| Budget Amount *help |
¥54,800,000 (Direct Cost: ¥54,800,000)
Fiscal Year 2009: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2008: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2007: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2006: ¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000)
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| Research Abstract |
The ribosomal RNA genes (rDNA) are one of the most fragile sites for deletional recombination. Even though the rDNA is susceptible to this kind of instability, each organism maintains a specific copy number of rDNA, thereby indicating presence of a mechanism for the maintenance of copy number. I revealed that there is a gene amplification system to maintain the copy number. Moreover, I found that rDNA instability was a cause of cellular senescence.
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