン脂質キナーゼ / 神経細胞 / 腫瘍血管形成 / 肝臓 / スパイン / 神経突起 / ARF6 / PIP5K / 血管形成 / 癌 / ノックアウトマウス / 抗ガン剤 / 脳神経発生 / JLP / ターゲット蛋白質 / 形態形成 / 管形成 / 肝臓発生 / 血管内皮細胞 / 脂質性シグナル分子産生酵素 / シグナル伝達 / PIP5Kβ / 海馬神経細胞 / シナプス |
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| Research Abstract |
In this study, mechanisms and physiological functions of the cellular signaling through the small G protein Arf6 have been investigated at the molecular, cellular and whole animal levels. It was found that (1) Arf6 regulates retraction of the spine in neurons through activation of the lipid kinase PIP5K・, (2) Arf6 plays critical roles in the development of the liver and tumor angiogenesis, indicating a possible target of Arf6 as the anti-cancer drug, and (3) Arf6 regulates neurite elongation and branching through the JNK-interacting protein.
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Report
(6 results)
Research Products
(100 results)
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[Journal Article] Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.2010
Author(s)
Nishida M., Suda R., Nagamatsu Y., Tanabe S., Onohara N., Nakaya M., Kanaho Y., Shibata T., Uchida K., Sumimoto H., Sato Y., Kurose H.
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Journal Title
J. Biol. Chem. 285
Pages: 15268-15277
Related Report
Peer Reviewed
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[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.2009
Author(s)
Nishikimi A., Fukuhara H., Su W., Hongu T., Takasuga S., Mihara H., Cao Q., Sanematsu F., Kanai M., Hasegawa H., Tanaka Y., Shibasaki M., Kanaho Y., Sasaki T., Frohman M.A., Fukui Y.
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Journal Title
Science 324
Pages: 384-387
Related Report
Peer Reviewed
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[Journal Article] Loss of PIP5KI・demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.2008
Author(s)
Wang Y., Chen X., Lian L., Tang T., Stalker TJ., Sasaki T., Kanaho Y., Brass LF., Choi J.K., Hartwig J.H., Abrams C.S.
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Journal Title
Proc. Natl. Acad. Sci. 105
Pages: 14064-16069
Related Report
Peer Reviewed
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[Journal Article] Loss of PIP5KI・, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.2008
Author(s)
Wang Y., Litvinov RI., Chen X., Bach TL., Lian L., Petrich B.G., Monkley S.J., Kanaho Y., Critchley D.R., Sasaki T., Birnbaum M.J., Weisel J.W., Hartwig J., Abrams C.S.
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Journal Title
J. Clin. Invest. 118
Pages: 812-819
Related Report
Peer Reviewed
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[Journal Article] Control of cell polarity and motility by the PtdIns(3, 4, 5)P(3) phosphatase SHIP1.2007
Author(s)
Nishio M., Watanabe K., Sasaki J., Taya C., Takasuga S., Iizuka R., Balla T., Yamazaki M., Watanabe H., Itoh R., Kuroda S., Horie Y., Forster I., Mak T.S., Yonekawa H., Penninger J.M., Kanaho Y., Suzuki A., Sasaki T.
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Journal Title
Nat. Cell Biol. 9
Pages: 36-44
Related Report
Peer Reviewed
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[Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.2006
Author(s)
Suzuki T., Kanai Y., Hara T., Sasaki J., Sasaki T., Kohara M., Maehama T., Taya C., Shitara H., Yonekawa H., Frohaman M.A., Yokozeki T., Kanaho Y.
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Journal Title
Mol. Cell. Biol. 26
Pages: 6149-6156
Related Report
Peer Reviewed
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[Journal Article] Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I・.2005
Author(s)
Sasaki J., Sasaki T., Yamazaki M., Matsuoka K., Taya C., Shitara H., Takasuga S., Nishio M., Mizuno K., Wada T., Miyazaki H., Watanabe H., Iizuka R., Kubo S., Murata S., Chiba T., Maehama T., Frohman M.A., Tanaka K., Penninger J.M., Yonekawa H., Suzuki A., Kanaho Y.
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Journal Title
J. Exp. Med. 201
Pages: 859-870
Related Report
Peer Reviewed
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