Analysis on regulatory factors and functional mechanisms for the initiator protein of the chromosomal replication

• Project/Area Number: 17080005
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: TSUTOMU Katayama Kyushu University, 大学院・薬学研究院, 教授 (70264059)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥81,000,000 (Direct Cost: ¥81,000,000); Fiscal Year 2009: ¥13,500,000 (Direct Cost: ¥13,500,000); Fiscal Year 2008: ¥18,000,000 (Direct Cost: ¥18,000,000); Fiscal Year 2007: ¥18,000,000 (Direct Cost: ¥18,000,000); Fiscal Year 2006: ¥22,500,000 (Direct Cost: ¥22,500,000); Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: DNA複製 / 複製開始 / DnaA / DiaA / ヘリカーゼ / DARS / 試験管内再構成 / タンパク質複合体 / タンパク質高次複合体 / 試験管内再構成系 / タンパク質高次復合体 / DNA 複製 / 細胞周期 / タンパク質高吹複合体 / タンパク質機能構造解析 / プロテオミクス / システム連携 / ネットワーク / クランプ / フィードバック制御 / ATP

Research Abstract

Initiation of the chromosomal DNA replication is a crucial reaction that regulates the cell proliferation. The active form of Escherichia coli DnaA protein initiates the chromosomal replication, whereas the inactive form does not. This study revealed for the first time that specific DNA sequences (termed DARS) on the chromosome directly activate DnaA. Moreover, it revealed molecular mechanisms in stimulation for the initiation reaction by the DnaA-binding protein DiaA and in post-initiational inactivation of DnaA by Hda protein.

Research Products

• [Journal Article] Novel essential residues of Hda for interaction with DnaA in the regulatory inactivation of DnaA: Unique roles for Hda AAA+ Box VI and VII motifs (2010)
  • Author(s): Nakamura, K., Katayama, T.
  • Journal Title: Mol. Microbiol. 76 Pages: 302-317
• [Journal Article] Regulation of the replication cycle: Conserved and diverse regulatory systems for DnaA and oriC (2010)
  • Author(s): Katayama, T., Ozaki, S., Keyamura, K., Fujimitsu, K.
  • Journal Title: Nature Rev. Microbiol. 8 Pages: 163-170
• [Journal Article] DnaA, ORC, and Cdc6: Similarity beyond the domains of life and diversity. Biochem (2010)
  • Author(s): Kawakami, H., Katayama, T.
  • Journal Title: Cell Biol. 88 Pages: 49-62
• [Journal Article] Regulation of the replication cycle : Conserved and diverse regulatory systems for DnaA and oriC (2010)
  • Author(s): Katayama, T., ほか
  • Journal Title: Nature Rev.Microbiol. 8 Pages: 163-170
  • Peer Reviewed
• [Journal Article] DnaA, ORC, and Cdc6 : Similarity beyond the domains of life and diversity (2010)
  • Author(s): Kawakami, H., ほか
  • Journal Title: Biochem.Cell Biol. 88 Pages: 49-62
  • Peer Reviewed
• [Journal Article] Novel essential residues of Hda for interaction with DnaA in the regulatory inactivation of DnaA : Unique roles for Hda AAA+ Box VI and VII motifs (2010)
  • Author(s): Nakamura, K., ほか
  • Journal Title: Mol.Microbiol 76 Pages: 302-317
  • Peer Reviewed
• [Journal Article] DnaA structure, function, and dynamics in the initiation at the chromosomal Origin (2010)
  • Author(s): Ozaki, S., ほか
  • Journal Title: Plasmid 62 Pages: 71-82
  • Peer Reviewed
• [Journal Article] Specific genomic sequences of E. coli promote replicational initiation by directly reactivating ADP-DnaA (2009)
  • Author(s): Fujimitsu, K., Senriuchi, T., Katayama, T.
  • Journal Title: Genes Dev. 23 Pages: 221-1233
• [Journal Article] DiaA dynamics are coupled with changes in initial origin complexes leading to helicase loading. (2009)
  • Author(s): Keyamura, K., Abe, Y., Higashi, M., Ueda, T., Katayama, T.
  • Journal Title: J. Biol. Chem. 284 Pages: 25038-25050
• [Journal Article] A. Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli (2009)
  • Author(s): Riber, L., Fujimitsu, K., Katayama, T., Lobner-Olesen
  • Journal Title: Mol. Microbiol. 71 Pages: 107-22
• [Journal Article] DnaA structure, function, and dynamics in the initiation at the chromosomal origin (2009)
  • Author(s): Ozaki, S., Katayama, T.
  • Journal Title: Plasmid 62 Pages: 71-82
• [Journal Article] Specific genomic sequences of E. coli promote replicational initiation by directly reactivating ADP-DnaA (2009)
  • Author(s): Fujimitsu, K, ほか
  • Journal Title: Genes Dev. 23 Pages: 1221-1233
  • Peer Reviewed
• [Journal Article] DiaA dynamics are coupled with changes in initial origin complexes leading tohelicase loading (2009)
  • Author(s): Keyamura, K, ほか
  • Journal Title: J.Biol.Chem. 284 Pages: 25038-25050
  • Peer Reviewed
• [Journal Article] Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli (2009)
  • Author(s): Riber, L., ほか
  • Journal Title: Mol.Microbiol. 71 Pages: 107-122
  • Peer Reviewed
• [Journal Article] 大腸菌の染色体複製開始制御機構 (2009)
  • Author(s): 片山勉
  • Journal Title: 蛋白質核酸酵素 54 Pages: 343-349
• [Journal Article] Specific genomic sequences of E. coli promote replicational initiation by directly reactivating ADP-DnaA (2009)
  • Author(s): Fujimitsu, Kほか
  • Journal Title: Genes & Development 23(印刷中)
  • Peer Reviewed
• [Journal Article] Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli (2009)
  • Author(s): Riber, L. ほか
  • Journal Title: Molecular Microbiogy 71 Pages: 107-122
  • Peer Reviewed
• [Journal Article] A common mechanism for the ATP-DnaA-dependent formation of open complexes at the replication origin. (2008)
  • Author(s): Ozaki, S., Kawakami, H., Nakamura, K., Fujikawa, N., Kagawa, W., Park, S. -Y., Yokoyama, S., Kurumizaka, H., Katayama, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 8351-8362
• [Journal Article] Hda monomerization by ADP binding promotes replicase clamp-mediated DnaA-ATP hydrolysis (2008)
  • Author(s): Su'etsugu, M., Nakamura, K., Keyamura, K., Kudo, Y., Katayama, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 36118-36131
• [Journal Article] Modes of over-initiation, dnaA gene expression and the inhibition of cell division in a novel cold-sensitive hda mutant in Escherichia coli J. (2008)
  • Author(s): Fujimitsu, K., Su'etsugu, M., Yamaguchi, Y., Mazda, K., Fu, N., Kawakami, H., Katayama, T.
