| Budget Amount *help |
¥84,900,000 (Direct Cost: ¥84,900,000)
Fiscal Year 2009: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2008: ¥25,500,000 (Direct Cost: ¥25,500,000)
Fiscal Year 2007: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2006: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2005: ¥12,700,000 (Direct Cost: ¥12,700,000)
|
|---|
| Research Abstract |
DNA replication checkpoint plays a crucial role for the maintenance of genome integrity. With the help of research grant, we have found that replication checkpoint mediator complex (that consists of Tof1, Mrc1, and Csm3) is a key linker between DNA polymerase and helicase. This function as a linker is important for proper mediator function to sense different types of replication stress for the activation of the DNA replication checkpoint and protection of the replisome.
|
