Interplay among recombination, replication, segregation, and chromatin structure.

• Project/Area Number: 17080011
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo (2007-2009); The Institute of Physical and Chemical Research (2005-2006)
• Principal Investigator: OHTA Kunihiro The University of Tokyo, 大学院・総合文化研究科, 教授 (90211789)
• Co-Investigator(Kenkyū-buntansha): HIROTA Kouji 独立行政法人理化学研究所, 基礎科学特別研究員 (00342840) ; FUKUDA Tomoyuki 独立行政法人理化学研究所, 基礎科学特別研究員 (90415282) ; BRANZEI Dana 独立行政法人理化学研究所, 基礎科学特別研究員 (20392102)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Takatomi 東京大学, 大学院・総合文化研究科, 助教 (30451850)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥64,700,000 (Direct Cost: ¥64,700,000); Fiscal Year 2009: ¥10,300,000 (Direct Cost: ¥10,300,000); Fiscal Year 2008: ¥12,200,000 (Direct Cost: ¥12,200,000); Fiscal Year 2007: ¥13,100,000 (Direct Cost: ¥13,100,000); Fiscal Year 2006: ¥14,400,000 (Direct Cost: ¥14,400,000); Fiscal Year 2005: ¥14,700,000 (Direct Cost: ¥14,700,000)
• Keywords: 組換え / 減数分裂 / 複製 / クロマチン / ヒストン / 姉妹染色体 / 染色体 / エビジェネティクス / 細胞周期 / ヒストン修飾 / 酵母 / 相同組換え / DNA複製 / 姉妹染色体結合 / セントロメア / Spo11

Research Abstract

Meiotic recombination plays crucial roles in establishment of genetic diversity and gametes formation. The regulation of meiotic recombination involves various DNA-related processes. This project uncovered that meiotic recombination initiator Spo11 is activated by phosphorylation of a Spo11-accesspry protein Mer2 by Cdc7-Dbf4 kinase, which is a master regulator of DNA replication cycle. We also discovered that Spo11 distribution is regulated by meiotic chromatid cohesion protein Rec8 and replication. In addition, we found several factors involved in chromatin modification required for the activation of meiotic recombination hotspots. Finally, we discovered a new class of long mRNA-type non-coding RNA involved in chromatin control for the stress-induced gene activation in fission yeast.

Research Products

• [Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores. (2010)
  • Author(s): Yoshida T., Shimada K., Oma Y., Kalck V., Akimura K., Taddei A., Iwahashi H., Kugou K., Ohta K., Gasser S.M., Harata M.
  • Journal Title: PLoS Genetics (in press)
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and-independent gene expression and links ribosomal protein genes to nuclear pores (2010)
  • Author(s): Yoshida T., et al.
  • Journal Title: PLoS Genetics (印刷中(掲載確定))
  • Peer Reviewed
• [Journal Article] Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. (2009)
  • Author(s): Kugou K., Yamada S., Itoh M., Fukuda T., Sasanuma H., Mori S., Katou Y., Itoh T., Matsumoto K., Shibata T., Shirahige K., Ohta K.
  • Journal Title: Mol. Biol. Cell 20 Pages: 3064-3076
  • Peer Reviewed
• [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication. (2009)
  • Author(s): Ohuchi T., Seki M., Kugou K., Tada S., Ohta K., Enomoto T.
  • Journal Title: DNA repair 8 Pages: 690-696
  • Peer Reviewed
• [Journal Article] Transcription of mRNA-type long non-coding RNAs (mlonRNAs) disrupts chromatin array. (2009)
  • Author(s): Hirota K., Fukuda T., Yamada T., Ohta K. Hirota K., Ohta K.
  • Journal Title: Communicative & Integrative Biology 2 Pages: 25-26
  • Peer Reviewed
• [Journal Article] Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling. (2009)
  • Author(s): Hirota K, Ohta K.
  • Journal Title: Epigenetics 4 Pages: 5-7
  • Peer Reviewed
• [Journal Article] Ctp1CtIP and the Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but this activity is dispensable for other MRN-dependent meiotic functions. Mol. (2009)
  • Author(s): Hartsuiker E., Mizuno K., Molna M., Kohli J., Ohta K., Carr A.M.
