Comprehensive functional analysis of genes involved in chromosome segregation

• Project/Area Number: 17080002
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: NAKASEKO Yukinonbu Kyoto University, 生命科学研究科, 准教授 (30231468)
• Co-Investigator(Kenkyū-buntansha): IKENO Masashi 藤田保健衛生大学, 総合医科学研究所, 講師 (80298546) ; KITAJIMA Tomoya 東京大学, 分子細胞生物学研究所, 助教 (00376641) ; TANAKA Kouichi 東京大学, 分子細胞生物学研究所, 助教 (90282615) ; SAKUNO TAKESHI 東京大学, 分子細胞生物学研究所, 特任助教 (10504566)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥85,700,000 (Direct Cost: ¥85,700,000); Fiscal Year 2009: ¥14,100,000 (Direct Cost: ¥14,100,000); Fiscal Year 2008: ¥16,400,000 (Direct Cost: ¥16,400,000); Fiscal Year 2007: ¥18,400,000 (Direct Cost: ¥18,400,000); Fiscal Year 2006: ¥18,400,000 (Direct Cost: ¥18,400,000); Fiscal Year 2005: ¥18,400,000 (Direct Cost: ¥18,400,000)
• Keywords: ゲノム機能・発現 / 染色体 / 染色体分配 / 遺伝学 / ゲノム / 遺伝子

Research Abstract

We have analyzed functional interactions of gene clusters involved in chromosome segregation to elucidate the global image of the regulatory network of the chromosome segregation. Using the fission yeast temperature sensitive mutant library, we examined the effect for the growth by genes involved in chromosome segregation for all of the mutants. Also, we tried to clone genes responsible for their mutation and suppressor genes for all of the mutants in this library. As a result, many novel functional interactions have been identified among these genes.

Research Products

• [Journal Article] Shugoshin-PP2A counteracts Casein Kinase 1-dependent cleavage of Rec8 by separase. (2010)
  • Author(s): Ishiguro T, Tanaka K, Sakuno T, Watanabe Y.
  • Journal Title: Nat. Cell Biol. 12 Pages: 500-506
  • Peer Reviewed
• [Journal Article] Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster. (2010)
  • Author(s): Suzuki N, Itou T, Hasegawa Y, Okazaki T, Ikeno M.
  • Journal Title: Nucleic Acids Res 38
  • Peer Reviewed
• [Journal Article] Construction and use of a bottom-up HAC vector for transgene expression. (2010)
  • Author(s): M.Ikeno, N.Suzuki
  • Journal Title: Method in Molecular Biology (印刷中)
  • Peer Reviewed
• [Journal Article] Cell to cell transfer of the chromatin-packaged human β-globin gene cluster. (2010)
  • Author(s): N.Suzuki, T.Itou, Y.Hasegawa, T.Okazaki, M.Ikeno
  • Journal Title: Nucleic Acid Research 38
  • Peer Reviewed
• [Journal Article] CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis. (2009)
  • Author(s): Tanaka K, Chang HL, Kagami A, Watanabe Y.
  • Journal Title: Dev Cell 17 Pages: 334-343
  • Peer Reviewed
• [Journal Article] Studies of meiosis disclose distinct roles of cohesion in the core centromere and pericentromeric regions. (2009)
  • Author(s): Sakuno T, Watanabe Y.
  • Journal Title: Chromosome Res 17 Pages: 239-249
  • Peer Reviewed
• [Journal Article] Kinetochore geometry defined by cohesion within the centromere. (2009)
  • Author(s): Sakuno T, Tada K, Watanabe Y.
  • Journal Title: Nature 458 Pages: 852-858
  • NAID: 40016861869
  • Peer Reviewed
• [Journal Article] Genetic control of cellular quiescence in S. pombe. (2009)
  • Author(s): Sajiki K, Hatanaka M, Nakamura T, Takeda K, Shimanuki M, Yoshida T, Hanyu Y, Hayashi T, Nakaseko Y, Yanagida M.
  • Journal Title: J Cell Sci 122 Pages: 1418-1429
  • Peer Reviewed
• [Journal Article] CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis. (2009)
  • Author(s): Saito A, Muro Y, Sugiura K, Ikeno M, Yoda K, Tomita Y.
  • Journal Title: J Rheumatol 36 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. (2009)
  • Author(s): Irvine DV, Goto DB, Vaughn MW, Nakaseko Y, McCombie WR, Yanagida M, Martienssen R.
  • Journal Title: Genome Res 19 Pages: 1077-1083
  • Peer Reviewed
• [Journal Article] Manipulating transgenes using a chromosome vector. (2009)
  • Author(s): Ikeno M, Suzuki N, Hasegawa Y, Okazaki T.