  • Journal Title: Bacteriol. 190 Pages: 5368-5381
• [Journal Article] Roles for the AAA+ motifs of DnaA in the initiation of DNA replication (2008)
  • Author(s): Katayama, T.
  • Journal Title: Biochem. Soc. Trans. 36 Pages: 78-82
• [Journal Article] Roles for the AAA+ motifs of DnaA in the initiation of DNA replication (2008)
  • Author(s): Katayama. T.
  • Journal Title: Biochem. Soc. Trans 36 Pages: 78-82
  • Peer Reviewed
• [Journal Article] A common mechanism for the ATP-DnaA-dependent formation of open complexes at the replication origin (2008)
  • Author(s): Ozaki, S. ほか
  • Journal Title: IJ. Biol. Chem 283 Pages: 8351-8362
  • Peer Reviewed
• [Journal Article] Hda monomerization by ADP binding promotes replicase clamp-mediated DnaA-ATP hydrolysis (2008)
  • Author(s): Su'etsugu, M. ほか
  • Journal Title: J. Biol. Chem 283 Pages: 36118-36131
  • Peer Reviewed
• [Journal Article] Modes of over-initiation, dnaA gene expression and the inhibition of cell division in a novel cold-sensitive hda mutant in Escherichia coli (2008)
  • Author(s): Fujimitsu, K., ほか
  • Journal Title: J. Bacteriol 190 Pages: 5368-5381
  • Peer Reviewed
• [Journal Article] Roles for the AAA+ motifs of DnaA in the initiation of DNA replication (2008)
  • Author(s): Katayama., T.
  • Journal Title: Biochem. Soc. Trans. 36 Pages: 78-82
  • Peer Reviewed
• [Journal Article] A common mechanism for the ATP-DnaA-dependent formation of open complexes at the relication origin (2008)
  • Author(s): Ozaki, S., et. al.
  • Journal Title: J. Biol. Chem. 283 Pages: 8351-8362
  • Peer Reviewed
• [Journal Article] The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP-DnaA-specific initiation complexes (2007)
  • Author(s): Keyamura, K., Fujikawa, N,, Ishida, T., Ozaki, S., Su'etsugu, M., Fujimitsu, K., Kagawa, W., Yokoyama, S., Kurumizaka, H., Katayama, T.
  • Journal Title: Genes Dev. 21 Pages: 2083-2099
• [Journal Article] Structure and function of DnaA N-terminal domains: Specific sites and mechanisms in inter-DnaA interaction and in DnaB helicase loading on oriC (2007)
  • Author(s): Abe, Y., Jo, T., Matsuda, Y., Matsunaga, C., Katayama, T., Ueda, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 17816-17827
• [Journal Article] Assignment of 1H, 13C and 15N resonances of N-terminal domains of DnaA protein (2007)
  • Author(s): Abe, Y., Watanabe, N., Yoshida, Y., Ebata, F., Katayama, T., Ueda, T.
  • Journal Title: Biomol. NMR Assign. 1 Pages: 57-59
• [Journal Article] The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP-DnaA-specific initiation complexes (2007)
  • Author(s): Keyamura, K., et. al.
  • Journal Title: Genes Dev 21 Pages: 2083-2099
  • Peer Reviewed
• [Journal Article] Structure and function of DnaA N-terminal domains: Specific sites and mechanisms in inter-DnaA interaction and in DnaB helicase loading on oriC (2007)
  • Author(s): Abe, Y., et. al.
  • Journal Title: J. Biol. Chem 282 Pages: 17816-17827
  • Peer Reviewed
• [Journal Article] Assignment of ^1H, ^<13>C and ^<15>N resonances of N-terminal domains of DnaA protein (2007)
  • Author(s): Abe, Y., et. al.
  • Journal Title: Biomol. NMR Assign. 1 Pages: 57-59
  • Peer Reviewed
• [Journal Article] 複製再開始抑制の分子機構 (2007)
  • Author(s): 片山 勉
  • Journal Title: 実験医学 25 Pages: 49-55
• [Journal Article] Structure and function of DnaA N-terminal domains : Specific sites and mechanisms in inter-DnaA interaction and in DnaB helicase loading on oriC (2007)
  • Author(s): Abe, Y.et al.
  • Journal Title: Journal of Biological Chemistry (印刷中)
• [Journal Article] Assignment of ^1H, ^<13>C and ^<15>N resonances of N-terminal domains of DnaA protein (2007)
  • Author(s): Abe, Y.et al.
  • Journal Title: Biomolecular NMR Assignments (印刷中)
• [Journal Article] The exceptionally tight affinity of DnaA for ATP/ADP requires a unique aspartic acid residue in the AAA+ sensor 1 motif (2006)
  • Author(s): Kawakami, H., Ozaki, S., Suzuki, S., Nakamura, K., Senriuchi, T., Su'etsugu, M., Fujimitsu, K., Katayama, T.