  • Journal Title: Cell Biol. 29 Pages: 1671-1681
  • Peer Reviewed
• [Journal Article] mlonRNA仮説:ノンコーディングRNA転写による新規クロマチン構造変化機構 (2009)
  • Author(s): 廣田耕志、太田邦史
  • Journal Title: 化学と生物 47巻 Pages: 296-298
  • NAID: 10026435320
• [Journal Article] mlonRNA:クロマチン再編成を通じて遺伝子活性化にかかわるノンコーディングRNA (2009)
  • Author(s): 廣田耕志、太田邦史
  • Journal Title: 蛋白質核酸酵素 54巻 Pages: 459-465
• [Journal Article] ADLibRシステム太田邦史、瀬尾秀宗 (2009)
  • Author(s): 橋本修一
  • Journal Title: 分子細胞治療 8 Pages: 54-58
• [Journal Article] 減数分裂期特異的DNA二重鎖切断機構 (2009)
  • Author(s): 笹沼博之、太田邦史
  • Journal Title: 蛋白質核酸酵素増刊号 54巻 Pages: 459-465
• [Journal Article] Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes (2009)
  • Author(s): Kugou K., et al.
  • Journal Title: Mol.Biol.Cell 20 Pages: 3064-3076
  • Peer Reviewed
• [Journal Article] Analysis of chromatin structure at meiotic DSB sites in yeasts (2009)
  • Author(s): Hirota K., et al.
  • Journal Title: Methods in Molecular Biology, Meiosis, Molecular and Genetic Method 557 Pages: 253-266
• [Journal Article] Genome-wide high-resolution chromatin immunoprecipitation of meiotic chromosomal proteins in S.cerevisiae (2009)
  • Author(s): Kugou K., et al.
  • Journal Title: Methods in Molecular Biology, Meiosis, Molecular and Genetic Method 557 Pages: 285-304
• [Journal Article] Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling (2009)
  • Author(s): Hirota K., et.al.
  • Journal Title: Epigenetics (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] CtplCtIP and the Rad32Mrell nuclease activity are required for Recl2Spoll removal, but this activity is dispensable for other MRN-dependent meiotic functions (2009)
  • Author(s): Hartsuiker E., et.al.
  • Journal Title: Mol. Cell Biol (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication (2009)
  • Author(s): Ohuchi T., et.al.
  • Journal Title: DNA repair (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Molecular characterization of the Schizosaccharomyces pombe nip 1+/ctp 1+ gene in DNA double strand break repair in association with the Mrell-Rad50-Nbsl complex (2009)
  • Author(s): Akamatsu Y., et.al.
  • Journal Title: Mol. Cell Biol 28 Pages: 3639-3651
  • Peer Reviewed
• [Journal Article] Ohta K. Essential roles of Snf21, a Swi2/Snf2 family chromatin remodeler, in fission yeast mitosis. (2008)
  • Author(s): Yamada K., Hirota K., Mizuno K, Shibata T.
  • Journal Title: Genes & Genet. Sys. 83 Pages: 361-372
  • Peer Reviewed
• [Journal Article] In-cell viscosity measurement using a fluorescence up-conversion microscope. (2008)
  • Author(s): Fujino T., Hirota K., Ohta K., Tahara T.
  • Journal Title: Chemistry Letters 37 Pages: 1240-1241
  • NAID: 10024397974
  • Peer Reviewed
• [Journal Article] Ohta K. Stepwise chromatin remodeling by a cascade of transcription initiation of non-coding RNAs. (2008)
  • Author(s): Hirota K., Miyoshi T., Kugou K., Hoffman C.S., Shibata T.
  • Journal Title: Nature 456 Pages: 130-134
  • Peer Reviewed
• [Journal Article] Structural and functional analyses of the DMC1-M200V polymorphism found in the human population. Nucl. (2008)
  • Author(s): Hikiba J., Hirota K., Kagawa W., Ikawa S., Kinebuchi T., Sakane I., Takizawa, Yokoyama S., Mandon-Pepin B., Nicolas A., Shibata S., Ohta K. Kurumizaka H.
  • Journal Title: Acids Res. 36 Pages: 4181-4190
  • Peer Reviewed
• [Journal Article] Ino80 chromatin remodeling complex promotes recovery of stalled replication forks. (2008)
  • Author(s): Shimada K., Oma Y., Schleker T., Kugou K., Ohta K., Harata M., Gasser SM.
  • Journal Title: Curr. Biol. 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] Molecular characterization of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double strand break repair in association with the Mre11-Rad50-Nbs1 complex Mol. (2008)
  • Author(s): Akamatsu Y., Murayama Y., Yamada T., Nakazaki T., Tsutsui Y., Ohta K., Iwasaki H.
  • Journal Title: Cell Biol. 28 Pages: 3639-3651
  • Peer Reviewed
• [Journal Article] Distinct chromatin modulators regulate to form accessible and repressive chromatin in fission yeast recombination hotspot ade6-M26. (2008)
  • Author(s): Hirota K., Mizuno K., Shibata T., Ohta K.
  • Journal Title: Mol. Biol. Cell 19 Pages: 1162-1173
  • Peer Reviewed
• [Journal Article] Regulation of histone H4 acetylation by transcription factor E2A in immunoglobulin gene conversion. (2008)
  • Author(s): Kitao H., Kimura M., Yamamoto K., Seo H., Namikoshi K., Agata Y., Ohta K., Takata M.
