Analysis of gene amplification that is promoted by DNA replication and homologous recombination
| Project/Area Number |
17080010
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute of Genetics (2006-2009)
National Institute for Basic Biology (2005) |
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Principal Investigator |
KOBAYASHI Takehiko National Institute of Genetics, 細胞遺伝研究系, 教授 (40270475)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥54,800,000 (Direct Cost: ¥54,800,000)
Fiscal Year 2009: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2008: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2007: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2006: ¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000)
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| Keywords | リボソームRNA遺伝子 / 遺伝子増幅 / ゲノムの安定性 / 非コード転写 / 細胞老化 / 若返り / DNA複製 / ゲノムの不安定性 / リボソーム / 出芽酵母 / DNAヘリカーゼ / 酸化タンパク質 / 遺伝子の増幅 / 組み換え / 複製阻害点 / 複製開始点 / noncodingな転写 / 複製阻害 / 遺伝学 / 核酸 / コヒーシン / サイレンシング |
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| Research Abstract |
The ribosomal RNA genes (rDNA) are one of the most fragile sites for deletional recombination. Even though the rDNA is susceptible to this kind of instability, each organism maintains a specific copy number of rDNA, thereby indicating presence of a mechanism for the maintenance of copy number. I revealed that there is a gene amplification system to maintain the copy number. Moreover, I found that rDNA instability was a cause of cellular senescence.
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Report
(6 results)
Research Products
(102 results)
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[Journal Article] Abnormality in initiation program of DNA replication in monitored by the highly repetitive rDNA array on chromosome XII in budding yeast.2007
Author(s)
Ide, S., Watanabe, K., Watanabe, H., Shirahige, K., Kobayashi, T., Maki, H.
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Journal Title
Mol. Cell. Biol. 27
Pages: 568-578
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