  • Journal Title: Mol. Microbiol. 62 Pages: 1310-1324
• [Journal Article] The DnaA homolog of the hyperthermophilic eubacterium Thermotoga maritima forms an open complex with a minimal 149-bp origin region in an ATP-dependent manner (2006)
  • Author(s): Ozaki, S., Fujimitsu, K., Kurumizaka, H., Katayama, T.
  • Journal Title: Genes Cells 11 Pages: 425-438
• [Journal Article] An isolated Hda-clamp complex is functional in the regulatory inactivation of DnaA and DNA replication (2006)
  • Author(s): Kawakami, H., Su'etsugu, M., Katayama, T.
  • Journal Title: J. Struct. Biol. 156 Pages: 220-229
• [Journal Article] Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation (2006)
  • Author(s): Ote, T., Hashimoto, M., Ikeuchi, Y., Su'etsugu, M., Suzuki, T., Katayama, T., Kato, J.
  • Journal Title: Mol. Microbiol. 59 Pages: 265-274
• [Journal Article] The exceptionally tight affinity of DnaA for ATP/ADP requires a unique aspartic acid residue in the AAA+ sensor 1 motif (2006)
  • Author(s): Kawakami, H. et al.
  • Journal Title: Molecular Microbiolgy 62,5 Pages: 1310-1324
• [Journal Article] The DnaA homolog of the hyperthermophilic eubacterium Thermotoga maritima forms an open complex with a minimal 149-bp origin region in an ATP-dependent manner (2006)
  • Author(s): Ozaki, S. et al.
  • Journal Title: Genes to Cells 11 Pages: 425-438
• [Journal Article] An isolated Hda-clamp complex is functional in the regulatory inactivation of DnaA and DNA replication (2006)
  • Author(s): Kawakami, H. et al.
  • Journal Title: Journal of Structural Biology 156 Pages: 220-229
• [Journal Article] Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation (2006)
  • Author(s): Ote, T.et al.
  • Journal Title: Molecular Microbiolgy 59,1 Pages: 265-274
• [Journal Article] An isolated Hda-clamp complex is functional in the regulatory inactivation of DnaA and DNA replication (2006)
  • Author(s): Kawakami, H. et al.
  • Journal Title: Journal of Structural Biology (印刷中)
• [Journal Article] The DnaA homolog of the hyperthermophilic eubacterium Thermotoga maritima forms an open complex with a minimal 149-bp orogin region in an ATP-dependent manner (2006)
  • Author(s): Ozaki, S. et al.
  • Journal Title: Genes to Cells 11(印刷中)
• [Journal Article] Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation (2006)
  • Author(s): Ote, T.et al.
  • Journal Title: Mol.Microbiol. 59(1) Pages: 265-274
• [Journal Article] Formation of an ATP-DnaA-specific initiation complex requires DnaA arginine-285, a conserved motif in the AAA+ protein family (2005)
  • Author(s): Kawakami, H., Keyamura, K., Katayama, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 27420-27430
• [Journal Article] Protein associations in DnaA-ATP hydrolysis mediated by the Hda-replicase clamp complex. (2005)
  • Author(s): Su'etsugu, M., Shimuta, T., Ishida, T., Kawakami, H., Katayama, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 6528-6536
• [Journal Article] Cell size and nucleoid organization of engineered Escherichia coli cells with a reduced genome. (2005)
  • Author(s): Hishimoto, M., Ichimura, Y., Mizoguchi, H., Tanaka, K., Fujimitsu, K., Keyamura, K., Ote, T., Yamakawa, T., Yamazaki, Y., Mori, H., Katayama, T., Kato, J.
  • Journal Title: Mol. Microbiol. 55 Pages: 137-149
• [Journal Article] Crystal structure of a biologically functional form of PriB from Escherichia coli reveals a potential single-stranded DNA-binding site. Biochem (2005)
  • Author(s): Shioi, S., Ose, T., Maenaka, K., Shiroishi, M., Abe, Y., Kohda, D., Katayama, T., Ueda, T.
  • Journal Title: Biophys. Res. Commun. 326 Pages: 766-776
• [Journal Article] Formation of an ATP-DnaA-specific initiation complex requires DnaA arginie-285,a conserved motif in the AAA+ protein family (2005)
  • Author(s): Kawakami, H. et al.
  • Journal Title: Journal of Biological Chemistry 280(29) Pages: 27420-27430
• [Presentation] 染色体複製開始タンパク質の機能制御因子とその作動メカニズムの解析:まとめと展望 (2010)
  • Author(s): 片山勉
  • Organizer: 最終回「染色体サイクル」特定領域会議
  • Place of Presentation: 霧島
• [Presentation] 染色体複製開始タンパク質の機能制御因子とその作動メカニズムの解析:まとめと展望 (2010)
  • Author(s): 片山勉
  • Organizer: 特定領域「染色体サイクル」最終領域会議
  • Place of Presentation: 霧島
• [Presentation] Functional mechanism and regulation for the E. coli chromosomal replication initiator DnaA (2009)
  • Author(s): Katayama, T.
  • Organizer: 12th Asia-Pacific International Molecular Biology Network Conference
  • Place of Presentation: Penang, Malaysia
• [Presentation] The replication initiator DnaA is reactivated in a specific nucleoprotein complex (2009)
  • Author(s): Fujimitsu, K., Senriuchi, T., Katayama, T.
  • Organizer: 8th International Conference on AAA Proteins
  • Place of Presentation: Tronto, Canada
• [Presentation] AAA+ domain-specific interaction of Hda with DnaA in the replicase clamp-mediated DnaA-ATP hydrolysis (2009)
  • Author(s): Nakamura, K., Katayama, T.