  • Journal Title: Int. Immunol. 20 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. (2008)
  • Author(s): Lin W., Hashimoto S., Seo H., Shibata T., Ohta K.
  • Journal Title: Genes Cells 3 Pages: 255-268
  • Peer Reviewed
• [Journal Article] Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. (2008)
  • Author(s): Sasanuma H., Hirota K., Fukuda T., Kakusho N., Kugou K., Kawasaki Y., Shibata T., Masai H., Ohta K.
  • Journal Title: Genes Dev. 22 Pages: 398-410
  • Peer Reviewed
• [Journal Article] Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination. (2008)
  • Author(s): Fukuda T., Kugou K., Sasanuma H., Shibata T., Ohta K.
  • Journal Title: Nucl. Acids Res. 36 Pages: 984-997
  • Peer Reviewed
• [Journal Article] Essential roles of Snf21, a Swi2/Snf2 family chromatin remodeler, in fission yeast mitosis (2008)
  • Author(s): Yamada K., et.al.
  • Journal Title: Genes & Genet. Sys 83 Pages: 361-372
  • Peer Reviewed
• [Journal Article] Stepwise chromatin remodeling by a cascade of transcription initiation of non-coding RNAs (2008)
  • Author(s): Hirota K., et.al.
  • Journal Title: Nature 456 Pages: 130-134
  • Peer Reviewed
• [Journal Article] Structural and functional analyses of the DMC1-M200V polymorphism found in the human population (2008)
  • Author(s): Hikiba J., et.al.
  • Journal Title: Nucl. Acids Res 36 Pages: 4181-4190
  • Peer Reviewed
• [Journal Article] Ino80 chromatin remodeling complex promotes recovery of stalled replication forks (2008)
  • Author(s): Shimda K., et.al.
  • Journal Title: Curr. Biol 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] In-cell viscosity measurement using a fluorescence up-conversion microscope (2008)
  • Author(s): Fujino T., et.al.
  • Journal Title: Chemistry Lett 37 Pages: 1240-1241
  • Peer Reviewed
• [Journal Article] Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination (2008)
  • Author(s): Sasanuma H., et. al.
  • Journal Title: Genes & Development 22 Pages: 398-410
  • Peer Reviewed
• [Journal Article] Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination (2008)
  • Author(s): Fukuda T., et. al.
  • Journal Title: Nucleic Acids Research 36 Pages: 984-997
  • Peer Reviewed
• [Journal Article] Multiple modes of chromatin configuration at natural meiotic recombination hotspots in fission yeast. (2007)
  • Author(s): Hirota K., Steiner W.W., Shibata T., Ohta K.
  • Journal Title: Euk. Cell 6 Pages: 2072-2080
  • Peer Reviewed
• [Journal Article] Conditional genomic rearrangement by designed meiotic recombination using VDE (PI-SceI) in yeast. (2007)
  • Author(s): Fukuda T., Ohya Y., Ohta K.
  • Journal Title: Mol. Genet. Genomics 278 Pages: 467-478
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly. Nucl. (2007)
  • Author(s): Ogiwara H., Ui, A., Kawashima S., Kugou K., Onoda F., Iwahashi H., Harata M., Ohta K., Enomoto T., Seki M.
  • Journal Title: Acids Res. 35 Pages: 3109-3117
  • Peer Reviewed
• [Journal Article] Ohta K. Mre11 mediates gene regulation in yeast spore development. (2007)
  • Author(s): Kugou K., Sasanuma H., Matsumoto K., Shirahige K., Ohta K.
  • Journal Title: Genes & Genet. Sys. 82 Pages: 21-33
  • Peer Reviewed
• [Journal Article] Meiotic association between Spo11 regulated by Rec102, Rec104, and Rec114 Nucl. (2007)
  • Author(s): Sasanuma H., Murakami H., Fukuda T., Shibata T., Nicolas A., Ohta K.