  • Journal Title: Nucleic Acids Res 37
  • Peer Reviewed
• [Journal Article] Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. (2009)
  • Author(s): Hanyu Y, Imai KK, Kawasaki Y, Nakamura T, Nakaseko Y, Nagao K, Kokubu A, Ebe M, Fujisawa A, Hayashi T, Obuse C, Yanagida M.
  • Journal Title: Genes Cells 14 Pages: 539-554
  • Peer Reviewed
• [Journal Article] Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. (2009)
  • Author(s): D.V.Irvine, D.B.Goto, M.W.Vaughn, Y.Nakaseko, W.R.McCombie, M.Yanagida, R.Martienssen
  • Journal Title: Genome Research 19 Pages: 77-83
  • Peer Reviewed
• [Journal Article] Genetic control of cellular quiescence in S.pombe. (2009)
  • Author(s): K.Sajiki, M.Hatanaka, T.Nakamura, K.Takeda, M.Shimanuki, T.Yoshida, Y.Hanyuu, T.Hayashi,Y.Nakaseko, M.Yanagida
  • Journal Title: Journal of Cell Science 122 Pages: 1418-1429
  • Peer Reviewed
• [Journal Article] Schizosaccharomyces pombe cell division cycle under limited glucose requires Sspl kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. (2009)
  • Author(s): Y.Hanyu, K.K.Imai, Y.Kawasaki, T.Nakamura, Y.Nakaseko, K.Nagao, A.Kokubu, M.Ebe, T.Hayashi, C.Obuse, M.Yanagida
  • Journal Title: Genes to Cells 14 Pages: 539-554
  • Peer Reviewed
• [Journal Article] CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis (2009)
  • Author(s): K.Tanaka, H.L.Chang, A.Kagami, Y.Watanabe
  • Journal Title: Developmental Cell 17 Pages: 334-343
  • Peer Reviewed
• [Journal Article] Kinetochore geometry defined by cohesion within the centromere. (2009)
  • Author(s): T.Sakuno, K.Tada, Y.Watanabe
  • Journal Title: Nature 458 Pages: 852-858
  • NAID: 40016861869
  • Peer Reviewed
• [Journal Article] Genetic control of cellular quiescence in S. pombe (2009)
  • Author(s): K. Sajiki, M. Hatanaka, T. Nakamura, K. Takeda, M. Shimanuki, T. Yoshida, Y. Hanyuu, T. Hayashi, Y. Nakaseko, and M.,Yanagida
  • Journal Title: Journal of Cell Science
  • Peer Reviewed
• [Journal Article] Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artificial human chromosome. (2009)
  • Author(s): M. Ito, M. Ikeno, H. Nagata, T. Yamamoto, A. Horiguchi, IJ Fox, and S. Miyakawa
  • Journal Title: Transplant Proc. 41 Pages: 422-444
  • Peer Reviewed
• [Journal Article] Manipulating transgenes using a chromosome vector (2009)
  • Author(s): M. Ikeno, N. Suzuki, Y. Hasegawa, and T. Okazaki
  • Journal Title: Nucleic Acids Res.
  • Peer Reviewed
• [Journal Article] CENP-0, a protein localized at the centromere throughout cell cycle, is a novel target antigen in systemic sclerosis. (2009)
  • Author(s): A. Saito, Y. Muro, K. Sugiura, M. Ikeno. K. Yoda. and Y. Tomita
  • Journal Title: Journal of Rheumatology 36 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Heterochromatin links to centromeric protection by recruiting shugoshin. (2008)
  • Author(s): Yamagishi Y, Sakuno T, Shimura M, Watanabe Y.
  • Journal Title: Nature 455 Pages: 251-255
  • Peer Reviewed
• [Journal Article] Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. (2008)
  • Author(s): Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake M, Watanabe Y.
  • Journal Title: Nat Cell Biol 10 Pages: 42-52
  • Peer Reviewed
• [Journal Article] Immortalized hepatocytes using human artificial chromosome. (2008)
  • Author(s): Ito M, Ito R, Yoshihara D, Ikeno M, Kamiya M, Suzuki N, Horiguchi A, Nagata H, Yamamoto T, Kobayashi N, Fox IJ, Okazaki T, Miyakama S.
  • Journal Title: Cell Transplant 17 Pages: 165-171
  • Peer Reviewed
• [Journal Article] Immortalized hepatocytes using human artificial chromosome. (2008)
  • Author(s): M. Ito, R. Ito, D. Yoshihara, M. Ikeno, M. Kamiya, N. Suzuki A Horiguchi, H. Nagata, T. Yamamoto, N Kobayashi, IJ Fox, T Okazaki, and S Miyakawa
  • Journal Title: Cell Transplantation 17 Pages: 165-171
  • Peer Reviewed
• [Journal Article] Chromatid cohesion : acetylation joins the sisters (2008)
  • Author(s): K. Tanaka and Y. Watanabe
  • Journal Title: Curr. Biol 18
• [Journal Article] Heterochromatin links to centromeric protection by recruiting shugoshin (2008)
  • Author(s): Y. Yamagishi, T. Sakuno, M. Shimura, and Y. Watanabe
  • Journal Title: Nature 455 Pages: 251-255
  • Peer Reviewed
• [Journal Article] Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. (2008)
  • Author(s): Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake M, Watanabe Y.