  • Organizer: 8th International Conference on AAA Proteins
  • Place of Presentation: Tronto, Canada
• [Presentation] DARS:大腸菌DnaAを活性化する新規染色体DNA因子 (2009)
  • Author(s): 片山勉
  • Organizer: 第5回「染色体サイクル」特定領域会議
  • Place of Presentation: 伊豆市
• [Presentation] 大腸菌の複製開始因子DnaAの構造、機能、および制御 (2009)
  • Author(s): 片山勉
  • Organizer: 日本遺伝学会第81回大会シンポジウム「日本のDNA複製研究の過去、現在、未来」
  • Place of Presentation: 信州大学
• [Presentation] 大腸菌の複製開始複合体形成におけるDiaA-DnaA相互作用メカニズムの解析 (2009)
  • Author(s): 毛谷村賢司、東雅裕、片山勉
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学
• [Presentation] DnaAと複製クランプに依存したDnaA不活性化因子Hdaの活性制御 (2009)
  • Author(s): 中村賢太、末次正幸、片山勉
  • Organizer: 第20回DNA複製・組換え・修復ワークショップ
  • Place of Presentation: 彦根市
• [Presentation] 大腸菌染色体複製イニシエーターDnaAは特異的なDNA配列上で高次複合体を形成し活性化される (2009)
  • Author(s): 藤光和之、片山勉
  • Organizer: 第82回日本生化学会大会シンポジウム「高次タンパク質複合体構造の変遷によるDNA複製の進行制御」
  • Place of Presentation: 神戸
• [Presentation] Novel fundamental mechanism regulating the replicational initiation in E. coli (2009)
  • Author(s): Katayama, T., Keyamura, K., Fujimitsu, K., Ozaki, S., Shinozuka, S., Hatano, T., Niki, H.
  • Organizer: 第32回日本分子生物学会ワークショップ「Frontier of Bacterial Cell Duplication」
  • Place of Presentation: 横浜
• [Presentation] The replication initiator DnaA is reactivated in a specific nucleoprotein complex (2009)
  • Author(s): Fujimitsu, K., et al.(招待)
  • Organizer: 8th International Conference on AAA Protein
  • Place of Presentation: Tronto,Canada
• [Presentation] AAA+ domain-specific interaction of Hda with DnaA in the replicaseclamp-mediated DnaA-ATP hydrolysis (2009)
  • Author(s): Nakamura, K., et al
  • Organizer: 8th International Conference on AAA Protein
  • Place of Presentation: Tronto, Canada
• [Presentation] Functional mechanism and regulation for the E.coli chromosomal replication initiator DnaA (2009)
  • Author(s): Katayama, T.(招待)
  • Organizer: 12th Asia-Pacific International Molecular Biology Network Conference
  • Place of Presentation: Penang, Malaysia
• [Presentation] DnaA再活性化因子DARS2に対するマルチコピーサプレッサーの分離 (2009)
  • Author(s): 加生和寿, ほか
  • Organizer: 第6回21世紀大腸菌研究会
  • Place of Presentation: 熱海市
• [Presentation] DNA分配に関与する新規因子RisAに相互作用する因子の探索 (2009)
  • Author(s): 永田小桃, ほか
  • Organizer: 第6回21世紀大腸菌研究会
  • Place of Presentation: 熱海市
• [Presentation] DARS:大腸菌DnaAを活性化する新規染色体DNA因子 (2009)
  • Author(s): 片山勉
  • Organizer: 特定領域「染色体サイクル」第5回領域会議
  • Place of Presentation: 伊豆市
• [Presentation] 大腸菌の複製開始因子DnaAの構造、機能、および制御 (2009)
  • Author(s): 片山勉
  • Organizer: 日本遺伝学会第81回大会シンポジウム
  • Place of Presentation: 信州大学
• [Presentation] DnaAによる2本鎖開裂を制御するための複製開始点の新規機能構造特性 (2009)
  • Author(s): 尾崎省吾, ほか
  • Organizer: 第20回DNA複製・組換え・修復ワークショップ
  • Place of Presentation: 彦根市
• [Presentation] 大腸菌染色体複製イニシエーターDnaAは特異的なDNA配列上で高次複合体を形成し活性化される (2009)
  • Author(s): 藤光和之, ほか
  • Organizer: 第82回日本生化学会大会シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 複製開始点の2本鎖開裂を制御するDnaA複合体の最小機能構造 (2009)
  • Author(s): 尾崎省吾, ほか
  • Organizer: 第82回日本生化学会大会シンポジウム
  • Place of Presentation: 神戸
• [Presentation] ATP結合型DnaAと複製クランプによるDnaA不活性化因子Hdaの活性制御 (2009)
  • Author(s): 中村賢太, ほか
  • Organizer: 第82回日本生化学会大会シンポジウム
  • Place of Presentation: 神戸
• [Presentation] DARS : the chromosomal locus for reactivation of the replication initiator DnaAin E.coli (2009)
  • Author(s): Fujimitsu, K., et al.
  • Organizer: International Symposium on Chromosomal Cycie and Genome Dynamics
  • Place of Presentation: Nasu, Tochigi
• [Presentation] Novel fundamental mechanism regulating the replicational initiation in E.coli (2009)
  • Author(s): Katayama, T., et al.
  • Organizer: 第32回日本分子生物学会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] 開始複合体の活性化に必要なATP-DnaA特異的DnaA間相互作用の解析 (2009)
  • Author(s): 林靖久, ほか
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Hda相互作用因子の探索とその機能解析 (2009)
  • Author(s): 平井麻美, ほか
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] CysB protein binds specifically to DARS2, a genomic sequence of E.coli that promotes replicational initiation by directly reactivating ADP-DnaA (2009)
  • Author(s): Asmaa, B.M.A., et al.