  • Journal Title: Acids Res. 35 Pages: 1119-1133
  • Peer Reviewed
• [Journal Article] 新しい原理に基づく生体外モノクローナル抗体作製技術:ADLibシステム (2007)
  • Author(s): 太田邦史
  • Journal Title: バイオサイエンスとバイオインダストリー 65巻 Pages: 16-20
  • NAID: 10019803367
• [Journal Article] 新しいモノクローナル抗体作製技術-ADLibシステム (2007)
  • Author(s): リン和花、太田邦史
  • Journal Title: 化学と生物 45巻 Pages: 751-753
• [Journal Article] ADLibシステムを用いた抗体作成 (2007)
  • Author(s): 太田邦史、瀬尾秀宗
  • Journal Title: メディカルサイエンスダイジェスト 66巻 Pages: 6-7
• [Journal Article] 減数分裂の組換え開始機構」in「染色体サイクル (2007)
  • Author(s): 廣田耕志、福田智行、太田邦史
  • Journal Title: 実験医学 25巻 Pages: 160-166
• [Journal Article] ADLibシステムを用いたモノクローナル抗体の迅速作製 (2007)
  • Author(s): 太田邦史、瀬尾秀宗
  • Journal Title: 薬学雑誌 127巻 Pages: 81-89
  • NAID: 110006155012
  • Peer Reviewed
• [Journal Article] 「酵母の全て」(組換え、修復、突然変異) (2007)
  • Author(s): 福田智行、太田邦史
  • Journal Title: シュプリンガー・フェアラーク東京 Pages: 237-242
• [Journal Article] Regulation of histone H4 acetylation by transcription factor E2A in immunoglobulin gene conversion (2007)
  • Author(s): Kitao H., et. al.
  • Journal Title: Int. Immunol. 20 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40 (2007)
  • Author(s): Lin W., et. al.
  • Journal Title: Genes to Cells 3 Pages: 255-268
  • Peer Reviewed
• [Journal Article] Multiple modes of chromatin configuration at natural meiotic recombination hotspots in fission yeast (2007)
  • Author(s): Hirota K., et. al.
  • Journal Title: Eukaryotic Cell 6 Pages: 2072-2080
  • Peer Reviewed
• [Journal Article] Conditional genomic rearrangement by designed meiotic recombination using VDE (Pl-Scel) in yeast. (2007)
  • Author(s): Fukuda T., et. al.
  • Journal Title: Mol. Genet. Genomics 278 Pages: 467-478
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly (2007)
  • Author(s): Ogiwara H., et. al.
  • Journal Title: Nucleic Acids Research 35 Pages: 3109-3117
  • Peer Reviewed
• [Journal Article] Meiotic association between Spol l regulated by Rec102, Rec104, and Rec114 (2007)
  • Author(s): Sasanuma H, Murakami H, Fukuda T, Shibata T, Nicolas A, Ohta K
  • Journal Title: Nucleic Acids Research (印刷中)
• [Journal Article] Reciprocal nuclear shuttling of two antagonizing Zn-finger proteins that modulates the Tup-family co-repressors function to repress chromatin remodeling. (2006)
  • Author(s): Hirota K., Hoffman C., Ohta K.
  • Journal Title: Eukary Cell 5 Pages: 1980-1989
  • Peer Reviewed
• [Journal Article] An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). (2006)
  • Author(s): Seo H., Hashimoto S., Tsuchiya K., Lin W., Shibata T., Ohta K.
  • Journal Title: Nature Protot. 1 Pages: 1502-1506
  • Peer Reviewed
• [Journal Article] Foiani M. Ubc9 and Mms21 mediated sumoylation counteracts recombinogenic events at damaged replication forks. (2006)
  • Author(s): Branzei D., Sollier J., Liberi G., Maeda D., Seki M., Enomoto T., Ohta K.
  • Journal Title: Cell 127 Pages: 509-522
  • Peer Reviewed
• [Journal Article] Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site. Euk. (2006)
  • Author(s): Fukuda T., Ohta K., Ohya Y.
  • Journal Title: Cell 5 Pages: 981-990
  • Peer Reviewed
• [Journal Article] Hsk1 kinase is required for induction of meiotic double-strand DNA breaks without involving checkpoint kinases in fission yeast. (2006)
  • Author(s): Ogino K., Hirota K., Matsumoto S., Takeda T., Ohta K., Arai K., Masai H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 103 Pages: 8131-8136
  • Peer Reviewed
• [Journal Article] 体細胞DNA複製に重要な役割を果たす分裂酵母Cdc7類似キナーゼ, Hsk1タンパク質は減数分裂期組換えの開始に必要とされる (2006)
  • Author(s): 荻野桂子, 廣田耕志, 太田邦史, 正井久雄
  • Journal Title: 細胞工学 25巻
• [Journal Article] DNA組換えの制御 (2006)
  • Author(s): 太田邦史、久郷和人
  • Journal Title: 蛋白質核酸酵素増刊号 51巻 Pages: 2134-2140
• [Journal Article] ADLibシステム~新原理に基づく迅速で自在な抗体作製法太田邦史 (2006)
  • Author(s): 瀬尾秀宗
  • Journal Title: バイオテクノロジージャーナル Pages: 77-80
• [Journal Article] Hsk1 kinase is required for induction of meiotic double-strand DNA breaks without involving checkpoint kinases in fission yeast (2006)
