| Budget Amount *help |
¥182,500,000 (Direct Cost: ¥182,500,000)
Fiscal Year 2009: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2008: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2007: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2006: ¥36,500,000 (Direct Cost: ¥36,500,000)
Fiscal Year 2005: ¥36,500,000 (Direct Cost: ¥36,500,000)
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| Research Abstract |
We determined whole-genome localization of replication origins on fission yeast chromosomes and found that heterochromatin in centromere and mating type locus replicates in early S phase, whereas that in subtelomere replicates late. We discovered that the heterochromatin protein HP1, which was considered as a negative factor to DNA replication, stimulate replication in early S phase at centromere and mating type locus through the interaction with DDK that is an essential kinase for DNA replication. On the other hand, in subtelomeric regions telomere binding proteins play roles in regulation of DNA replication.
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