| Budget Amount *help |
¥81,200,000 (Direct Cost: ¥81,200,000)
Fiscal Year 2009: ¥19,900,000 (Direct Cost: ¥19,900,000)
Fiscal Year 2008: ¥19,900,000 (Direct Cost: ¥19,900,000)
Fiscal Year 2007: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2006: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2005: ¥12,400,000 (Direct Cost: ¥12,400,000)
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| Research Abstract |
Chromosome DNA replication is strictly regulated by the cell division cycle, so that chromosome DNA replicates once per cell cycle. This is mainly because the cyclin-dependent protein kinase (CDK), a protein phosphorylating enzyme, regulates the initiation step of chromosome DNA replication. Using budding yeast, we revealed that CDK phosphorylates Sld2 and Sld3 proteins, both phosphorylated proteins bind to the Dpb11 protein and these bindings promote DNA replication. We also found a clue how these bindings function for the initiation of DNA replication.
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