  • Author(s): Ogino K, Hirota K, Matsumoto S, Takeda T, Ohta K, Arai K, Masai H
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 8131-8136
• [Journal Article] Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site. (2006)
  • Author(s): Fukuda T, Ohta K, Ohya Y
  • Journal Title: Eukaryotic Cell 5 Pages: 981-990
• [Journal Article] Ubc9 and Mms21 mediated sumoylation counteracts recombinogenic events at damaged replication forks (2006)
  • Author(s): Branzei D, Sollier J, Liberi G, Maeda D, Seki M, Enomoto T, Ohta K, Foiani M
  • Journal Title: Cell 127 Pages: 509-522
• [Journal Article] An ex vivo method for rapid generation of monoclonal antibodies (ADLib system) (2006)
  • Author(s): Seo H, Hashimoto S, Tsuchiya K, Lin W, Shibata T, Ohta K
  • Journal Title: Nature Protocols 1 Pages: 1502-1506
• [Journal Article] Reciprocal nuclear shuttling of two antagonizing Zn-finger proteins that modulates the Tup-family co-repressors function to repress chromatin remodeling (2006)
  • Author(s): Hirota K, Hoffman C, Ohta K
  • Journal Title: Eukaryotic Cell 5 Pages: 1980-1989
• [Journal Article] Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis. (2005)
  • Author(s): Tokai T., Koshino, H., Kawasaki, T., Igawa, T., Suzuki, Y., Sato, M., Fujimura, M., Eizuka, T., Watanabe, H., Ohta, K., Shibata, T., Kudo, T., Inoue, H., Yamaguchi, I., Kimura, M.
  • Journal Title: FEMS Microbiol. Lett. 251 Pages: 193-201
  • Peer Reviewed
• [Journal Article] Rapid generation of specific antibodies by enhanced homologous recombination Nature Biotech. (2005)
  • Author(s): Seo H., Masuoka M., Murofushi H., Takeda S., Shibata T., Ohta K.
  • Journal Title: 23 Pages: 731-735
  • Peer Reviewed
• [Journal Article] 抗体多様化のメカニズムを活用する-ADLibシステム:迅速で自在な抗体作製法- (2005)
  • Author(s): 太田邦史、瀬尾秀宗
  • Journal Title: Bionics 2巻 Pages: 57-63
• [Journal Article] 減数分裂の機構とその制御 (2005)
  • Author(s): 福田智行、太田邦史
  • Journal Title: 化学と生物 43巻 Pages: 654-661
  • NAID: 10019350467
• [Journal Article] 相同組換え活性化による迅速なモノクローナル抗体の作製法 (2005)
  • Author(s): 瀬尾秀宗、柴田武彦、太田邦史
  • Journal Title: 細胞工学 24巻 Pages: 834-835
• [Journal Article] Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis (2005)
  • Author(s): Tokai T., ら(15名)
  • Journal Title: FEMS Microbiology Letters 251 Pages: 193-201
• [Journal Article] Rapid generation of specific antibodies by enhanced homologous recombination (2005)
  • Author(s): Seo H., Masuoka M., Murofushi H., Takeda S., Shibata T., Ohta K.
  • Journal Title: Nature Biotechnology 23 Pages: 731-735
• [Journal Article] Concordant evolution of trichothecene 3-O-acetyltransferase and a rDNA species phylogeny of trichothecene-producing and non-producing fusaria and other ascomycetous fungi (2005)
  • Author(s): Tokai T., ら(8名)
  • Journal Title: Microbiology 151 Pages: 509-519
• [Journal Article] 減数分裂の機構とその制御 (2005)
  • Author(s): 福田智行, 太田邦史
  • Journal Title: 化学と生物 43 Pages: 654-661
  • NAID: 10019350467
• [Presentation] Glucose starvation and chromatin regulation in fission yeast (2009)
  • Author(s): 太田邦史, ら
  • Organizer: The 4th International Workshop on Cell Regulations in Division and Arrest
  • Place of Presentation: 沖縄
  • Year and Date: 2009-12-01
• [Presentation] Chromatin modification coupled with cascade transcription of non-coding RNA during glucose derepression of fbp1 (2009)
  • Author(s): 太田邦史, ら
  • Organizer: The Fifth International Fission Yeast Meeting
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] 長鎖ノンコーディングRNAとクロマチン再編成 (2009)
  • Author(s): 太田邦史
  • Organizer: 日本生化学会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Control of meiotic DSB formation by chromatin, cohesin, and Spo11-accessory proteins (2009)
  • Author(s): 太田邦史
  • Organizer: The EMBO conference on Meiosis
  • Place of Presentation: Isle sur la Sorgue, France
  • Year and Date: 2009-09-19
• [Presentation] Control of meiotic recombination initiation by Cdc7-Dbf4 (2009)
  • Author(s): 太田邦史, et al.