  • Journal Title: Nature Cell Biology 10 Pages: 42-52
  • Peer Reviewed
• [Journal Article] Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. (2007)
  • Author(s): Kawashima SA, Tsukahara T, Langegger M, Hauf S, Kitajima TS, Watanabe Y.
  • Journal Title: Genes Dev 21 Pages: 420-435
  • Peer Reviewed
• [Journal Article] Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. (2007)
  • Author(s): Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, Ebe M, Yanagida M.
  • Journal Title: Genes Cells 12 Pages: 1357-1370
  • Peer Reviewed
• [Journal Article] Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of twohighly phosphorylated TOR complexes by specific and common subunits. (2007)
  • Author(s): Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, Ebe M, Yanagida M.
  • Journal Title: Genes to Cells 12 Pages: 1357-1370
  • Peer Reviewed
• [Journal Article] Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. (2007)
  • Author(s): Kawashima SA, Tsukahara T, Langegger M, Hauf S, Kitajima TS, Watanabe Y.
  • Journal Title: Genes and Development 21・4 Pages: 420-435
• [Journal Article] Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice. (2006)
  • Author(s): Suzuki N, Nishii K, Okazaki T, Ikeno M.
  • Journal Title: J Biol Chem 281,51
  • Peer Reviewed
• [Journal Article] Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (2006)
  • Author(s): Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y.
  • Journal Title: Nature 441 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (2006)
  • Author(s): Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K.
  • Journal Title: Genes Cells 11 Pages: 673-684
  • Peer Reviewed
• [Journal Article] CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation. (2006)
  • Author(s): Aoki K, Nakaseko Y, Kinoshita K, Goshima G, Yanagida M.
  • Journal Title: Curr Biol 16 Pages: 1627-1635
  • Peer Reviewed
• [Journal Article] CDC2 phosphorylation of the fission yeast disl ensures accurate chromosome segregation (2006)
  • Author(s): Aoki K, Nakaseko Y, Kinoshita K, Goshima G, Yanagida M.
  • Journal Title: Current Biology 16・6 Pages: 1627-1635
• [Journal Article] Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice. (2006)
  • Author(s): Suzuki N, Nishii K, Okazaki T, Ikeno M.
  • Journal Title: Journal of Biochemistry 281・36 Pages: 26615-26623
• [Journal Article] Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (2006)
  • Author(s): Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K.
  • Journal Title: Genes to Cells 11・6 Pages: 673-684
• [Journal Article] Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (2006)
  • Author(s): Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y.
  • Journal Title: Nature 441・7089 Pages: 46-52
• [Journal Article] Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. (2005)
  • Author(s): Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y.
  • Journal Title: Curr Biol 15 Pages: 353-359
  • Peer Reviewed
• [Presentation] 相同染色体の結合は動原体の配向と連携して減数第一分裂における染色体分配の方向性を決定する (2010)
  • Author(s): 田中晃一、作野剛士、Silke Hauf、渡邊嘉典
  • Organizer: 第27回染色体ークショップ
  • Place of Presentation: 御殿場市時之栖
  • Year and Date: 2010-01-21
• [Presentation] ヒトCENP-Aのセントロメア局在機構の解析 (2009)
  • Author(s): 池野正史
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] ヒトCENP-Aのセント・メア局在機構の解析 (2009)
  • Author(s): 池野正史、長谷川嘉則、鈴木伸卓、中世古幸信、工藤純、岡崎恒子
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] ヒト人工染色体の安定維持に必要なセントロメア蛋白質の解析 (2009)
  • Author(s): 鈴木伸卓、岡崎恒子、池野正史
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] ヒト人工染色体(HAC)保有マウスの作成とマウス組織における各種ヒト遺伝子の発現 (2009)
  • Author(s): 宮本憲一、鈴木伸卓、堺弘介、浅川修一、岡崎恒子、清水信義、池野正史、工藤純
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] ヒトセントロメア構造形成の特異性と生物種共通性 (2009)
  • Author(s): 池野正史
  • Organizer: 染色体学会
  • Place of Presentation: 松江市くにびきメッセ
  • Year and Date: 2009-11-13
• [Presentation] Linkage between homologs secures mono-orientation of sister kinetochores in meiosis I. (2009)
  • Author(s): 田中晃一
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-29
• [Presentation] Kinetochore geometry defined by cohesion within the centromere. (2009)
  • Author(s): 作野剛士
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. (2009)