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] DnaA再活性化因子DARS2を抑制する因子の探索 (2009)
  • Author(s): 加生和寿, ほか
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] 大腸菌染色体の複製開始を制御する新たな基本分子機構 (2009)
  • Author(s): 片山勉, ほか
  • Organizer: 第1回P&P合同公開シンポジウム
  • Place of Presentation: 福岡市
• [Presentation] 染色体複製開始点で形成される超高次DnaA複合体による2重鎖DNA開裂のメカニズム (2009)
  • Author(s): 尾崎省吾, ほか
  • Organizer: 第1回P&P合同公開シンポジウム
  • Place of Presentation: 福岡市
• [Presentation] 大腸菌のDnaA結合因子DiaAにより形成された複製開始複合体へのDnaBヘリカーゼ装着メカニズムの解析 (2009)
  • Author(s): 毛谷村賢司, ほか
  • Organizer: 第1回P&P合同公開シンポジウム
  • Place of Presentation: 福岡市
• [Presentation] 片山勉,DnaAを再活性化する染色体領域とその活性化因子の探索 (2009)
  • Author(s): 藤光和之, ほか
  • Organizer: 第1回P&P合同公開シンポジウム
  • Place of Presentation: 福岡市
• [Presentation] 複製開始反応を適時的に制御するDiaA-DnaA相互作用機構の解析 (2009)
  • Author(s): 毛谷村賢司. ほか
  • Organizer: 遺伝研研究会「単細胞における複合システム系の連帯と統合」
  • Place of Presentation: 三島
• [Presentation] 大腸菌染染色体DNA複製のイニシエーターDnaAの構造と機能 (2008)
  • Author(s): 片山勉
  • Organizer: 福岡歯科大学シンポジウム---環境とゲノムをつなぐ細胞機能
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-08
• [Presentation] Mechanism and Regulation for the Initiation of Chromosomal DNA Replication in Escherichia coil : ATP-DnaA assembly and duplex unwinding (2008)
  • Author(s): Katayama, T. ほか
  • Organizer: PUSAN-KYUSHU JOINT SYMPOSIUM
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-11-28
• [Presentation] 真正細菌の染色体複製開始のメカニズムと新規因子 DiaA の役割 (2008)
  • Author(s): 片山 勉, et. al.
  • Organizer: 薬学研究フォーラムin東京2008
  • Place of Presentation: 日本薬学会長井記念館
  • Year and Date: 2008-03-14
• [Presentation] A novel initiation-stimulator DiaA directly promotes ATP-DnaA-specific initiation complexes in E. coli (2008)
  • Author(s): Keyamura, K., Fujikawa, N., Ishida, T., Ozaki, S., Su'etsugu, M., Fujimitsu, K., Kagawa, W., Yokoyama, S., Kurumizaka, H., Katayama, T.
  • Organizer: Keysone Symposia in Molecular and Cellular Biology: DNA Replication and Recombination
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Analysis on Mechanisms of ATP-DnaA Assembly on oriC and Duplex Unwinding (2008)
  • Author(s): Katayama, T., Ozaki, S., Keyamura, K., Kawakami, H., Fujikawa, N., Kagawa, W., Nakamura, K., Fujimitsu, K., Su'etsugu, M., Yokoyama, S., Kurumizaka, H.
  • Organizer: EMBO Workshop on Replication & Segregation of Chromosomes
  • Place of Presentation: Geilo, Norway
• [Presentation] 新規因子DiaA蛋白質を含む, 複製開始複合体の構造とメカニズム (2008)
  • Author(s): 片山勉, 毛谷村賢司, 尾崎省吾, 藤川乃り映, 香川亘, 川上広宣, 中村賢太, 石田琢磨, 末次正幸, 藤光和之, 横山茂之, 胡桃坂仁志
  • Organizer: 第8回蛋白質科学会年会ワークショップ「構造から理解するDNA結合タンパク質の機能」
  • Place of Presentation: 東京都江戸川区
• [Presentation] DnaAによる2重鎖開裂における複製起点の最小機能構造 (2008)
  • Author(s): 尾崎省吾, 片山勉
  • Organizer: 第80回日本遺伝学会大会ワークショップ「染色体機能とDNAトランスアクション」
  • Place of Presentation: 名古屋大学
• [Presentation] Mechanisms of ATP-DnaA Assembly and Duplex DNA Unwinding for the Initiation of DNA Replication in Reconstituted Systems (2008)
  • Author(s): Katayama, T.
  • Organizer: The 17th RIKEN CDB Meeting "Towards Synthesis of Cells"
  • Place of Presentation: Kobe, Japan
• [Presentation] Mechanism and Regulation for ATP-DnaA Assembly and Duplex DNA Unwinding on the E. coli Chromosomal Origin oriC (2008)
  • Author(s): Katayama, T.
  • Organizer: 6th 3R (Replication, Recombination, Repair) Symposium
  • Place of Presentation: Kakegawa, Japan
• [Presentation] Functional regulation of Hda, a replicase clamp-binding protein that promotes the regulatory inactivation of DnaA in E. coli (2008)
  • Author(s): Su'etsugu, M., Nakamura, K., Keyamura, K., Katayama, T.