  • Organizer: The EMBO conference on Meiosis
  • Place of Presentation: Isle sur la Sorgue, France
  • Year and Date: 2009-09-19
• [Presentation] Chromatin regulation of CRE-regulated recombination and transcription (2009)
  • Author(s): 太田邦史
  • Organizer: FASEB Summer conference on genetic rearrangements
  • Place of Presentation: Snowmass, USA
  • Year and Date: 2009-08-03
• [Presentation] Chromatin regulation of CRE-regulated recombination and transcription (2009)
  • Author(s): 太田邦史
  • Organizer: FASEB Sammer conference on genetic rearrangements
  • Place of Presentation: Snowmass, USA
  • Year and Date: 2009-08-03
• [Presentation] Chromatin regulation by long non-coding RNA (2009)
  • Author(s): 太田邦史
  • Organizer: Switzerland-Japan Joint meeting 2009
  • Place of Presentation: Villars sur Ollon, Swiss
  • Year and Date: 2009-05-16
• [Presentation] Chromatin control of CRE-regulated recombination and gene activation (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 米国細胞生物学会
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-17
• [Presentation] Chromatin control of CRE-regulated recombination and gene activation (2008)
  • Author(s): Ohta, et.al.
  • Organizer: American Society of Cell Biology Annual Meeting 2008
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-17
• [Presentation] Chromatin regulation of stress-induced gene activation (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 日本分子生物学会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Chromtitin regulation of stress-induced gene activation (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] ATF/CREBファミリータンパク質による減数分裂諸現象の総合的制御 (2008)
  • Author(s): 山田貴富, ら
  • Organizer: 日本分子生物学会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ATF/CREBファミリ7タンパク質による減数分裂諸現象の総合的制御 (2008)
  • Author(s): 山田貴富, ら
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Cell-cycle control of meiotic recombination initiation (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 6th 3R meeting
  • Place of Presentation: 嬬恋・静岡
  • Year and Date: 2008-10-28
• [Presentation] Cell-cycle control of meiotic recombination initiation (2008)
  • Author(s): Ohta, et.al.
  • Organizer: 6th 3R meeting
  • Place of Presentation: 嬬恋、静岡
  • Year and Date: 2008-10-28
• [Presentation] 分裂酵母ATF/CREBファミリータンパク質Atf21の機能解析 (2008)
  • Author(s): 山田貴富, ら
  • Organizer: 日本遺伝学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-11
• [Presentation] 分裂酵母クロマチン再編成因子Snf21の機能解析 (2008)
  • Author(s): 山田健太郎, ら
  • Organizer: 日本遺伝学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-11
• [Presentation] 減数分裂組換え開始のDNAトランスアクション (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 日本遺伝学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-05
• [Presentation] 減数分裂組換え開始のDNAトランスアクション (2008)
  • Author(s): 太田邦史, ら
  • Organizer: 日本遺伝学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-05
• [Presentation] Control of meiotic recombination initiation by Cdc7-Dbf4 (2008)
  • Author(s): 太田邦史, ら
  • Organizer: Gordon conference on "Meiosis"
  • Place of Presentation: Colby-Sawyer College, NH, USA
  • Year and Date: 2008-06-11
• [Presentation] Control of meiotic recombination initiation by Cdc7-Dbf4 (2008)
  • Author(s): Ohta, et.al.
  • Organizer: Gordon conference on "Meiosis"
  • Place of Presentation: Colby-Sawyer College, USA
  • Year and Date: 2008-06-11
• [Presentation] 鳥類抗体偽可変領域遺伝子クラスターにおける遺伝子変換による抗体遺伝子創出機能 (2007)
  • Author(s): 太田邦史
  • Organizer: 日本分子生物学会(ワークショップ)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-14
• [Presentation] 減数分裂期のおけるCdc7キナーゼの役割 (2007)
