Studies on molecular assembly of replication proteins and regulation of their functions in initiation of chromosome DNA replication
| Project/Area Number |
17080003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
MASUKATA Hisao Osaka University, 大学院・理学研究科, 教授 (00199689)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Haruhiko 大阪大学, 大学院・理学研究科, 教授 (60154944)
ISHIMI Yukio 茨城大学, 理学部, 教授 (80159772)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥182,500,000 (Direct Cost: ¥182,500,000)
Fiscal Year 2009: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2008: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2007: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2006: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2005: ¥36,500,000 (Direct Cost: ¥36,500,000)
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| Keywords | 細胞周期 / 染色体 / クロマチン / セントロメア / テロメア / MCMヘリカーゼ / DNA複製 / 分裂酵母 / 複製開始複合体 / ヘテロクロマチン / リン酸化制御 / 複製開始点 / 複製チェックポイント / クロマチン構造 / 複製チェッポイント / 遺伝学 / 核酸 / ゲノム / 蛋白質 / 微生物 |
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| Research Abstract |
We determined whole-genome localization of replication origins on fission yeast chromosomes and found that heterochromatin in centromere and mating type locus replicates in early S phase, whereas that in subtelomere replicates late. We discovered that the heterochromatin protein HP1, which was considered as a negative factor to DNA replication, stimulate replication in early S phase at centromere and mating type locus through the interaction with DDK that is an essential kinase for DNA replication. On the other hand, in subtelomeric regions telomere binding proteins play roles in regulation of DNA replication.
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Report
(6 results)
Research Products
(173 results)
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[Journal Article] Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe.2008
Author(s)
Nakamura KI, Okamoto A, Katou Y, Yadani C, Shitanda T, Kaweeteerawat C, Takahashi TS, Itoh T, Shirahige K, Masukata H., Nakagawa T
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Journal Title
EMBO J. 27
Pages: 3036-3046
Related Report
Peer Reviewed
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