  • Organizer: 第31回日本分子生物学会年会/第81回日本生化学会大会合同大会シンポジウム「染色体サイクルの制御機構」
  • Place of Presentation: 神戸
• [Presentation] DiaA promotes the unwinding of oriC by directly stimulating the formation of ATP-DnaA-oriC complexes in E. coli. (2008)
  • Author(s): Keyamura, K. ほか
  • Organizer: EMBO Workshop on Replication & Segregation of Chromosomes
  • Place of Presentation: Geilo, Norway
• [Presentation] Specific E. coli chromosomal regions can reactivate replication initiation activity of DnaA by exchanging bound nucleotide from ADP to ATP in vitro (2008)
  • Author(s): Fujimitsu, K. ほか
  • Organizer: EMBO Workshop on Replication & Segregation of Chromosomes
  • Place of Presentation: Geilo, Norway
• [Presentation] 新規因子DiaA蛋白質を含む, 複製開始複合体の構造とメカニズム (2008)
  • Author(s): 片山勉, ほか
  • Organizer: 第8回蛋白質科学会年会
  • Place of Presentation: 東京都江戸川区
• [Presentation] DnaAによる2重鎖開裂における複製起点の最小機能構造 (2008)
  • Author(s): 尾崎省吾, ほか
  • Organizer: 第80回日本遺伝学会大会
  • Place of Presentation: 名古屋
• [Presentation] 大腸菌染色体の複製開始促進因子DiaAの細胞内局在性解析 (2008)
  • Author(s): 篠崎沙織, ほか
  • Organizer: 第80回日本遺伝学会大会
  • Place of Presentation: 名古屋
• [Presentation] Multiple copies of the ribonucleotide reductase genes repress overinitiation of chromosomal replication caused by a novel cold-sensitive hda mutant in Escherichia coli (2008)
  • Author(s): Fujimitsu, K. ほか
  • Organizer: 6th 3R (Replication, Recombination, Repair) Symposium
  • Place of Presentation: Kakegawa, Japan
• [Presentation] A common role of the DUE binding activity of DnaA for the initiation of chromosomal replication (2008)
  • Author(s): Ozaki, S. ほか
  • Organizer: 6th 3R (Replication, Recombination, Repair) Symposium
  • Place of Presentation: Kakegawa, Japan
• [Presentation] 構造生物学的アプローチによる大腸菌複製開始因子DnaAの機能解析 (2008)
  • Author(s): 阿部義人, ほか
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 福岡
• [Presentation] 大腸菌DNAヘリカーゼ装着因子DnaCにおける高度保存性アミノ酸残基の機能解析 (2008)
  • Author(s): 山野裕介, ほか
  • Organizer: 第5回21世紀大腸菌研究会
  • Place of Presentation: 藤枝
• [Presentation] ATP型DnaA間相互作用に関与するアミノ酸残基の同定 (2008)
  • Author(s): 林靖久, ほか
  • Organizer: 第5回21世紀大腸菌研究会
  • Place of Presentation: 藤枝
• [Presentation] 大腸菌における複製開始不活性化機構におけるタンパク質問相互作用 (2008)
  • Author(s): 中村賢太
  • Organizer: 九州大学P&P「DNA複製研究の次世代育成プログラム」研究合宿
  • Place of Presentation: 九重
• [Presentation] ADP型DnaAを再活性化する特異的DNA配列の促進因子のin vitro探索 (2008)
  • Author(s): 大山祐樹
  • Organizer: 九州大学P&P「DNA複製研究の次世代育成プログラム」研究合宿
  • Place of Presentation: 九重
• [Presentation] 大腸菌の複製開始を促進する因子DiaAの細胞内局在性解析 (2008)
  • Author(s): 篠崎沙織
  • Organizer: 九州大学P&P「DNA複製研究の次世代育成プログラム」研究合宿
  • Place of Presentation: 九重
• [Presentation] 大腸菌DNAヘリカーゼ装着因子DnaCの変異体解析 (2008)
  • Author(s): 山野裕介
  • Organizer: 九州大学P&P「DNA複製研究の次世代育成プログラム」研究合宿
  • Place of Presentation: 九重
• [Presentation] Hda相互作用因子の探索 (2008)
  • Author(s): 平井麻美
  • Organizer: 九州大学P&P「DNA複製研究の次世代育成プログラム」研究合宿
  • Place of Presentation: 九重
• [Presentation] 1回性複製の制御に必要なHdaタンパク質の機能解析 (2008)
  • Author(s): 片山勉, ほか
  • Organizer: 2008年度「染色体サイクル」領域会議
  • Place of Presentation: 御殿場
• [Presentation] Brief Introduction to Reconstituted systems of the E. coli Minichromosomal Replication and the Regulation of Replicational Initiation (2008)
  • Author(s): Katayama, T. ほか
  • Organizer: The 1st Annual Meeting of the Japanese Society for Cell Synthesis Research
  • Place of Presentation: Osaka, Japan
• [Presentation] Functional regulation of Hda, a replicase clamp-binding protein that promotes the regulatory inactivation of DnaA in E. col (2008)
  • Author(s): Suletsugu, M, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] ADP型DnaAからめADP解離およびATP再結合を促す特異的DNA配列の促進因子のin vitro探索 (2008)
  • Author(s): 大山祐樹, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本隼化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 大腸菌の複製開始複合体形成を促進するDnaA結合因子DiaAの細胞内局在性の解析 (2008)
  • Author(s): 篠崎沙織, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 大腸菌DNAヘリカーゼ装着因子DnaCの変異体解析 (2008)
  • Author(s): 山野裕介, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 大腸菌hda低温感受性変異株からの多コピー抑圧遺伝子の探索 (2008)
  • Author(s): 藍原竜夫, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 複製クランプに依存する制御的DnaA不活性化機構におけるDIlaA-Hda間相互作用メカニズムの解析 (2008)
  • Author(s): 中村賢太, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 大腸菌の染色体分配におけるRisAのβクランプ結合の役割の解析 (2008)
  • Author(s): 付尼斯, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 開始複合体め形成過程における複製開始促進因子DiaA 蛋白質の作動メカニズム (2008)
  • Author(s): 片山 勉, et. al.
  • Organizer: 「染色体サイクル」第-回公開領域会議
  • Place of Presentation: 東京大学
• [Presentation] A novel initiation-stimulator DiaA directly promotes ATP-specific innitiation complexes in E. coli (2008)
  • Author(s): Kenji Keyamure et al.
  • Organizer: Keysone Symposia in Molecular and Cellular Biology
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Specific E. coli chromosomal regions can promote exchanging of DnaA-bound nucleotide form ADP to ATP. (2008)
  • Author(s): Kazuyuki Fujimitsu et al.
  • Organizer: Keysone Symposia in Molecular and Cellular Biology
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Role for the DnaA sensorl motif in the tight affinity for ATP/ADP (2008)
  • Author(s): Shogo, Ozaki, et. al.