  • Author(s): 笹沼博之
  • Organizer: 日本分子生物学会(ワークショップ)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-13
• [Presentation] 減数分裂期相同組換え開始酵素Spo11の活性化機構 (2007)
  • Author(s): 太田邦史, ら
  • Organizer: 日本遺伝学会シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-19
• [Presentation] 減数分裂期相同組換え開始酵素Spo11の活性化機構 (2007)
  • Author(s): 太田邦史
  • Organizer: 日本遺伝学会(シンポジウム)
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-09-19
• [Presentation] Dynamic distribution of meiotic chromosomal proteins along yeast chromosomes (2007)
  • Author(s): 太田邦史, ら
  • Organizer: EMBO workshop on Meiosis
  • Place of Presentation: 湘南国際村、神奈川
  • Year and Date: 2007-09-15
• [Presentation] ニワトリb細胞抗体遺伝子のクロマチン制御と抗体デザイン (2007)
  • Author(s): 太田邦史
  • Organizer: 日本農芸化学会シンポジウム
  • Place of Presentation: 東京農大
• [Presentation] ADLib法による迅速モノクローナル抗体作製 (2006)
  • Author(s): 太田邦史, 瀬尾秀宗
  • Organizer: 日本薬学会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-29
• [Presentation] 1週間でモノクロナール抗体-広がる抗体の可能性、鳥インフルエンザ、sarsなど喫緊対応に期待 (2005)
  • Author(s): 太田邦史
  • Organizer: 東京テクノフォーラム第89回研究交流会
  • Place of Presentation: 東京
  • Year and Date: 2005-12-15
• [Presentation] ADLib法:迅速で自由度の高い新世代のモノクローナル抗体作製法 (2005)
  • Author(s): 太田邦史、瀬尾秀宗
  • Organizer: 発生工学・疾患モデル研究会講演会
  • Place of Presentation: 東京大学
  • Year and Date: 2005-11-15
• [Presentation] ヒストンアセチル化やクロマチン再編成を介した相同組換え反応の制御 (2005)
  • Author(s): 太田邦史
  • Organizer: 日本放射線影響学会ワークショップ
  • Place of Presentation: 広島
  • Year and Date: 2005-11-15
• [Presentation] 出芽酵母Mre11、Spo11の染色体への結合と減数分裂期DNA複製、コヒーシンとの関係 (2005)
  • Author(s): 久郷和人, ら
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] 減数分裂期特異的DNA二重鎖切断機構の解明 (2005)
  • Author(s): 笹沼博之, ら
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] 減数分裂期組換えホットスポットでのクロマチンリモデリング (2005)
  • Author(s): 廣田耕志, ら
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Book] Methodx in Molecular Biology(Analysis of chromatin structure at meiotic DSB sites in yeasts."Meiosis: Vol 1, Molecular and Genetic Method") (2009)
  • Author(s): eds, Scott Keeney
  • Publisher: Springer
• [Book] Methods in Molecular Biology(eds Scott Keeney, Genome-wide high-resolution chromatin immunoprecipitation of meiotic chromosomal proteins in S. cerevisiae "Meiosis: Vol 1, Molecular and Genetic Method") (2009)
  • Author(s): Kugou K., Ohta K.
  • Publisher: Springer
• [Book] Biotechnology and Genetic Engineering Reviews (UK)(Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation and its application to antibody engineering.) (2007)
  • Author(s): Seo H., Yamada T., Hashimoto S., Lin W., Ohta K.
• [Book] B細胞ディスプレイによる新しい生体外抗体作製技術:ADLibシステム太田邦史in「抗体医薬の最前線」 (2007)
  • Publisher: CMC出版
• [Book] 特集「染色体サイクル」における「減数分裂の組換え開始機構」 (2007)
  • Author(s): 廣田耕志、福田智行、太田邦史
  • Total Pages: 215
  • Publisher: 羊土社
• [Book] DNA組換えの制御(蛋白質核酸酵素増刊号「細胞核の世界」p2134-2140) (2006)
  • Author(s): 太田邦史, 久郷和人
  • Total Pages: 383
  • Publisher: 共立出版
• [Book] 細胞生物学実験法 III 細胞解析法(IV) (2005)
  • Author(s): 大熊勝治編, 安藤祥司ら(14名)
  • Total Pages: 110
  • Publisher: 廣川書店
• [Remarks] Genes & Genetic Systems Award 2008(日本遺伝学会論文賞)
• [Remarks] 平成19年(2007年)文部科学大臣表彰科学技術賞(研究部門)プレス発表
• [Remarks] 「ガラクタ」RNAの遺伝子活性化における新しい役割(2008/9/29)
• [Remarks] 生命多様化のエンジン:組み換え酵素Spo11活性化機構を解明(2008. 2. 1)
• [Remarks] ガン化と関連する異常なdna組換えを抑えるタンパク質のsumo化を発見(2006/11/3)
• [Remarks]
  • URL: http://www.riken.go.jp/r-world/info/release/press/2008/080201_2/detail.html
• [Remarks]
  • URL: http://www.u-tokyo.ac.jp/public/public01_200929_j.html
• [Remarks]
