Regulatory mechanism of replication complex formation and relationship between the complex, checkpoints and cell division
| Project/Area Number |
17080008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
ARAKI Hiroyuki National Institute of Genetics, 細胞遺伝研究系, 教授 (20151160)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥81,200,000 (Direct Cost: ¥81,200,000)
Fiscal Year 2009: ¥19,900,000 (Direct Cost: ¥19,900,000)
Fiscal Year 2008: ¥19,900,000 (Direct Cost: ¥19,900,000)
Fiscal Year 2007: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2006: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2005: ¥12,400,000 (Direct Cost: ¥12,400,000)
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| Keywords | DNA複製 / 染色体 / 細胞周期 / サイクリン依存性キナーゼ / 真核生物 / 酵母 / チェックポイント / CDK / 細胞分裂 / 複製開始 |
|---|
| Research Abstract |
Chromosome DNA replication is strictly regulated by the cell division cycle, so that chromosome DNA replicates once per cell cycle. This is mainly because the cyclin-dependent protein kinase (CDK), a protein phosphorylating enzyme, regulates the initiation step of chromosome DNA replication. Using budding yeast, we revealed that CDK phosphorylates Sld2 and Sld3 proteins, both phosphorylated proteins bind to the Dpb11 protein and these bindings promote DNA replication. We also found a clue how these bindings function for the initiation of DNA replication.
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Report
(6 results)
Research Products
(89 results)