  • Organizer: Keysone Symposia in Molecular and Cellular Biology
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] 複製開始複合体中で特異的に形成ざ五るDnaA機i能領域を介した複製開始点開裂の分子機構 (2008)
  • Author(s): 尾崎省吾, et. al.
  • Organizer: 2007年度組換え・第19回複製分配合同ワークシヨップ
  • Place of Presentation: 修善寺
• [Presentation] クランプ及びHdaに依存した大腸菌DnaA不活性化の分子機構:DnaAとの相互作用における HdaN 末モチーフと AAA+ドメインの役割 (2008)
  • Author(s): 中村賢太, et. al.
  • Organizer: 007年度組換え・第19回複製分配合同ワークショップ
  • Place of Presentation: 修善寺
• [Presentation] 大腸菌の DnaA 制御システムRIDAの分子機構 (2008)
  • Author(s): 片山 勉, et. al.
  • Organizer: 国立遺伝研究所研究会「単細胞の細胞周期における複合システム系の分子生物学」
  • Place of Presentation: 三島市
• [Presentation] Biochemical analysis of DnaA AAA+ domain on the ATP-dependent regulation for the initiation of chromosomal replication (2007)
  • Author(s): Katayama, T., Ozaki, S., Kawakami, H., Nakamura, N., Keyamura, K., Fujikawa, N., Kagawa, W., Yokoyama, S., Kurumizaka, H.
  • Organizer: 7th International Meeting on AAA Proteins
  • Place of Presentation: Royal Agricultural College, Cirencester, UK
• [Presentation] Role for specific residues of DnaA AAA+ domain in duplex DNA unwinding during the initiation of chromosomal replication (2007)
  • Author(s): Ozaki, S., Kawakami, H., Nakamura, N., Fujikawa, N., Kagawa, W., Yokoyama, S., Kurumizaka, H., Katayama, T.
  • Organizer: 7th International Meeting on AAA Proteins
  • Place of Presentation: Royal Agricultural College, Cirencester, UK
• [Presentation] DnaA結合因子DiaA蛋白質による複製開始の制御機構 (2007)
  • Author(s): 片山勉、毛谷村賢司、藤川乃り映、石田琢磨、尾崎省吾、末次正幸、藤光和之、香川亘、横山茂之、胡桃坂仁志
  • Organizer: 日本遺伝学会第79回大会、ミニシンポジウム「染色体の複製機構とゲノム安定性」
  • Place of Presentation: 岡山大学
• [Presentation] DnaAによる複製開始複合体の形成と2重鎖開裂機構モデル (2007)
  • Author(s): 片山勉、尾崎省吾、川上広宣、中村賢太、藤川乃り映、香川亘、横山茂之、胡桃坂仁志
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ「複製開始複合体形成のダイナミクスと分子制御」(オーガナイザー:片山勉、西谷秀男)
  • Place of Presentation: 横浜
• [Presentation] 新たなDnaA N末ドメインの機能構造、および、DnaA結合因子DiaA の機能メカニズムについて (2007)
  • Author(s): 片山 勉
  • Organizer: 第3回 「染色体サイクル」 領域会議
  • Place of Presentation: 加賀山代温泉
• [Presentation] 新規クランプ結合因子RisAの機能解析 = RisA-βクランプ相互作用の染色体分配における役割 = (2007)
  • Author(s): 松田雄作, et. al.
  • Organizer: 第4回 21世紀大腸菌研究会
  • Place of Presentation: 藤枝市
• [Presentation] 複製開始蛋白質DnaAを再活性化する2種類の機能性DNA部位は異なる制御様式をもつ (2007)
  • Author(s): 藤光和之, et. al.
  • Organizer: 第4回 21世紀大腸菌研究会
  • Place of Presentation: 藤枝市
• [Presentation] 大腸菌の染色体複製開始反応の適時的活性化を制御する分子機構 (2007)
  • Author(s): 毛谷村賢司, et. al.
  • Organizer: 第19回微生物シンポジウム「微生物科学の発展と感染症対策」
  • Place of Presentation: 東京大学
• [Presentation] Biochemical analysis of DnaA AAA+ domain on the ATP-dependent regulation for the initiation of chromosomal replication (2007)
  • Author(s): Tsutomu, Katayama, et. al.
  • Organizer: The Seventh International Meeting on AAA Proteins
  • Place of Presentation: Royal Agricultural College, Cirencester, England
• [Presentation] DnaA結合因子DiaA蛋白質による複製開始の制御機構 (2007)
  • Author(s): 片山 勉, et. al.
  • Organizer: 日本遺伝学会第79回天会ミニシンポジウム
  • Place of Presentation: 岡山大学
• [Presentation] 染色体複製開始点の2重鎖DNA開裂を制御するDnaA新奇機能構造の解析 (2007)
  • Author(s): 尾崎省吾, et. al.
  • Organizer: 日本遺伝学会第79回大会ミニシンポジウム
  • Place of Presentation: 岡山大学
• [Presentation] 大腸菌の染色体複製開始抑制因子Hdaの転写単位及び遺伝子発現橿構 (2007)
  • Author(s): 中村賢太, et. al.
  • Organizer: 日本遺伝学会第79回大会ミニシンポジウム
  • Place of Presentation: 岡山大学
• [Presentation] DnaAによる複製開始複合体の形成と2重鎖開裂機構モデル (2007)
  • Author(s): 片山 勉, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] 大腸菌における染色体複製開始の抑制因子 hda の低温感受性株の解析と抑圧変異遺伝子の探索 (2007)
  • Author(s): 松田健作, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] 大腸菌スライディングクランプの新たな蛋白質相互作用部位の探索とその意義の解析 (2007)
  • Author(s): 木吉壯太, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] dinG遺伝子の多コピー化による大腸菌dnaAcos変異株の低温感受性の抑圧 (2007)
  • Author(s): 付 尼斯, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] 大腸菌の複製開始制御因子の探索:diaAオペロンの機能未知ORFの解析 (2007)
  • Author(s): 森田泰江, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] 大腸菌染色体の複製開始促進因子DiaA は ATP-DnaA特異的な開裂複合体形成を促進する (2007)
  • Author(s): 毛谷村賢司, et. al.