  • URL: http://www.ohta-lab.c.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.ohta-lab.c.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.riken.goJp/r-world/info/release/press/2008/080201-2/detail.html
• [Remarks]
  • URL: http://www.u-tokyo.acJp/public/public01200929j.html
• [Remarks]
  • URL: http://www.riken.go.jp/r-world/info/release/press/2008/080201_2/detail.html
• [Patent(Industrial Property Rights)] 変異体植物、その製造方法及び遺伝学的組換え頻度を上昇させる方法 (2010)
  • Inventor(s): 太田邦史、大里修一、近藤聡、大音徳、光川典宏、村本伸彦、杉本広樹
  • Industrial Property Rights Holder: 理化学研究所、トヨタ自動車、豊田中央研究所
  • Filing Date: 2010-01-15
• [Patent(Industrial Property Rights)] 変異体植物、その製造方法及び遺伝学的組換え頻度を上昇させる方法 (2010)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・トヨタ自動車・豊田中研
  • Industrial Property Number: 2010-007220
  • Filing Date: 2010-01-15
• [Patent(Industrial Property Rights)] キメラ抗体の一段階作製方法 (2009)
  • Inventor(s): 太田邦史、Lin Waka
  • Industrial Property Rights Holder: 理化学研究所、東京大学
  • Filing Date: 2009-10-19
• [Patent(Industrial Property Rights)] 光反応性化合物を有する磁気ビーズへの化合物の固定法 (2009)
  • Inventor(s): 太田邦史、村山晃歩、長田裕之、本田香織
  • Industrial Property Rights Holder: 理化学研究所、東京大学
  • Filing Date: 2009-05-13
• [Patent(Industrial Property Rights)] キメラ抗体の一段階作製方法 (2009)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・東京大学
  • Industrial Property Number: 2009-240270
  • Filing Date: 2009-10-19
• [Patent(Industrial Property Rights)] 光反応性化合物を有する磁気ビーズへの化合物の固定法 (2009)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・東京大学
  • Industrial Property Number: 2009-116325
  • Filing Date: 2009-05-13
• [Patent(Industrial Property Rights)] 耐熱性多頻度dna切断酵素の細胞内活性化によるゲノム再編成の誘発方法 (2008)
  • Inventor(s): 太田邦史、廣田耕志、瀬尾秀宗、柴田武彦
  • Industrial Property Rights Holder: (独)理化学研究所・(独)科学技術振興機構
  • Acquisition Date: 2008-07-25
• [Patent(Industrial Property Rights)] クロマチン再編成因子の機能改変による相同組換えの制御方法 (2008)
  • Inventor(s): 太田邦史、水野健一、柴田武彦
  • Industrial Property Rights Holder: (独)理化学研究所・(独)科学技術振興機構
  • Acquisition Date: 2008-12-26
• [Patent(Industrial Property Rights)] 体細胞相同組換えの促進方法及び特異的抗体の作製方法 (2008)
  • Inventor(s): 太田邦史、瀬尾秀宗、柴田武彦
  • Industrial Property Rights Holder: (独)理化学研究所・(独)科学技術振興機構
  • Acquisition Date: 2008-11-04
• [Patent(Industrial Property Rights)] 体細胞相同組換えの促進方法及び特異的抗体の作製方法 (2008)
  • Inventor(s): 太田邦史、瀬尾秀宗、柴田武彦
  • Industrial Property Rights Holder: (独)理化学研究所・(独)科学技術振興機構
  • Acquisition Date: 2008-04-09
• [Patent(Industrial Property Rights)] 耐熱性多頻度DNA切断酵素の細胞内活性化によるゲノム再編成の誘発方法 (2008)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・JST
  • Filing Date: 2008-07-25
• [Patent(Industrial Property Rights)] クロマチン再編成因子の機能改変による相同組換えの制御方法 (2008)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・JST
  • Filing Date: 2008-12-26
• [Patent(Industrial Property Rights)] 体細胞相同組換えの促進方法及び特異的抗体の作製方法 (2008)
  • Inventor(s): 太田邦史, ら
  • Industrial Property Rights Holder: 理化学研究所・JST
  • Filing Date: 2008-11-14
• [Patent(Industrial Property Rights)] 抗体遺伝子変異部位の分布状況の調節法 (2006)
  • Inventor(s): Lin Waka, 太田邦史、瀬尾秀宗
  • Industrial Property Rights Holder: 理化学研究所
  • Filing Date: 2006
• [Patent(Industrial Property Rights)] 組換え開始酵素認識配列の低侵襲染色体導入による減数分裂期組換え分布の制御法 (2006)
  • Inventor(s): 福田智行、太田邦史
  • Industrial Property Rights Holder: 理化学研究所
  • Filing Date: 2006-10-12
• [Patent(Industrial Property Rights)] 組換え開始酵素認識配列の低侵襲染色体導入による減数分裂期組換え分布の制御法 (2006)
  • Inventor(s): 福田智行, 太田邦史
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2006-278217
  • Filing Date: 2006-10-12
• [Patent(Industrial Property Rights)] 耐熱性多頻度DNA切断酵素の細胞内活性化によるゲノム再編成の誘発方法 (2005)
  • Inventor(s): 太田 邦史, 瀬尾 秀宗, 廣田 耕志, 柴田 武彦
  • Industrial Property Rights Holder: 理化学研究所・JST
  • Filing Date: 2005-11-22