  • Author(s): D.V.Irvine, D.Goto, M.W.Vaughn, Y.Nakaseko W.R.McCombie, M.Yanagida, R.Martienssen
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] CoA synthesis pathway affects chromosome segregation through protein acetylation in S.pombe. (2009)
  • Author(s): T.Nakamura, T.Pluskal, T.Hayashi, Y.Nakaseko, M.Yanagida
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] Genetic control of cellular quiescence in S.pombe. (2009)
  • Author(s): K.Sajiki, M.Hatanaka, T.Nakamura, K.Takeda, M.Shimanuki, T.Yoshida, Y.Hanyuu, T.Hayashi, Y.Nakaseko, M.Yanagida
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] Identification of genetic loci of temperature-sensitive mutations that are rescued by a deacetylase inhibitor. (2009)
  • Author(s): T.Matsumura, Y.Nakaseko, T.Nakamura, A.Matsuyama, M.Yanagida, M.Yoshida
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] Kinetochore geometry defined by cohesion within the centromere (2009)
  • Author(s): T.Sakuno, K.Tada, Y.Watanabe
  • Organizer: 第5回国際分裂酵母学会
  • Place of Presentation: 国立オリンピック記念センター
  • Year and Date: 2009-10-26
• [Presentation] ヒト人工染色体の安定維持に必要なセントロメア蛋白質の解析 (2008)
  • Author(s): 鈴木伸卓、岡崎恒子、池野正史
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11
• [Presentation] 分裂酵母CENP-C(Cnp3)の機能解析 (2008)
  • Author(s): 田中晃一、Chang Hui Li、加々美綾乃、渡邊嘉典
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11
• [Presentation] クロマチン構造のin vivo再構築を利用した遺伝子の発現制御領域の解析 (2008)
  • Author(s): 池野正史
  • Place of Presentation: 神戸市ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] 分裂酵母CENP-C(Cnp3)の機能解析 (2008)
  • Author(s): 田中晃一
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] The orientation of kinetochore defined by cohesion within the centromere. (2008)
  • Author(s): 作野剛士
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] クロマチン構造のin vivo再構築を利用した遺伝子の発現制御領域の解析 (2008)
  • Author(s): 池野正史、神谷恵
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-10
• [Presentation] The orientation of kinetochore defined by cohesion within the centromere (2008)
  • Author(s): 作野剛士、多田健志、渡邊嘉典
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-10
• [Presentation] 多種生物細胞を利用したCBNP-Aのセントロメア局在機構の解析 (2008)
  • Author(s): 長谷川嘉則、岡崎恒子、池野正史
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-09
• [Presentation] マウスに導入されたヒト人工染色体(HAC)上のヒト遺伝子の発現 (2008)
  • Author(s): 宮本憲一、鈴木伸卓、堺弘介、浅川修一、岡崎恒子、清水信義、池野正史、工藤純
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-09
• [Presentation] Cnp3 (CENP-C) plays an essential role in monopolar attachment by recruiting Moa1 onto centromeres at meiosis I. (2008)
  • Author(s): 田中晃一
  • Organizer: Asia-Pacific Regional S. pombe Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2008-07-26
• [Presentation] CNP3(CENP-C)PLAYS AN ESSENTIAL ROLE IN MONOPOLAR ATTACHMENT BY REQRUITING MOA1 ONTO CENTROMERES AT MEIOSIS I (2008)
  • Author(s): K. Tanaka, C. H. Li, A. Kagami and Y. Watanabe
  • Organizer: Asia-Pacific Regional S. pombe Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2008-07-26
• [Presentation] Maintenance of human centromere structure. International symposium on chromosome dynamycs. (2008)
  • Author(s): 池野正史
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 三重県アクアビラ志摩
  • Year and Date: 2008-05-30
• [Presentation] A brute force post-genome approach using a randomly isolated mutant library of fission yeast toward comprehensive analysis of functional interaction of mitotic regulators. (2008)
  • Author(s): 中世古幸信
  • Organizer: International symposium on chromosome dynamics
  • Place of Presentation: 三重県アクアビラ志摩
  • Year and Date: 2008-05-30
• [Presentation] A brute force post-genome approach using a randomly isolated mutant library of fission yeast toward comprehensive analysis of functional interaction of mitotic regulators (2008)
  • Author(s): 中世古幸信
  • Organizer: International symposium on chromosome dynamycs
  • Place of Presentation: 三重県志摩市
  • Year and Date: 2008-05-30
• [Presentation] Maintenance of human centromere structure (2008)
  • Author(s): M. Ikeno, N. Suzuki, and Y. Hasegawa
  • Organizer: International symposium on chromosome dynamycs
  • Place of Presentation: 三重県志摩市
  • Year and Date: 2008-05-30