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] Mechanism in the ATP-specific Conformational Activation of the Initiation Complex by DnaA initiator, The First International Symposium on the MEXT Priority Research Project (2006)
  • Author(s): Katayama, T., Ozaki, S., Kawakami, H., Kurumizaka, H.
  • Organizer: he Chromosome Cycle (A Satellite Meeting of 20th IUBMB International Congress of Biochemistry and Molecular Biology & 11th FAOBMB Congress)
  • Place of Presentation: Sanjo Conference Hall (Tokyo University Hongo Campus)
• [Presentation] Analysis on molecular mechanism of the clamp/Hda-dependent DnaA-ATP hydrolysis and on a novel role for the clamp EMBO Workshop (2006)
  • Author(s): Katayama, T., Matsuda, Y., Kawakami, H., Su'etsugu, M.
  • Organizer: Cell Cycle and Cytoskeletal Elements in Bacteria
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] The nucleotide-dependent activation of Hda in the replicase clamp-mediated DnaA-ATP hydrolysis in Escherichia coli, EMBO Workshop (2006)
  • Author(s): Su'etsugu, M., Keyamura, K., Kudo, Y., Nakamura, K., Katayama, T.
  • Organizer: Cell Cycle and Cytoskeletal Elements in Bacteria
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] 特異的なDNA配列による大腸菌染色体複製イニシエーターDnaAの再活性化 (2006)
  • Author(s): 藤光和之、千里内啓行、片山勉
  • Organizer: 第18回DNA複製ワークショップ
  • Place of Presentation: 熱海
• [Presentation] 大腸菌スライディングクランプ新規相互作用因子の同定とその機能解析 (2006)
  • Author(s): 松田雄作、片山勉
  • Organizer: 第18回DNA複製ワークショップ
  • Place of Presentation: 熱海
• [Presentation] DnaA蛋白質の特異的AAA+領域を介した複製開始点開裂のメカニズム、日本分子生物学会2006フォーラム (2006)
  • Author(s): 尾崎省吾、川上広宣、中村賢太、胡桃坂仁志、片山勉
  • Organizer: シンポジウム「染色体複製開始サイクルの分子機構と制御スイッチ」(世話人:片山勉、西谷秀男)
  • Place of Presentation: 名古屋
• [Presentation] 毛谷村賢治染色体複製開始におけるATP依存的高次複合体形成の分子機構 (2005)
  • Author(s): 片山勉、川上広宣、尾崎省吾、藤光和之
  • Organizer: 日本遺伝学会第77回大会ミニシンポジウム「大腸菌の染色体ダイナミクス」(世話人:堀内嵩、片山勉)
  • Place of Presentation: 東京
• [Presentation] Analysis on Structure and Regulation of a Bacterial Initiation Complex (2005)
  • Author(s): Katayama, T., Kawakami, H., Ozaki, S., Kurumizaka, H.
  • Organizer: 第28回日本分子生物学会年会、シンポジウム「複製装置の集合と維持」
  • Place of Presentation: 福岡
• [Presentation] クランプ依存性DnaA不活化機構におけるHdaの機能構造とヌクレオチド依存性 (2005)
  • Author(s): 末次正幸、工藤由佳、毛谷村賢司、松永千佳、紫牟田透、石田琢磨、川上広宣、片山勉
  • Organizer: 第28回日本分子生物学会年会、ワークショップ「タンパク質構造から展開するDNA複製システムのダイナミクス」(世話人:石野良純、片山勉)
  • Place of Presentation: 福岡
• [Presentation] DnaA結合性ATPの複製開始複合体形成における役割 (2005)
  • Author(s): 川上広宣、尾崎省吾、鈴木滋夫、中村賢太、千里内啓行、毛谷村賢司、末次正幸、藤光和之、片山勉
  • Organizer: 第28回日本分子生物学会年会、ワークショップ「細胞機能のキープレイヤーAAA+タンパク質の世界」
  • Place of Presentation: 福岡
• [Presentation] DARS: the chromosomal locus for reactivation of the replication initiator DnaA in E. coli
  • Author(s): Fujimitsu, K., Kasho, K., Senriuchi, T., Ohyama, H., Katayama, T.
  • Organizer: International Symposium on Chromosomal Cycle and Genome Dynamics
  • Place of Presentation: Nasu, Tochigi, Japan
• [Book] 染色体サイクル(正井久雄、升方久夫、釣本敏樹、仁木宏典、篠原彰編集, 大腸菌の染色体複製開始制御機構) (2009)
  • Author(s): 片山勉
  • Publisher: 共立出版
• [Book] 細胞工学(複製再開始抑制の分子機構実験医) (2008)
  • Author(s): 片山勉
  • Publisher: 秀潤社
• [Book] 染色体サイクル(正井久雄, 渡邊嘉典編集, 複製再開始抑制の分子機構実験医) (2007)
  • Author(s): 片山勉
  • Publisher: 羊土社
• [Book] 実験医学増刊「染色体サイクル」 (2007)
  • Author(s): 片山 勉
  • Total Pages: 7
  • Publisher: 羊土社
• [Book] タンパク質実験マニュアル(胡桃坂仁志編集, 大腸菌DnaA) (2006)
  • Author(s): 毛谷村賢司、尾崎省吾、片山勉
  • Publisher: 朝倉書店
• [Book] タンパク質実験マニュアル (2006)
  • Author(s): 毛谷村賢司ほか(分担執筆)
  • Publisher: 朝倉書店(印刷中)
• [Remarks]
  • URL: http://bunsei.phar.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://210.233.60.66/~bunsei/
• [Remarks]
  • URL: http://210.233.60.66/~bunsei/
• [Remarks]
  • URL: http://210.233.60.66/~bunsei/